Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis.

The objective of the present study was to elucidate the mechanism by which glycyrrhizin enhances the antitumor activity of cisplatin in non-small cell lung cancer. Initially, A549 cells were treated with different concentrations of glycyrrhizin (0.25-8 mM) or cisplatin (10-160 µM) for 48 h to investigate the effect of glycyrrhizin combined with cisplatin on A549 cells .

A bacteria-based bioorthogonal platform disrupts the flexible lipid homeostasis for potent metabolic therapy.

Cancer cells exhibit altered metabolism and energetics, prominently reprogramming lipid metabolism to support tumor growth and progression, making it a promising target for cancer therapy. However, traditional genetic and pharmaceutical approaches for disrupting lipid metabolism face challenges due to the adaptability of tumor metabolism and potential side effects on normal tissues. Here, we present a bacteria-based bioorthogonal platform combining transition metal catalysts and to disrupt the flexible lipid homeostasis in tumors.

Dissecting ionic favorable hydrogen bond chemistry in hybrid separators for aqueous zinc-ion batteries.

Separators, regulating the ion transport channels between electrodes, are crucial for maintaining the properties of electrochemical batteries. However, sluggish ion transport and desolvation kinetics in aqueous zinc-ion batteries (AZIBs) cause uneven ion flux at the separator-electrode interface, accelerating Zn dendrite growth. Herein, we systematically dissect ionic favorable hydrogen bond chemistry in a hybrid separator engineered through rational boron nitride (BN) doping into polyacrylonitrile (PAN) separators.

Palladium-catalyzed carbon-carbon bond cleavage of primary alcohols: decarbonylative coupling of acetylenic aldehydes with haloarenes.

In the current work, a palladium-catalyzed C-C bond cleavage reaction of primary alcohols has been developed. This transformation was characterized by a broad substrate scope, superior functional group tolerance, and high efficiency for selective C-C bond cleavage and was then followed by alkynyl-aryl cross coupling. Mechanism studies indicated that the propargyl alcohols underwent β-H elimination to form aldehydes rather than having undergone β-C elimination.

Facile preparation of fluorescent carbon dots from water caltrop shells and their application in amikacin sensing.

Amikacin (AMK) effectively treats infections from Gram-negative bacilli and penicillin-resistant . However, prolonged administration of AMK may result in adverse effects such as nausea, headache, ototoxicity, and hearing loss, necessitating a reliable detection method. Carbon dots (CDs), known for their excellent optical properties, are a promising fluorescent probe.

Efficient total synthesis of dehydro--viniferin through metal-halogen exchange cyclization.

Bioactive dehydro--viniferin was synthesized through an efficient and practical eight-step route, achieving an overall yield of 27%. The synthesis process involves an intramolecular cyclization and dehalogenation a metal-halogen exchange, producing 3-arylbenzofuran, with the di-iodinated -aryloxyketone serving as the key intermediate. Long reaction times and the use of excess reagent -PrMgCl·LiCl facilitate metal-halogen exchange cyclization and dehalogenation.

Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions.

The initial injection of PEGylated nanoparticles can activate antibodies and the complement system, leading to the accelerated blood clearance (ABC) phenomenon, characterized by reduced circulation time and abnormal liver and spleen accumulation upon re-exposure. However, PEGylation is not essential for ABC induction, as non-PEGylated nanoparticles can also trigger the similar ABC phenomenon. In this study, we found non-PEGylated nanoemulsions (CE) could accelerate the blood clearance of subsequent injection of PEGylated nanoemulsions (PE) in beagles and rats, which was independent of antibodies and the complement system, but was associated with an increase in neutrophil numbers and phagocytic activity.

Chinese Medicine for the Treatment of Liver Cirrhosis: The Mechanism of Cellular Autophagy.

Liver cirrhosis is a critical stage in the progression of various chronic liver diseases, often leading to severe complications such as ascites, hepatic encephalopathy, and a high mortality rate, and it thus poses a serious threat to patient life. The activation of hepatic stellate cells is a central driver of disease progression. Cellular autophagy, a lysosome-mediated degradation process, plays a key role in maintaining cellular function and dynamic homeostasis.

Composition and diversity of rumen mycobiota in Jiani yaks ( jiani): insights into microbial ecology and functions.

This study aimed to explore the diversity and functions of rumen mycobiota in 14‑ (PLf) and 15‑rib (DLf) Jiani yaks using ITS sequencing. A total of 1,079,105 and 1,086,799 filtered sequences were obtained for the PLf and DLf groups, respectively, with 491 ASVs common to both. No significant difference regarding the α‑diversity of mycobiota within the two groups was observed.

Causal Relationship Between Electrocardiogram Parameters and Brugada Syndrome: A Bidirectional Mendelian Randomization Study.

Background: Brugada syndrome (BrS) is associated with an electrocardiogram (ECG), but the causal relationship remains unclear. This study aimed to assess the bidirectional causal relationship between ECG parameters and BrS using Mendelian randomization (MR) analysis.

Methods: A bidirectional MR analysis using data from the OpenGWAS database.

Coverage of surfactants on polyoxometalate tunes the selectivity of alkene epoxidation.

Self-assembled nanosheets were formed through the interaction between polyoxometalate (POM) and dodecyltrimethylammonium bromide (DTB), which has hydrophilic groups at both ends of the carbon chain and serves as a "bridge" connecting the POMs. The resulting POM assemblies demonstrated high efficiency in the epoxidation of cyclohexene, with the selectivity of the reaction being tunable by adjusting the coverage of DTB on the POM.

Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds.

Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules a chemoselective C-H functionalization/dearomatization sequence was developed.

Portable and Self-Powered Sensing AI-Enabled Mask for Emotional Recognition in Virtual Reality.

With the increasing development of metaverse and human-computer interaction (HMI) technologies, artificial intelligence (AI) applications in virtual reality (VR) environments are receiving significant attention. This study presents a self-sensing facial recognition mask (FRM) utilizing triboelectric nanogenerators (TENG) and machine learning algorithms to enhance user immersion and interaction. Various TENG negative electrode materials are evaluated to improve sensor performance, and the efficacy of a single sensor is confirmed.

Efficient synthesis of Au(SR) nanoclusters the cluster-from-cluster approach.

Monodisperse gold nanoclusters constitute a new branch of nanomaterials with atomically precise molecular structures. Recently, we developed a "cluster-from-cluster" approach to assemble gold nanoclusters [Au(SR)] (Au25) atomically precise Au13 precursors. Herein we demonstrated that efficient synthesis of Au(SR) (Au36) nanoclusters can be realized this facile approach.

Strain-Modulated Deposition Mechanism on a Flexible Zinc Anode.

Flexible aqueous zinc-ion batteries (AZIBs) are considered one of the most attractive flexible devices owing to their high theoretical capacity, low cost, and high security. However, the formation of Zn dendrites and the poor flexibility of the Zn material greatly impede the application of wearable AZIBs. Herein, by transferring graphene onto the surface of polyethylene terephthalate-indium tin oxide (PET-ITO-G), a substrate combining excellent flexibility and dendrite suppression ability was prepared.

Switchable Multi-Spectral Electromagnetic Defense in the Ultraviolet, Visible, Infrared, Gigahertz, and Terahertz Bands Using a Magnetically-Controllable Soft Actuator.

Traditional passive single-spectrum electromagnetic defense materials are inadequate to defend against complex multispectral electromagnetic threats. Herein, a bilayer heterofilm (BLH film)-based magnetically controllable soft actuator (MCSA), comprising a defense unit and a drive unit, is constructed. The defense unit offers multispectral electromagnetic protection, while the drive unit enables active defense via magnetic actuation.

MOF-Based Electrocatalysts: An Overview from the Perspective of Structural Design.

The electrocatalytic technique, as an efficient energy storage and conversion technology, has attracted significant attention to address energy exhaustion and environmental pollution. Usually, the activity and selectivity of electrocatalytic reactions are largely dominated by the dynamic process occurring on electrocatalysts. Therefore, high-performance electrocatalysts, which can dominate the pathway and energy barrier of reactions, are of great significance for the advancement of the electrocatalytic technique.

Plant-Plant Interactions Drive the Decomposition of Soil Organic Carbon via Nutrition Competition in Dryland.

Plant-plant interactions are often overlooked when assessing carbon (C) cycling in plant community. Limited research exists on how nutrient competition influences soil organic carbon (SOC) dynamics via modifying rhizosphere C turnover. To address this issue, quantitative model of plant-plant interactions was established in three intercropping systems across 4 years.

One neuroprotective lignanamide from Solanum Septemlobum Thunb.

The whole plant of Thunb., called Shu Yangquan in traditional Chinese medicine, has the traditional function of clearing away heat and toxic material. Chemical investigation on the ethanol extract of afforded a new lignanamide () and a known compound caffeic acid ethyl ester ().

Danuglipron Ameliorates Pressure Overload-Induced Cardiac Remodelling Through the AMPK Pathway.

Cardiac remodelling, a pathological process induced by various cardiovascular diseases, remains a significant challenge in clinical practice. Here, we investigate the potential of Danuglipron (PF-06882961, PF), a novel oral glucagon-like peptide-1 (GLP-1) receptor agonist, in alleviating pressure overload (PO)-induced cardiac hypertrophy and fibrosis. Using both in vivo and in vitro models, we demonstrate that PF treatment (1 mg/kg/day, orally for 8 weeks) significantly attenuates aortic banding-induced cardiac dysfunction and pathological remodelling in mice.

Diagnostic value of contrast-enhanced ultrasound in ovarian cancer: a meta-analysis.

BackgroundOvarian cancer has been reported to be the eighth most common cancer among women worldwide.PurposeTo assess the diagnostic efficacy of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant ovarian tumors.Material and MethodsA comprehensive search of scientific literature databases, including PubMed, Cochrane Library, Web of Science, Wanfang, and CNKI, was conducted from their inception to November 2019 to identify relevant studies on the use of CEUS in the differential diagnosis of benign and malignant ovarian tumors.

Fabrication of Bioconjugates Clacked Chitosan-Coated SN-38 Liposomal Nanoparticles: Improved Precise Chemotherapy Efficacy in Lung Cancer Cells and Its Apoptosis.

Employing an active targeting method with monoclonal antibodies for chemotherapeutics-loaded nanocarriers represents a promising option to enhance the specific drug delivery and alleviate the detrimental effects of chemotherapeutic agents. Targeted delivery to the human epidermal growth factor receptor-2 (HER2), which is overexpressed in HER2+ lung cancerous cells, can be accomplished by conjugating nanoparticles with a monoclonal antibody (anti-HER2). We developed trastuzumab (TZ)-conjugated chitosan iodoacetamide (CsIA)-coated liposomal nanoparticles carrying SN-38 (TZ-SN-CsIA LNPs) as a lung-targeted delivery.

Modulating the electronic structure of NiFe layered double hydroxide via anion engineering for enhanced oxygen evolution.

Alkaline water electrolysis is emerging as a promising technology for large-scale hydrogen production. However, NiFe layered double hydroxide (NiFe LDH), one of the leading-edge oxygen evolution reaction (OER) electrocatalysts in alkaline water electrolysis, still faces challenges in effectively modulating highly active species to enhance its advanced performance, which is crucial for promoting industrial development. Herein, we report a facile anion engineering strategy to construct a novel NiFe LDH as an efficient anode electrocatalyst.

CAS1-synthesized β-Caryophyllene enhances broad-spectrum stress resistance in tomatoes.

Plants have evolved a variety of regulatory mechanisms to adapt to changing environment conditions. Secondary metabolites play a crucial role in these adaptive processes. However, little is known about whether specific secondary metabolites confer broad-spectrum resistance to various biotic and abiotic stresses.

Imaging Aspect Ratio-Dependent Anisotropic Conversion of Bismuth-Based Metal-Organic Frameworks into Bismuth Oxides.

Metal-organic frameworks (MOFs) have emerged as promising templates and precursors that can be converted to a series of functional materials. Probing the dynamic conversion processes within individual MOF crystal particles in real-time is key to understanding the structure-activity relationship, but this remains challenging, particularly for anisotropic MOF crystals. Here, using dark-field optical microscopy, we visually image and quantify the dynamic oxidation conversion of a single bismuth-based metal-organic framework (Bi-MOF) into bismuth oxides by NaClO.