Cross-coupling reaction of cyclic quaternary ammonium salts with arylzinc reagents, arylboron reagents, and silylboronates.

The nickel-catalyzed reaction of benzocyclic quaternary ammonium salts with arylzinc reagents or arylboron reagents affords amino-retentive arylation products in 40%-95% yields. This protocol is suitable for various substituted benzocyclic quaternary ammonium salts and arylzinc or arylboron reagents. The transition-metal-free reaction of benzocyclic quaternary ammonium salts with PhMeSiBpin in the presence of LiOBu leads to amino-retentive silylation products.

Hydrogen-Bonded Organic Framework Films Integrated with Wavy Structured Design for Wearable Bioelectronics.

The integration of hydrogen-bonded organic frameworks (HOFs) with flexible electronic technologies offers a promising strategy for monitoring detailed health information, owing to their inherent porosity, excellent biocompatibility, and tunable catalytic capabilities. However, their application in wearable and real-time health monitoring remains largely unexplored, primarily due to the mechanical mismatch between the traditionally fragile HOFs particles and the softness of human skin. Herein, this study demonstrates an epidermal biosensor that maintains reliable sensing capability even under extreme deformation and complex environmental conditions by integrating HOFs films with wavy bioelectrodes.

Identification of disulfide bond-linking sites in biosynthesized platelet factor 4 by establishing a partial reduction method without alkylation.

Platelet factor 4 (PF4), a specific protein primarily found in megakaryocytes and platelet α-granules, plays an essential role in the coagulation process. It carries a high positive charge and thus has a unique ability to readily form complexes with negatively charged heparin. This interaction between PF4 and heparin plays a crucial role in platelet aggregation and thrombosis, resulting in heparin-induced thrombocytopenia (HIT).

Cation-Vacancy Engineering in Cobalt Selenide Boosts Electrocatalytic Upcycling of Polyester Thermoplastics at Industrial-Level Current Density.

The past decades have witnessed the increasing accumulation of plastics, posing a daunting environmental crisis. Among various solutions, converting plastics into value-added products presents a significant endeavor. Here, an electrocatalytic upcycling route that efficiently converts waste poly(butylene terephthalate) plastics into high-value succinic acid with high Faradaic efficiency of 94.

Generating Beta Zeolite Nanosheets of Intergrown Polymorph B and C Using Polycationic Structure-Directing Agent.

Zeolitic nanosheets possess great potential in catalysis due to their enhanced transport property and accessibility toward bulky molecules compared to conventional micron- meter scale crystals. However, the generation of Beta zeolite nanosheets, which are crucial for industrial catalysis, is still challenging for its intergrowth nature. In this work, aluminosilicate Beta nanosheets of ca.

Enhanced Photocatalytic Degradation of Chlorsulfuron by MoS/MIL101(Fe) S-Scheme Heterojunction: A Conversion Mechanism Dominated by Electrons and Long-Lifetime Reactive Species.

Altering the generation route of reactive species is a potent means to augment the photocatalytic activity. In this study, MoS/MIL-101(Fe) S-scheme heterojunction (MF2) is prepared using a water/solvent thermal method for photocatalytic degradation of chlorsulfuron. Driven by the internal electric field, the local electron density of MF2 is redistributed, thus enhancing the adsorption of O.

Chemo-Mechanical Due-Biomimetic Approach for Ultra-Stable Adsorption Across Multiple Scenarios.

The unique adhesion capabilities of soft-bodied creatures such as leeches and octopuses have provided considerable inspiration for the development of artificial adhesive materials. However, previous studies have either focused on the design of sucker structures or concentrated on the synthesis of adhesive materials, with the combination of these two aspects not yet having been deeply investigated. In this study, inspired from leech's unique adsorption ability, a biomimetic approach is proposed that combined artificial sucker and mucus, to achieve remarkable adhesion stability on rough surfaces using 5 cm diameter silicone suction cups.

Lobelia-Inspired Photothermal Storage Flexible Film for Efficient Deicing.

The insufficient density and discontinuity of solar energy of photothermal superhydrophobic flexible film seriously affect the practical application. Light energy harvesting and heat energy storage are effective ways to solve this problem. Inspired by the viscous temperature-regulating material within the inflorescence of Lobelia telekii and the arrangement of bracts on its surface, a flexible film for photoheat storage is proposed that integrated a three-order photoheat trap and one-order heat storage.

Light-Induced Transformation from Covalent to Supramolecular Polymer Networks.

Stimuli-responsive polymers have demonstrated significant potential in the development of smart materials due to their capacity to undergo targeted property changes in response to external physical or chemical stimuli. However, the scales of response in most existing stimuli-responsive polymer systems are mainly focused on three levels: functional units, chain conformations, or polymer topologies. Herein, we have developed a covalent polymer network (CPN) capable of converting into a supramolecular polymer network (SPN) within bulk materials directly at the scale of polymer network types.

A OHCs-Targeted Strategy for PEDF Delivery in Noise-Induced Hearing Loss.

Noise-induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage to sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery to the inner ear. This study applied a retro-auricular round window membrane (RWM) method to bypass the BLB, enabling the transport of macromolecular proteins into the inner ear.

Magnetic resonance imaging of focal organizing pneumonia: differential diagnosis with peripheral lung carcinoma.

Background: Computed tomography (CT) is the most common way to evaluate focal organizing pneumonia (FOP); however, sometimes it is difficult to differentiate FOP and peripheral lung carcinoma (PLC).

Purpose: To clarify the MRI manifestation of FOP and the value of MR in the differential diagnosis of FOP and PLC in comparison to CT.

Material And Methods: Chest MR (3D T1WI, T2WI TSE, DWI) and CT images of 72 patients (50 men: mean age=64.

Comparative diagnostic performance of Ga-PSMA-11 PET/CT and Ga-PSMA-11 PET/MRI in detecting biochemical recurrent bone metastasis in prostate cancer: a systematic review and meta-analysis.

Background: The comparative diagnostic performance of Gallium (Ga)-PSMA-11 PET/CT and Ga-PSMA-11 PET/MRI in detecting bone metastases in prostate cancer (PCa) remains unclear.

Purpose: To systematically evaluate the early detection rate of biochemical recurrent (BCR) bone metastasis in PCa utilizing Ga-PSMA-11 PET/CT and Ga-PSMA-11 PET/MRI.

Material And Methods: We searched PubMed, Embase, and Web of Science for relevant articles up to April 2023 and extracted studies that examined the positivity rate of both Ga-PSMA-11 PET/CT and Ga-PSMA-11 PET/MRI in the context of the BCR bone metastasis of PCa patients.

10-year experience with single-site laparoscopic-assisted Soave operation for Hirschsprung disease.

Background: The aim of this study was to investigate the clinical outcomes after a transumbilical single-site laparoscopic-assisted Soave operation (TSLSO) for Hirschsprung disease (HD) in children, with a 10-year follow‑up results assessment.

Methods: We retrospectively analyzed the clinical data of 165 children with HD from January 2013 to January 2023. The operation method was a TSLSO.

Photoresponse Design in Metal Oxide Semiconductor TFTs toward Diverse Applications: Display Drivers, Photodetectors, and Optoelectronic Synapses.

Different application domains impose diverse and often conflicting requirements on the optoelectronic performance of metal oxide semiconductor (MOS) thin-film transistors (TFTs). These varying demands present substantial challenges in the selection of TFT materials and the optimization of device performance. This study begins by examining three primary application areas for TFTs: display drivers, photodetectors, and optoelectronic synapses.

Wireless Flexible Actuator Photoelectric Synergistically Driven for Environment Adaptability Crawling Robots.

Wirelessly driven flexible actuators are crucial to the development of flexible robotic crawling. However, great challenges still remain for the crawling of flexible actuators in complex environments. Herein, we reported a wireless flexible actuator synergistically driven by wireless power transmission (WPT) technology and near-infrared (NIR) light, which consists of a poly(dimethylsiloxane)-graphene oxide (PDMS-GO) composite layer, eutectic gallium-indium alloy (EGaIn), a PDMS layer, and a polyimide (PI) layer.

Neutrophil extracellular traps promote growth of lung adenocarcinoma by mediating the stability of m6A-mediated SLC2A3 mRNA-induced ferroptosis resistance and CD8(+) T cell inhibition.

To investigate the potential mechanisms underlying neutrophil extracellular traps (NETs) confer ferroptosis resistance and CD8(+) T cell inhibition in lung adenocarcinoma (LUAD). By the intravenous injection of LLC cells into the tail vein, a LUAD mouse model was created. Phorbol-12-myristate-13-acetate (PMA) stimulated neutrophils to facilitate NETs formation and combined with NETs inhibitor DNase I to explore NETs mechanism on LLC cell proliferation, migration, ferroptosis resistance, and CD8(+) T cell activity.

Understanding the Effects of Edge Planes in Porous Carbon: Quantum Capacitance and Electrolyte Behavior in Supercapacitor.

Electric double layer capacitors (EDLC) require large specific surface area to provide high power density. The generation of pores increases the electrochemical capacitance with more graphitic edge planes exposed to the electrolyte. Conventional theory believes this increasing in capacitance is owed to the increased specific surface area, but our work uncovers another mechanism.

Cuproplasia and cuproptosis, two sides of the coin.

Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory network, defined as cuproplasia. Thus, targeting copper chelation to reduce copper levels has been considered a rational tumor therapy strategy.

Porous 3d-4f Coordination Clusters for Selective Visible-Light Photocatalytic CO2 Reduction to CO.

We report herein two families of porous coordination clusters (PCCs) with 216 nuclearity (M120RE96 or PCC-216MR) and 300 nuclearity (Co144Gd156 or PCC-300CG). For the first family M could be either nickel or cobalt, and RE = Pr, Nd, Sm, Eu, and Gd; while the latter features the highest nuclearity of transition-rare earth metal clusters. Characterized by their cube-like, hollow structures, these clusters exhibit the ability to absorb N2 and CO2.

CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.

Purpose: Glucose starvation induces the accumulation of disulfides and F-actin collapse in cells with high expression of SLC7A11, a phenomenon termed disulfidptosis. This study aimed to confirm the existence of disulfidptosis in pancreatic ductal adenocarcinoma (PDAC) and elucidate the role of Cancer Susceptibility 8 (CASC8) in this process.

Methods: The existence of disulfidptosis in PDAC was assessed using flow cytometry and F-actin staining.

The heterogeneity of Pinus yunnanensis plantation growth was driven by soil microbial characteristics in different slope aspects.

The slope aspect is an important environmental factor, which can indirectly change the acceptable solar radiation of forests. However, the mechanism of how this aspect changes the underground ecosystem and thus affects the growth of aboveground trees is not clear. In this study, Pinus yunnanensis plantation was taken as the research object, and the effects of soil and microbial characteristics on tree growth under different slope aspects and soil depths were systematically analyzed.

Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice.

Background: Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation in experimental allergic diseases, representing a potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated in migrating cells and facilitate intercellular communication.

PSMA PET/CT based multimodal deep learning model for accurate prediction of pelvic lymph-node metastases in prostate cancer patients identified as candidates for extended pelvic lymph node dissection by preoperative nomograms.

Purpose: To develop and validate a prostate-specific membrane antigen (PSMA) PET/CT based multimodal deep learning model for predicting pathological lymph node invasion (LNI) in prostate cancer (PCa) patients identified as candidates for extended pelvic lymph node dissection (ePLND) by preoperative nomograms.

Methods: [Ga]Ga-PSMA-617 PET/CT scan of 116 eligible PCa patients (82 in the training cohort and 34 in the test cohort) who underwent radical prostatectomy with ePLND were analyzed in our study. The Med3D deep learning network was utilized to extract discriminative features from the entire prostate volume of interest on the PET/CT images.

Mechano-gated iontronic piezomemristor for temporal-tactile neuromorphic plasticity.

In bioneuronal systems, the synergistic interaction between mechanosensitive piezo channels and neuronal synapses can convert and transmit pressure signals into complex temporal plastic pulses with excitatory and inhibitory features. However, existing artificial tactile neuromorphic systems struggle to replicate the elaborate temporal plasticity observed between excitatory and inhibitory features in biological systems, which is critical for the biomimetic processing and memorizing of tactile information. Here we demonstrate a mechano-gated iontronic piezomemristor with programmable temporal-tactile plasticity.

Recovery of nearly 3,000 archaeal genomes from 152 terrestrial geothermal spring metagenomes.

Terrestrial geothermal springs, reminiscent of early Earth conditions, host diverse and abundant populations of Archaea. In this study, we reconstructed 2,949 metagenome-assembled genomes (MAGs) from 152 metagenomes collected over six years from 48 geothermal springs in Tengchong, China. Among these MAGs, 1,431 (49%) were classified as high-quality, while 1,518 (51%) were considered as medium-quality.