Combination Drug Therapy for the Management of Chronic Neuropathic Pain.

Chronic neuropathic pain (NP) is an increasingly prevalent disease and leading cause of disability which is challenging to treat. Several distinct classes of drugs are currently used for the treatment of chronic NP, but each drug targets only narrow components of the underlying pathophysiological mechanisms, bears limited efficacy, and comes with dose-limiting side effects. Multimodal therapies have been increasingly proposed as potential therapeutic approaches to target the multiple mechanisms underlying nociceptive transmission and modulation.

Fast-Acting Sub-perception Spinal Cord Stimulation for a Case of Painful Diabetic Polyneuropathy. Just an Antalgic Treatment or Even a Therapy?

Introduction: Painful diabetic polyneuropathy (P-DPN) occurs in 20% - 30% of diabetic patients. Currently, therapeutic strategies include lifestyle modifications, good glycemic control, and neuropathic pain drugs. Spinal cord stimulation (SCS) has been shown to be successful in patients who have not responded to other treatments.

The Role of Hypertonic Saline in Ablative Radiofrequency of the Sacroiliac Joint: Observational Study of 40 Patients.

Background: The aim of this retrospective uncontrolled article is to illustrate a technique of neurotomy of the sensitive branches of S1 S2 S3 in RFA that appears to result in a better success rate and longer-lasting pain relief.

Methods: 40 patients were treated, 26 females and 14 males, with an average age of 74 (92-55). After the examination, the patients underwent an ultrasound-guided diagnostic block of the affected sacroiliac joint.

Peripheral Nerve Stimulation: Two Cases of Intractable Neuropathic Pain.

Introduction: Neuropathic pain can be caused by several pathologies affecting the nervous system. Peripheral neuralgias may be related to nerve entrapment, traumatic or iatrogenic events, and may also accompany many other diseases. Peripheral nerve stimulation is effective in treating many of these neuralgic syndromes.