Facile Access to Quaternary Carbon Centers via Ni-Catalyzed Arylation of Alkenes with Organoborons.

Quaternary carbon centers are widespread structural motifs, thus representing extensive interest in organic synthesis. We describe here an efficient nickel-catalyzed intermolecular, -selective arylation of minimally functionalized alkenes with stable organoborons, affording a broad range of cyclic or acyclic quaternary carbon centers under mild conditions. The utilization of the diimine ligand is critical for high reactivity and chemoselectivity.

Supramolecular Combination Chemotherapy: Directly Inducing Immunogenic Cell Death To Inhibit Tumor Metastasis via Host-Guest Interactions.

Tumor metastasis is a difficult clinical problem to solve due to tumor heterogeneity and the emergence of antiapoptotic clones driven by tumor evolution. Clinical combination chemotherapy remains a standard treatment for solid metastasis tumors but with worse treatment efficiency. It is worth exploring a high-efficiency and low-side-effect therapeutic method to solve solid metastases.

DBU-catalyzed annulation strategy for modular assembly of 2,3-difunctionalized dihydrobenzofurans.

An organocatalytic approach for the construction of 2,3-dihydrobenzofuran scaffold through a formal [4 + 1] annulation of 2-(2-nitrovinyl)phenols and α-bromoacetophenones in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed.

A Stable Zn(II) Metal-Organic Framework as Turn-On and Blue-Shift Fluorescence Sensor for Amino Acids and Dipicolinic Acid in Living Cells or Using Aerosol Jet Printing.

Amino acids and dipicolinic acid (DPA) are important biomarkers for identifying human health. Establishing rapid, accurate, sensitive, and simple assays is essential for disease prevention and early diagnosis. In this work, a novel Zn(II) metal-organic framework (MOF) with the formula {[Zn(μ-OH)(BTDI)(dpp)]·dpp·4HO·2DMF} (, where denotes Jiangxi University of Science and Technology, HBTDI = 5,5'-(benzo[][1,2,5]thiadiazole-4,7-diyl)diisophthalic acid; dpp = 1,3-di(4-pyridyl)propane) was successfully synthesized via a mixed-ligands strategy.

Ultrafast chirality-dependent dynamics from helicity-resolved transient absorption spectroscopy.

Chirality, a pervasive phenomenon in nature, is widely studied across diverse fields including the origins of life, chemical catalysis, drug discovery, and physical optoelectronics. The investigations of natural chiral materials have been constrained by their intrinsically weak chiral effects. Recently, significant progress has been made in the fabrication and assembly of low-dimensional micro and nanoscale chiral materials and their architectures, leading to the discovery of novel optoelectronic phenomena such as circularly polarized light emission, spin and charge flip, advocating great potential for applications in quantum information, quantum computing, and biosensing.

Digital devices usage and neck and shoulder pain among college students: a cross-sectional study in China.

Neck and shoulder pain (NSP) is a common issue among college students, yet no studies have linked digital device usage to NSP prevalence in China. This cross-sectional survey aimed to explore this relationship among students in Shanghai. A total of 6,000 students were randomly selected, with 4,848 (80.

Mechanism of dexmedetomidine in brain injury of infant rats via the IRE1α/NF-κB/CHOP pathway.

Objective: We investigated the mechanism of Dexmedetomidine (Dex) in infant rats with brain injury.

Methods: The infant rats underwent brain injury modelling. The motor function, spatial learning and memory abilities in rats, and the hippocampal CA1 region Nissl body level and apoptosis were evaluated by behavioural tests and histological stainings.

Photoenzyme Coupling System: Covalent Organic Frameworks In Situ Production of Hydrogen Peroxide Cascaded with Unspecific Peroxygenase to Achieve C-H Bonds Selective Activation.

As an efficient, sustainable, and environmentally friendly semiconductor material, covalent organic frameworks (COFs) can generate hydrogen peroxide (HO) by photocatalysis, attracting wide attention in recent years. Herein, the effects of hydroxyl, methoxyl, and vinyl groups of imide-linked two-dimensional (2D) COFs on the photocatalytic production of HO were studied theoretically and experimentally. The introduction of vinyl groups greatly promotes the photogenerated charge separation and migration of COFs, providing more oxygen adsorption sites, stronger proton affinity, and lower intermediate binding energy, which effectively facilitates the rapid conversion of oxygen to HO.

Unraveling the Function Mechanism of N-Doped Carbon-Encapsulated NaV(PO) Cathode toward High-Performance Sodium-Ion Battery with Ultrahigh Cycling Stability.

The NASICON-type NaV(PO) (NVP) is recognized as a potential cathode material for Na-ion batteries (SIBs). Nevertheless, its inherent small electronic conductivity induces limited cycling stability and rate performance. Carbon coating, particularly N-doped carbon, has been identified as an effective strategy to address these challenges.

Constructing a Robust Interphase with 1,1'-Oxalyldiimidazole (ODI) Additive to Enhance the Temperature and Rate Performance of LiNiCoMnO/Graphite Batteries.

This work develops 1,1'-oxalyldiimidazole (ODI) as a functional electrolyte additive. This film-forming additive improves the wide range of temperature and rate performances of LiNiCoMnO/graphite (NCM811) batteries. After 1200 cycles at room temperature (25 °C), the discharge capacity retention rate is 51.

High-Performance Perovskite Photodetectors with Suppressed Dark Current Density via Small Molecule in Antisolvent Strategy.

Dark current density, a critical parameter in perovskite photodetectors (PPDs), largely depends on the quality of the perovskite film. Herein, we introduce a new small molecule in antisolvent strategy to enhance perovskite film quality during the crystallization of Cs(FAMA)Pb(IBr). COTIC-4Cl, an N-type narrow bandgap nonfullerene small molecule with specific functional group, could strongly bind to the uncoordinated Pb in the perovskite with assistance of antisolvent, enabling rapid supersaturation of perovskite solution and form dense structures under low-temperature annealing.

Magnetic Bistable Dome Actuators for Soft Robotics with High Volume Capacity and Motion Stability.

Magneto-responsive soft actuators hold significant promise in soft robotics due to their rapid responsiveness and untethered operation. However, controlling their deformations presents challenges because of their inherent flexibility and high degrees of freedom. Here, we present a magnetically driven bistable dome-shaped soft actuator that simplifies deformation by limiting it to two distinct states.

Inflammation Targeting-Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa.

Inflammatory bowel disease (IBD) is characterized by intestinal mucosal damage that exacerbates inflammation and promotes disease recurrence. Although hydrogel-based therapies have shown potential for mucosal repair, challenges remain due to inadequate targeting and low hydrogel density, leading to ongoing infiltration of harmful substances and delayed mucosal healing. In this study, an inflammation-targeting-triggered healing hydrogel (ITTH hydrogel) is developed, composed of polyvinyl alcohol-alginate microgels (PALMs) and a cyclodextrin polymer crosslinker (CPC).

Engineering Atom-Scale Cascade Catalysis via Multi-Active Site Collaboration for Ampere-Level CO Electroreduction to C Products.

Electrochemical reduction of CO to value-added multicarbon (C) productions offers an attractive route for renewable energy storage and CO utilization, but it remains challenging to achieve high C selectivity at industrial-level current density. Herein, a MoCu single-atom alloy (SAA) catalyst is reported that displays a remarkable C Faradaic efficiency of 86.4% under 0.

Recent Progress and Advances of Perovskite Crystallization in Carbon-Based Printable Mesoscopic Solar Cells.

Carbon-based printable mesoscopic solar cells (p-MPSCs) offer significant advantages for industrialization due to their simple fabrication process, low cost, and scalability. Recently, the certified power conversion efficiency of p-MPSCs has exceeded 22%, drawing considerable attention from the community. However, the key challenge in improving device performance is achieving uniform and high-quality perovskite crystallization within the mesoporous structure.

A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment.

With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and targeted therapy. However, the heterogeneity, drug resistance, and poor prognosis of breast cancer highlight an urgent need for further exploration of its underlying mechanisms.

Location or size? A finite element analysis study of necrotic lesion impact on femoral head collapse.

Background: The location and size of necrotic lesions are important factors for collapse, The preserved angles (PAs) are divided into anterior preserved angle (APA) and lateral preserved angle (LPA), which could accurately measure the location of necrosis lesion. We used them to evaluate the effect of the location and size of necrotic lesions on collapse by finite element analysis, to offer a framework for evaluating the prognosis of osteonecrosis of the femoral head (ONFH) in clinical settings.

Methods: 3 left hip models were constructed based on CT data.

ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner.

The N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a significant role in tumorigenesis and cancer progression. However, the detailed biological functions and underlying mechanisms of m6A regulation in gastric cancer (GC) are poorly understood. Our research revealed that the m6A demethylase ALKBH5 was markedly downregulated in GC tissues, which was associated with poor patient prognosis.

Attitudes and knowledge for CBT-based psychotherapy among medical students and residents in China: a survey study.

Background/aim: Psychotherapy training for medical students and residents in China is still in development. To establish an appropriate training program, understanding medical students' and residents' current knowledge and attitudes toward psychotherapy is needed.

Methods: One hundred and forty-nine participants, including medical students, residents, and other health providers (HCPs), self-reported their understanding of 18 types of psychotherapy, negative attitude towards cognitive behavioral therapy (CBT), and their attitude towards psychological interventions and counseling in primary care (APIC-PC) through an online survey.

Clinical and imaging features of co-existent pulmonary tuberculosis and lung cancer: a population-based matching study in China.

Background: Co-existent pulmonary tuberculosis and lung cancer (PTB-LC) represent a unique disease entity often characterized by missed or delayed diagnosis. This study aimed to investigate the clinical and radiological features of patients diagnosed with PTB-LC.

Methods: Patients diagnosed with active PTB-LC (APTB-LC), inactive PTB-LC (IAPTB), and LC alone without PTB between 2010 and 2022 at our institute were retrospectively collected and 1:1:1 matched based on gender, age, and time of admission.

Smoking cessation is a protective factor for lung cancer onset and mortality: a population-based prospective cohort study.

Background: Smoking is a pivotal modifiable risk factor for lung cancer (LC). Previous studies have indicated that a smoking cessation program might be incorporated into the LC screening program. However, the effects of smoking cessation and its duration with the age at onset (AAO) of LC, all-cause mortality, and LC-specific mortality remain unclear.

Chemo-optogenetic Dimerization Dissects Complex Biological Processes.

Light offers superior control in terms of high temporal precision, high spatial precision, and non-invasiveness for the regulation of cellular functions. In recent years, chemical biologists have adopted chemo-optogenetic dimerization approaches, such as photo-triggered chemical inducers of dimerization (pCIDs), as a general tool for spatiotemporal regulation of cellular functions. Traditional chemo-optogenetic dimerization triggers either a single ON or a single OFF of cellular activity.

Exploring Brain Imaging and Genetic Risk Factors in Different Progression States of Alzheimer's Disease Through OSnetNMF-Based Methods.

Alzheimer's disease (AD) is a neurodegenerative disease with no effective treatment, often preceded by mild cognitive impairment (MCI). Multimodal imaging genetics integrates imaging and genetic data to gain a deeper understanding of disease progression and individual variations. This study focuses on exploring the mechanisms that drive the transition from normal cognition to MCI and ultimately to AD.

METTL14 Promotes the Osteogenic Differentiation of Human Bone Marrow Stromal Cells via m6A-Dependent Stabilization of USP7 mRNA.

Osteoporosis (OP) is a common clinical bone disease that can cause a high incidence of non-stress fractures and is one of the main degenerative diseases that endangers the health and life of middle-aged and older women. The mechanism underlying the abnormal differentiation and function of human bone marrow stem cells (hBMSCs) remains to be elucidated. Cell proliferation and differentiation were determined using 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, alkaline phosphatase (ALP) staining, and Alizarin Red Staining.

Long-term trends in the incidence of male breast cancer and nomogram for predicting survival in male breast cancer patients: a population-based epidemiologic study.

Male breast cancer (MBC) is rare, and due to the absence of male-specific screening programs, many patients are diagnosed at advanced stages and older ages. This study aims to analyze the long-term trend of MBC incidence and develop a competing risk model to improve survival rates. MBC data from the Surveillance, Epidemiology, and End Results (SEER) database (1975-2019) were analyzed using the Age-Period-Cohort (APC) model to examine trends in age, period, and birth cohort effects of MBC incidence.