2 results match your criteria: "PR China. liuliang.zlhospital@fudan.edu.cn.[Affiliation]"
Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression.
J Transl Med
June 2024
Department of Pancreatic Surgery, Affiliated Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Xuhui District, Shanghai, PR China.
Article Synopsis
- The study focuses on understanding how a protein called IQGAP1 is changed by another protein (SOX4) and a signaling pathway (MAPK1) in pancreatic cancer.
- Researchers used data from a database to analyze different proteins and their effects on pancreatic cancer, looking for ways to predict how patients will respond to treatment.
- They conducted experiments in cells and animals to see how SOX4 affects the growth and spread of pancreatic cancer by influencing IQGAP1 and MAPK1, which could help in developing new treatments.
The platelet pannexin 1-IL-1β axis orchestrates pancreatic ductal adenocarcinoma invasion and metastasis.
Oncogene
May 2023
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 20032, P. R. China.
We aimed to investigate the protumor mechanisms of platelets in pancreatic ductal adenocarcinoma (PDAC). Serum samples were collected from 656 PDAC patients and 3105 healthy people, and a Panx1 knockout tumor model and an adoptive platelet transfusion mouse model were established. We showed that the blood platelet counts were not significantly different between stage III/IV and stage I/II patients, while the number of the CD41+/CD62P+ platelets was significantly elevated in stage III/IV patients, indicating that CD41+/CD62P+ platelets are associated with a poor prognosis.
View Article and Find Full Text PDF