CDK1 inhibitor RO-3306 enhances BTKi potency in diffuse large B-cell lymphoma by suppressing JAK2/STAT3 signaling.

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in adults, which characterized by a high degree of heterogeneity in terms of clinical presentation, molecular phenotype, and genetic features. However, approximately 30 %-40 % of patients are refractory to standard chemotherapy, and their prognosis is poor. The emergence of small-molecule inhibitors, such as Bruton's tyrosine kinase inhibitors (BTKi), has greatly improved the treatment of DLBCL; however, drug resistance associated with small-molecule inhibitors has greatly limited their clinical application.

Hepatic adverse events associated with ketamine and esketamine: A population-based disproportionality analysis.

Background And Objective: To determine whether there is disproportionate reporting of hepatobiliary disorders in the United States (US) FDA Adverse Event Reporting System (FAERS) for individuals prescribed ketamine or esketamine.

Design: We identified Medical Dictionary for Regulatory Activities (MedDRA) terms in the FAERS related to hepatobiliary disorders.

Main Measures: Formulations of ketamine and esketamine were evaluated for the proportionality of reporting for each hepatobiliary disorder parameter using the reporting odds ratio (ROR).

Clinical value of multi-slice spiral CT in evaluating preoperative TNN staging and postoperative recurrence and metastasis of colon carcinoma.

To evaluate the clinical value of multi-slice spiral CT in preoperative TNN staging and postoperative recurrence and metastasis of colon carcinoma, and to provide evidence for the reliability of CT in the diagnosis of colon carcinoma METHODS: 89 patients with colon carcinoma diagnosed pathologically in our hospital from July 2020 to April 2023 were selected retrospectively. The preoperative TNN staging and postoperative recurrence and metastasis were monitored by 64 row 128 layer spiral CT. The diagnostic coincidence rate, TNM staging coincidence rate and postoperative recurrent TNM staging accuracy were evaluated according to the pathological diagnosis RESULTS: The diagnostic coincidence rate of multi-slice spiral CT was 97.

Differentiation therapy targeting the stalled epigenetic developmental programs in pediatric high-grade gliomas.

Pediatric high-grade gliomas (pHGGs) are the most common brain malignancies in children and are characterized by blocked differentiation. The epigenetic landscape of pHGGs, particularly the H3K27-altered and H3G34-mutant subtypes, suggests these tumors may be particularly susceptible to strategies that target blocked differentiation. Differentiation therapy aims to overcome this differentiation blockade by promoting glioma cell differentiation into more mature and less malignant cells.

Can microbiota gut-brain axis reverse neurodegenerative disorders in human?

The trillions of microbial populations residing in the gut have recently shown that they can be used as a remedy for various diseases. The gut microbiota-brain-axis interface is one unique pathway that the microbiota demonstrates its medicinal value. This medicinal value is further seen when there is a decline in gut microbial diversity (dysbiosis).

Unusual depolymerization mechanism of Poly(ethylene terephthalate) by hydrolase 202.

Polyethylene terephthalate (PET) waste significantly contributes to the global plastic crisis, but enzymatic conversion has become an efficient and environmentally friendly strategy to combat it. Therefore, this study explored the Re-face selective depolymerization mechanisms of a novel PET-degradation peptidase, hydrolase 202. Theoretical calculations revealed that the first step, a catalytic triad-assisted nucleophilic attack, is the rate-determining step.

Core-shell In/H-Beta@Ce catalyst with enhanced sulfur and water tolerance for selective catalytic reduction of NO by CH.

A series of core-shell In/H-Beta@Ce catalysts were synthesized by encapsulating In/H-Beta within an amorphous CeO shell and then evaluated for the selective catalytic reduction of NO by CH (CH-SCR) under challenging conditions with SO and HO. IB@Ce-2 achieved 57.7 % NO conversion at 625°C, representing a 23.

Less toxic combined microplastics exposure towards attached Chlorella sorokiniana in the presence of sulfamethoxazole while massive microalgal nitrous oxide emission under multiple stresses.

Microalgae-based wastewater treatment could realize simultaneous nutrients recovery and CO sequestration. However, impacts of environmental microplastics (MPs) and antibiotic co-exposure on microalgal growth, nutrients removal, intracellular nitric oxide (NO) accumulation and subsequent nitrous oxide (NO) emission are unclarified, which could greatly offset the CO sequestration benefit. To reveal the potential impacts of environmental concentrations of MPs and antibiotic co-exposure on microalgal greenhouse gas mitigation, this study investigated the effects of representative MPs (PE, PVC, PA), antibiotic sulfamethoxazole (SMX), and nitrite (NO-N) in various combinations on attached Chlorella sorokiniana growth, nutrients removal, anti-oxidative responses, and NO emission originated from intracellular NO build-up.

SO derivatives impair ovarian function by inhibiting Serpine1/NF-κB pathway-mediated ovarian granulosa cell survival.

Sulfur dioxide (SO) is a contributor to air pollution. Human evidence has demonstrated an association between SO exposure and diminished ovarian reserve. The toxicity of SO is mainly attributed to its derivatives, bisulfite and sulfite, which have a variety of adverse effects on both human health and the environment, yet have been widely used as additives in food processing and transportation.

Efficient Hg(Ⅱ) removed by l-cysteine modified UiO-66 through chemical adsorption via a facile partial ligand replacement strategy.

In this work, UiO-66-l-cys with enhanced adsorption capacity for Hg(Ⅱ) in water was synthesized through a facile two-step partial ligand replacement strategy. The presence of the functional groups significantly enhanced the capacity of the material for Hg(Ⅱ). According to the Langmuir model, the maximum theoretical adsorption capacity was calculated to be 1321.

Design of a Co doped carbon Backbone with self-grown Au nanoparticles via a 'Triple Advantage' Strategy for sensitive dopamine detection.

In this study, a Co doped polyhedral carbon skeleton (Co CN) was prepared by nitrogen carbonization using ZIF-67 as a precursor. The Co CN features a rough surface with excellent electrical conductivity, and the Co atoms exhibit unique catalytic properties. Based on these characteristics, we used Co CN as a carrier to load Au nanoparticles (NPs) onto its surface through the linkage and reduction effects of polyoxometalates (POMs).

Cellulose filter paper immobilized acetylcholinesterase for rapid screening of enzyme inhibitors in Phyllanthus emblica L.

Acetylcholinesterase (AChE) is widely recognized as a promising therapeutic target enzyme for Alzheimer's disease (AD). The screening of AChE inhibitors (AChEIs) holds great significance for the treatment of AD. In this study, cellulose filter paper (CFP) -immobilized AChE was prepared and firstly applied to screening AChEIs from 30 % ethanol extract of Phyllanthus emblica L.

New insights into the neurophysiological effects of heat stress on the Chinese mitten crab (Eriocheir sinensis).

Climate warming and frequent incidents of extreme high temperatures are serious global concerns. Heat stress induced by high temperature has many adverse effects on animal physiology, especially in aquatic poikilotherms. Chinese mitten crab (Eriocheir sinensis) is sensitive to high temperatures, this study evaluated the harmful effects of heat stress on the neurotoxicity, intestinal health, microbial diversity, and metabolite profiles.

Developmental changes of skin quality from breast, back, and thigh of Pekin ducks from 1 to 6 weeks of age.

Good skin quality not only improved carcass quality but also increased consumer demand for fresh poultry meat. This study aimed to investigate the developmental changes in skin growth and quality of Pekin ducks during 1-6 weeks of age. The skin samples were collected from the breast, back, and thigh tissues of six male ducks at the end of each week.

High selectivity, capacity and stability for electrochemical lithium extraction on boron-doped HMnO by tailoring lattice constant and intercalation energy.

A sustainable supply of lithium from salt-lake brines is necessary due to the surge in demand of the lithium-battery market. However, the presence of coexisting ions, particularly Na, poses a significant challenge due to the similarities in charge, electronic structure, and hydrated size. The electrochemical system with manganese (Mn)-based lithium-ion (Li) sieves electrodes is a promising method for Li recovery, but often suffers from geometric configuration distortion, which reduces their selectivity and capacity.

Impact of residual aluminum on nanofiltration gypsum scaling: Mitigation roles played by different species.

Residual aluminum (Al) is a growing pollutant in nanofiltration (NF) membrane-based drinking water treatment. To investigate the impact of distinct Al species fouling layers on gypsum scaling during NF, gypsum scaling tests were conducted on bare and three Al-conditioned (AlCl-, Al, and Al-) membranes. The morphology of gypsum, the role of Al species on Ca adsorption during gypsum scaling, and the interactions between gypsum crystals and Al-conditioned membranes were investigated.

Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis.

Menin is a scaffold protein encoded by the Men1 gene, and it interacts with a variety of chromatin regulators to activate or repress cellular processes. The potential importance of menin in immune regulation remains unclear. Here, we report that myeloid deletion of Men1 results in the development of spontaneous pulmonary alveolar proteinosis (PAP).

Solvent Mediated Interfacial Microenvironment Design for High-Performance Electrochemical CO Reduction to C Products.

Electrochemical CO reduction (CORR) in membrane electrode assembly (MEA) represents a viable strategy for converting CO into value-added multi-carbon (C) compounds. Therefore, the microstructure of the catalyst layer (CL) affects local gas transport, charge conduction, and proton supply at three-phase interfaces, which is significantly determined by the solvent environment. However, the microenvironment of the CLs and the mechanism of the solvent effect on C selectivity remains elusive.

Catalytic effects of iron adatoms in poly(-phenylene) synthesis on rutile TiO(110).

-Armchair graphene nanoribbons (nAGNRs) are promising components for next-generation nanoelectronics due to their controllable band gap, which depends on their width and edge structure. Using non-metal surfaces for fabricating nAGNRs gives access to reliable information on their electronic properties. We investigated the influence of light and iron adatoms on the debromination of 4,4''-dibromo--terphenyl precursors affording poly(-phenylene) (PPP as the narrowest GNR) wires through the Ullmann coupling reaction on a rutile TiO(110) surface, which we studied by scanning tunneling microscopy and X-ray photoemission spectroscopy.

Scalable synthesis of (±)-gregatin A a 1,3-dipolar cycloaddition strategy.

A 6-step gram-scale synthesis of the fungal polyketide (±)-gregatin A is described. The synthetic route features an intermolecular 1,3-dipolar cycloaddition, a Mo-mediated disconnection of the isoxazole skeleton, and an acid-mediated deprotection/enamine hydrolysis and hemiketalization cascade.

Cesium-Based Molecular Perovskites With Superior Stability for High-Performance X-Ray Detection.

Metal-free molecular perovskites have shown great potential for X-ray detection due to their tunable chemical structures, low toxicity, and excellent photophysical properties. However, their limited X-ray absorption and environmental instability restrict their practical application. In this study, cesium-based molecular perovskites (MDABCO-CsX, X = Cl, Br, I) are developed by introducing Cs at the B-site to enhance X-ray absorption while retaining low toxicity.

Modulating Built-In Electric Field Via N-Doped Carbon Dots for Robust Oxygen Evolution at Large Current Density.

Constructing a built-in electric field (BIEF) within heterostructures has emerged as a compelling strategy for advancing electrocatalytic oxygen evolution reaction (OER) performance. Herein, the p-n type nanosheet array heterojunction NiP-NCDs-Co(OH)-NF are successfully prepared. The variation in interaction affinity between nitrogen within N-doped carbon dots (NCDs) and Ni/Co induces charge redistribution between Co and Ni in the NiP-NCDs-Co(OH)-NF-3 heterostructure, thereby enhancing the intensity of the BIEF, facilitating electron transfer, and markedly improving OER activity.

Design and Synthesis of Hederagenin Derivatives for the Treatment of Sepsis by Targeting TAK1 and Regulating the TAK1-NF-κB/MAPK Signaling.

Sepsis is a systemic inflammatory response caused by infection and is a leading cause of death worldwide. We designed and synthesized a series of hederagenin analogues with anti-inflammatory activity. The most effective compound, , reduced the release of TNF-α and IL-6 in RAW264.

Achieving advanced hydrogen evolution under large current density using an amorphous/crystalline core-shell electrocatalyst of a-NiCoP/CoP.

Non-precious transition metal-based electrocatalysts with high activities are promising candidates for substituting Pt- or Ru-based electrocatalysts in hydrogen evolution. In this study, we propose core-shell engineering to combine the amorphous NiCoP and crystalline CoP (a-NiCoP/CoP@NF), which requires an ultra-low overpotential of only 26 mV to achieve the benchmark current density of 10 mA cm. Furthermore, it achieves an industrial-level hydrogen evolution current density of 500 mA cm with excellent stability.

Factors influencing hepatitis B vaccination intention and behavior among college students in Tibet: Insights from the expanded theory of planned behavior.

Hepatitis B (Hep B) remains a critical public health issue globally, particularly in Tibet, where vaccination rates and influencing factors among college students are yet understudied. This study applies a cross-sectional design to investigate the Hep B vaccination rate among 1,126 college students in Tibet and utilizes the expanded theory of planned behavior (ETPB) to identify vaccination behavior intention (BI) and vaccination behavior (VB). Stratified cluster sampling across three universities was used to assess behavioral attitudes (BA), subjective norms (SN), perceived behavioral control (PBC), past vaccination history (PVH) and vaccination knowledge (VK), and used structural equation modeling (SEM) for model validation and multi-group comparison.