Vertical flow immunoassay for multiplex mycotoxins based on photonic nitrocellulose and SERS nanotags.

Here, we report a SERS based VFA using PNC as a sensing substrate for highly sensitive multiplex mycotoxins detection. The PNC was fabricated by filtration-based self-assembled monodisperse SiO NPs on a filter membrane as a template, and the obtained PNC had an ordered complementary inverse opal structure. In parallel, three kinds of Raman dyes encoding Au@Ag, Au@Ag and Au@Ag SERS nanotags were synthesized for the detection of OTA, AFB1 and ZON.

Rapid introgression of the clubroot resistance gene into cabbage skeleton inbred lines through marker assisted selection.

Unlabelled: Clubroot, caused by , is a globally pervasive soil-borne disease that poses a significant challenge primarily in cruciferous crops. However, the scarcity of resistant materials and the intricate genetic mechanisms within cabbage present major obstacles to clubroot resistance (CR) breeding. In our previous research, we developed an Ogura CMS cabbage variety, "17CR3", which harbors the gene, crucial for CR.

3D printing of biological tooth with multiple ordered hierarchical structures.

Natural teeth fulfill functional demands by their heterogeneity. The composition and hydroxyapatite (HAp) nanostructured orientation of enamel differ from those of dentin. However, mimicking analogous materials still exhibit a significant challenge.

Click chemistry-enabled gold nanorods for sensitive detection and viability evaluation of copper(II)-reducing bacteria.

The rise of antibiotic resistance poses a significant and ongoing challenge to public health, with pathogenic bacteria remaining a persistent threat. Traditional culture methods, while considered the gold standard for bacterial detection and viability assessment, are time-consuming and labor-intensive. To address this limitation, we developed a novel point-of-care (POC) detection method leveraging citrate- and alkyne-modified gold nanorods (AuNRs) synthesized with click chemistry properties.

Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy.

Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. The discovery of exosomes' role in intercellular communication has sparked a great deal of interest in them recently.

A Pair of Fluorescent Probes Enabling Precise Diagnosis of Liver Cancer by Complementary Imaging.

Hepatocellular carcinoma (HCC) is by far the predominant malignant liver cancer, with both high morbidity and mortality. Early diagnosis and surgical resections are imperative for improving the survival of HCC patients. However, limited by clinical diagnosis methods, it is difficult to accurately distinguish tumor tissue and its boundaries in the early stages of cancer.

Facile Labeling of Gram-Negative Bacteria with NIR-II Fluorescent Nanoprobes for Intestinal Bacteria Imaging.

The gut bacteria not only play a crucial role in maintaining human health but also exhibit close associations with the occurrence of numerous diseases. Understanding the physiological and pathological functions of gut bacteria and enabling early diagnosis of gut diseases heavily relies on accurate knowledge about their in vivo distribution. Consequently, there is a significant demand for noninvasive imaging techniques capable of providing real-time localization information regarding gut bacteria.

Identifying Natural Products as Feline Coronavirus M Inhibitors by Structural-Based Virtual Screening and Enzyme-Based Assays.

The main protease (M) is a pivotal target in the life cycle of feline coronavirus (FCoV), which causes a high mortality feline disease, feline infectious peritonitis (FIP). Virtual screening was performed against the feline coronavirus M to find active compounds with low toxicity from a library of natural products. Eighty-six compounds were selected by using the rank of docking score and binding pose analysis.

Neutrophil-derived apoptotic body membranes-fused exosomes targeting treatment for myocardial infarction.

Myocardial infarction (MI) poses a substantial threat to human health, prompting extensive research into effective treatment modalities. Preclinical studies have demonstrated the therapeutic potential of mesenchymal stem cell-derived exosomes for cardiac repair. Despite their promise, the inherent limitations of natural exosomes, mainly their restricted targeting capabilities, present formidable barriers to clinical transformation.

Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes.

Triple-negative breast cancer (TNBC) is a unique breast cancer subtype characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression in tumor cells. TNBC represents about 15% to 20% of all breast cancers and is aggressive and highly malignant. Currently, TNBC diagnosis primarily depends on pathological examination, while treatment efficacy is assessed through imaging, biomarker detection, pathological evaluation, and clinical symptom improvement.

Methodological study on coal-based microbial modification of mineral black clay to overcome plant growth challenges on open-pit mine dumps in cold regions.

A critical challenge in ecological restoration of open-pit mine dumps in cold regions with limited topsoil resources is how to rapidly mitigate the plant growth-inhibitory effects of mineral black clay, thereby converting it into arable soil. Leveraging the high degradation capacity of coal seam-associated microorganisms on fossil carbon materials, combined with soil conditioning techniques, this study developed a microbial-based approach for modifying black clay. Seed germination experiments informed both laboratory and field trial designs.

Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer.

Objective: This study aims to assess the clinical significance of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) in predicting chemotherapy outcomes for patients with small cell lung cancer (SCLC).

Methods: A cohort of 44 patients diagnosed with SCLC between January 2021 to June 2022 at Fuyang People's Hospital was selected for analysis. All patients in this group received a first-line platinum-based doublet chemotherapy regimen.

Recent developments and challenges of molecular design in linear cyanido-bridged multimetallic complexes.

Cyanido-bridged multimetallic complexes have been extensively studied for their potential applications in molecular electronics and spintronics. The design of these complexes involves the strategic placement of metal centers and the use of cyanide bridges to facilitate electron transfer between metal ions. The challenges in this field include the precise control of the electronic states and the stability of the complexes under various conditions.

Effects of porous hedgehog-like morphology and graphene oxide on the cycling stability and rate performance of CoO/NiO microspheres.

A porous hedgehog-like CoO/NiO/graphene oxide (denoted as PHCNO/GO) microsphere was prepared by a facile solvothermal method, followed by an annealing treatment under argon atmosphere. Benefiting from the thin CoO/NiO nanosheets with a large specific surface area, abundant pores distributed between the CoO/NiO nanosheets, and GO firmly wrapped around the surface of PHCNO microspheres, the PHCNO/GO microspheres showed excellent lithium storage performance. The CoO/NiO nanosheets provided numerous active sites, achieving a high reversible specific capacity.

Developing tough, fatigue-resistant and conductive hydrogels growth of metal dendrites.

Developing hydrogels with high conductivity and toughness a facile strategy is important yet challenging. Herein, we proposed a new strategy to develop conductive hydrogels by growing metal dendrites. Water-soluble Sn ions were soaked into the gel and then converted to Sn dendrites an electrochemical reaction; the excessive Sn ions were finally removed by water dialysis, accompanied by dramatic shrinkage of the gel.

An isolable boron-centered radical anion stabilized by a carbazole moiety.

The isolation of a stable persistent carbazole-stabilized boron-centered monoradical anion 1˙, which has a high spin density at the B atom, has been reported. It is characterized using the crystal structure and UV-vis absorption spectrum, as well as electron paramagnetic resonance spectroscopy. Interestingly, the B-N bond was activated by the boron-centered radical anion 1˙, which had not been reported before.

Heteroatom number-dependent cluster frameworks in structurally comparable Pd-Au nanoclusters.

Investigating the impact of heteroatom alloying extents on regulating the cluster structures is crucial for the fabrication of cluster-based nanomaterials with customized properties. Herein, two structurally comparable PdAu ( = 1, 2) nanoclusters with a uniform surface environment but completely distinct kernel configurations were controllably synthesized and structurally determined. The single Pd-alloyed Pd1Au12 nanocluster retained an icosahedral metal framework, while the Pd2Au12 nanocluster with two Pd heteroatoms exhibited a unique toroidal configuration.

Construction of organic heterojunctions as metal-free photocatalysts for enhancing water splitting and phenol degradation by regulating charge flow.

Metal-free photocatalysts derived from earth-abundant elements have drawn significant attention owing to their ample supply for potential large-scale applications. However, it is still challenging to achieve highly efficient photocatalytic performance owing to their sluggish charge separation and lack of active catalytic sites. Herein, we designed and constructed a series of covalently bonded organic semiconductors to enhance water splitting and phenol degradation.

Lead Phosphate Material for Exclusive Detection of Hydrogen Sulfide Gas.

Efficient gas sensors that can accurately detect and identify hydrogen sulfide are essential for various practical applications. Conventional resistive sensors often lack the necessary selectivity, which hampers timely and effective HS detection. This study presents lead phosphate-based gas sensors specifically designed for HS detection, which effectively eliminate interference effects.

Platinum/(Carbon-Nanotube) Electrocatalyst Boosts Hydrogen Evolution Reaction in Acidic, Neutral and Alkaline Solutions.

Widely used catalysts for electrocatalytic hydrogen (H) evolution reaction (HER) have high platinum (Pt) contents and show low efficiencies in neutral and alkaline solutions. Herein, a carbon nanotube (CNT) supported Pt catalyst (Pt/CNT45) with 1 wt.% Pt is fabricated.

Atmospheric oxygen mediated oxidation coupling of primary and secondary alcohols: synthesis of pyrazolo[1,5-]pyrimidines.

An atmospheric oxygen-mediated oxidative coupling of primary and secondary alcohols for the synthesis of nitrogen-containing heterocycles has been developed. This method utilizes atmospheric oxygen as the sole, environmentally friendly oxidant to convert a variety of alkyl and aromatic primary alcohols into aldehyde equivalents, avoiding over-oxidation to carboxylic acids. Notably, these mild oxidation conditions are compatible with both primary and secondary alkyl alcohols as substrates.

Hollow TiO@TpPa S-Scheme Photocatalyst for Efficient HO Production Through O in Deionized Water Using Phototautomerization.

Hydrogen peroxide (HO) production through photocatalytic O reduction reaction (ORR) is a mild and cost-efficient alternative to the anthraquinone oxidation strategy. Of note, singlet state oxygen (O) plays a crucial role in ORR. Herein, a hollow TiO@TpPa (TOTP) S-scheme heterojunction by the Schiff base reactions involving 1,3,5-triformylphloroglucinol (Tp) and paraphenylenediamine (Pa) for efficient photocatalytic HO production in deionized water has been developed.

Interfacial Work Function Modulation of Wide Bandgap Perovskite Solar Cell for Efficient Perovskite/CIGS Tandem Solar Cell.

Wide-bandgap perovskite solar cells (PVSCs), a promising top-cell candidate for high-performance tandem solar cells, often suffer from larger open-circuit voltage (V) deficits as the bandgap increases. Surface passivation is a common strategy to mitigate these V deficits. However, understanding the mechanisms underlying the differences in passivation effects among various types of molecules remains limited, which is crucial for developing universal interface passivation strategies and guiding the design of passivation molecules.

Instar identification and weight prediction of (Guenée) larvae using machine learning.

The Asian corn borer, (Guenée), emerges as a significant threat to maize cultivation, inflicting substantial damage upon the crops. Particularly, its larval stage represents a critical point characterised by significant economic consequences on maize yield. To manage the infestation of this pest effectively, timely and precise identification of its larval stages is required.