Early Mobilization in Post-Orthopedic Surgery Patients: A Scoping Review.

Post-orthopedic surgery patients need to undergo a recovery process with immobilization to minimize pain or swelling. Maximum care through early mobilization intervention can accelerate the return of body function and minimize medical complications. This literature review aims to determine early mobilization-based interventions that can be applied to post-orthopedic surgery patients.

Peripheral Classic and Intermediate Monocyte Subsets as Immune Biomarkers of Systemic Lupus Erythematosus Disease Activity.

Background: Monocytes are evolutionarily preserved innate immune cells that play essential roles in immune response regulation. Three activated monocyte subsets-classical (CD14++CD16-), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++)-are associated with systemic lupus erythematosus (SLE) progression. This study aims to determine the association of monocyte subsets with SLE disease activity.

Benefits of Remote-Based Mindfulness on Physical Symptom Outcomes in Cancer Survivors: Systematic Review and Meta-Analysis.

Background: Many cancer survivors experience a wide range of symptoms closely linked to psychological problems, highlighting the need for psychological treatment, one of the most popular being mindfulness. The use of the internet has greatly increased in the last decade, and has encouraged the use of remote-based interventions to help people living with cancer access treatment remotely via devices.

Objective: The primary aim of this study was to explore the efficacy of internet-based mindfulness interventions on the physical symptoms of people living with cancer, where physical symptoms are defined as distressing somatic experiences (eg fatigue, insomnia, and pain) regardless of the underlying cause.

Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach.

The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, a specific form of arthritis. The condition calls for a combined curative and preventive management model. A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines.

Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus.

Objective: To estimate the prevalence of organ damage (damage) and flare and to examine longitudinal associations between flares and subsequent damage accrual, in patients with systemic lupus erythematosus (SLE).

Methods: Patients enrolled in the Asia Pacific Lupus Collaboration cohort with ≥3 years of prospectively captured data were studied. Flares were assessed at routine visits, while damage ((Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index) was assessed annually.

First-trimester Doppler Ultrasound for Predicting Successful Management of Pregnancy with Recurrent Pregnancy Losses Due to Antiphospholipid Syndrome and Thrombophilia: A Cohort Study.

Background: Recurrent pregnancy loss (RPL) often stems from a hypercoagulable state that exacerbates conditions such as antiphospholipid syndrome (APS) and thrombophilia, leading to early placental issues. Although treatments such as low-molecular-weight heparin (LMWH) and low-dose aspirin (LDA) are used, outcomes vary. This study proposes using first-trimester Doppler ultrasound - specifically, uterine radial artery resistance index (URa-RI) at 8 weeks and uterine artery pulsatility index (Ut-PI) with pre-diastolic notching (Ut-notch) at 11-13 weeks - to better predict successful pregnancies and reduce risks of adverse outcomes.

Association between bacterial presence in urinalysis and hypertension during pregnancy in women at Margono Hospital, Purwokerto: A single-center study in Indonesia.

Introduction: Urinary tract infections are prevalent among pregnant women and can lead to serious maternal and neonatal complications. Hypertensive disorders of pregnancy, a leading cause of maternal morbidity, may be associated with urinary tract infections. This study investigates whether bacteriuria detected via routine urinalysis, a standard screening in Indonesia, contributes to hypertension risk during pregnancy, aiming to enhance clinical management and screening protocols.

Characterization of Alpha Mangostin Loaded-Mesoporous Silica Nanoparticle and the Impact on Dissolution and Physical Stability.

Purpose: Improving drug solubility is crucial in formulating poorly water-soluble drugs, especially for oral administration. The incorporation of drugs into mesoporous silica nanoparticles (MSN) is widely used in the pharmaceutical industry to improve physical stability and solubility. Therefore, this study aimed to elucidate the mechanism of poorly water-soluble drugs within MSN, as well as evaluate the impact on the dissolution and physical stability.

Review on antibacterial flavonoids from genus : Structure-activity relationship and mode of action.

The Fabaceae family, particularly genus , is renowned for significant medicinal properties. These plants have been used as natural remedies to address various health issues and are rich in flavonoids. Therefore, this review aimed to provide a comprehensive overview of antibacterial activity, structure-activity relationship, especially against drug-resistance and mode of action for flavonoids isolated from .

The Impact of Health Promotion Using Leaflet Media on Mothers' Knowledge of the Early Stimulation of Toddlers' Development and Growth.

Introduction: Children who get inadequate stimulation will develop slower than those who receive regular and purposeful stimulus. Toddler-age toddlers face a variety of growth and development issues as a result of their mother's lack of information about stimulating their development.

Objective: The purpose of this study is to analyze the impact of health education using leaflet media on mothers' knowledge of early stimulation for toddler-age kids from Gunung Tua village, Subang Regency.

Noninvasive Detection of Alpha-Amylase in Saliva Using Screen-Printed Carbon Electrodes: A Promising Biomarker for Clinical Oral Diagnostics.

Background: Biomarkers are essential tools for diagnosing diseases. Saliva, as a human fluid, effectively reflects the body's condition due to its rich composition. Analyzing saliva components allows for noninvasive, cost-effective, and time-efficient screening and diagnosis.

Pregnancy Complicated by Rapidly Progressing Vulvar Melanoma: A Case Study.

BACKGROUND Vulvar melanoma during pregnancy is exceptionally rare. Hormonal and immunological changes in pregnancy have raised concerns about the potential for accelerated melanoma progression and poorer maternal outcomes. This case report describes an unusual presentation of vulvar melanoma in a pregnant patient, which rapidly progressed despite previous treatments, but resulted in a favorable fetal outcome.

Association of Bacteriuria with Hypertension Risk in Pregnant Women.

BACKGROUND Urinary tract infections (UTIs) are common during pregnancy and can negatively impact maternal and neonatal health. Hypertension in pregnancy is a leading cause of maternal morbidity. UTIs can contribute to hypertension development through mechanisms like inflammation, leading to endothelial dysfunction and impaired placental development.

The 2024 APLAR Consensus on the Management of Lupus Nephritis.

The APLAR has published a set of recommendations on the management of systemic lupus erythematosus (SLE) in 2021. The current consensus paper supplements and updates specifically the treatment of lupus nephritis (LN) according to two rounds of Delphi exercise from members of the APLAR SLE special interest group, invited nephrologists, histopathologists, and lupus nephritis patients. For initial treatment of LN, we recommend a combination of glucocorticoids (GCs) with cyclophosphamide (CYC), mycophenolate mofetil (MMF), or the calcineurin inhibitors (CNIs) as first-line options.

Prospects of e-Coaching as a Platform for Empowering Families of Person With Mental Disorder: A Qualitative Study.

Introduction: In all countries, the burden of mental disorders (MDs) spans the entire life course. Smartphones are currently widely used by families with a history of MD looking for the required mental health information. The use of digital media is an alternative to improving the ability of families to care for person with MD at home.

Public exposure from inhalation of radon and thoron around the tin mine and smelter areas in Bangka, Indonesia.

Radon (Rn) and thoron (Rn) were reported as the highest contributors to natural radiation received by humans. Furthermore, radon has been stated as the second-highest cause of lung cancer. The concentrations of U and Th (the parent nuclide of radon and thoron, respectively) in nature vary with geological conditions and can be enhanced by human activities.

Association Between Pre-Pregnancy Body Mass Index and Labor Induction Success Rates: A Case Control Study.

BACKGROUND Obesity is described as excessive fat accumulation. Almost 47% of pregnant women gain more weight than recommended. The prevalence of obesity doubled from 2007 to 2018 (10.

Effectiveness and Efficiency Comparison of One-Day vs Eight-Day Methotrexate Protocols in Managing Low-Risk Gestational Trophoblastic Neoplasia.

Background: Gestational Trophoblastic Neoplasia (GTN) has a high incidence in Bandung, Indonesia, with a mortality rate between 31% and 51%. The most common type is low-risk GTN with various treatment protocols available. The 8-day Methotrexate (MTX) 50 mg protocol has been implemented at our center; however, due to limitation of government insurance, this study aims to compare its effectiveness against the 1-day Methotrexate (MTX) 300 mg/m² protocol.

Classification of images using Gaussian copula model in empirical cumulative distribution function space.

This study introduces an innovative approach to image classification that uses Gaussian copulas with an Empirical Cumulative Distribution Function (ECDF) approach. The strategic use of distribution functions as feature descriptors simplifies the approach and enables a better understanding of the correlation structure between features in the image. This approach helps the model understand the contextual relationships between different parts of the image, resulting in a more abstract representation than a direct representation of individual pixel values.

Giant scalp dermatofibrosarcoma protuberans at mid-occipital scalp: A rare case report.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare type of skin cancer that arises in the deeper layers of the skin, most commonly on the trunk and limbs. The presentation of DFSP on the scalp is worth documentation due to its extremely rare occurrence in the literature.

Case Description: We describe a case of a 41-year-old female presented with a lump on the back of the head with gradual enlargement.

Surgical treatment of tuberculum sellae meningioma: A retrospective review of single institutional experience.

Background: Tuberculum sellae meningiomas (TSMs) represent a distinct entity among intracranial meningiomas. Both transcranial approaches (TCAs) and endoscopic endonasal approaches (EEAs) have provided neurosurgeons with options for managing these difficult tumors. Still, controversies persist regarding the selection criteria for the most optimal approach.