Implementation strategies to support recovery support workers serving criminal legal involved people who use drugs.

Introduction: Recovery support workers (RSWs) who provide social support interventions for people who use drugs (PWUD) often face challenges that can jeopardize the well-being, efficacy and sustainability of this essential workforce. To date, little has been reported on the types of implementation strategies used to support RSWs. We describe and evaluate a multifaceted implementation strategy package to support Reducing Opioid Mortality in Illinois (ROMI), a paired peer recovery coach and case manager (PRC-CM) intervention for PWUD with recent criminal-legal involvement in urban and rural settings.

Self-Adaptive Smart Thermochromic Film with Quick Response for All-Year Radiative Cooling and Solar Heating.

The advancement of energy-saving buildings requires both high-performance passive radiative cooling (PRC) and solar absorption heating (SAH) materials. Although many materials with PRC or SAH functions have been developed, they cannot adapt to the large fluctuations of ambient temperature in different seasons. Herein, we report the design and fabrication of a new thermochromic porous film (TMRC) with combined temperature-adaptive SAH and PRC performance to achieve "warm in winter and cool in summer" for all-year radiative cooling and solar heating.

Outcomes of Proximal Row Carpectomy With Interposition Arthroplasty for Advanced Wrist Arthritis.

Background: This study aimed to evaluate and compare the outcomes of proximal row carpectomy (PRC) with interposition arthroplasty using dorsal wrist capsule interposition, lateral meniscus allograft, or dermal allograft in patients with lunate facet/capitate degeneration.

Methods: Patients who underwent PRC with interposition arthroplasty between 2010 and 2022 at a single institution were identified. Preoperative and postoperative visual analog scale (VAS) pain, functional outcomes, and complications were recorded.

Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma.

Background: Subacute and chronic subdural hematomas are common and frequently recur after surgical evacuation. The effect of adjunctive middle meningeal artery embolization on the risk of reoperation remains unclear.

Methods: In a prospective, multicenter, interventional, adaptive-design trial, we randomly assigned patients with symptomatic subacute or chronic subdural hematoma with an indication for surgical evacuation to undergo middle meningeal artery embolization plus surgery (treatment group) or surgery alone (control group).

Differentially Expressed Genes and Alternative Splicing Analysis Revealed the Difference in Virulence to American Eels (Anguilla rostrata) Infected by Edwardsiella anguillarum and Aeromonas hydrophila.

Edwardsiella anguillarum and Aeromonas hydrophila are two common bacterial pathogens affecting cultivated eels, and the differences in their virulence remain unclear. In this study, after two groups of American eels (Anguilla rostrata) were administered the LD dose of E. anguillarum and A.

Maltodextrin-derived nanoparticles resensitize intracellular dormant Staphylococcus aureus to rifampicin.

Intracellular bacteria are recognized as a crucial factor in the persistence and recurrence of infections. The efficacy of current antibiotic treatments faces substantial challenges due to the dormant state formation of intracellular bacteria. In this study, we devised a strategy aimed at reverting intracellular dormant bacteria to a metabolically active state, thereby increasing their vulnerability to antibiotics.

Machine learning outperforms the Canadian Triage and Acuity Scale (CTAS) in predicting need for early critical care.

Study Objective: This study investigates the potential to improve emergency department (ED) triage using machine learning models by comparing their predictive performance with the Canadian Triage Acuity Scale (CTAS) in identifying the need for critical care within 12 h of ED arrival.

Methods: Three machine learning models (LASSO regression, gradient-boosted trees, and a deep learning model with embeddings) were developed using retrospective data from 670,841 ED visits to the Jewish General Hospital from June 2012 to Jan 2021. The model outcome was the need for critical care within the first 12 h of ED arrival.

Transitive reasoning in the adult domestic hen in a six-term series task.

Transitive inference (TI) is a disjunctive syllogism that allows an individual to indirectly infer a relationship between two components, by knowing their respective relationship to a third component (if A > B and B > C, then A > C). The common procedure is the 5-term series task, in which individuals are tested on indirect, unlearned relations. Few bird species have been tested for TI to date, which limits our knowledge of the phylogenetic spread of such reasoning ability.

Association of precuneus Aβ burden with default mode network function.

Introduction: It remains unclear whether the local amyloid-beta (Aβ) burden in key regions within the default mode network (DMN) affects network and cognitive functions.

Methods: Participants included 1002 individuals from the Chinese Preclinical Alzheimer's Disease Study cohort who underwent 18F-florbetapir positron emission tomography resting-state functional magnetic resonance imaging scanning and neuropsychological tests. The correlations between precuneus (PRC) Aβ burden, DMN function, and cognitive function were investigated.

Identifying and quantifying multiple pollution sources in estuaries using fluorescence spectra and gradient-based deep learning.

This study developed an intelligent method for identifying and quantifying water pollution sources in estuarine areas. It characterized the excitation-emission matrix (EEM) fluorescence spectra from seven end-members, including seawater, rainwater, and five pollution sources typical of these areas. A deep learning model was established to identify and quantify these pollution sources in mixed water bodies.

Metabolic status is a key factor influencing proteomic changes in ewe granulosa cells induced by chronic BPS exposure.

Background: Bisphenol S (BPS) is the main substitute for bisphenol A (BPA), a well-known plasticiser and endocrine disruptor. BPS disrupts ovarian function in several species. Moreover, a few studies have reported that the effects of BPS might be modulated by the metabolic status, and none have characterised the granulosa cell (GC) proteome after chronic BPS exposure.

Quantifying the Cooling Effect of Urban Greening Driven by Ecological Restoration Projects in China.

Urban greening (UG) affects local climate by altering surface energy balance, while long-term UG cooling potential, patterns, and contribution to curbing urban warming remain unclear. Here, we designed an novel statistical model to evaluate the cooling potential of UG (CPUG) and created the first CPUG map for China. By exploring the trends in observed and simulated urban surface temperatures (UST), we quantified the CPUG of 0.

Cell division cycle fluctuation of Pal concentration in Escherichia coli.

The Tol-Pal proteins stabilize the outer membrane during cell division in many Gram-negative bacteria, including . Pal is an outer membrane lipoprotein that can bind peptidoglycan. It accumulates at the septum during division by a mobilization-and-capture mechanism.

Practices for Reporting Scale Structure and Summarizing Scores in Studies Using FAMCARE Scale to Assess Caregiver Satisfaction with Cancer Care: A Scoping Review.

Background: Satisfaction with care is a concept quantified through diverse measurement tools. However, studies have indicated that measuring satisfaction is challenging due to the construct's multidimensional expression. Thus, obtaining valid results requires careful consideration of the construct's nature and measurement methods.

Using a Pre-Radiation Window to Identify Potentially Active Cytotoxic Agents in Adults with Newly Diagnosed Glioblastoma.

Background: Therapies shown to improve outcomes in patients with recurrent cancers are commonly used in the neoadjuvant setting to optimize surgery, reduce radiation fields, and treat micro-metastatic disease. While pre-radiation chemotherapy (PRC) use has flourished in systemic cancers, it has not in glioblastomas. This review documents these trajectories and highlights the potential of PRC to rapidly and safely screen cytotoxic drugs for efficacy in patients with newly diagnosed glioblastoma.

Comparative Lipidomics Analysis Provides New Insights into the Metabolic Basis of Color Formation in Green Cotton Fiber.

Green fiber (GF) is a naturally colored fiber. A limited understanding of its color formation mechanism restricts the improvement of colored cotton quality. This experiment used upland cotton green fiber germplasm 1-4560 and genetic inbred line TM-1; the lipid profiles of green fibers at 30 (white stage) and 35 days post-anthesis (DPA) (early greening stage), as well as those of TM-1 at the same stages, were revealed.

Reactions of an Anionic Gallylene with Azobenzene or Azide Compounds Through C(sp)-H and C(sp)-H Activation.

The activation of inert C-H bonds remains a challenge in current chemistry. Here, we report the excellent reactivity of the anionic gallylene species [LGa:][Na(THF)] (L = [(2,6-PrCH)NC(CH)], ) that allows the selective activation one sp C-H bond of several azobenzene and azide derivatives at ambient temperature, with the transfer of the hydrogen atom to one of the nitrogen atoms. The process leads to the formation of the aryl amido products [LGa-κN,C-PhNN(H)(-R-CH)][Na(solvent)] (, R = H solvent = DME (1,2-Dimethoxyethane); , R = -OMe, solvent = DME; , R = -NMe solvent = THF), [LGa-κN,C-(-CH-CH)NN(H)(-CH-CH)][Na(15-C-5)] () with new Ga-C and Ga-N bonds.

Spectrally selective and thermally insulating hybrid nanofiber aerogel coolers for building energy conservation.

With the advancement of worldwide carbon neutralization, passive radiative cooling (PRC) has attracted tremendous interest in energy conservation by dissipating heat into the ultracold outer space without any electricity consumption. Despite some progress has been made in tailoring spectral properties for PRC, it still remains a crucial challenge in fabricating efficient and low-cost coolers for building energy saving. Herein, hierarchical cellulose-based aerogel coolers consisting of beads-on-string structural electrospun nanofibers are manufactured for all-day and all-region energy saving by combining radiative cooling and thermal insulation in one design.

Repeat mediated excision of gene drive elements for restoring wild-type populations.

Here, we demonstrate that single strand annealing (SSA) can be co-opted for the precise autocatalytic excision of a drive element. We have termed this technology Repeat Mediated Excision of a Drive Element (ReMEDE). By engineering direct repeats flanking the drive allele and inducing a double-strand DNA break (DSB) at a second endonuclease target site within the allele, we increased the utilization of SSA repair.

Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism.

Autism spectrum disorders (ASD) are complex, polygenic and heterogenous neurodevelopmental conditions. The severity of autism-associated variants is influenced by environmental factors, particularly social experiences during the critical neurodevelopmental period. While early behavioral interventions have shown efficacy in some children with autism, pharmacological support for core features - impairments in social interaction and communication, and stereotyped or restricted behaviors - is currently lacking.

Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment.

Although immunotherapy has revolutionized cancer treatment, its efficacy is affected by multiple factors, particularly those derived from the complexity and heterogeneity of the tumor-immune microenvironment (TIME). Strategies that simultaneously and synergistically engage multiple immune cells in TIME remain highly desirable but challenging. Herein, we report a multimodal and programmable platform that enables the integration of multiple therapeutic modules into single agents for tumor-targeted co-engagement of multiple immune cells within TIME.