Phase and Orbital Engineering Effectuating Efficient Adsorption and Catalysis toward High-Energy Lithium-Sulfur Batteries.

The delicate construction of electrocatalysts with high catalytic activity is a strategic method to enhance the kinetics of lithium-sulfur batteries (LSBs). Adjusting the local structure of the catalyst is always crucial for understanding the structure-activity relationship between atomic structure and catalyst performance. Here, in situ induction of electron-deficient B enables phase engineering MoC, realizing the transition from hexagonal (h-MoC) to cubic phase (c-B-MoC).

The Effect of Deep Cryogenic Treatment on the Electrocatalytic Performance of a Pd@CFs Catalyst for Methanol Oxidation.

To enhance the electrocatalytic performance of a flexible Pd@CFs catalyst for methanol oxidation, deep cryogenic treatment in liquid nitrogen was introduced. The effects of the frequency and time of the deep cryogenic treatment on the surface crystal orientation, microstructure morphology, mechanical performance, and electrocatalytic performance for methanol oxidation were studied. The results showed that when the frequency of the deep cryogenic treatment was 2 times and the deep cryogenic time was 24 h, the electrocatalytic performance of the catalyst was the best.

Electroactive Dressing with Selective Sorption of Exudate Enables Treatment of Complicated Wound.

Exudate management and cell activity enhancement are vital to complicated wound healing. However, current exudate management dressings indiscriminately remove exudate, which is detrimental to cell activity enhancement. Herein, a novel class of electroactive bilayer (cMO/PVA) dressing is developed by constructing manganese oxide nanoneedle-clusters decorated commercial carbon cloth (MO), in situ casting polyvinyl alcohol (PVA) hydrogel, and finally charging.

Socioeconomic Inequalities in PM Exposure and Local Source Contributions at Community Scales Using Hyper-Localized Taxi-Based Mobile Monitoring in Xi'an, China.

The relationship between the socioeconomic status (SES) and PM exposure is rather inconclusive. We employed taxi-based measurements with 30 m resolution to characterize PM exposure with local source contribution (PM adjusted concentration) discerned for 2019 winter and 2020 summer, in Xi'an. A big data set comprising ∼6 × 10 hourly PM measurements and SES data from ∼5000 communities was utilized to examine the socioeconomic inequalities in community-level PM exposure.

Synergistic Bifunctional Covalent Organic Framework for Efficient Photocatalytic CO Reduction and Water Oxidation.

The scientific community has been actively researching artificial photosynthesis to promote ecologically sustainable living and address environmental issues. However, designing photocatalysts with active sites that are effective for both CO reduction and water oxidation remains a significant challenge. Thus, we present the development of a donor-acceptor covalent organic framework (D-A COF), that integrates two distinct metal coordination environments through structure-activity relationships.

Efficient Metabolomics Profiling from Plasma Extracellular Vesicles Enables Accurate Diagnosis of Early Gastric Cancer.

Accurate diagnosis of early gastric cancer is valuable for asymptomatic populations, while current endoscopic examination combined with pathological tissue biopsy often encounters bottlenecks for early-stage cancer and causes pain to patients. Liquid biopsy shows promise for noninvasive diagnosis of early gastric cancer; however, it remains a challenge to achieve accurate diagnosis due to the lack of highly sensitive and specific biomarkers. Herein, we propose a protocol combining metabolomics profiling from plasma extracellular vesicles (EVs) and machine learning to identify the metabolomics discrepancies of early gastric cancer individuals from other populations.

Antioxidant Activities of the Cell-Free Supernatant of a Potential Probiotic Cutibacterium acnes Strain CCSM0331, Isolated From a Healthy Skin.

Objective: Oxidative stress activates the reactive oxygen species (ROS) and excessive ROS can damage skin cells, initiating oxidative stress responses that contribute to inflammation, aging, and other skin issues. As a resident skin bacterium, Cutibacterium acnes (C. acnes) plays an important role in maintaining skin homeostasis and provides antioxidant benefits.

Effect of persulfate dosage on organic degradation using N-doped biochar: Reaction pathway and environmental implications.

Persulfate-based advanced oxidation processes (PS-AOPs) catalyzed by carbon-based catalysts are promising for removing organic pollutants via radical/non-radical pathways. However, the activation efficiency of peroxymonosulfate (PMS) or peroxydisulfate (PDS) usage and the reaction mechanism remain insufficiently understood. In this study, the effects of PMS/PDS dosage on the degradation of bisphenol A (BPA, 10 mg/L) were evaluated using N-doped biochar (N-BC, 0.

Research on the Development of Rural Human Settlement Environment in the Upper Reaches of the Lancang River Based on Ecological Carrying Capacity Constraints.

The development of rural human settlement environments in ecologically sensitive areas, particularly the upper reaches of the Lancang River within the Sanjiangyuan region, has garnered significant attention due to its paramount importance in balancing economic growth and ecological conservation. However, the comprehension of sustainable development strategies within the confines of ecological carrying capacity in these regions remains inadequate. The present study aims to investigate the rural human settlement environment in Nangqen County, situated within the Sanjiangyuan region, and to explore adaptive construction strategies that facilitate harmonious coexistence between human settlements and the natural environment.

Technological Innovation and Trade Orientation as Drivers of Renewable Energy Consumption: Panel Evidence from G7 Economies.

Recent advancements in industrialization have sparked substantial interest among the academic community and policymakers regarding energy consumption. The consumption patterns of distinct energy types seem to be influenced by many national and international factors. In this essence, this study investigates the effects of technological innovation and trade orientation on renewable energy consumption (REC).

Leveraging Large Language Models for Predicting Postoperative Acute Kidney Injury in Elderly Patients.

The objective of this work is to develop a framework based on large language models (LLMs) to predict postoperative acute kidney injury (AKI) outcomes in elderly patients. Our study demonstrates that LLMs have the potential to address the issues of poor generalization and weak interpretability commonly encountered in disease prediction using traditional machine learning (ML) models. AKI is a severe postoperative complication, especially in elderly patients with declining renal function.

A patient with penile metastasis secondary to small cell lung cancer successfully treated with PD-1 inhibitors and chemotherapy: a case report and literature review.

Background: Penile metastasis is an uncommon condition, with most primary malignancies originating in the abdominal cavity and pelvis. There have been very few reported cases originating from lung cancer, most of squamous cell carcinoma without small cell lung cancer.

Methods: We presented a case of penile metastasis secondary to small cell lung cancer, along with a review of relevant literature from the CNKI database.

Association between magnesium depletion score and Klotho levels among U.S. adults: Findings from NHANES 2007-2016.

Background: Magnesium is a vital mineral that plays a crucial role in various physiological processes, and its imbalance has been associated with many chronic aging-related diseases. Traditional assessment methods are insufficient, and the Magnesium Depletion Score (MDS) has been proposed as a significant indicator. Klotho, a transmembrane protein, is involved in aging regulation and oxidative stress modulation.

Ischaemic and bleeding risk after ST-elevation myocardial infarction in patients with active cancer: a nationwide study.

Aims: Treatment of patients with cancer presenting with ST-elevation myocardial infarction (STEMI) is complex given the increased risk of both thrombotic and major bleeding complications.

Methods And Results: A nationally linked cohort of STEMI patients between January 2005 and March 2019 was obtained from the UK Myocardial Infarction National Audit Project and the UK National Hospital Episode Statistics Admitted Patient Care registries. The primary outcomes were major bleeding and re-infarction at 1 year following admission with STEMI.

Efficacy and safety of PD-1/PD-L1 inhibitors alone or in combination in the treatment of metastatic or advanced renal cell carcinoma: a network meta-analysis.

Background: This study systematically reviews the efficacy and safety of the single or combined use of programmed factor 1 (PD-1)/programmed factor 1 ligand (PD-L1) inhibitors for treating metastatic or advanced renal cell carcinoma (RCC).

Methods: Relevant articles were collected for meta-analysis through searches on PubMed, Web of Science, Embase, Cochrane Library, and Clinical Trials, as well as for relevant randomized controlled experiments.

Results: Based on eleven studies, the effectiveness of the experimental group was found to be significantly better than the control in terms of overall survival (OS) [R=0.

hsa_circ_0004846 enhances the malignant phenotype of papillary thyroid carcinoma cells via the miR‑142‑3p/PELI1 axis.

Circular RNAs (circRNAs) are closely associated with human tumorigenesis; however, whether hsa_circ_0004846 serves a role in the progression of papillary thyroid carcinoma (PTC) remains unclear. Therefore, the present study aimed to investigate the effect of hsa_circ_0004846 on PTC. The results demonstrated that circ_0004846 was abnormally upregulated in PTC tissues and thyroid cancer cell lines (BCPAP, TPC-1 and IHH-4).

Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report.

Primary gingival diffuse large B-cell lymphoma (DLBCL) with muscle invasion is rare and accounts for ~0.5% of all reported cases of extranodal lymphoma. The present study describes the case of a 49-year-old man that initially presented at Yingshan County People's Hospital (Nanchong, China) in August 2017 with a chief complaint of tenderness and swelling of the jaw.

Timing of thoracic radiotherapy combined with immunotherapy influences pulmonary injury.

The present study aimed to assess the impact of chest radiotherapy combined with immunotherapy at different time points in lung injury. This retrospective study analyzed 35 patients with thoracic tumors (29 lung cancer cases and 6 esophageal cancer cases) who received radiotherapy combined with immunotherapy between January 2021 and December 2023 at at Capital Medical University, affiliated with Beijing Luhe Hospital (Beijing, China), with a median follow-up time of 21 months. Patients were divided into two groups: Group A (sequential, n=17), who received immunotherapy 2 weeks to 6 months before or after radiotherapy, and group B (synchronous, n=18), who received immunotherapy within 2 weeks before or after radiotherapy.

Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review.

Primary diffuse malignant peritoneal mesothelioma (MPEM) is a malignant disease without standard treatments recommended. Recently, immunotherapy has revolutionized the field of tumor therapy. According to current clinical evidence, advanced MPEM may gain potential clinical benefits from immune checkpoint inhibitors.

Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression.

Hepatocellular carcinoma (HCC) ranks among the most prevalent and lethal cancers affecting humans. Currently, there are limited effective treatments available for HCC. Carfilzomib, a proteasome inhibitor, is known to exert anti-HCC activities; however, its underlying mechanisms of action remain unclear.

Effects of circulating RNAs on tumor metabolism in lung cancer (Review).

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis and abnormal lipid and amino acid metabolism to obtain energy and nutrients for growth, proliferation and drug resistance. Circular RNAs (circRNAs), a class of non-coding RNAs, serve important biological roles in the growth and development of tumors.

Clinical characteristics and survival analysis of cancer of unknown primary.

Cancer of unknown primary (CUP) is a diagnosis that the primary lesion cannot be confirmed by a series of imaging, endoscopic and pathological examinations. The present study aimed to assess the clinical characteristics and survival outcomes of patients with CUP. The present retrospective observational study included patients diagnosed with malignancies confirmed as CUP using histopathology at the Oncology Department of the Fourth Hospital of Hebei Medical University (Shijiazhuang, China) from January 2009 to January 2021.

Rare multiple schwannomas of the left upper extremity: A case report.

Schwannomas are rare benign neoplasms originating from Schwann cells of peripheral nerve sheaths. The current study presents a distinctive case involving multiple schwannomas along the peripheral nerves of the left upper extremity. The patient exhibited multiple gradually enlarging subcutaneous masses distributed along the nerves of the left upper limb, without pain, neurological deficits or a positive Tinel's sign upon physical examination.

Bacterial metabolites: Effects on the development of breast cancer and therapeutic efficacy (Review).

Evidence suggests that various gut metabolites significantly impact breast cancer (BC) and its treatment. However, the underlying mechanisms remain poorly understood and require further investigation. In the present study, the current literature was reviewed to evaluate the roles of microbial metabolites in the development of BC and its response to treatment.

SNS‑032 combined with decitabine induces caspase‑3/gasdermin E‑dependent pyroptosis in breast cancer cells.

SNS-032 is a synthetic compound that specifically inhibits cyclin-dependent kinases 2, 7 and 9. Its primary anticancer activity involves cell cycle arrest, which prevents tumor cell growth. However, there are limited reports on whether SNS-032 induces pyroptosis, a novel inflammation-mediated programmed cell death pathway in breast cancer (BC).