Metabolites in Serum Small Extracellular Vesicles Instead of Small Extracellular Vesicles-depleted Serum Have Better Diagnostic Value for Cancers at Early Stage.

Serum is one of the most commonly used biofluids for biomarker exploration. Some studies examine serum directly, while others focus on specific components like small extracellular vesicles (sEVs), which are lipid-bilayer encapsulated particles carrying a variety of molecular cargos. However, the diagnostic value of serum sEVs versus sEVs-depleted fractions (EV-free serum) for early cancer detection are unclear.

Plasma-Enhanced Grain Growth and Non-Radiative Recombination Mitigation in CsSnBr Perovskite Films for High-Performance, Lead-Free Photodetectors.

Tin-based halide perovskites represent a highly promising and eco-friendly alternative to lead-based materials with significant potential for optoelectronic applications. However, their advancement is hampered by challenges such as poor film crystallinity and unintended self-doping. Herein, this work reports the fabrication of high-quality CsSnBr perovskite films by plasma-assisted chemical vapor deposition (PACVD), which improves the film quality.

Multi-Dimensional Color Tunable Long Persistent Luminescence in Metal Halide-Based CPs Through Precise Manipulation of Electronic and Steric Effects.

Regulating strategies for long persistent luminescence (LPL) are always in high demand. Herein, a series of coordination polymers (CPs) (SUST-Z1-Z4) are fabricated using 1,10-phenanthroline derivatives involving different substituents (─H, ─CH, ─Cl, and ─Br) as ligands, respectively. Crystallographic data demonstrate that these CPs adopt alternating arrangements of cadmium halide chains and π-conjugated ligands.

Fine-Tuning Intra/Inter-Molecular Interaction via Ternary Copolymerization Strategy to Obtain Efficient Polymer Donors.

Incorporating a third component through ternary copolymerization strategy has proven to be a promising and effective approach for further improving the device performance of polymer donors. However, terpolymer donors typically exhibit negative effects on molecular stacking and weaken charge transport due to the irregular distribution of the polymer skeleton. Herein, two terpolymers PBBQ-5 (5% ff-Qx) and PBBQ-10 (10% ff-Qx) are developed by introducing the difluoro-2-(3-hexyldecyloxy) quinoxaline (ff-Qx) to the main chain of PM6.

CoO with the Enhancement of Peroxymonosulfate Adsorption Capacity by Rare Earth Europium-Doping for High-Efficiency Organic Dye Degradation.

Cobalt-based metal-organic framework (MOFs)-derived catalysts are acknowledged for their effectiveness in activating peroxymonosulfate (PMS) for the treatment of persistent pollutants. However, the limited adsorption of PMS on the catalyst surface markedly reduces its degradation efficiency. To overcome this limitation, nanoflower-like EuO/CoO-0.

Association of antidepressants with cataracts and glaucoma: a disproportionality analysis using the reports to the United States Food and Drug Administration Adverse Event Reporting System (FAERS) pharmacovigilance database.

Background: Antidepressants are commonly prescribed for mood disorders. Epidemiological studies suggest antidepressant use may be associated with cataracts and glaucoma. We aim to investigate the association between antidepressants and cataracts and glaucoma.

Inherent Ultrahigh Proton Conductivity of Two Highly Stable COOH-Functionalized Hafnium-Based Metal-Organic Frameworks.

Although there has been some recent interest in the proton conductivity (σ) of highly stable carboxyl metal-organic frameworks (MOFs) made of tetravalent metal ions, given their potential applications in fuel cells and electrochemical sensing, research on MOFs constructed by hafnium(IV) ions needs to be expanded significantly. Based on this, we used two common and easily prepared phenylpoly(carboxylic acid) ligands, 1,2,4-phenyltricarboxylic acid and 1,2,4,5-phenyltetracarboxylic acid, to react with hafnium tetrachloride, respectively, creating two porous hafnium(IV)-based MOFs, () and UiO-66-(COOH)-Hf (), with the same structure as UiO-66-Hf but with different numbers of free carboxylic groups. A series of stability assays revealed that the two MOFs had excellent structural rigidity, including thermal and water stability.

Regulating Supramolecular Assembly and Disassembly of Chitosan toward Efficiently Antibacterial Lubricous and Biodegradable Hydrogel Urinary Catheters.

Urinary catheters serve as critical medical devices in clinical practice. However, the currently used urinary catheters lack efficient antibacterial and lubricating properties, often leading to discomfort with patients and even severe urinary infections. Herein, a new strategy of supramolecular assembly and disassembly of chitosan (Cs) is developed that enables efficient antibacterial lubricous and biodegradable hydrogel urinary catheters.

Dual-Phase Ligand Engineering Enables 18.21% FAPbI Quantum Dot Solar Cells.

Formamidinium lead triiodide (FAPbI) perovskite quantum dot (PQD) are promising candidate for high-performing quantum dot photovoltaic due to its narrow bandgap, high ambient stability, and long carrier lifetime. However, the carrier transport blockage and nonradiative recombination loss, originating from the high-dielectric ligands and defects/trap states on the FAPbI PQD surface, significantly limit the efficiency and stability of its photovoltaic performance. In this work, through exploring dual-site molecular ligands, namely 2-thiophenemethylammonium iodide (2-TM) and 2-thiopheneethylammonium iodide (2-TE), a dual-phase synergistic ligand exchange (DSLE) protocol consisting of both solution-phase and solid-state ligand engineering is demonstrated.

Research Progress and Perspectives on Anti-Poisoning Hydrogen Oxidation Reaction Electrocatalysts for Hydrogen Fuel Cells.

As global demand for clean and sustainable energy continues to rise, fuel cell technology has seen rapid advancement. However, the presence of trace impurities like carbon monoxide (CO) and hydrogen sulfide (H₂S) in hydrogen fuel can significantly deactivate the anode by blocking its active sites, leading to reduced performance. Developing electrocatalysts that are resistant to CO and H₂S poisoning has therefore become a critical priority.

In situ Polymerized Solid-State Electrolyte Enabling Inorganic-Organic Dual-Layered SEI Film for Stable Lithium Metal Batteries.

In situ polymerization of cyclic ethers is a promising strategy to construct solid-state lithium (Li) metal batteries with high energy density and safety. However, their practical applications are plagued by the unsatisfactory electrochemical properties of polymer electrolytes and the unstable solid electrolyte interphase (SEI). Herein, organic perfluorodecanoic acid (PFDA) is proposed as a new initiator to polymerize 1,3-dioxolane electrolyte (PDOL), which enables the as-obtained PDOL electrolyte to deliver greatly enhanced ionic conductivity and broadened electrochemical window.

A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas.

Bacterial pneumonia is a significant public health burden, contributing to substantial morbidity, mortality, and healthcare costs. Current therapeutic strategies beyond antibiotics and adjuvant therapies are limited, highlighting the need for a deeper understanding of the disease pathogenesis. Here, we employed single-cell RNA sequencing of 444,146 bronchoalveolar lavage fluid cells (BALFs) from a large cohort of 74 individuals, including 58 patients with mild (n = 22) and severe (n = 36) diseases as well as 16 healthy donors.

A rare case of extrapulmonary hamartoma on the visceral pleura treated by uniportal VATS: case report and literature review.

Pulmonary hamartomas are common. However, extrapulmonary hamartomas on the Visceral Pleura are very rare. We treated a patient with a pulmonary nodule at the left lower lobe by uniportal video-assisted thoracoscopic wedge resection, which showed a yellow nodule located on the visceral pleura.

Thoracoscopic resection of primary mediastinal liposarcoma: a case report and literature review.

Background: Primary mediastinal liposarcomas (PLMs) are extremely rare. Patients typically present with symptoms caused by tumor size, as the mass can compress surrounding tissues and organs. Here, we report a case of a large primary mediastinal liposarcoma that was successfully resected thoracoscopically.

Ocular hypertension after silicone oil filling surgery for high myopia: a case-control study.

Purpose: This study aims to examine the correlation between specific clinical parameters, such as axial eye length, and the onset of ocular hypertension "OH" following the use of silicone oil filling in patients with high myopia.

Method: In this retrospective analysis, we reviewed 214 eyes from 432 patients diagnosed with severe myopia, all of whom underwent vitrectomy and were treated with silicone oil filling. The study aimed to document the incidence and timing of postoperative ocular hypertension "OH" while assessing various factors, including demographic details, medical history, additional surgical interventions, and findings from supplementary examinations (such as axial length, silicone oil emulsification, and anterior chamber penetration).

Establishing the reference intervals of plasma PLG, FXII activity, and FXIII antigen in healthy adults in Guangzhou.

Objective: To establish the reference intervals of plasma Plasminogen, Factor XII activity, and Factor XIII Antigen in healthy adults in Guangzhou.

Methods: A total of 168 young people (75 males and 93 females, aged 18-65 years) who underwent physical examination in Zhujiang Hospital of Southern Medical University from 2020 to 2022 were recruited. Sysmex CS5100 automatic coagulation analyzer and matching reagents were used to detect Plasminogen.

Health-related quality of life and health state utility value in idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Background: Idiopathic pulmonary fibrosis (IPF) is associated with high mortality, heavy economic burden, limited treatment options and poor prognosis, and seriously affects the health-related quality of life (HRQoL) and life expectancy of patients. This systematic review and meta-analysis of HRQoL and health state utility value (HSUV) in IPF patients and the instruments used in this assessment aimed to provide information sources and data support for the future research on IPF HRQoL and HSUV.

Methods: We searched the PubMed, EMBASE, Web of Science and Cochrane Library databases for studies reporting the HRQoL or HSUV of IPF patients, with the retrieval time from the establishment of each database to April 2024.

Daily sodium intake and constipation in US adult males: an uncommon negative association revealed by national health and nutrition examination survey data from the United States (2005-2010).

Background: High sodium intake has been linked to various health outcomes; however, its association with constipation remains unclear, particularly in adult males. This population-based study aimed to investigate the association between daily sodium intake and constipation using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2010.

Methods: Using data from the NHANES database spanning from 2005 to 2010, a cross-sectional study including 7116 adult male participants from the United States was performed to assess the relationship between daily sodium intake and constipation.

Enhancing Stability and Activity of Fe-based Catalysts for Propane Dehydrogenation via Anchoring Isolated Fe-Cl Sites.

The eco-friendly features and desirable catalytic activities of Fe-based catalysts make them highly promising for propane dehydrogenation (PDH). However, simultaneously improving their stability and activity remains a challenge. Here, we present a strategy to address these issues synergistically by anchoring single-atom Fe-Cl sites in Al3+ vacancies of Al2O3.

Total IgE levels are associated with mortality risk partially mediated by vitamin status: A nationally representative population-based study.

Background And Aims: Elevated total IgE levels are traditionally associated with allergic conditions; however, their potential role as biomarker for mortality risk beyond allergic diseases has not been extensively explored. Recent studies have suggested that IgE is associated with cardiovascular (CV) disease. We aimed to investigate the association between total IgE levels and the risk of all-cause and cause-specific mortality, as well as to explore the potential mediating role of vitamin status in these associations.

Value of Abbreviated Magnetic Resonance Sequence in Hepatocellular Carcinoma Screening: A Systematic Review and Meta-analysis.

Rationale And Objectives: To systematically review the diagnostic efficacy of abbreviated magnetic resonance imaging sequence (AMRI) screening for hepatocellular carcinoma (HCC).

Materials And Methods: Medline (via PubMed), EMbase, The Cochrane Library, Web of Science, CNKI, WanFang Data, and VIP databases were electronically searched to collect studies on the diagnostic efficacy of AMRI screening for HCC from inception to August 10th, 2024. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies using the Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2), then, the meta-analysis with a bivariate mixed-effects regression model was performed by using Stata 14.

The Traditional Applications, Phytochemistry, Pharmacology, Pharmacokinetics, Quality Control and Safety of Paeoniae Radix Alba: A Review.

Paeoniae Radix Alba (PRA, called Baishao in China) is the dried root of Pall. In clinical practice, PRA has been used to treat cardiovascular disease, menstrual disorders, abdominal pain, diarrhea, and liver disease, among other conditions. This review provides a systematic summary of its traditional uses, geographical distribution and current cultivation situation, phytochemistry, pharmacokinetics, pharmacology, quality control, and toxicology.

Ginsenoside Rb1 Relieves Cellular Senescence and Pulmonary Fibrosis by Promoting NRF2/QKI/SMAD7 Axis.

Cellular senescence is an adverse factor in the development of pulmonary fibrosis (PF). Ginsenoside Rb1 has been found to inhibit both cellular senescence and PF. This study aimed to elucidate the molecular mechanisms by which ginsenoside Rb1 regulates cellular senescence and PF.

Research Progress in Ulcerative Colitis: The Role of Traditional Chinese Medicine on Gut Microbiota and Signaling Pathways.

Ulcerative colitis (UC), one among other refractory diseases worldwide, has shown an increasing trend of progression to colorectal cancer in recent years. In the treatment of UC, traditional Chinese medicine has demonstrated good efficacy, with a high cure rate, fewer adverse effects, great improvement in the quality of patient survival, and reduction in the tendency of cancerous transformation. It shows promise as a complementary and alternative therapy.

The diagnostic and therapeutic potential of multiple myeloma-associated circular RNAs.

Circular RNA (circRNA) was first discovered in viruses in 1974, they are primarily formed through back-splicing, where a downstream splice donor is joined to an upstream splice acceptor, resulting in a closed circRNA transcript. Under normal conditions, most circRNAs are stably expressed, however, in pathological conditions, circRNAs can play critical roles in the disease process of multiple myeloma (MM) through mechanisms such as competing endogenous RNAs (ceRNAs), regulation of transcription and splicing, affecting protein expression and localization, and even direct encoding of peptides. In recent years, there has been increasing interest in the role of circRNAs in MM and their regulatory functions during the disease process.