1 results match your criteria: "PRIMA Barn och Vuxenpsykiatri AB hChild and Adolescent Psychiatry Research Center[Affiliation]"
Genetic variants of increased waist circumference in psychosis.
Psychiatr Genet
December 2017
Departments of aMolecular Medicine and Surgery, Neurogenetics Unit bNeurobiology, Care Sciences and Society, Centre for Family Medicine cClinical Neuroscience dMolecular Medicine and Surgery, Endocrine and Diabetes Unit eMedicine, Cardiovascular Medicine Unit, Karolinska Institutet fCenter for Molecular Medicine, Karolinska University Hospital Solna gDepartment of Adult Psychiatry, PRIMA Barn och Vuxenpsykiatri AB hChild and Adolescent Psychiatry Research Center, Stockholm, Sweden.
Objective: We examined whether established metabolic risk genetic variants in the population confer a risk for increased waist circumference in patients with schizophrenia spectrum disorders and also an association with schizophrenia spectrum disorders irrespective of waist circumference.
Patients And Methods: We analyzed the association in (i) a case-case model in which patients with schizophrenia spectrum disorder with increased waist circumference (≥80 cm for women and ≥94 cm for men) (n=534) were compared with patients with normal waist circumference (<80 cm for women; <94 cm for men) (n=124), and in (ii) a case-control model in which schizophrenia spectrum disorder patients with increased waist circumference or irrespective of waist circumference were compared with population-derived controls (n=494) adjusted for age, sex, fasting glucose, smoking, and family history of diabetes.
Results: Genetic variants in five genes (MIA3, MRAS, P2RX7, CAMKK2, and SMAD3) were associated with increased waist circumference in patients with schizophrenia spectrum disorder (P<0.