9 results match your criteria: "Padm. Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research[Affiliation]"
Evaluation of Anti-inflammatory and Antimicrobial Activity of AHPL/AYCAP/0413 Capsule.
Pharmacognosy Res
January 2017
Manager - Analytical Department, R & D Center, Ari Healthcare Private Limited, Unit No. 401, International Biotech Park, BTS 2 Building, Chrysalis Enclave, 4 Floor, Plot No - 2A, MIDC Phase II, Hinjewadi, Pune, Maharashtra, India.
Background: Conventional therapeutic agents used for treatment of Acne are associated with various adverse effects necessitating development of safe and effective alternative therapeutic agents. In this context, a polyherbal formulation AHPL/AYCAP/0413 was developed for treatment of Acne.
Objectives: To evaluate Anti-inflammatory and antimicrobial activity of AHPL/AYCAP/0413.
Evaluation of anti-diabetic activity of AHPL/AYTAB/0513 tablet in streptozotocin induced diabetes in rats.
Int J Pharm Investig
January 2017
Ari Healthcare Private Limited, International Biotech Park, Hinjewadi, Pune, Maharashtra, India.
Background: Diabetes is a chronic, progressive disease associated with several complications leading to significant mortality and morbidity. Limitations and drawbacks of the conventional treatment generate need for safer, effective complimentary therapies to prevent complications, and maintain normoglycemic status.
Aim And Objectives: The aim of this study is to to evaluate antidiabetic activity of AHPL/AYTAB/0513 tablet alone, oral hypoglycemic agents (OHA[s]), and combination of AHPL/AYTAB/0513 tablet and OHA(s) in streptozotocin-induced diabetes in rats.
Ameliorative effect of Luffa acutangula Roxb. on doxorubicin induced cardiac and nephrotoxicity in mice.
Indian J Exp Biol
February 2013
Department of Pharmacology, Padm Dr D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411 018, India.
The present study reports protective effect of hydro-alcoholic extract of Luffa acutangula (HAELA) on doxorubicin (DXR) induced cardio and nephrotoxicity in mice by studying various serum biomarkers, antioxidants in target organs and histoarchitecture alterations. Pretreatment with HAELA reversed significantly the elevated serum biomarkers, alanine amino transferase, lactate dehydrogenase and creatinine phosphokinase in heart and kidney in DXR treated mice. In addition, HAELA treatment inhibited elevated malondialdehyde formation and restored the depleted glutathione, catalase, superoxide dismutase in heart and kidney tissue.
View Article and Find Full Text PDFAmelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model.
Life Sci
July 2013
Department of Pharmacology, Sinhgad Technical Education Society, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410 401, India. Electronic address:
Article Synopsis
- The study evaluated the neuroprotective effects of silymarin, piracetam, and protocatechuic acid ethyl ester (PCA) on cerebral global ischemic/reperfusion in a rat model.
- The methods included a blockage of blood flow in the carotid arteries for 30 minutes followed by a 24-hour recovery period, during which various neurological and physiological functions were assessed.
- Silymarin and PCA improved cognitive and motor functions, along with reducing brain damage, while piracetam showed some benefits but did not significantly enhance the body's natural defense systems.
Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: a comparative evaluation with piracetam and protocatachuic acid.
Pharmacol Biochem Behav
August 2012
Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune 411018, India.
Article Synopsis
- A study was conducted on rats with focal ischemia to compare the neuroprotective effects of silymarin, piracetam, and protocatechuic acid ethyl ester (PCA).
- Both silymarin (200 mg/kg) and PCA showed significant improvements in behavioral, biochemical, and histopathological outcomes, and they reduced brain water content and infarct size.
- Silymarin was found to be more effective than both PCA and piracetam, particularly in restoring behavior and antioxidant levels during focal ischemia/reperfusion.
DPP IV inhibitors: successes, failures and future prospects.
Diabetes Metab Syndr
August 2013
Department of Pharmacology, Padm. Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, Maharashtra, India.
The dipeptidyl peptidase IV (DPP IV) enzyme is a novel target for the treatment of type 2 diabetes. Several DPP IV inhibitors are in the clinical development, since they are safe and tolerable with no increased risk of adverse events compared to placebo and have a low risk of hypoglycemia. They are flourishing as monotherapy and also in combination with commonly prescribed antidiabetic agents and are appropriate for once-daily oral dosing.
View Article and Find Full Text PDFHepatoprotective activity of Luffa acutangula against CCl4 and rifampicin induced liver toxicity in rats: a biochemical and histopathological evaluation.
Indian J Exp Biol
August 2010
Department of Pharmacology, Padm Dr D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411 018, India.
Hepatoprotective activity of hydroalcoholic extract of Luffa acutangula (HAELA) against carbon tetrachloride (CCl4) and rifampicin-induced hepatotoxicity in rats was evaluated and probable mechanism(s) of action has been suggested. Administration of standard drug- silymarin and HAELA showed significant hepatoprotection against CCl4 and rifampicin induced hepatotoxicity in rats. Hepatoprotective activity of HAELA was due to the decreased levels of serum marker enzymes viz.
View Article and Find Full Text PDFStem bark extraction of Ficus bengalensis Linn for anti-inflammatory and analgesic activity in animal models.
Indian J Exp Biol
January 2010
Department of Pharmacology, Padm Dr D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune 411018, India.
In the present study, anti-inflammatory and analgesic effect of aqueous extract of Ficus bengalensis (AEFB) and methanolic extract of F. bengalensis (MEFB) was evaluated in animal models. Preliminary results indicated that MEFB treatment possesses significant anti-inflammatory potential as compared to AEFB.
View Article and Find Full Text PDFEffect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice.
J Ethnopharmacol
March 2009
Department of Pharmacology, Padm. Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune 411018, India.
Ethnopharmacological Relevance: The bark of Tectona grandis Linn. is traditionally used in the treatment of diabetes.
Aim: The present study was undertaken to investigate the effect of ethanolic extract of bark of Tectona grandis Linn.