2 results match your criteria: "PR China. zdyzf1@163.com and National Engineering Research Center of Seafood[Affiliation]"
,-2,4-Decadienal induces endothelial cell injury by impairing mitochondrial function and autophagic flux.
Food Funct
June 2021
School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, PR China. and National Engineering Research Center of Seafood, Dalian, 116034, PR China and Collaborative Innovation Center of Seafood Deep Processing, Dalian, 116034, PR China.
This study investigated the toxic effects of trans,trans-2,4-decadienal (tt-DDE) on vascular endothelial cells as well as the underlying mechanisms involved. Human umbilical vascular endothelial cells (HUVECs) were treated with different concentrations of tt-DDE for 24 h, and cell viability, colony formation ability, apoptosis, mitochondrial function and autophagy pathway were determined. The results showed that tt-DDE dose-dependently inhibited cell viability and colony formation, and increased lactate dehydrogenase (LDH) release and apoptosis in HUVECs.
View Article and Find Full Text PDFFormation and disappearance of aldehydes during simulated gastrointestinal digestion of fried clams.
Food Funct
April 2020
School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, PR China. and National Engineering Research Center of Seafood, Dalian, 116034, PR China.
Article Synopsis
- The study examined how aldehydes form and disappear during the simulated digestion of fried clams, focusing on the impact of lipase.
- Initially, the total amount of aldehydes decreased during gastric digestion but increased significantly during the intestinal phase.
- An analysis identified eight specific aldehydes and revealed a positive link between lipid breakdown (especially with lipase) and the production of these aldehydes, suggesting unsaturated free fatty acids may be key contributors to aldehyde generation.