Towards a Unified Management Interface for 5G Sensor Networks: Interoperability between Yet Another Next Generation and Open Platform Communication Unified Architecture.

Fifth-generation (5G) sensor networks are critical enablers of Industry 4.0, facilitating real-time monitoring and control of industrial processes. However, significant challenges to their deployment in industrial settings remain, such as a lack of support for interoperability and manageability with existing industrial applications and the specialized technical expertise required for the management of private 5G sensor networks.

In-silico transcriptome analysis of antibiotic-treated Mycobacterium tuberculosis identifies novel antibiotic resistance factors.

The emergence of drug resistant Mycobacterium tuberculosis strains increases the burden on the treatment of tuberculosis. In this study, through in-silico transcriptome analysis of drug-treated M. tuberculosis samples, novel drug targets for the treatment of drug resistance in tuberculosis were identified.

Network pharmacology: an efficient but underutilized approach in oral, head and neck cancer therapy-a review.

The application of network pharmacology (NP) has advanced our understanding of the complex molecular mechanisms underlying diseases, including neck, head, and oral cancers, as well as thyroid carcinoma. This review aimed to explore the therapeutic potential of natural network pharmacology using compounds and traditional Chinese medicines for combating these malignancies. NP serves as a pivotal tool that provides a comprehensive view of the interactions among compounds, genes, and diseases, thereby contributing to the advancement of disease treatment and management.

Development of an aptasensor for highly sensitive detection of cardiac troponin I using cobalt-nickel metal-organic framework (CoNi-MOF).

Objective And Rationale: This study aimed to develop a highly sensitive and selective single-stranded DNA (ssDNA) aptamer targeting cardiac troponin I (cTnI), a crucial biomarker for acute myocardial infarction (AMI). The objective was to fabricate a novel aptamer electrochemical sensor using a composite material of cobalt-nickel metal-organic framework (CoNi-MOF) on screen-printed carbon electrodes (SPCE), leveraging the composite's large surface area and excellent electrical conductivity alongside the aptamer's high affinity for cTnI.

Methods: The aptamer electrochemical sensor was fabricated using the CoNi-MOF composite on SPCE and characterized its properties.

Mitigation of bio-corrosion characteristics of coronary artery stent by optimising -laser micromachining parameters.

Cardiovascular diseases, particularly coronary artery disease, pose big challenges to human life. Deployment of the stent is a preferable treatment for the above-mentioned disease. However, stents are usually made up of shape memory alloy called Nitinol.

Pioneering superior efficiency in Methylene blue and Rhodamine b dye degradation under solar light irradiation using CeO/CoO/g-CN ternary photocatalysts.

In this research work, we have successfully synthesized the CeO/CoO/g-CN ternary nanocomposite for hydrothermal method for photocatalytic applications. The synthesized nanocomposites were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy TEM, Photoluminescent spectra (PL), X-ray photoelectron spectroscopy (XPS), Brunauer- Emmett-Teller (BET) and Ultraviolet diffuse reflectance spectroscopy (UV-DRS) technique. As per the optical spectroscopic investigations CeO/CoO/g-CN ternary nanocomposite exhibited the high optical absorption range and its band gap is reduced from 2.

Novel MoS-decorated CuO hybrid nanoparticles for enhanced non-enzymatic electrochemical cholesterol detection.

Precise identification of cholesterol levels is crucial for the early diagnosis of cardiovascular risk factors. This paper presents a novel approach for cholesterol detection that circumvents the reliance on enzymatic processes. Leveraging the unique properties of advanced materials and electrochemical principles, our non-enzymatic approach demonstrates enhanced sensitivity, specificity, and limit of detection in cholesterol analysis.

Exploration of comprehensive marine natural products database against dengue viral non-structural protein 1 using high-throughput computational studies.

Dengue virus (DENV) non-structural protein 1 (NS1) is a versatile quasi-protein essential for the multiplication of the virus. This study applied high-throughput virtual screening (HTVS) and molecular dynamics (MD) simulation to detect the potential marine natural compounds against the NS1 of DENV. The structure of the NS1 protein was retrieved from Protein Data Bank with (PDB ID: 4O6B).

Overcoming multi drug resistance mediated by ABC transporters by a novel acetogenin- annonacin from Annona muricata L.

Ethnopharmacological Relevance: Multi-Drug Resistance (MDR), mediated by P-glycoprotein (P-gp) is one of the barriers to successful chemotherapy in colon cancer patients. Annona muricata L. (A.

Performance assessment of vegetable-based additive enriched cutting fluid for eco-friendly machining environment.

The investigation focuses on determining the effects of canola oil-based cutting fluid with three different volume percentages of boric acid additives over the machining forces and surface roughness while turning hardened AISI 1018 mild steel. Experiments were carried out under Taguchi's design of the experiment concept. The minimum quantity lubrication (MQL) technique was followed to minimize the cutting fluid consumption.

Formulation and validation of probioticated foxtail millet laddu as a source of antioxidant for biological system using response surface methodology.

Probiotics play a critical role in supporting a healthy gut microbiome, which significantly impacts overall health and well-being. While there has been an increase in the availability of probiotic foods in recent years, there may still be limited options and accessibility in certain regions. This study focused on formulating a traditional Indian sweet called laddu enriched with millet and Lactobacillus acidophilus.

Microstructural and mechanical behaviours of Y-TZP prepared via slip-casting and fused deposition modelling (FDM).

This paper reports the microstructural characteristics and mechanical properties of yttria-stabilized zirconia prepared via fused deposition modelling and slip casting. X-Ray Diffraction peaks indicated that yttria-stabilized zirconia crystallized in tetragonal structure for both slip casted(SC) and fused deposition modelled(FDM) samples. Further, scanning electron microscopy of slip casted sample showcased closely packed structure with fine grains and an average grain size of ∼65 nm whilst fused deposition modelled samples showcased non-homogeneous pores with ∼20 nm grain size.

Synthesis, crystal structure, spectroscopic characterization, DFT calculations, Hirshfeld surface analysis, molecular docking, and molecular dynamics simulation investigations of novel pyrazolopyranopyrimidine derivatives.

A series of new pyrazolopyranopyrimidine derivatives () were synthesized from 5-amino-2,4-dihydro-3-methyl-4-phenylpyrano-[2,3-c]pyrazole-5-carbonitrile by multicomponent reactions (MCR) involving malononitrile, benzaldehyde, and pyrazolone under refluxing ethanol in the presence of piperidine. Compound was then converted to 2-acetylpyrazolopyranopyrimidine ( through a reaction with acetic anhydride. The deprotection of using ammonium hydroxide in ethanol, leads to .