7,389 results match your criteria: "PRC; Stanford University School of Medicine[Affiliation]"
Biol Res
October 2024
INRAE, CNRS, Université de Tours, PRC, INRAE Val-de-Loire, Nouzilly, 37380, France.
Background: In vitro embryo production is increasingly used for genetic improvement in cattle but bypasses the oviduct environment and exposes the embryos to oxidative stress with deleterious effects on further development. Here we aimed to examine the effect of oviduct epithelial spheroids (OES) on embryo development and quality in terms of morphology and gene expression during two co-culture times (4 days: up to embryonic genome activation at 8-16 cell stage vs. 7 days: up to blastocyst stage) and under two oxygen levels (5% vs.
View Article and Find Full Text PDFEur J Surg Oncol
December 2024
Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK; Department of Colorectal Surgery, Manchester University NHS Foundation Trust, Manchester, UK.
Aim: National clinical registries offer the benefits of a comprehensive dataset, particularly when linked with patient-reported outcome (PRO) data. This aim of this study was to utilise UK registry data to assess cross-sectional differences in health-related quality of life (HrQoL) in patients with primary rectal (PRC) and locally recurrent rectal cancer (LRRC).
Materials And Methods: Data were extracted from the COloRECTal cancer Repository (CORECT-R) and the Locally Recurrent Rectal Cancer - Quality of Life (LRRC-QoL) datasets.
Plant Cell
December 2024
The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, Shandong Key Laboratory of Precision Molecular Crop Design and Breeding, School of Life Sciences, Shandong University, Qingdao 266237, China.
The evolutionarily conserved Polycomb repressive complexes (PRCs) mediate genome-wide transcriptional silencing and regulate a plethora of development, as well as environmental responses in multicellular organisms. The PRC2-catalyzed trimethylation of lysine 27 on histone H3 (H3K27me3) is recognized by reader-effector modules of Polycomb repressive complex 1 (PRC1) to implement gene repression. Here, we report that the Arabidopsis (Arabidopsis thaliana) H3K27me3 effector EMBRYONIC FLOWER 1 (EMF1) interacts with and constrains the R2R3 DNA binding transcription factor MYB26 by a eudicot-conserved motif in the stamen.
View Article and Find Full Text PDFFASEB J
October 2024
INRAE, CNRS, Université de Tours, PRC, Nouzilly, France.
Psychol Health Med
January 2025
Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
proposes that co-occurring, mutually reinforcing psychosocial challenges (mental health, substance use, minority stress [discrimination/stigma], abuse, unmet basic needs) drive HIV risk behavior and create barriers to care for marginalized populations. It is thus necessary to address this holistic, complex picture in HIV prevention. Emergency department (ED) visits are a prime opportunity to engage key risk groups, given their low engagement in regular clinic-based care and high utilization of drop-in care via EDs.
View Article and Find Full Text PDFPLoS One
October 2024
IFCE (French Horse and Riding Institute), Saumur Technical Platform, Saumur, France.
Health and performance of vaulting horses cantering with reins might be affected by rein tensions. The primary aim of this present study was to measure rein and lunge line tensions in international-level vaulting horses with several types of reins adjusted in accordance with the requirements of the FEI Vaulting Rules and study the effect of reins types on it. The secondary aim was to evaluate behavioural signs of discomfort under the same conditions and study the effect of reins types on it.
View Article and Find Full Text PDFPlants (Basel)
October 2024
State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, China.
Br J Radiol
January 2025
Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Front Psychol
September 2024
Psychology Research Center - Cognition, Psychism, Organizations, PRC-CPO (EA7273), Jules Verne University of Picardie, Amiens, France.
Introduction: There are no published data on the written language skills of gifted children (GC). The objective of the present study was to evaluate reading abilities of GC vs. normative data from typically developing French children (TDC).
View Article and Find Full Text PDFDatabase (Oxford)
October 2024
Institute of Botany of the Czech Academy of Sciences, Zámek 1, Průhonice 252 43, Czech Republic.
Sci Rep
October 2024
INRAE, CNRS, Université de Tours, PRC, Nouzilly, F-37380, France.
Biomed Chromatogr
December 2024
Department of Orthopedics, Fuzhou Second General Hospital, Fuzhou, China.
Bone healing is crucial in managing osteomyelitis after fracture fixation. Understanding the mechanism of extensive callus formation in pediatric osteomyelitis is highly important. This study aims to analyze bone and periosteum samples from pediatric patients to elucidate the essential processes involved in callus formation during osteomyelitis.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Neurology, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA, 15261, USA.
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease characterized by mutations in the dystrophin gene, causing motor and pulmonary function decline. Viltolarsen is indicated for patients with dystrophin gene mutations amenable to exon 53 skipping. Here, we report safety, motor function, and the first pulmonary function results from the open-label, phase II Galactic53 trial of viltolarsen (NCT04956289).
View Article and Find Full Text PDFSci Rep
October 2024
Key Laboratory of Advanced Manufacturing Technology for Automobile Parts, Ministry of Education, Chongqing University of Technology, Chongqing, 400050, China.
The design of the reactant gas flow field structure in bipolar plates significantly influences the performance of proton exchange membrane fuel cells (PEMFCs). In this study, we introduced four innovative U-shaped flow field designs, namely: In-Out Multi-U, Out-In Multi-U, Distro In-Out Multi-U, and Distro Out-In Multi-U. To investigate the impact of these various flow fields on PEMFC performance, we conducted computational fluid dynamics (CFD) numerical simulations, validated through model experiments.
View Article and Find Full Text PDFThe development and distribution of educational materials is a key strategy to support the implementation of evidence-based interventions (EBIs). Rural communities have higher rates of physical inactivity and face higher burden of many diseases that increased physical activity can prevent. To support the translation of a developed physical activity intervention for adults in micropolitan communities (10,000-50,000 people), called Active Iowa, the University of Iowa Prevention Research Center for Rural Health (PRC-RH) created a toolkit and supplemental resources designed to guide implementers through the implementation of the intervention.
View Article and Find Full Text PDFJ Gastrointest Surg
December 2024
Department of General Surgery, Youyang Hospital, A Branch of The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Cell Syst
October 2024
Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115, USA. Electronic address:
The tumor suppressor p53 responds to cellular stress and activates transcription programs critical for regulating cell fate. DNA damage triggers oscillations in p53 levels with a robust period. Guided by the theory of synchronization and entrainment, we developed a mathematical model and experimental system to test the ability of the p53 oscillator to entrain to external drug pulses of various periods and strengths.
View Article and Find Full Text PDFTransl Psychiatry
October 2024
INRAE, CNRS, Université de Tours, PRC, 37380, Nouzilly, France.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in social interaction and communication, as well as restrained or stereotyped behaviors. The inherent heterogeneity within the autism spectrum poses challenges for developing effective pharmacological treatments targeting core features. Successful clinical trials require the identification of robust markers to enable patient stratification.
View Article and Find Full Text PDFBrain Inj
January 2025
Department of Neurology, Toulouse University Hospital, Toulouse, France.
Purpose: We conducted a proof-of-concept study to evaluate the effects of galantamine treatment versus placebo combined to cognitive rehabilitation (CR) after stroke.
Materials And Methods: In this 12-week, double blinded, randomized, controlled trial, patients were assigned to either combined approach of galantamine and CR (G-CR) or placebo and CR (P-CR). Primary outcome was the proportion of patients who crossed over from vascular cognitive disorder (VCD) to no-VCD at 12 weeks.
Eur J Pharm Sci
December 2024
College of Pharmacy, Sookmyung Women's University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul, 04310, Republic of Korea. Electronic address:
Histone deacetylases (HDACs) are important epigenetic regulators of gene expression and various cellular processes, and are potential targets for anticancer therapy. In particular, HDAC8 is a promising therapeutic target for childhood neuroblastoma. To date, five HDAC inhibitors have been approved as anticancer drugs; however, all are non-selective HDAC inhibitors with various side effects.
View Article and Find Full Text PDFNeural Netw
January 2025
Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, USA. Electronic address:
Bio-inspired Autonomous Underwater Vehicles with soft bodies provide significant performance benefits over conventional propeller-driven vehicles; however, it is difficult to control these vehicles due to their soft underactuated bodies. This study investigates the application of Physical Reservoir Computing (PRC) in the swimmer's flexible body to perform state estimation. This PRC informed state estimation has potential to be used in vehicle control.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Ultrasonography, Hunan Provincial Maternal and Child Health Care Hospital, No. 53 Xiangchun Road, Changsha, 410008, Hunan, China.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine & PET Center, National Center for Neurological Disorders, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.