Unusual Iron-Independent Ferroptosis-like Cell Death Induced by Photoactivation of a Typical Iridium Complex for Hypoxia Photodynamic Therapy.

Ferroptosis is a unique cell death mode that relies on iron and lipid peroxidation (LPO) and is extensively utilized to treat drug-resistant tumor. However, like the other antitumor model, requirement of oxygen limited its application in treating the malignant tumors in anaerobic environments, just as photodynamic therapy, a very promising anticancer therapy. Here, we show that an iridium(III) complex (Ir-dF), which was often used in proton-coupled electron transport (PCET) process, can induce efficient cell death upon photo irradiation, which can be effectively protected by the typical ferroptosis inhibitor Fer-1 but not by the classic iron chelating agents and ROS scavengers.

APE1-Activated and NIR-II Photothermal-Enhanced Chemodynamic Therapy Guided by Amplified Fluorescence Imaging.

The development of intelligent nanotheranostic technology that integrates diagnostic and therapeutic functions holds great promise for personalized nanomedicine. However, most of the nanotheranostic agents exhibit "always-on" properties and do not involve an amplification step, which may largely limit imaging contrast and restrict therapeutic efficacy. Herein, we construct a novel nanotheranostic platform (Hemin/DHPs/PDA@CuS nanocomposite) by assembling DNA hairpin probes (DHPs) and hemin on the surface of PDA@CuS nanosheets that enables amplified fluorescence imaging and activatable chemodynamic therapy (CDT) of tumors.

Monitoring technology for Cr(VI) adsorption and reduction by NMR spectroscopy.

This study employs a low-field NMR (LF-NMR) method to investigate Cr(VI) adsorption and reduction in solid-liquid systems, focusing on three cellulose-based amine adsorbents. NMR revealed the effects of molecular structure on adsorption and reduction processes, providing insights into adsorbent design and mass transfer advantages for high-performance Cr(VI) adsorbents.

Promising Nanoparticles-Based Oral Therapy for Effective Inhibition of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus.

Portal vein tumor thrombus (PVTT) is a poor prognostic factor for hepatocellular carcinoma (HCC) patients, highlighting the need for an oral drug delivery system that combines convenience, simplicity, biosafety, and improved patient compliance. Leveraging the unique anatomy of the portal vein and insights from single-cell RNA sequencing of the PVTT tumor microenvironment, we developed oral pellets using CaCO@PDA nanoparticles (NPs) encapsulating both doxorubicin hydrochloride and low molecular weight heparin. These NPs target the tumor thrombus microenvironment, aiming to break down the thrombus barrier and turn the challenge of portal vein blockage into an advantage by enhancing drug delivery efficiency through oral administration.

Zinc Chloride-Doped g-CN Microtubes for Enhanced Photocatalytic Degradation of Tetracycline Hydrochloride.

Morphology regulation and element doping are effective means to improving the photocatalytic performance of graphite-phase carbon nitride (g-CN). In this article, using melamine and zinc chloride as raw materials, a novel kind of Zn/Cl-doped hollow microtubular g-CN (Zn-HT-CN) by a hydrothermal method was developed. The structure and morphology of Zn-HT-CN and reference samples were characterized by X-ray diffraction patterns (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), etc.

A dendritic drug-drug conjugate self-assembled hypoxia-responsive supramolecular nanoparticle for combination therapy.

Hypoxia, a condition that enhances tumor invasiveness and metastasis, poses a significant challenge for diverse cancer therapies. There is a pressing demand for hypoxia-responsive nanoparticles with integrated photodynamic functions in order to address the aforementioned issues and overcome the reduced efficacy caused by tumor hypoxia. Here, we report a hypoxia-responsive supramolecular nanoparticle SN@IR806-CB consisting of a dendritic drug-drug conjugate (IR806-Azo-CB) and anionic water-soluble [2]biphenyl-extended-pillar[6]arene modified with eight ammonium salt ions (AWBpP6) the synergy of π-π stacking interaction, host-guest complexation, and hydrophobic interactions for synergistic photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy (CT; , PTT-PDT-CT).

Copper-catalysed radical cascade reaction of -(2-oxo-2-phenylethyl) substituted 2-pyridones with styrene to access 1,6-carboannulated 2-pyridone scaffolds.

Herein, we present that treating -(2-oxo-2-phenylethyl) substituted 2-pyridones with styrenes in DMSO/HO at 120 °C affords 1,6-carboannulated 2-pyridone scaffolds with up to 79% yield. This protocol provides a simple and efficient method for obtaining complicated bicyclic 2-pyridones through a radical cascade reaction. Additionally, we have successfully synthesized 27 target compounds, which confirms the practicality and wide applicability of the proposed reaction.

Mutual suppression of MnO and SiO in an innovative anode design for enhanced cycling stability.

We designed a SiO@C/MnO composite material with ultrafine particle size using a simple sol-gel method and calcination process. SiO and MnO components produce a mutual suppression effect during the charge/discharge process to mitigate volume expansion and maintain the long-term stability of composite.

Unveiling Microscopic Variations during Photodynamic Therapy via Polarity-Responsive Fluorescence Lifetime Imaging.

Photodynamic therapy is a highly promising method for cancer adjuvant treatment. However, the current research on the microscopic changes during the photodynamic therapy process is still quite limited, which seriously impedes the deep understanding of the procedure. For this purpose, a novel polarity-responsive probe, , with excellent mitochondrial targeting and anchoring capabilities has been rationally designed and synthesized.

TRIB1 facilitates the proliferation and migration of ovarian cancer cells by inducing EMT progression.

Aim: Ovarian cancer (OC) is a fatal female malignant tumor that severely impacts the health of women worldwide. Due to the lack of diagnostic biomarkers, 70% of OC patients are considered in the advanced stage at the first diagnosis. Exploring novel biomarkers for OC diagnosis has become an urgent clinical need to address.

Polychlorinated biphenyls in aquatic products from Shandong, China.

PCBs were analysed in 110 samples, including marine fish, freshwater fish and marine bivalves. The levels of ∑PCBs in marine fish ranged from 0.18 to 5.

A Highly Selective Probe for Real-Time Monitoring of Ethylenediamine with Ratiometric Luminescent and Colorimetric Dual-Mode Responses.

Ethylenediamine (EDA), as an important chemical raw material and fine chemical intermediate, has been widely applied in various industries. Real-time monitoring of EDA is highly desirable in daily life due to its potential threat to human health. Herein, we report a molecular probe named 4,4'-(9-carbazole-3,6-diyl)bis(1-(naphthalen-2-ylmethyl)pyridin-1-ium) iodide (p-N-DPC·I) with ratiometric luminescent and colorimetric dual-mode responses toward EDA, endowing a highly sensitive and selective detection method for its real-time monitoring.

Unraveling the conversion mechanism toward spinel sulfides as cathode materials for Mg-ion batteries.

Rechargeable Mg batteries are promising candidates for achieving considerable high-energy-density. Enhancing the energy density can be achieved by integrating metallic Mg anodes with conversion-type cathode materials, which are characterized by multi-electron transfer process and elevated specific capacities in contrast to intercalation-type materials. Despite these advantages, the conversion-type cathodes still have some challenges of substantial volume expansion, sluggish diffusion kinetics and intricate mesophase evolution during repeated electrochemical reactions.

Graphene quantum dot-modified CoO/NiCoO yolk-shell polyhedrons as a polysulfide-adsorptive sulfur host for lithium-sulfur batteries.

The shuttle effect of lithium polysulfides and non-ideal reaction kinetics restrict the development of high-energy-density lithium-sulfur (Li-S) batteries. Here, we report a graphene quantum dot (GQD)-modified CoO/NiCoO yolk-shell polyhedron as a sulfur host for Li-S batteries. GQDs shorten transport pathways of electrons, while strong binding of CoO and NiCoO to LiS, LiS and LiS are demonstrated from density functional theory calculations.

3d-5d Orbital Hybridization in Nanoflower-Like High-Entropy Alloy for Highly Efficient Overall Water Splitting at High Current Density.

Exploring highlyefficient electrocatalysts for overall water splitting is a challenging butnecessary task for development of green and renewable energy. Herein, PtIrFeCoNi high-entropy alloy nanoflowers (HEA NFs) withstrong 3d-5d orbital hybridization were fabricated to achieve highly efficientoverall water splitting at high current density. The PtIrFeCoNi HEA NFs achieved a 57.

BaFS: Birefringence Enhanced by the Transformation from Optical Isotropy to Anisotropy via Interlayer Anion Substitution.

Improved birefringence, given its capacity to modulate polarized light, holds a lively role in the optoelectronic industry. Traditionally, alkaline-earth metal halides have possessed low birefringence due to their nearly optical isotropic properties. Herein, the substitution of interlayer anion with linear S─S unit that meticulously engineered by reduced valence state and strong covalent bond is integrated into the optically isotropic BaF, offering the new salt-inclusion chalcogenide BaFS.

Regulating Intermediate Adsorption and Promoting Charge Transfer of CoCr-LDHs by Ce Doping for Enhancing Electrooxidation of 5-Hydroxymethylfurfural.

Electrochemical oxidation of 5-hydroxymethylfurfural (HMFOR) to generate high-value chemicals under mild conditions acts as an energy-saving and sustainable strategy. However, it is still challenging to develop electrocatalysts with high efficiency and good durability. Here, nickel foam (NF) supported CoCrCe(7.

Clinical utility of plasma p-tau217 in identifying abnormal brain amyloid burden in an Asian cohort with high prevalence of concomitant cerebrovascular disease.

Introduction: Using an Asian cohort with high prevalence of concomitant cerebrovascular disease (CeVD), we evaluated the performance of a plasma immunoassay for tau phosphorylated at threonine 217 (p-tau217) in detecting amyloid beta positivity (Aβ+) on positron emission tomography and cognitive decline, based on a three-range reference, which stratified patients into low-, intermediate-, and high-risk groups for Aβ+.

Methods: Brain amyloid status (Aβ- [n = 142] vs Aβ+ [n = 73]) on amyloid PET scans was assessed along with the plasma ALZpath p-tau217 assay to derive three-range reference points for PET Aβ+ based on 90% sensitivity (lower threshold) and 90% specificity (upper threshold).

Results: Plasma p-tau217 (area under the curve [AUC] = 0.

A non-interpenetrated mesoporous hydrogen-bonded organic framework constructed with 1,3,5-tri(4-carboxyphenyl)benzene.

The discovery of porous molecular solids has been constantly hindered by phase transformation and interpenetration. Here, we crystallize two molecules with three substituted carboxylic groups. A mesoporous, non-interpenetrated HOF that is constructed from 1,3,5-tri(4-carboxyphenyl)benzene (TCPB) is discovered and reported for the first time.

Molecular Mechanisms of Humic Acid in Inhibiting Silica Scaling during Membrane Distillation.

Membrane distillation (MD) efficiently desalinizes and treats high-salinity water as well as addresses the challenges in handling concentrated brines and wastewater. However, silica scaling impeded the effectiveness of MD for treating hypersaline water and wastewater. Herein, the effects of humic acid (HA) on silica scaling behavior during MD are systematically investigated.

Effect of Reaction Interface Structure on the Morphology and Performance of Thin-Film Composite Membrane.

Thin-film composite (TFC) membrane has been extensively utilized and investigated for its excellent properties. Herein, we have constructed an active layer (AL) containing cave-like structures utilizing large meniscus interface. Furthermore, the impact of interface structure on the growth process, morphology, and effective surface area of AL has been fully explored with the assistance of sodium dodecyl benzenesulfonate (SDBS).

Dynamic Methane Emissions from China's Fossil-Fuel and Food Systems: Socioeconomic Drivers and Policy Optimization Strategies.

In response to the 2023 "Action Plan for Methane Emission Control" in China, which mandates precise methane (CH) emission accounting, we developed a dynamic model to estimate CH emissions from fossil-fuel and food systems in China for the period 1990-2020. We also analyzed their socioeconomic drivers through the Logarithmic Mean Divisia Index (LMDI) model. Our analysis revealed an accelerated emission increase (850.

Simultaneous Copper and EDTA Ligands Recovery from Electroless Effluent with Metallic Copper and Formaldehyde.

The traditional treatment of toxic and refractory copper(II)-ethylenediaminetetraacetic acid chelate (Cu(II)-EDTA) in electroless effluents often generates hazardous waste and secondary nitrogen-containing pollutants without maximizing the resource recovery. This study demonstrates a facile strategy to simultaneously recover Cu and EDTA ligands from Cu(II)-EDTA electroless effluent with commercially available metallic Cu and formaldehyde. In this strategy, metallic Cu is used to activate formaldehyde, a prevalent yet often overlooked cocontaminant in Cu(II)-EDTA effluents, to produce highly reductive hydrogen radical (H), which in situ decomplex Cu(II)-EDTA, reduces the central Cu(II) into metallic Cu, and release EDTA ligand.

HIV OctaScanner: A Machine Learning Approach to Unveil Proteolytic Cleavage Dynamics in HIV-1 Protease Substrates.

The rise of resistance to antiretroviral drugs due to mutations in human immunodeficiency virus-1 (HIV-1) protease is a major obstacle to effective treatment. These mutations alter the drug-binding pocket of the protease and reduce the drug efficacy by disrupting interactions with inhibitors. Traditional methods, such as biochemical assays and structural biology, are crucial for studying enzyme function but are time-consuming and labor-intensive.

Aminobenzoic Acid Covalently Modified Polyoxotungstates Based on {XW} Clusters with Proton Conductivity Property.

Three cases of aminobenzoic acid hybrid polyoxotungstates, Na(HO)[(HPWO) (OCCHNH)]·7HO (), K(HO)[(AsWO)(OCCHNH)]·4HO (), and [(HN(CH)]Na(HO)[(SbWO) (OCCHNH)]·7HO (), were successfully synthesized. This is the first report of the successful assembly of the hexanuclear {XW} (X = HP, As, or Sb) clusters and organic carboxylic acid (para aminobenzoic acid) ligands. All three hybrids feature a common {XW} unit composed of a six-membered {WO} octahedral ring capped by one {XO} trigonal pyramid.