Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials.

Background: Impaired intrauterine growth, a significant global health problem, contributes to a higher burden of infant morbidity and mortality, mainly in resource-poor settings. Maternal anemia and undernutrition, two important causes of impaired intrauterine growth, are prioritized by global nutrition targets of 2030. We synthesized the evidence on the role of preconception nutrition supplements in reducing maternal anemia and improving intrauterine growth.

Synergistic effects of PGPRs and fertilizer amendments on improving the yield and productivity of Canola (Brassica napus L.).

Background: Organic fertilizers are safer and more eco-friendly than chemical fertilizers; hence, organic fertilizers can be used to support sustainable farming. The effects of PGPRs are manifold in agriculture, especially in monoculture crops, where the soil needs to be modified to increase germination, yield, and disease resistance. The objective of this study was to assess the effects of PGPRs combined with fertilizer on the yield and productivity of canola.

A combinatory approach of non-chain ring and henon map for image encryption application.

Algebraic structures play a vital role in securing important data. These structures are utilized to construct the non-linear components of block ciphers. Since constructing non-linear components through algebraic structures is crucial for the confusion aspects of encryption schemes, relying solely on these structures can result in limited key spaces.

Photocatalytic removal of textile wastewater-originated methylene blue and malachite green dyes using spent black tea extract-coated silver nanoparticles.

The spent black tea extract was utilized in order to synthesize the spent black tea silver nanoparticles (SBT-AgNPs). Various parameters were tested to yield the best production of SBT-AgNPs. The characterization was conducted by X-Ray diffraction, Scanning electron microscopy, Zeta potential and energy dispersive X-ray (EDX).

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores.

Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D and T2D have been shown to work relatively well in South Asians, despite being derived from largely European-ancestry samples. Here we used PRSs to investigate the rate of potential misclassification of diabetes amongst British Bangladeshis and Pakistanis.

Exploring novel solitary wave phenomena in Klein-Gordon equation using model expansion method.

In this study, the -model expansion method is showed to be useful for finding solitary wave solutions to the Klein-Gordon (KG) equation. We develop a variety of solutions, including Jacobi elliptic functions, hyperbolic forms, and trigonometric forms, so greatly enhancing the range of exact solutions attainable. The 2D, 3D, and contour plots clearly show different types of solitary waves, like bright, dark, singular, and periodic solitons.

Green synthesized FeNPs ameliorate drought stress in Spinacia oleracea L. through improved photosynthetic capacity, redox balance, and antioxidant defense.

The present study was designed to highlight the ameliorative role of iron nanoparticles (FeNPs) against drought stress in spinach (Spinacia oleracea L.) plants. A pot experiment was performed in two-way completely randomize design with three replicates.

Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders.

Tyrosine-protein kinase Src plays a key role in cell proliferation and growth under favorable conditions, but its overexpression and genetic mutations can lead to the progression of various inflammatory diseases. Due to the specificity and selectivity problems of previously discovered inhibitors like dasatinib and bosutinib, we employed an integrated machine learning and structure-based drug repurposing strategy to find novel, targeted, and non-toxic Src kinase inhibitors. Different machine learning models including random forest (RF), k-nearest neighbors (K-NN), decision tree, and support vector machine (SVM), were trained using already available bioactivity data of Src kinase targeting compounds.

Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms.

Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms.

Assessing the Efficacy of Farnesoid X Receptor Agonists in the Management of Metabolic Dysfunction-associated Steatotic Liver Disease: A Systematic Review and Meta-analysis: Efficacy of Farnesoid X Receptor Agonists in Metabolic Dysfunction-associated Steatotic Liver Disease: Systematic Review and Meta-analysis.

Background And Aims: Several randomized clinical trials have been conducted assessing the potential efficacy of Farnesoid X receptor (FXR) agonists in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive review and analysis were needed to evaluate the findings of these trials. Hence, this systematic review and meta-analysis aim to study the association between FXR agonists and hepatic outcomes in patients with MASLD.

Comparing the efficacy and safety of extended vs standard dosing of ocrelizumab in MS: A systemic review and meta-analysis.

Introduction: Multiple Sclerosis (MS) is a challenging autoimmune disease that disrupts the central nervous system, leading to a range of symptoms. Ocrelizumab, a treatment commonly used for MS, targets B cells to help manage the disease. While the standard-interval dosing (SID) is effective, the COVID-19 pandemic raised concerns about safety, particularly around immune responses.

Molecular epidemiology and phylogenetic insights of lumpy skin disease in cattle from diverse agro-ecological regions of Punjab, Pakistan.

Lumpy skin disease (LSD) is an emerging, highly contagious transboundary disease of bovines caused by the Lumpy skin disease virus (LSDV), responsible for substantial economic losses to the dairy, meat, and leather industries in Pakistan as well as various countries around the world. Epidemiological information on LSD is scarce in Punjab, Pakistan. Therefore, a molecular epidemiological study was conducted in two agro-ecologically diverse districts (Bhakkar and Jhang) of Punjab, Pakistan.

Trends in the levels, causes, and risk factors of maternal mortality in Pakistan: A comparative analysis of national surveys of 2007 and 2019.

Background: Maternal mortality ratio (MMR) has decreased worldwide but Pakistan is still striving towards achieving the SDG targets for maternal health. This study highlights the trends in maternal mortality levels and risk factors in Pakistan between 2007 and 2019.

Methods: This study compares the results of secondary data analysis of the Pakistan Maternal Mortality Survey 2019 with the Pakistan Demographic and Health Survey 2007.

Identification of differentially expressed non-coding RNAs in the plasma of women with preterm birth.

This study aimed to identify differentially expressed non-coding RNAs (ncRNAs) associated with preterm birth (PTB) and determine biological pathways being influenced in the context of PTB. We processed cell-free RNA sequencing data and identified seventeen differentially expressed (DE) ncRNAs that could be involved in the onset of PTB. Per the validation via customized RT-qPCR, the recorded variations in expressions of eleven ncRNAs were concordant with the analyses.

Phytochemical Profiling and Biological Activities of Nigella sativa Vinegar Extract: An Insight Into Hypoglycemic Potential Using In Vivo and In Silico Studies.

The current study was conducted to characterize the vinegar extract of Nigella sativa and evaluate its biological activities using in vitro and in vivo studies. The N. sativa extract (NSE) was prepared by macerating seeds in a mixture of water and synthetic vinegar (1:10).

Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis.

Background: Patients on long-term dialysis for end-stage kidney disease have a high mortality rate, predominantly due to sudden cardiac death (SCD), which is associated with an increased risk of arrhythmias compared to the general population. Thus, the current systematic review and meta-analysis aimed to investigate the incidence of SCD among dialysis patients at risk of arrhythmia.

Methods: This systematic review and meta-analysis followed the PRISMA guidelines.

Psychometric validation of the 8-Item Urdu Stigma Scale for Chronic Illness (SSCI-8) in people with Parkinson's disease.

Objectives: Disease-related stigma is associated with poor mental health and wellbeing in people with Parkinson's disease. Urdu language tools for measuring stigma are not yet available. The aim of this study was therefore to develop and validate an Urdu version of the Stigma Scale for Chronic Illness-8 (SSCI-8).

Commentary on "A Pilot Study Investigating the Influence of Dietary Boron Levels on Osteoporosis in Postmenopausal Women".

This letter discusses the potential influence of dietary boron on osteoporosis in postmenopausal women, a demographic significantly affected by this condition. Recent studies suggest that boron plays a critical role in bone health by modulating mineral metabolism and hormonal balance. Despite its potential benefits, boron is often overlooked in dietary recommendations for this group.

Citronellol Induces Apoptosis via Differential Regulation of Caspase-3, NF-κB, and JAK2 Signaling Pathways in Glioblastoma Cell Line.

Citronellol (CT) is a naturally occurring lipophilic monoterpenoid which has shown anticancer effects in numerous cancerous cell lines. This study was, therefore, designed to examine CT's potential as an anticancer agent against glioblastoma (GBM). Network pharmacology analysis was employed to identify potential anticancer targets of CT.

Recent Perspectives on Anticancer Potential of Coumarin Against Different Human Malignancies: An Updated Review.

Coumarins, a group of naturally occurring compounds, have been reported to demonstrate anticancer potential. These substances, distinguished by their combined benzene and α-pyrone rings, have been demonstrated to impact multiple cellular mechanisms essential for the initiation and advancement of cancer. These agents work in different ways that prevent different tumor cells from growing, spreading, and increasing.

Unlocking the Potential: How Flavonoids Affect Angiogenesis, Oxidative Stress, Inflammation, Proliferation, Invasion, and Alter Receptor Interactions in Endometriosis.

Endometriosis, though not classified as a carcinogenic condition, shares features such as oxidative stress, migration, invasion, angiogenesis, and inflammation with tumor cells. This study aims to review the effects of flavonoids on these processes and their molecular mechanisms in preventing and treating endometriosis. A comprehensive review was conducted, involving a literature search in online databases using keywords like "endometriosis," "endometrioma," and "flavonoid.

Synergistic Beneficial Effects of Flaxseed ( L.) Oil and Olive ( L.) Oil Against Metabolic Dysfunction Associated Fatty Liver and Its Complications.

Flaxseed and olive oil effectively treat numerous diseases and health conditions, particularly metabolic disorders. Traditional medicine has used both oils for managing cardiovascular disease, diabetes, gastrointestinal dysfunctions, metabolic-dysfunction-associated fatty liver disease (MAFLD), obesity, and more. This review explores the bioactive and polyphenolic compounds in flaxseed and olive oils that provide anti-inflammatory, antioxidant, anti-microbial, hepatoprotective, cardioprotective, antidiabetic, and gastroprotective benefits.

Comparative Investigation of the Nutritional Profiling and Antipyretic Activity of Leaves, Bark, and Root From Different Sites of Punjab, Pakistan.

The utilization of various plant sections as a medicinal and nutritional source for humans and animals has been the subject of significant research in recent years. This study aimed to investigate the nutritional profiling through proximate analysis and the antipyretic activity of leaves, bark, and root in methanolic extract from different sites of Punjab, Pakistan. Methanolic extract of leaves, bark, and root from sites i to e of Southern Punjab, Central Punjab, and Northwest Punjab as S1, S2, and S3, respectively, at doses of 50, 100, and 150 mg/kg bw showed statistically significant results as compared to the positive and negative controls.

Novel Transfer Learning Approach for Detecting Infected and Healthy Maize Crop Using Leaf Images.

Maize is a staple crop worldwide, essential for food security, livestock feed, and industrial uses. Its health directly impacts agricultural productivity and economic stability. Effective detection of maize crop health is crucial for preventing disease spread and ensuring high yields.