Dimethyl fumarate alleviate hepatic ischemia-reperfusion injury through suppressing cGAS-STING signaling.

Hepatic ischemia-reperfusion (I/R) injury frequently occurs during the perioperative phase of liver surgery. Inappropriate activation of STING signaling can trigger excessive inflammation response to aggravate hepatic I/R injury. Dimethyl fumarate (DMF) is an FDA-approved immunomodulatory drug used to treat multiple sclerosis and psoriasis due to its notable anti-inflammation properties.

Difficulties in the diagnosis and treatment of axillary malignant triton tumors: A case report.

Malignant triton tumor (MTT), a subtype of malignant peripheral nerve sheath tumor, is a rare soft-tissue sarcoma with a difficult diagnosis and poor prognosis. The course of MTT progression is rapid and the degree of malignancy is high. Patients with MTT can be treated with postoperative adjuvant radiotherapy and chemotherapy; however, treatment results are still poor.

The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice.

Purpose: The effective compound combination of Bufei Yishen formula III (ECC-BYF III) has shown protective effects against chronic obstructive pulmonary disease (COPD). However, its effect on mitochondrial dysfunction remains unclear. The current study aimed to investigate the effect of ECC-BYF III on mitochondrial dysfunction in COPD mice and elucidate its potential mechanisms.

Role of limited medical resources in an epidemic model with media report and general birth rate.

This paper formulates an SEIRSHM epidemic model with general birth rate, media report and limited medical resources. Firstly, the well-posedness of the solutions and the extinction of the disease are discussed. Then, the existence of the endemic equilibrium is discussed and we find when ∗ > 1 and  = 1, there exhibits a backward bifurcation, if ∗ < 1 and  = 1, there exhibits a forward bifurcation.

Single-Step Ethylene Purification and MTO Product Separation in a Nitrogen-Rich Microporous Metal-Organic Framework.

The nitrogen-rich metal-organic framework (MOF) , featuring a melamine (MA) functional group, enables efficient one-step CH purification and methanol-to-olefins (MTO) product separation. At 298 K, its adsorption capacity follows the order CH > CH > CH > CH. Breakthrough experiments showed that produced pure CH from C mixtures with a productivity of 22.

Precise detection of NSE and ProGRP with nanoprobes for early diagnosis of small cell lung cancer.

A DNA strand-based fluorescent probe was developed for the direct simultaneous detection of small cell lung cancers' tumor markers NSE and ProGRP. The probe offers stability, simplicity, and rapid response, making it highly promising for application in clinical serum samples' diagnosis.

Self-assembly processes of 2D Au(I)-S(CH)COOH lamellae.

Solving the assembled structure of Au(I)-thiolate linear coordination polymers has been a challenging task as they generally lack good crystallinity. This has prevented the elucidation of their assembly processes at the molecular level. In this paper, selected area electron diffraction (SAED) patterns of two-dimensional (2D) Au(I)-S(CH)COOH (Au(I)-MPA) lamellae are obtained by applying cryogenic transmission electron microscopy.

Zengye decoction regulated the expression of aquaporin in colon tissue of rats with constipation through miR-10a-5p targeting Drd2/AC/cAMP axis.

Slow transit constipation (STC) is a colonic motor disorder characterized by a marked delay in the movement of substances through the colon. Traditional Chinese medicine (TCM) is a treasure trove of natural compounds, which is effective in treating constipation with relatively minor side effects. Zengye decoction (ZYD), a classic herbal formula in TCM, is used for moistening the intestines and relieving constipation.

Recent advances in antiaromatic metallacycles.

Several antiaromatic metallacycles have been reported in the past 5 years, opening an emerging area of (anti)aromaticity and organometallic chemistry. In this work, we briefly review the synthesis and characterization of these complexes. Generally, experimental criteria, including planarity, bond length alternation, NMR chemical shift, chemical transformation, and theoretical criteria, mainly involving NICS, AICD, ASE or ISE, are applied for the antiaromaticity judgement.

An ultra-high absorptivity solar absorber with excellent thermal radiation efficiency based on a metal-dielectric stacked structure.

Metamaterials hold great promise for application in the field of perfect absorbers due to their remarkable ability to manipulate electromagnetic waves. In this work, a full-spectrum ultra-wideband solar absorber with a multilayer metal-dielectric stacked structure is designed. Our absorber is simple and easy to manufacture, with Ti serving as the substrate, overlaid with SiN spacer layers and four pairs of Ti-SiN ring columns.

Top-Down Strategy Enabling Elastic Wood Nanocarbon Sponges with Wrinkled Multilayer Structure and High Compressive Strength for High-Performance Compressible Supercapacitors.

3D porous carbon electrodes have attracted significant attention for advancing compressible supercapacitors (SCs) in flexible electronics. The micro- and nanoscale architecture critically influences the mechanical and electrochemical performance of these electrodes. However, achieving a balance between high compressive strength, electrochemical stability, and cost-effective sustainable production remains challenging.

Oxygen Evolution Reaction of Amorphous/Crystalline Composites of NiFe(OH)/NiFeO.

Orbital structures are strongly correlated with catalytic performance, whereas their regulation strategy is still in pursuit. Herein, the Fe 3 and O 2 orbital hybridization was optimized by controlling the content of amorphous NiFe(OH) (a-NiFe(OH)), which was grown in situ on crystalline NiFeO (c-NiFeO) using an ultrasonic reduction method. The results of electron energy loss spectroscopy (EELS) and X-ray absorption spectra (XAS) revealed that the Fe-O orbital hybridization in a-NiFe(OH) is effectively strengthened by jointing with the adjacent oxygen (O) in c-NiFeO, which is further confirmed by the higher antibonding orbital energies based on density functional theory (DFT) calculations.

Chiral Locomotion Transitions of an Active Gel and Their Chemomechanical Origin.

Transitions between chiral rotational locomotion modes occur in a variety of active individuals and populations, such as sidewinders, self-propelled chiral droplets, and dense bacterial suspensions. Despite recent progress in the study of active matter, general principles governing rotational chiral transition remain elusive. Here, we study, experimentally and theoretically, rotational locomotion and its chiral transition in a 2D polyacrylamide (PAAm)-based BZ gel driven by Belousov-Zhabotinsky reaction-diffusion waves.

Facile Access to Highly Efficient 3D Printing Using Robust Self-Healing CDs/Polymer Hybrids.

3D printing efficiency, as a key indicator of additive manufacturing technology, directly affects its competitiveness in rapid prototyping, small batch production, and even large-scale industrial applications. Compared with traditional manufacturing methods, the high efficiency of 3D printing is often considered a bottleneck, hindering its application across various fields. Herein, a versatile and efficient strategy is proposed, namely, the dimensional reduction printing (DRP) process, to break the obstacle of high efficiency of 3D printing.

Tandem construction of flavone-bridged conjugated porous polymers for photosynthesis of 2,3-dihydrobenzofurans.

Conjugated porous polymers bearing flavone moieties (FL-CPPs) were synthesized a tandem approach. The carbonylative Sonogashira coupling in tandem with cyclization guided the assembling of building blocks with the accompanied production of flavone skeletons. The FL-CPPs were proved to be efficient metal-free photocatalysts for the [3+2] cycloaddition of phenols with olefins under the irradiation of visible-light.

Dynamic regulation of ferroelectric polarization using external stimuli for efficient water splitting and beyond.

Establishing and regulating the ferroelectric polarization in ferroelectric nano-scale catalysts has been recognized as an emerging strategy to advance water splitting reactions, with the merits of improved surface charge density, high charge transfer rate, increased electronic conductivity, the creation of real active sites, and optimizing the chemisorption energy. As a result, engineering and tailoring the ferroelectric polarization induced internal electric field provides significant opportunities to improve the surface and electronic characteristics of catalysts, thereby enhancing the water splitting reaction kinetics. In this review, an interdisciplinary and comprehensive summary of recent advancements in the construction, characterization, engineering and regulation of the polarization in ferroelectric-based catalysts for water splitting is provided, by exploiting a variety of external stimuli.

Enantioselective Catalytic Synthesis of Inherently Chiral Calixarenes.

Since the introduction of the concept of inherent chirality by Böhmer, an important part of research focused on the asymmetric synthesis of calixarene macrocycles. However, long synthetic procedures and tedious separation strategies hampered the application of this technology in many topics of organic chemistry, including enantioselective molecular recognition and catalysis. Very recently, a new generation of enantioselective catalytic methodologies has been reported, able to provide highly functionalized, inherently chiral calixarenes in a straightforward manner.

Advances in adhesion of microneedles for bioengineering.

Microneedles have provided promising platforms in various fields thanks to their safety, painlessness, minimal invasiveness and ease of operation. The excellent adhesion of microneedles is the key characteristic to achieve long-term and comfortable treatment. However, a complex environment, such as the roughness of skin, various bodily fluids , and the movement of the body, presents great challenges to the adhesion characteristics of microneedles.

A biomass-derived multifunctional conductive coating with outstanding electromagnetic shielding and photothermal conversion properties for integrated wearable intelligent textiles and skin bioelectronics.

Intelligent electronic textiles have important application value in the field of wearable electronics due to their unique structure, flexibility, and breathability. However, the currently reported electronic textiles are still challenged by issues such as their biocompatibility, photothermal conversion, and electromagnetic wave contamination. Herein, a multifunctional biomass-based conductive coating was developed using natural carboxymethyl starch (CMS), dopamine and polypyrrole (PPy) and then further employed for constructing multifunctional intelligent electronic textiles.

Advancements in 2D Titanium Carbide (MXene) for Electromagnetic Wave Absorption: Mechanisms, Methods, Enhancements, and Applications.

With the advent of the 5G era, there has been a marked increase in research interest concerning electromagnetic wave-absorbing materials. A critical challenge remains in improving the wave-absorbing properties of these materials while satisfying diverse application demands. MXenes, identified as prominent "emerging" 2D materials for wave absorption, offer unique advantages that are expected to drive advancements and innovations in this field.

ZNF169 promotes thyroid cancer progression via upregulating FBXW10.

Background: Zinc finger protein 169 (ZNF169) plays a key role in cancer development. However, the specific role of ZNF169 in the tumorigenesis of thyroid carcinoma (THCA) remains poorly understood.

Methods: The expression of ZNF169 was measured using immunohistochemistry, RT-qPCR, and western blot.

Alzheimer's disease: an integrative bioinformatics and machine learning analysis reveals glutamine metabolism-associated gene biomarkers.

Background: Alzheimer's disease (AD), a hallmark of age-related cognitive decline, is defined by its unique neuropathology. Metabolic dysregulation, particularly involving glutamine (Gln) metabolism, has emerged as a critical but underexplored aspect of AD pathophysiology, representing a significant gap in our current understanding of the disease.

Methods: To investigate the involvement of GlnMgs in AD, we conducted a comprehensive bioinformatic analysis.

Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment.

Growing evidence implicates that intratumoral microbiota are closely linked to cancer progression; however, research on the role of these microbiota in the development of gastric cancer remains limited. Here, using 16 S rRNA sequencing, tumor tissue proteomics and serum cytokines analysis, we identified enrichment of specific microbial communities within tumors of gastric cancer patients, possibly affecting the tumor microenvironment by immune modulation, metabolic processes, and inflammatory responses. Based on the results of in vivo experiments and intratumoral microbiota analysis, we found that Streptococcus mitis can inhibit gastric cancer progression via suppressing M2 macrophage polarization and infiltration, as well as altering the intratumoral microbial community.

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer.

Background: DNA hypomethylation and uracil misincorporation into DNA, both of which have a very important correlation with colorectal carcinogenesis. Folate plays a crucial role in DNA synthesis, acting as a coenzyme in one-carbon metabolism, which involves the synthesis of purines, pyrimidines, and methyl groups. MTHFR, a key enzyme in folate metabolism, has been widely studied in relation to neural tube defects and hypertension, but its role in colorectal cancer remains underexplored.

Research Progress in the Molecular Mechanism of NLRP3 Inflammasome in Alzheimer's Disease and Regulation by Natural Plant Products.

Alzheimer's disease (AD) is a prominent neurodegenerative disorder affecting the central nervous system in the elderly. Current understanding of AD primarily centers on the gradual decline in cognitive and memory functions, believed to be influenced by factors including mitochondrial dysfunction, β-amyloid aggregation, and neuroinflammation. Emerging research indicates that neuroinflammation plays a significant role in the development of AD, with the inflammasome potentially mediating inflammatory responses that contribute to neurodegeneration.