6,926 results match your criteria: "Pacemaker Syndrome"

Background: This case highlights the management of concomitant acute myocarditis and congenital long QT syndrome with electrical storm and incessant Torsade de Pointes.

Case Presentation: An 18 years-old Southeast Asian para 1 abortus 0 (P1A0) postpartum patient with cesarean section owing to severe preeclampsia, acute lymphocytic myocarditis, and prolonged QT interval owing to long QT syndrome. She has incessant Torsade de Pointes treated with beta-blocker, lidocaine, overdrive pacing with a temporary transvenous pacemaker, left cardiac sympathetic denervation per video-assisted thoracoscopic surgery, and implantable cardioverter-defibrillator implantation.

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Unlabelled: New cardiac implantable electronic devices (CIEDs), such as leadless pacemakers and subcutaneous implantable cardioverter defibrillators (S-ICDs), are being used in patients with adult congenital heart disease. The selection of CIEDs often requires careful consideration due to technical challenges posed by a unique heart structure. A 27-year-old man following a surgical tetralogy of Fallot (TOF) repair developed non-sustained ventricular tachycardia, sick sinus syndrome, and complete atrioventricular block.

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A circadian disruption, manifested by disturbed sleep and low-grade inflammation, is commonly seen in noncommunicable diseases (NCDs). Cardiovascular, respiratory and renal disorders, diabetes and the metabolic syndrome, cancer, and neurodegenerative diseases are among the most common NCDs prevalent in today's 24-h/7 days Society. The decline in plasma melatonin, which is a conserved phylogenetic molecule across all known aerobic creatures, is a constant feature in NCDs.

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An ECG-based machine-learning approach for mortality risk assessment in a large European population.

J Electrocardiol

November 2024

Health Authority and Services of Modena, Department of Primary Care, Via del Pozzo 71, 41100 Modena, Italy; Modena University Hospital, S. Agostino-Estense Hospital, Via Giardini 1355, 41126 Baggiovara, Modena, Italy. Electronic address:

Aims: Through a simple machine learning approach, we aimed to assess the risk of all-cause mortality after 5 years in a European population, based on electrocardiogram (ECG) parameters, age, and sex.

Methods: The study included patients between 40 and 90 years old who underwent ECG recording between January 2008 and October 2022 in the metropolitan area of Modena, Italy. Exclusion criteria established a patient cohort without severe ECG abnormalities, namely, tachyarrhythmias, bradyarrhythmias, Wolff-Parkinson-White syndrome, second- or third- degree AV block, bundle-branch blocks, more than three premature beats, poor signal quality, and presence of pacemakers and implantable cardioverter- defibrillators.

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Background: Hypopituitarism may trigger the development of acute pancreatitis (AP) through multiple mechanisms. AP may alter normal intracardiac conduction leading to an atrioventricular block. Due to the lack of similar cases, the correct timing and indication for pacemaker implantation in such a setting are unknown.

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BRASH syndrome, characterized by bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia, is a recently identified syndrome typically caused by the interplay of electrolyte imbalances and medications such as beta-blockers and calcium channel blockers. This report presents the case of a 79-year-old woman with a history of epilepsy and hypertension, managed with carbamazepine, lamotrigine, and antihypertensive medications. She developed BRASH syndrome following reduced fluid intake and worsening renal function.

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Article Synopsis
  • - Limb-girdle muscular dystrophy (LGMD) is a diverse group of genetic muscle diseases that can often be misdiagnosed due to their varied symptoms and progressions.
  • - A case study details a 56-year-old woman with late-onset LGMD R1/2A, who faced multiple health issues including elevated creatine kinase levels, limb fatigue, and heart problems that required a pacemaker.
  • - The study highlights the importance of early diagnosis and targeted treatments for LGMD, especially since this patient also had rare conditions like sick sinus syndrome and primary hyperparathyroidism, which complicate the clinical picture.
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  • Twiddler's syndrome is a rare condition associated with cardiac pacemakers, characterized by the twisting and retraction of the device lead within the implantation site.
  • A 54-year-old woman was admitted to the emergency department due to chest pain and involuntary muscle contractions in her left side.
  • A cardiology specialist confirmed the diagnosis of Twiddler's syndrome after evaluating the patient's symptoms.
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Background: This study aimed to define and explain a novel form of pacemaker-mediated arrhythmia which is initiated and sustained by atrial capture loss coinciding with ventriculoatrial (VA) conduction within the postventricular atrial refractory period (PVARP). Unlike repetitive nonreentrant VA synchrony (RNRVAS), in the pseudo-RNRVAS, the atrium is not stimulated due to pacing below the threshold level, rather than because of refractory atrial myocardium.

Objective: The objective was to elucidate the mechanisms of this pseudo-RNRVAS, identify predisposing factors, and propose preventive strategies.

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Article Synopsis
  • A young patient with neuromyelitis optica spectrum disorder experienced recurrent cardiac asystole and syncope following persistent hiccups, but successfully underwent cardioneuroablation (CNA) treatment, avoiding the need for a permanent pacemaker.
  • Previous cases of symptomatic bradycardia-arrhythmia related to area postrema syndrome (APS) showed a significant number required pacemaker implantation, highlighting the severity of the condition.
  • The findings suggest that CNA can effectively treat bradyarrhythmia associated with APS, and healthcare professionals should consider the potential link between these symptoms and APS in their clinical assessments.*
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  • Postoperative atrioventricular block requiring pacemaker (AVB/PM) affects 14% to 25% of patients undergoing complex biventricular repair for congenital heart disease, especially those with heterotaxy syndrome.
  • This study explored the safety and effectiveness of intraoperative His bundle (HB) mapping to reduce the incidence of AVB/PM during these procedures.
  • Results showed that mapping significantly lowered AVB/PM rates in certain groups, while also highlighting the need for ongoing advancements in mapping technology for those still at risk.
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  • - The study investigated the higher risk of sinus node dysfunction (SND) that leads to pacemaker implantation and mortality among first-degree relatives of patients with pacemakers due to SND.
  • - Data was collected from various Danish health registries, tracking over 6 million individuals from 1982 to 2022, and findings indicated that those with a family history of SND had a significantly higher risk (RR = 2.9) of requiring a pacemaker compared to the general population.
  • - While overall mortality rates among these relatives were similar to the general population, there was a notable increase in mortality for those related to patients with early-onset SND (RR = 1.22), indicating a possible genetic
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  • - A 72-year-old man with faintness was diagnosed with sick sinus syndrome and experienced an Adams-Stokes attack, leading to the implantation of a permanent pacemaker.
  • - After developing seizures, CT scans revealed herpes simplex virus DNA in the cerebrospinal fluid, prompting immediate treatment with intravenous acyclovir.
  • - Despite treatment, the patient's condition worsened with additional brain damage and ultimately led to death from aspiration pneumonia, highlighting the need to consider herpes encephalitis in cases of sinus node dysfunction.
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  • This study examines the impact of genetic syndromes (GSs) on survival rates and outcomes following pediatric heart transplants (HT).
  • The analysis included 2,429 heart transplant recipients, finding that 9% had a GS, with common types being DiGeorge, muscular dystrophy, Down, and Turner syndromes.
  • Results showed no significant differences in demographics, complications, or 10-year survival rates between children with GS and those without, suggesting that children with GS can have outcomes similar to their peers after heart transplants.
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  • Cardioneuroablation (CNA) is a therapy for conditions like vasovagal syncope, atrioventricular block, and sinus node dysfunction, but its effectiveness for patients over 50 is unclear.
  • In a study with 50 patients divided into two age groups (under 50 vs. 50 and above), there was no significant difference in survival rates without syncope or the need for pacemakers between the groups after a median follow-up of 17 months.
  • Older patients had lower heart rate post-procedure compared to younger patients, but both age groups showed similar improvements in quality of life and a decrease in heart rate variability.
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  • Takotsubo syndrome (TS) is a heart condition that mimics heart attacks and can be triggered by emotional or physical stress, including surgical procedures like pacemaker implantation.
  • A case study presented a 62-year-old woman who developed TS after a left bundle branch area pacing procedure, showing significant heart dysfunction despite clear coronary arteries.
  • The case highlights the need for clinicians to recognize that CSP procedures, although usually safe, can rarely lead to TS and emphasizes the importance of monitoring patients for such complications post-surgery.
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  • * Research utilizing RNA-seq data and in situ hybridization showed that Odz4 is specifically expressed in the sinoatrial node (SAN) and the cardiac conduction system (CCS).
  • * Experiments using an inducible system to express Odz4's intracellular domain demonstrated that it enhances the development of pacemaker-like cells, suggesting its importance in SAN differentiation and biological pacemaker development.
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  • Fluid overload (FO) in critically ill children is linked to increased morbidity and mortality, and while CRRT is used to manage FO, its impact on children's heart function is not well understood.* -
  • This study analyzed 17 children receiving CRRT, finding that those with FO greater than 15% had significantly higher systemic vascular resistance and lower cardiac indices, though heart rate and mean arterial pressure remained stable.* -
  • The findings suggest that FO negatively affects the hemodynamic profile in children on CRRT, and highlight the potential of using electrocardiometry to study these effects further.*
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Atrial flutter and sick sinus syndrome.

Heart Rhythm

October 2024

Division of Cardiology, Department of Medicine, University of California-San Francisco, San Francisco, California. Electronic address:

Article Synopsis
  • Sick sinus syndrome (SSS) can lead to serious health issues like fainting and the need for pacemakers, and researchers wanted to see if atrial flutter (AFL) could predict SSS better than other factors.
  • The study analyzed data from over 29 million adults in California from 2005 to 2019, focusing on those diagnosed with AFL and atrial fibrillation (AF) while adjusting for various demographics.
  • Results showed that both AFL and AF significantly increased the risk of developing SSS, with AFL notably heightening the risks of syncope and needing a pacemaker in patients already diagnosed with AF.
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  • A 74-year-old male with Kartagener's syndrome and permanent atrial fibrillation underwent successful cardiac resynchronization therapy (CRT) and atrioventricular node (AVN) ablation using remote magnetic navigation (RMN) through peripheral access.
  • The patient had severe heart failure, a low ejection fraction of 30%, and significant complications from a left bundle branch block, leading to unsuccessful bi-ventricular pacing prior to the procedure.
  • Post-ablation, the patient's bi-ventricular pacing efficiency improved to 100%, and there were notable improvements in both cardiac function and overall symptoms, highlighting the effectiveness of RMN-guided techniques in treating complex cardiac cases.
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  • - The study focuses on the increasing detection of wild-type transthyretin (ATTR) amyloidosis and evaluates the effectiveness of Tc-labeled pyrophosphate (Tc-PYP) scintigraphy for diagnosing ATTR cardiac amyloidosis in patients across Japan from 2018 to 2022.
  • - Out of 180 patients, 135 were analyzed, with 62 testing positive for Tc-PYP; researchers developed a scoring system based on five clinical factors to predict positivity, revealing that a higher score correlates with a greater likelihood of positive results.
  • - The study concludes that combining commonly available clinical data can significantly enhance the pretest prediction accuracy for Tc-PYP scintigraphy, aiding clinicians in the early diagnosis of ATTR amyloidosis
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