Drug Development.

Background: Solanezumab, a promising treatment for Alzheimer's disease, has captured the attention of the medical community. This monoclonal antibody is designed to target and clear beta-amyloid plaques, a hallmark feature of Alzheimer's, from the brain. While initial clinical trials showed mixed results, ongoing research is exploring its potential to slow cognitive decline and improve the lives of those affected by this devastating neurodegenerative condition.

Dementia Care Practice.

Integrating balance and cognitive training of varied intensities through exergame balance training may offer a distinct approach to enhancing balance and cognitive abilities in patients with mild cognitive impairment. The objective is to determine the relationship and effects of exergame balance training of different intensities on balance and cognition in patients with mild cognitive impairment (MCI). In this four-arm parallel design Randomized Clinical Trial, ninety-seven participants with mild cognitive impairments MoCA (18-24), between the ages of 50 and 75 years, participated in novel exergame balance training.

Trends and disparities in cardiovascular disease-related mortality among adults with myeloproliferative neoplasms in USA.

Aims: We aimed to perform a retrospective cohort study using the Centers for Disease Control and Prevention's (CDC's) Wide-Ranging Online Data for Epidemiologic Research (WONDER) database to analyse the trends in cardiovascular disease (CVD)-related mortality in patients with myeloproliferative neoplasms (MPNs) from 1999 to 2020.

Methods And Results: We analysed the death certificate data from the CDC WONDER database from 1999 to 2020 for CVD with co-morbid myeloproliferative disorders in the US population. Age-adjusted mortality rates (AAMRs) and 95% confidence intervals (CIs) were computed per 1 million population by standardizing crude mortality rates to the 2000 US census population.

Assessment of Coronary Collaterals Among Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention and its Impact on In-hospital and 30-day Mortality: A Prospective Observational Study.

Objectives: This study aimed to determine the distribution of coronary collaterals (CC) as per the Rentrop Collateral Score (RCS) among patients with ST-segment elevation myocardial infarction (STEMI) and its impact on in-hospital and 30-day mortality after primary percutaneous coronary intervention (PCI).

Methods: In this study, a selected sample of consecutive STEMI patients was assessed for the development of CC as per the RCS classification. An RCS grade of 2 or 3 was taken as the presence of CC with either partial or complete filling of the infarct-related artery (IRA).

Evaluating the potential of in alleviation of aluminium stress in .

Soil contamination with toxic heavy metals [such as aluminum (Al)] is becoming a serious global problem due to the rapid development of the social economy. Although plant growth-promoting rhizo-bacteria (PGPR) are the major protectants to alleviate metal toxicity, the study of these bacteria to ameliorate the toxic effects of Al is limited. Therefore, the present study was conducted to investigate the combined effects of different levels of (5 ppm and 10 ppm) of accession number of MT123456 on plant growth and biomass, photosynthetic pigments, gas exchange attributes, oxidative stress and response of antioxidant compounds (enzymatic and nonenzymatic), and their specific gene expression, sugars, nutritional status of the plant, organic acid exudation pattern and Al accumulation from the different parts of the plants, which was spiked with different levels of Al [0 µM (i.

Knowledge, Attitude, and Practice (KAP) Regarding the Use of Artificial Intelligence in Hospital Settings in Mardan, Khyber Pakhtunkhwa, Pakistan.

Background Artificial intelligence (AI) is revolutionizing healthcare globally by enhancing diagnostic accuracy, predicting patient outcomes, and enabling personalized treatment plans. However, in low- and middle-income countries (LMICs) like Pakistan, the integration of AI into healthcare is limited due to challenges such as lack of funding, provider resistance, and inadequate training. Despite these barriers, there is growing interest among healthcare providers in understanding and adopting AI technologies to improve professional efficiency.

Necessity of Tendoachilles Tenotomy in Patients With Congenital Talipes Equinovarus (CTEV) Treated Using the Ponseti Technique: A Prospective Cohort Study.

Aim: This study aims to determine how often Achilles tenotomy is performed on patients who have congenital talipes equinovarus (CTEV) and have been managed with Ponseti serial casts.

Materials And Methods: This prospective cohort study took place from November 2021 to May 2023 in the orthopedic unit of Hayatabad Medical Complex, Peshawar, Pakistan. About 38 pediatric patients with CTEV, who received treatment in the form of Ponseti casting, were enrolled in the study.

Impact of Metabolic Dysfunction-Associated Fatty Liver Disease on the Prognosis of Patients With Hepatocellular Carcinoma After Radical Resection: A Retrospective Study.

Introduction Although metabolic dysfunction-associated fatty liver disease (MAFLD) is becoming more common in individuals with hepatocellular carcinoma (HCC), it is still unknown how this condition relates to postoperative complications of HCC. While hepatitis B/C virus (HBV/HCV) infection and alcohol use are primary risk factors, MAFLD has emerged as a significant contributor to HCC incidence. Understanding the prognostic impact of MAFLD on HCC outcomes, particularly post-radical resection, is essential.

A Review for automated classification of knee osteoarthritis using KL grading scheme for X-rays.

Osteoarthritis (OA) is a musculoskeletal disorder that affects weight-bearing joints like the hip, knee, spine, feet, and fingers. It is a chronic disorder that causes joint stiffness and leads to functional impairment. Knee osteoarthritis (KOA) is a degenerative knee joint disease that is a significant disability for over 60 years old, with the most prevalent symptom of knee pain.

Cracking the code: the clinical and molecular impact of aminopyridines; a review (2019-2024).

Aminopyridines belong to a class of compounds that are monoamino and diamino derivatives of pyridine. They work primarily by blocking voltage-gated potassium channels in a dose-dependent manner. Essential heterocycles used extensively in synthetic, natural products, and medicinal chemistry are aminopyridine and its derivatives.

Effects of a multimedia campaign to increase human papillomavirus vaccine acceptance in Dhaka, Bangladesh.

Increasing the uptake of Human Papillomavirus (HPV) vaccine among adolescent girls is a high priority for the government of Bangladesh. This study examines correlates of HPV vaccine adoption in Dhaka Division, the largest division in Bangladesh. The 18-day vaccination campaign was accompanied by multimedia messages.

Removal of a circumferentially torn stuck balloon from a calcified right ventricle to pulmonary artery conduit.

We report a case of right ventricle to pulmonary artery conduit angioplasty in which a valvuloplasty balloon ruptured circumferentially and was retained within the conduit. A high-pressure balloon was used to relieve the obstruction and free the ruptured balloon. The procedure was further complicated when the distal part of the balloon broke away from the proximal part during an attempt to retrieve it back into the femoral sheath.

Microscopic Techniques for Nanomaterials Characterization: A Concise Review.

Nanomaterials have been gaining interest due to their remarkable properties at the nanoscale. The surface area of particles becomes high at the nanoscale because of this virtue, they have been used in a bundle of applications like electronics, biomedical, agriculture, wastewater treatment, semiconductor industry, cosmetics, drug delivery, paints, and so forth. The morphology (size and shape) of nanomaterials plays an important role because each application requires the appropriate morphology for better performance.

Morphological Features Influence the Drug Loading and Delivery Efficacy of Photoactivatable Gold Nanocarriers for Antitumor Photo/Chemotherapy.

Photoactivatable gold nanocarriers are transforming antitumor therapies by leveraging their distinctive physicochemical properties, enabling targeted drug delivery and enhanced therapeutic efficacy in cancer treatment. This study systematically investigates how surface topography and morphology of gold nanocarriers influence drug loading capacity, light-to-heat conversion efficiency, and overall therapeutic performance in photo/chemotherapy. We synthesized four distinct morphologies of gold nanoparticles: porous gold nanocups (PAuNCs), porous gold nanospheres (PAuNSs), solid gold nanocups (SAuNCs), and solid gold nanospheres (SAuNSs).

Reliability generalization meta-analysis of the internal consistency of the Big Five Inventory (BFI) by comparing BFI (44 items) and BFI-2 (60 items) versions controlling for age, sex, language factors.

Introduction: The Big Five Inventory (BFI) is a popular measure that evaluates personality on the Big-Five model. Apart from its utilization across cultures, the literature did not reveal any meta-analysis for the reliability of the different versions of the BFI and its translations. The current study carried out a reliability generalization meta-analysis (REGEMA) to establish the reliability of the BFI across cultures and languages.

Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic review and meta-analysis.

Background: Dental caries is one of the most common non-communicable diseases in humans. Various interventions are available for the management, of which microinvasive techniques such as infiltration, sealants, glass ionomers, are novel and convenient. The purpose of this systematic review and meta-analysis was to compare microinvasive techniques with noninvasive or invasive treatment modalities in terms of effectiveness in halting interproximal caries lesion progression radiographically assessed.

Detection and identification of Naegleria species along with Naegleria fowleri in the tap water samples.

Naegleria fowleri, the causative agent of Primary Amoebic Meningoencephalitis (PAM), is commonly found in warm freshwater environments and can enter the brain through nasal passages during activities like swimming or ablution. PAM has a high fatality rate, raising concerns about its global health impact. In Pakistan, particularly in Karachi, a significant number of cases have been reported, often with no history of recreational water exposure, but with regular ablution using tap water.

Fertigation with alpha-tocopherol enhances morphological, physiological, and antioxidant responses in radish (Raphanus sativus L.) under drought stress.

Water scarcity is a foremost environmental concern and is expected to hasten in the forthcoming years due to severe fluctuations in weather patterns worldwide. The present work was designed to explore the potential role of alpha-tocopherol (α-Toc), a form of vitamin E, on the morphological, physio-biochemical, and cellular antioxidant responses of two radish genotypes grown under drought conditions (38 ± 3% of field capacity). The individual and combined applications of α-Toc (100 ppm) were used as T0- Control, T1- Control + TF (TF-alpha-tocopherol), T2- Drought (D), and T3- D + TF with three replications.

HCV and HBV genotypes: vital in the progression of HCV/ HBV co-infection.

Background: Viral hepatitis is the major contributor to liver cirrhosis and hepatocellular carcinoma (HCC). Studies indicated that the co-infection of hepatitis C and hepatitis B virus also prompts liver damage progression. Therefore, in the present study, the prevalence of HCV-HBV co-infection and the impact of HCV-HBV co-infection on the progression of liver damage was evaluated amongst the HCV-infected patients in Pakistan.

Global Prevalence of Mental Health Problems Among Cancer Survivors: A Meta-Analysis From 31 Countries.

Background: With the improvement of medical treatment, the survival rate of cancer patients continues to rise; however, their psychological issues require further management. Currently, there is uncertainty regarding the prevalence of mental health problems among cancer survivors.

Objective: To quantitatively summarize the global prevalence of mental health problems in cancer survivors.

Optimizing concrete sustainability with bagasse ash and stone dust and its impact on mechanical properties and durability.

Addressing environmental challenges such as pollution and resource depletion requires innovative industrial and municipal waste management approaches. Cement production, a significant contributor to greenhouse gas emissions, highlights the need for eco-friendly building materials to combat global warming and promote sustainability. This study evaluates the simultaneous use of Sugarcane Bagasse Ash (SCBA) and Stone Dust (SD) as partial replacements by volume for cement and sand, respectively, at varying ratios in eco-strength concrete mixes designed for 28 MPa (ES-28) and 34 MPa (ES-34), emphasizing their economic and environmental benefits.

Antioxidant Responses in Chromium-Stressed Maize as Influenced by Foliar and Root Applications of Fulvic Acid.

Maize (Zea mays L.) faces significant challenges to its growth and productivity from heavy metal stress, particularly Chromium (Cr) stress, which induces reactive oxygen species (ROS) generation and damages photosynthetic tissues. This study aimed to investigate the effects of fulvic acid (FA) application, via foliar spray or root irrigation, on mitigating chromium stress in maize by evaluating its impact on antioxidant activity and growth parameters.