Biodegradable copper-doped calcium phosphate nanoplatform enables tumor microenvironment modulations for amplified ferroptosis in cervical carcinoma treatment.

As a recently discovered form of regulated cell death, ferroptosis has attracted much attention in the field cancer therapy. However, achieving considerably enhanced efficacy is often restricted by the overexpression of endogenous glutathione (GSH) in tumor microenvironment (TME). In this work, we report a ferroptosis-inducing strategy of GSH depletion and reactive oxygen species (ROS) generation based on a biodegradable copper-doped calcium phosphate (CaP) with L-buthionine sulfoximine (BSO) loading (denoted as BSO@CuCaP-LOD, BCCL).

Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential.

Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are prepared to mimic the hierarchical structure of natural bones, through the inheritance of the hierarchical structure of fiber silk and the integration with a polyester matrix. Due to the robust interface between the matrix and fiber silk, CFSCs show maintained stable long-term mechanical performance under wet conditions.

Causal Relationships Between 4 Exposure Factors and Rotator Cuff Syndrome Using Mendelian Randomization Analysis.

Background: Although previous studies have investigated the risk factors for rotator cuff syndrome (RCS), there remains controversy due to uncontrolled and uncertain confounding factors in their analyses.

Purpose: To perform Mendelian randomization (MR) analysis using single-nucleotide polymorphisms to investigate the causal relationship between RCS and 4 risk factors: type 2 diabetes mellitus (T2DM), high blood pressure (HBP), body mass index (BMI), and low high-density lipoprotein cholesterol (HDL-C).

Study Design: Descriptive epidemiology study.

Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy.

Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of tumor sites is still a critical aim in cancer therapy. Though there have been a variety of delivery strategies to improve the tumor targeting and enrichment, biological barriers still cause most delivered guests to fail or be excreted before they work.

Opportunities and challenges of lead-free metal halide perovskites for luminescence.

Metal halide perovskites (MHPs) have been developed rapidly for application in light-emitting diodes (LEDs), lasers, solar cells, photodetectors and other fields in recent years due to their excellent photoelectronic properties, and they have attracted the attention of many researchers. Perovskite LEDs (PeLEDs) show great promise for next-generation lighting and display technologies, and the external quantum efficiency (EQE) values of polycrystalline thin-film PeLEDs exceed 20%, which is undoubtedly a big breakthrough in lighting and display fields. However, the toxicity and instabilities of lead-based MHPs remain major obstacles limiting their further commercial applications.

A 3D four-fold interpenetrated conductive metal-organic framework for fast and robust sodium-ion storage.

Two-dimensional conductive metal-organic frameworks (2D c-MOFs) with high electrical conductivity and tunable structures hold significant promise for applications in metal-ion batteries. However, the construction of 3D interpenetrated c-MOFs for applications in metal-ion batteries is rarely reported. Herein, a 3D four-fold interpenetrated c-MOF (Cu-DBC) constructed by conjugated and contorted dibenzo[,]chrysene-2,3,6,7,10,11,14,15-octaol (DBC) ligands is explored as an advanced cathode material for sodium-ion batteries (SIBs) for the first time.

Recent advances and perspectives in synthetic applications of silylboronates as silyl radical precursors.

Silylboronates, as powerful and versatile reagents, have been widely used in synthetic chemistry over the past few decades, due to their ability to incorporate silicon and boron atoms into organic molecules. With the rapid development of radical chemistry, the use of silylboronates as silyl radical precursors has recently become a research focus in organic synthesis. Significant achievements have been made in the synthetic applications of silylboronates as silyl radical sources for various C-Si and C-X bond forming transformations.

Probiotics fermentation enhanced the bioactive properties of water extract and improved regulation ability of gut microbiota.

This study investigated the probiotic potential of fermented beverages derived from (). Three different beverages were prepared by fermenting water extract with A6-3 ( A6-3), A27-1 ( A27-1), or both for 48 h. The results demonstrated that bioactive compounds from promoted the growth of these two probiotics and preserved their viability for at least 28 days at 4 °C.

Nutritional and antioxidative characterization, antimicrobial and sensorial stability of flaxseed powder supplemented mutton patties.

Oxidative stress and microbial growth deteriorate food quality and cause safety risks. Therefore, the present study was investigated to explore the nutritional, sensorial, anti-oxidative and anti-microbial attributes of flaxseed powder (FP) supplemented at 2-8 % (i.e.

Recent Advances in Asymmetric Wettability Dressings for Wound Exudate Management.

The management of wound exudate is of vital importance for wound healing. Exudate accumulation around wound prolongs inflammation and hinders healing. Although traditional dressings can absorb wound exudate, they are unable to drain exudate in time, often resulting in a poor feature with wound healing.

A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens.

Pigeon paramyxovirus type-1 (PPMV-1) is the causative agent of pigeon Newcastle disease (ND), which has caused huge losses to the pigeon industry. In this study, a PPMV-1 strain, PPMV-1/QH-01/CH/23, was isolated from a sick racing pigeon in the Qinghai-Tibet Plateau, China in 2023. The mean death time of chicken embryos and the intracerebral pathogenicity index (ICPI) were 76.

Highly sensitive temperature sensors based on the fluorescence intensity ratio of dual-emissive lead-free metal halides.

Given that optical thermometers are widely used due to their unique advantages, this study aims to address critical challenges in existing technologies, such as insufficient sensitivity, limited temperature measurement ranges, and poor signal recognition capabilities. Herein, we develop a thermometer based on the fluorescence intensity ratio (FIR) of Sb-doped CsNaInCl (CsNaInCl:Sb). As the temperature increases from 203 to 323 K, the thermally induced transition from triplet to singlet self-trapped excitons (STEs) leads to enhanced 455 nm photoluminescence (PL) from singlet STE recombination.

Tyrosine-modified tilapia skin antioxidant peptides and their hydroxyl radical quenching activities.

In an antioxidant peptide study, the number and position of active amino acid sites, as well as the peptides' conformation, are found to be crucial for scavenging hydroxyl radicals (˙OH). Herein, ˙the OH scavenging activity of tilapia pentapeptide (P1, YGDQY) and its analogs including P2 (YYYGDQY), P3 (YYGDQYY) and P4 (YYGPDQYY) was investigated. The results showed that the tyrosine's amount, location and the peptides' conformation played important roles in determining peptides' scavenging activity (34.

formed CuSn alloy from multivariate metal-organic frameworks for tunable CO electroreduction.

A molecular ligand separation method based on multivariate metal-organic frameworks (MOF) is developed to precisely regulate CuSn alloy for tuning the selectivity of HCOOH and CO in CO reduction. With this method, the agglomeration and heterogeneous nucleations of metals are effectively inhibited during the electrochemical transformation of CuSn-MOFs into highly pure CuSn alloy. The low Sn content favors CO production, while the high Sn concentration facilitates HCOOH formation.

Synthesis of a three-phase heterojunction NdVO/VO/BiVO by cation exchange method for the degradation of anionic azo dye orange II.

Photocatalytic degradation of the azo dye orange II using NdVO/VO/BiVO under visible light is reported here, and this oxygen-rich defect three-phase heterojunction structure is constructed using a two-step cation exchange method. This heterojunction significantly enhances the separation and migration efficiency of photo-induced charges, while the accompanying oxygen defects effectively capture photogenerated electrons, thereby suppressing the recombination of electrons and holes. Experimental characterization and theoretical calculations demonstrate the efficient separation and transfer capabilities of photogenerated carriers and their excellent photocatalytic degradation performance.

Synchronous Photocatalytic Redox Conversion of Chromium(VI) and Arsenic(III) by Bimetallic Fe/Ti Metal-Organic Frameworks.

In this work, bimetallic organic frameworks NH-MOFs(Fe, Ti) with different Fe/Ti molar ratios were prepared by a hydrothermal method for the synchronous redox transformation of Cr(VI) and As(III). These results showed that NH-MIL-125(Ti) was less effective in the photocatalytic removal of Cr(VI), whereas NH-MIL-88B(Fe) was less effective in the photocatalytic oxidative removal of As(III). Due to the introduction of Fe, the photocatalytic reduction removal of Cr(VI) (23.

Vibronic Coupling and Multiple Electronic States Effect in ABS and ECD Spectra: Three [7]Helicene Derivatives.

Vibronic coupling and multiple electronic states effect play a pivotal role in the molecular spectroscopy of large systems. Herein, we present a detailed theoretical study on the absorption (ABS) and electronic circular dichroism (ECD) spectra of three [7]helicene derivatives in chloroform, with a particular emphasis on the significance of vibronic coupling and the multiple electronic states effect in spectral simulations. The vertical gradient (VG) and vertical Hessian (VH) models, incorporating the Franck-Condon (FC) effect and Herzberg-Teller (HT) contribution, are considered in the vibronic calculations.

In-Plane Bulk Photovoltaic Effect in a MoSe/NbOI Heterojunction for Efficient Polarization-Sensitive Self-Powered Photodetection.

Two-dimensional ferroelectric materials can generate a bulk photovoltaic effect, making them highly promising for self-powered photodetectors. However, their practical application is limited by a weak photoresponse due to a weak transition strength and wide band gap. In this study, we construct a van der Waals heterojunction using NbOI, which has significant in-plane polarization, with a highly absorbing MoSe layer.

LiOH Additive Triggering Beneficial Aging Effect of SnO Nanocrystal Colloids for Efficient Wide-Bandgap Perovskite Solar Cells.

Commercial SnO nanocrystals used for producing electron transporting layers (ETLs) of perovskite solar cells (PSC) are prone to aggregation at room temperature and contain many structural defects. Herein, we report that the LiOH additive can simultaneously delay the aggregation and donate the beneficial aging effect to SnO nanocrystals. The resulting SnO ETLs show the desired characteristics, including a broadened absorption range, reduced defects, improved transporting properties, and decreased work function.

Te@Se Core-Shell Heterostructures with Tunable Shell Thickness for Ultra-Stable NO Detection.

An effective long-term nitrogen dioxide (NO) monitoring at trace concentration is critical for protecting the ecological environment and public health. Tellurium (Te), as a recently discovered 2D elemental material, is promising for NO detection because of its suitable band structure for gas adsorption and charge mobility. However, the high activity of Te leads to poor stability in ambient and harsh conditions, limiting its application as a gas-sensitive material.

Smart and Noninvasive SERS Immunosensors for Monitoring Dynamic Expression of Cytokines during Cell Pyroptosis.

Accompanying the occurrence of inflammatory reaction to release cytokines, pyroptosis can activate an immune response for resistance against cancer. Consequently, elevated levels of cytokines released by cancer cells are highly correlated with the effectiveness of cancer treatment. Herein, a noninvasive surface-enhanced Raman spectroscopy (SERS) immunosensor was developed to sensitively and specifically measure the tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, during the cell pyroptosis process.

Functionalization of Graphene by Interfacial Engineering in Thermally Conductive Nanofibrillated Cellulose Films.

Flexible nanocomposites incorporating nanofibrillated cellulose (NFC) hold significant promise for thermal management applications. However, their heat dissipation performance is primarily constrained by the interfacial thermal resistance (). In this work, 1-pyrenemethylamine hydrochloride (PyNH) noncovalent functionalized graphene subsequently self-assembled with NFC through a vacuum-assisted filtration technique.

Efficient Bifunctional Electrocatalysts for Oxygen Evolution/Reduction Reactions in Two-Dimensional Metal-Organic Frameworks by a Constant Potential Method.

The evolution of bifunctional catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) catalysts that are highly active, stable, and conductive is crucial for advancing metal-air batteries and fuel cells. We have here thoroughly explored the OER and ORR performance for a category of two-dimensional (2D) metal-organic frameworks (MOFs) called TM(HADQ), and Rh(HADQ) exhibits a promising bifunctional OER/ORR activity, with an overpotential of 0.31 V for both OER and ORR.

Synergism and Mechanisms of Aging Resistance in the Use of Graphene and Carbon Nanotubes in Bitumen Composites.

Thermal oxidation has a significant effect on the durability of bitumen composites reinforced with carbon nanomaterials. However, the mechanisms of aging resistance and the effect of aging on the chemical properties, morphology, micromechanical properties, and rheology of bitumen with carbon nanomaterials are still unclear. This study investigated the mechanisms of aging resistance underlying the synergistic effects of graphene and carbon nanotubes (CNTs) on the durability of bitumen composites.