Ligand-to-Ligand Charge Transfer Induced Red-Shifted Room Temperature Phosphorescence in Metal-Organic Frameworks.

Research on room temperature phosphorescence (RTP) of metal-organic frameworks (MOFs) has been rapidly developed in recent years. However, it is still challenging to realize long-wavelength RTP (>580 nm). In this article, a new strategy is proposed to achieve the red-shifted RTP through constructing dual-ligand MOFs.

Qi-Huang decoction alleviates DSS-induced colitis with Candida albicans dysbiosis by enhancing innate immune response through Dectin-1-associated signaling.

Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract. Candida albicans, a common commensal fungus in the human gut, has been increasingly implicated in UC pathogenesis. Qi-Huang decoction (QHD), a traditional Chinese herbal formula known for its spleen-invigorating and purgative properties, is commonly used to restore gastrointestinal function.

Hyperreflective foci and subretinal fluid predicts microglia activation involved in the breakdown of outer blood-retinal barrier in treatment-naïve patients with diabetic macular edema.

Purpose: To evaluate the correlation between hyperreflective foci (HRF), the biomarker of activated microglia, and subretinal fluid (SRF), representing the dysfunction of retinal pigment epithelium (RPE), in treatment-naïve patients with diabetic macular edema (DME).

Methods: Sixty-one treatment-naïve patients (61 eyes) with DME were included in the research. Participants were divided into two categories based on the presence or absence of SRF.

Win-Win Integration of Genetically Engineered Cellular Nanovesicles with High-Absorbing Multimodal Phototheranostic Molecules for Boosted Cancer Photo-Immunotherapy.

Photo-immunotherapy is one of the most promising cancer treatment strategies. As immunotherapeutic agents, immune checkpoint blockade antibodies against programmed cell death protein 1 (PD-1) or programmed cell death ligand 1 (PD-L1) exhibit substantial potential, but have to face non-specific distribution and the subsequent immune-related adverse events. Meanwhile, high-performance phototheranostic agents concurrently possessing multiple phototheranostic modalities and high light-harvesting capacity are really attractive and highly desired as touching phototheranostic modules.

Chemical pollution drives taxonomic and functional shifts in marine sediment microbiome, influencing benthic metazoans.

Microbial communities in marine sediments contribute significantly to the overall health and resiliency of marine ecosystems. However, increased human disturbance undermines biodiversity and, hence, natural functionality provided by marine sediments. Here, through a deep shotgun metagenomics sequencing of the sediment microbiome and COI metabarcoding of benthic metazoans, we demonstrate that >50% of the microorganisms' and metazoan's taxonomic variation can be explained by specific chemical pollution indices.

Demonstration of therapeutic effect of plasma-synthesized polypyrrole/iodine biopolymer in rhesus monkey with complete spinal cord section.

Spinal cord injury (SCI) can cause paralysis, and although multiple therapeutic proposals have been developed in murine models, results have hardly been replicated in humans. As non-human primates (NHP) are more similar to humans than rodents, the current study investigated whether it was possible to reproduce in a NHP, the previously obtained beneficial results by using a plasma-synthesized polypyrrole/iodine (PPy/I) biopolymer, which reduce glial scar formation and inflammatory response and promotes nerve tissue preservation, regenerative processes and functional recovery in rats. In NHPs (Rhesus monkey) with SCI by complete transection (SCT) and with plasma-synthesized PPy/I application (experimental) or without (control), the expression of pro-inflammatory cytokines in blood, preservation of nervous tissue through magnetic resonance imaging and histological and morphometric techniques, regeneration through immunohistochemistry study and functional recovery through clinical examination, were evaluated.

A modified workflow for dynamic navigation implant surgery in fully edentulous patients utilizing a customized patient tracking module.

A refined navigated implant workflow for the edentulous patients is introduced utilizing a patient-customized tracking module. This technique initiates with the placement of an incisor implant to anchor the tracking module, enabling real-time tracing of the edentulous arch while eliminating the need for additional insertions. This approach optimizes surgical procedures, reduces trauma, and mitigates the risk of potential implant placement site occupation.

Measurement of multidifferential cross sections for dijet production in proton-proton collisions at .

A measurement of the dijet production cross section is reported based on proton-proton collision data collected in 2016 at by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of up to 36.3 . Jets are reconstructed with the anti- algorithm for distance parameters of and 0.

Constructing Anion Solvation Microenvironment Toward Durable High-Voltage Sodium-Based Batteries.

Sodium-based rechargeable batteries are some of the most promising candidates for electric energy storage with abundant sodium reserves, particularly, sodium-based dual-ion batteries (SDIBs) perform advantages in high work voltage (≈5.0 V), high-power density, and potentially low cost. However, irreversible electrolyte decomposition and co-intercalation of solvent molecules at the electrode interface under a high charge state are blocking their development.

sp. nov., isolated from a patient with ruptured appendicitis.

A clinical isolate, R131, was isolated from the peritoneal swab of a patient who suffered from ruptured appendicitis with abscess and gangrene in Hong Kong in 2018. Cells are facultatively anaerobic, non-motile, Gram-positive coccobacilli. Colonies were small, grey, semi-translucent, low convex and alpha-haemolytic.

Acceptor Elongation Boosted Intersystem Crossing Affords Efficient NIR Type-I and AIE-Active Photosensitizers for Targeting Ferroptosis-Based Cancer Therapy.

Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation-induced emission (AIE) activity offer a promising solution to achieve non-invasive and precise theranostics. However, the reported AIE luminogens (AIEgens) with both AIE characteristic and strong type-I ROS generation are still scarce and the structure-property relationship is still unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed to endow the AIEgen strong type-I ROS producibility.

Bioinspired Assembly of Natural Polyphenol-Amino Acid Surfactants as Multifunctional Durable Coatings for Anticorrosion Fruit Packaging.

Challenges emerge in the quest for highly efficient and biocompatible coatings to tackle microbial contamination. Here, we propose a bioinspired paradigm combining (-)-epigallocatechin gallate (EGCG) and l-arginine surfactants (LAM) as all-green building blocks for advanced coatings with superior performance. Molecular dynamics simulations reveal the natural assembly process of the EGCG/LAM supramolecular nanoparticles (ELA NPs).

Consensus and guidelines on diagnosis and management of polypoidal choroidal vasculopathy (PCV) from the Asia-Pacific Vitreo-retina Society (APVRS).

A panel of 21 international experts are formed by the Asia-Pacific Vitreo-retina Society to work out the consensus and guidelines on polypoidal choroidal vasculopathy (PCV). PCV is a common subtype of neovascular age-related macular degeneration and is more prevalent in Asian populations. Recent advancement in imaging technology allows greater understanding of the disease process of PCV.

Molecular Strain Accelerates Electron Transfer for Enhanced Oxygen Reduction.

Fe-N-C materials are emerging catalysts for replacing precious platinum in the oxygen reduction reaction (ORR) for renewable energy conversion. However, their potential is hindered by sluggish ORR kinetics, leading to a high overpotential and impeding efficient energy conversion. Using iron phthalocyanine (FePc) as a model catalyst, we elucidate how the local strain can enhance the ORR performance of Fe-N-Cs.

Chiral Nanostructures from Artificial Helical Polymers: Recent Advances in Synthesis, Regulation, and Functions.

Helical structures such as right-handed double helix for DNA and left-handed α-helix for proteins in biological systems are inherently chiral. Importantly, chirality at the nanoscopic level plays a vital role in their macroscopic chiral functionalities. In order to mimic the structures and functions of natural chiral nanoarchitectures, a variety of chiral nanostructures obtained from artificial helical polymers are prepared, which can be directly observed by atomic force microscopy (AFM), scanning tunneling microscopy (STM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

Do Risk Factors for HCC Impact the Association of CT/MRI LIRADS Major Features With HCC? An Individual Participant Data Meta-Analysis.

Guidelines suggest the Liver Imaging Reporting and Data System (LI-RADS) may not be applicable for some populations at risk for hepatocellular carcinoma (HCC). However, data assessing the association of HCC risk factors with LI-RADS major features are lacking. To evaluate whether the association between HCC risk factors and each CT/MRI LI-RADS major feature differs among individuals at-risk for HCC.

Accuracy of detection methods for secondary caries around direct restorations: A systematic review and meta-analysis.

Objective: To evaluate and compare the accuracy of detection methods for the diagnosis of secondary caries around direct restorations in posterior teeth.

Data: Accuracy parameters including sensitivity, specificity, diagnostic odds ratio (DOR), area under curve (AUC), and partial AUC (pAUC) are generated from studies assessing the accuracy of detection methods for secondary caries.

Sources: Publications from PubMed, Web of Science, Scopus, Medline, EMBASE and Cochrane Library databases.

Effective Detection of Cloud Masks in Remote Sensing Images.

Effective detection of the contours of cloud masks and estimation of their distribution can be of practical help in studying weather changes and natural disasters. Existing deep learning methods are unable to extract the edges of clouds and backgrounds in a refined manner when detecting cloud masks (shadows) due to their unpredictable patterns, and they are also unable to accurately identify small targets such as thin and broken clouds. For these problems, we propose MDU-Net, a multiscale dual up-sampling segmentation network based on an encoder-decoder-decoder.

Unlocking the neuroprotective potential of Ziziphora clinopodioides flavonoids in combating neurodegenerative diseases and other brain injuries.

Ziziphora clinopodioides Lam. (Z. clinopodioides) is a traditional Chinese and ethnic medicine in Xinjiang, China with various therapeutic effects.

A novel AI model for detecting periapical lesion on CBCT: CBCT-SAM.

Objectives: Periapical lesions are not always evident on radiographic scans. Sometimes, asymptomatic or initial periapical lesions on cone-beam computed tomography (CBCT) could be missed by inexperienced dentists, especially when the scan has a large field of view and is not for endodontic treatment purposes. Previously, numerous algorithms have been introduced to assist radiographic assessment and diagnosis in the field of endodontics.

Effect of shape and size of implant scan body on scanning accuracy: An in vitro study.

Objectives: Evaluating the effect of shape and size of implant scan body on the accuracy of optical 3D scanning.

Materials And Methods: Fifteen PEEK scan bodies were milled, including 1 spherical, 9 cylindrical, and 5 cuboidal. The 3D position and angulation of each scan body were measured using a CMM 3 times and a laboratory scanner 10 times.

Tumor Site-Specific In Vivo Theranostics Enabled by Microenvironment-Dependent Chemical Transformation and Self-Amplifying Effect.

Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor-specific imaging and therapy, few exhibit effective function in vivo. Herein, a probe called TQ-H is designed that can realize robust theranostic effects both in vitro and in vivo.

Estimations of biological motion walking direction are affected by observer and walker genders.

A facing-towards bias is commonly reported when observers are asked to judge the motion directions of others. However, it remains unclear just how accurately observers are able to estimate the motion direction of others and whether the gender of the observer and the walker affects the direction estimation. Here, we asked male and female participants to estimate the direction of a point-light walker (PLW) in three experiments.