PI3K/AKT/mTOR Activation is Associated with Malignant Severity and Poorer Prognosis in Parathyroid Carcinomas.

Context And Objective: Parathyroid carcinoma (PCa) is a rare endocrine neoplasm known for its high recurrence. The specific molecular properties influencing the prognosis of PCa remain largely elusive. The present study was designed to explore the significance of PI3K/AKT/mTOR activation in PCa.

Tunable Organic-Inorganic p-π-d Electron Conjugation Triggers d-π Hybridization in Quinonized MnO Superlattice toward Ultrastable and High-Rate Zn-MnO Batteries.

Zn-MnO batteries with two-electron transfer harvest high energy density, high working voltage, inherent safety, and cost-effectiveness. Zn as the dominant charge carriers suffer from sluggish kinetics due to the strong Zn-MnO coulombic interaction, which is also the origin of pestilent MnO lattice deformation and performance degradation. Current studies particularly involve H insertion-dominating chemistry, where the long-term cycle stability remains challenging due to the accumulative Zn insertion and structural collapse.

Performance of multiplex PCR-based targeted next-generation sequencing in bronchoalveolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients.

Background And Objective: Multiplex polymerase chain reaction (PCR)-based targeted next-generation sequencing (tNGS) is a promising tool for distinguishing lower respiratory tract infections (LRTIs) in clinical practice, and its detectable pathogen spectrum can cover more than 95% of clinical cases. but there is limited information on systematic evaluation of the clinical use of multiplex PCR-based tNGS (mp-tNGS) in IPA cases. We aim to assess mp-tNGS in bronchoalveolar lavage fluid (BALF) for Aspergillus detection in suspected IPA patients, and to provide a reliable basis for initiating antifungal therapy without microbiological or histopathological evidence.

A Deep Insight into the Microscopic Dynamics of the Electrode-Electrolyte Interface under Extreme Operating Conditions.

Understanding the interfacial dynamics during operation is critical for electrochemistry to make great advancements. However, breakthroughs on this topic under extreme conditions are very scarce. Here, as an example, we employ operando Raman spectroscopy to decode the interfacial dynamics of titanium electrolysis using a tailored instrument.

An Ultrasensitive Duplex Aptasensor Featuring the Target-Triggered Lanthanide Luminescence Antenna Effect for Wash-Free Detection of Epithelial Cancerous Exosomes.

Fluorescence sensing is widely used in in vitro detection due to its high sensitivity and rapid result delivery. However, detection systems based on nanomaterials involving complex and cumbersome purification steps can lead to sample loss and significantly reduce the accuracy of the results. To address this issue, we proposed a lanthanide-based aptasensor featuring the target-triggered antenna effect to significantly enhance the time-resolved luminescence (TRL) of chelated Tb combined with a wash-free strategy.

Identifying Carbon-Carbon Triple Bonds from Double Bonds via Single-Molecule Conductance.

Molecular-scale electronics focuses on understanding and utilizing charge transport through individual molecules. A key issue is the charge transport capability of a single molecule characterized by current decay. We visualize the on-site formation of conjugated polymers with varying carbon-carbon bond orders by using scanning tunneling microscopy and noncontact atomic force microscopy.

Effect of A-DNA and B-DNA Conformation on the Interplay between Local Excitations and Charge-Transfer States in the Ultrafast Decay of Guanine-Cytosine Stacked Dimers: A Quantum Dynamical Investigation.

We here simulate in the gas phase the population dynamics of guanine/cytosine (GC) and cytosine/guanine (CG) stacked dimers in B-DNA and A-DNA arrangement, following excitation in the lowest-energy band, and considering the four lowest-energy ππ* bright excited states, the three lowest-energy π* states, and the G → C charge-transfer (CT) state. We resort to a generalized Linear Vibronic Coupling (LVC) model parametrized with time-dependent density functional theory (TD-DFT) computations, exploiting a fragment-based diabatization and we run nonadiabatic quantum dynamical simulations with the multilayer version of the Multiconfigurational Time-Dependent Hartree (ML-MCTDH) approach. G → C CT results in a major decay process for GC in B-DNA but less in A-DNA arrangement, where also the population transfer to the lowest-energy excited state localized on C is an important intermonomer process.

Comparative Pharmacokinetics and Bioequivalence of 2 Formulations of Bosentan Dispersible Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions.

Bosentan is a dual endothelin receptor antagonist widely used in the treatment of pulmonary artery hypertension. However, there are few reports on the pharmacokinetics (PK) and bioequivalence of bosentan dispersible tablets (32 mg) in the Chinese population. This study aimed to evaluate the PK characteristics and bioequivalence of the test and reference formulations of bosentan dispersible tablets in healthy Chinese volunteers under fasting and fed conditions.

Development and validation of a preoperative prediction model for geriatric emergency general surgery.

Purpose: The aim of this study was to establish a scoring system for preoperative assessment of postoperative mortality in elderly patients undergoing emergency general surgery.

Methods: A retrospectively database of geriatric emergency general surgery (EGS) patients who underwent emergency surgery was used for the development of the scoring system.

Results: In total, 1500 patients were enrolled with mean age of 69.

Three-dimensional quantitative temporomandibular joint changes in skeletal class I malocclusion treated with extraction and non-extraction protocols: a comparative study of fixed orthodontic appliances and clear aligners.

Objective: This study aimed to evaluate the positional and morphological changes in the temporomandibular joint (TMJ) in adult patients with skeletal Class I malocclusion treated with fixed orthodontic appliances (FAs) and clear aligners (CAs), both with and without premolar extractions.

Methods: This retrospective study involved 120 adult patients divided into non-extraction and extraction groups, each further subdivided equally into those treated with FAs and CAs. Cone beam computed tomography (CBCT) was used to assess the TMJ measurements before (T0) and after treatment (T1).

Molecular ferroelectric self-assembled interlayer for efficient perovskite solar cells.

The interfacial molecular dipole enhances the photovoltaic performance of perovskite solar cells (PSCs) by facilitating improved charge extraction. However, conventional self-assembled monolayers (SAMs) face challenges like inadequate interface coverage and weak dipole interactions. Herein, we develop a strategy using a self-assembled ferroelectric layer to modify the interfacial properties of PSCs.

Soil fertility differences due to tillage methods modulate maize yield formation at different planting densities.

To address the problems of planting density and low soil nutrient content in maize cultivation and production in western Inner Mongolia. This study aims to elucidate the regulatory mechanism by which soil fertility augmentation affects maize yield formation under a variety of planting densities. In this study, nine soil fertility conditions were established by deep tillage, no-tillage and in situ straw return.

Explicit relation between thin film chromatography and column chromatography conditions from statistics and machine learning.

In chemistry, empirical paradigms prevail, especially within the realm of chromatography, where the selection of separation conditions frequently relies on the chemist's experience. However, the underlying rationale for such experiential knowledge has not been established or analysed. This study explicitly elucidates how chemists use thin-layer chromatography (TLC) to determine column chromatography (CC) conditions, employing statistical analysis and machine learning techniques.

Bilateral synchronous UBE for unilateral laminotomy and bilateral decompression as a potentially effective minimally Invasive approach for two-level lumbar spinal stenosis.

Currently, Unilateral biportal endoscopy is widely used in the surgical treatment of lumbar spinal stenosis. To investigate the feasibility of bilateral synchronous UBE to unilateral laminotomy and bilateral decompression(BS-UBE-ULBD) for treating two-level lumbar spinal stenosis (LSS). Sixty-four patients with two-level lumbar spinal stenosis (LSS) treated with BS-UBE-ULBD from October 2022 to January 2024 were retrospectively analyzed.

Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?

Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigates the differences in the gut microbiota between preterm neonates born to mothers with PE and those born to mothers without PE (PR), aiming to understand how maternal health conditions like PE influence neonatal gut microbiota. The early gut microbiota plays a crucial role in neonatal health, and disturbances in its development can have long-term consequences.

Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models.

Background: Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral imaging emerges as a promising modality due to its high spatial resolution and signal stability. However, its clinical application for in vivo imaging is limited by the inherently weak Raman scattering signal.

Bandgap Engineering Based on A-site Ions Tuning in Tin Halide Perovskite.

Tin-based halide perovskites (ASnX) have garnered substantial interest due to their unique photoelectric properties and environmentally friendly features. The A-site ions tuning strategy has been proven to promote material performance. However, there is a lack of systematic research on the optical properties, lattice structure variation, and band structure evolution in tin-based perovskites when the A-site ions tune from organic to inorganic.

Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi-Omics and Delivery Visualization.

The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in-depth study and global application, despite their abundance of bioactive compounds that make them valuable resources for disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise disease treatment. This involves elucidating the structure-activity relationships within their complex compositions, ensuring accurate in vivo delivery, and monitoring the delivery process.

Ten Years of Perovskite Lasers.

Over the past decade, semiconducting halide perovskite lasers have emerged as a transformative platform in optoelectronics, owing to unique properties such as high photoluminescence quantum yields, tunable bandgaps, and low-cost fabrication processes. This review systematically examines the advancements in halide perovskite lasers, covering diverse laser architectures, such as whispering gallery mode, Fabry-Pérot, plasmonic, bound states in the continuum (BIC), quantum dot, and polariton lasers. The mechanisms of optical gain, the role of material engineering in optimizing lasing performance, and the challenges associated with continuous-wave (CW) pumping and electrically driven lasing are discussed.

A Powerful Tumor Catalytic Therapy by an Enzyme-Nanozyme Cascade Catalysis (ENCAT) System.

Complexity of tumor and its microenvironment as obstacles often restrict traditional tumor therapies. Enzyme/nanozyme-mediated catalytic therapy has been emerged, but the efficacy of single catalytic therapy is still moderate. Inspired by the concepts of catalytic and synergetic therapy, an enzyme-nanozyme cascade catalysis (ENCAT)-enhanced tumor therapy is developed.

Fluorine Doping-Assisted Reconstruction of Isolated Cu Sites for CO Electroreduction Toward Multicarbon Products.

The electrocatalytic synthesis of multicarbon compounds from CO is a promising method for storing renewable electricity and addressing global CO issues. Single-atom catalysts are promising candidates for CO reduction, but producing high-value multicarbon (C) products using a single-atom structure remains a significant challenge. In this study, a fluorine doping strategy is proposed to facilitate the reconstruction of isolated Cu atoms, promoting multicarbon generation.

Enhanced Photocatalytic Efficiency Through Oxygen Vacancy-Driven Molecular Epitaxial Growth of Metal-Organic Frameworks on BiVO.

Efficient charge separation at the semiconductor/cocatalyst interface is crucial for high-performance photoelectrodes, as it directly influences the availability of surface charges for solar water oxidation. However, establishing strong molecular-level connections between these interfaces to achieve superior interfacial quality presents significant challenges. This study introduces an innovative electrochemical etching method that generates a high concentration of oxygen vacancy sites on BiVO surfaces (Ov-BiVO), enabling interactions with the oxygen-rich ligands of MIL-101.

Unveiling Aqueous Potassium-Ion Batteries with Prussian Blue Analogue Cathodes.

Aqueous rechargeable potassium-ion batteries have considerable advantages and potentials in the application of large-scale energy storage systems, owing to its high safety, abundant potassium resources, and environmental friendliness. However, the practical applications are fraught with numerous challenges. Identification of suitable cathode materials and potassium storage mechanisms are of great significance.

Hybrid Soft Segments Boost the Development of Ultratough Thermoplastic Elastomers with Tunable Hardness.

The hardness of thermoplastic elastomers (TPEs) significantly influences their suitability for various applications, but traditionally, enhancing hardness reduces toughness. Herein a method is introduced that leverages hybrid soft segments to fine-tune the hardness of TPEs without compromising their exceptional toughness. Through the selective copolymerization of polytetramethylene ether glycols (PTMEGs) at various molecular weights, supramolecular poly(urethane-urea) TPEs are molecularly engineered to cover a wide spectrum of hardness while retaining good toughness.

Photothermal Material-Based Solar-Driven Cogeneration of Water and Electricity: An Efficient and Promising Technology.

With the increasing demand for fresh-water and electricity in modern society, various technologies are being explored to obtain fresh-water and electricity. Due to advances in materials science, solar-driven interfacial evaporation (SDIE) systems have attracted widespread attention because they require only solar energy, and possess a high evaporation rate and little pollution. The researchers combined energy harvesting measures into the system to output electricity, further improving energy utilization.