Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies.

Introduction: Prostate cancer is one of the most common cancers in the United States with a high mortality rate. In recent years, the traditional opinion about prostate microbiome was challenged. Although there still are some arguments, an escalating number of researchers are shifting their focus toward the microbiome within the prostate tumor environment.

CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis.

Early diagnosis is critical for providing a timely window for effective therapy in pulmonary fibrosis (PF); however, achieving this remains a significant challenge. The distinct honeycombing patterns observed in computed tomography (CT) for the primary diagnosis of PF are typically only visible in patients with moderate to severe disease, often leading to missed opportunities for early intervention. In this study, we developed a nanoprobe designed to accumulate at fibroblastic foci and loaded with the CT sensitizer iodide to enable effective early diagnosis of PF.

Analysis of feasibility, effectiveness and safety of transvaginal natural orifice transluminal endoscopic surgery(vNOTES) of ectopic pregnancy: a retrospective study.

Background: vNOTES has been documented as a viable approach for conducting benign gynecologic surgery; however, its application in ectopic pregnancy cases remains relatively scarce. The principal objective of this investigation was to assess the practicability, effectiveness, and safety of vNOTES in surgical procedures related to ectopic pregnancy.

Methods: Clinical data pertaining to patients diagnosed with ectopic pregnancy at Beijing Hospital between January 2018 and August 2023 were retrospectively collected (This study retrospectively registered with the China Clinical Trial Registry with the registration number ChiCTR2100052223 in September 22, 2021.

Anatomical characterization of Semi-arid Bignoniaceae using light and scanning electron microscopy.

Background: The present research work was done to evaluate the anatomical differences among selected species of the family Bignoniaceae, as limited anatomical data is available for this family in Pakistan. Bignoniaceae is a remarkable family for its various medicinal properties and anatomical characterization is an important feature for the identification and classification of plants.

Methodology: In this study, several anatomical structures were examined, including stomata type and shape, leaf epidermis shape, epidermal cell size, and the presence or absence of trichomes and crystals (e.

A volumetric study of the choroid plexus in neuropsychiatric systemic lupus erythematosus.

Much evidence suggests that the choroid plexus (CP) plays an important role in the pathophysiology of systemic lupus erythematosus (SLE), but its imaging profile in neuropsychiatric SLE (NPSLE) remains unexplored. To evaluate CP volume in NPSLE patients using MRI. This retrospective study evaluated patients with SLE who underwent MRI of the brain, including three-dimensional T1-weighted imaging.

SP-1-activated LINC01016 overexpression promotes gastric cancer invasion and metastasis through inhibiting EIF4A3-mediated MMP9 mRNA decay.

Long noncoding RNAs (lncRNAs) are key regulators during gastric cancer (GC) development and may be viable treatment targets. In the present study, we showed that the expression of the long intergenic noncoding RNA 01016 (LINC01016) is significantly higher in GC tissues with lymph node metastasis (LNM) than those without LNM. LINC01016 overexpression predicts a poorer relapse-free survival (RFS) and overall survival (OS).

Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, and critically ill patients with T2DM in intensive care unit (ICU) have an increased risk of mortality. In this study, we investigated the relationship between nine inflammatory indicators and prognosis in critically ill patients with T2DM to provide a clinical reference for assessing the prognosis of patients admitted to the ICU. Critically ill patients with T2DM were extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and divided into training and testing sets (7:3 ratio).

Exploring the Association Between Overactive Bladder (OAB) and Cognitive decline: mediation by depression in elderly adults, a NHANES weighted analysis.

Overactive bladder (OAB) is a prevalent condition among older adults and may be linked to cognitive health. This study explored a relationship between OAB and cognitive health among adults aged 60 ≥ years in the United States, using NHANES 2011-2014. A cross-sectional analysis was conducted using a nationally representative sample of 2,324 (45.

In situ osteogenic activation of mesenchymal stem cells by the blood clot biomimetic mechanical microenvironment.

Blood clots (BCs) play a crucial biomechanical role in promoting osteogenesis and regulating mesenchymal stem cell (MSC) function and fate. This study shows that BC formation enhances MSC osteogenesis by activating Itgb1/Fak-mediated focal adhesion and subsequent Runx2-mediated bone regeneration. Notably, BC viscoelasticity regulates this effect by modulating Runx2 nuclear translocation.

Surface Copassivation Strategy for Developing Water-Soluble InP Colloidal Quantum Dots with High Luminescence and Suppressed Blinking.

Colloidal quantum dots (QDs) are promising emitters for biological applications because of their excellent fluorescence, convenient surface modification, and photostability. However, the toxic cadmium composition in the state-of-the-art QDs and their inferior properties in the aqueous phase greatly restrict further use. The performance of water-soluble indium phosphide (InP) QDs lags far behind those of Cd-containing counterparts due to the lack of effective surface protection.

Comparison of video laryngoscopy and direct laryngoscopy for urgent intubation in newborn infants: A meta-analysis.

Background: Securing a stable airway is a critical component in neonatal resuscitation. Compared to direct laryngoscopy, video laryngoscopy provides improved visualization of the glottis, potentially enhancing the success rate of intubation. This systematic review and meta-analysis were conducted to assess and compare the efficacy and safety of video laryngoscopy versus direct laryngoscopy in neonatal intubation.

Pharmacokinetics and Biological Activities of Notoginsenoside R1: A Systematical Review.

(PN) root is a renowned nutritional supplement, health food additive, and traditional medicine that maintains homeostasis within the human microcirculatory system. Notoginsenoside R1 (NG-R1), an active compound derived from PN root, has been reported to possess various pharmacological activities, including anti-inflammatory, antioxidant, anticancer, antimicrobial, and angiogenic effects. However, NG-R1's pharmacokinetic properties and pharmacological activities have not been systematically elucidated.

A Hepatic Oxidative Metabolite of Palmatine Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization Through AMPK/NF-κB Pathway.

Palmatine (PAL) and berberine are both classified as protoberberine alkaloids, derived from several traditional Chinese herbs such as Franch. and   Schneid. These compounds are extensively used in treating dysentery and colitis.

Role of Traditional Chinese Medicine in Lung Cancer Management: A Review.

With the continuous advancements in modern medicine, significant progress has been made in the treatment of lung cancer. Current standard treatments, such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, have notably improved patient survival. However, the adverse effects associated with these therapies limit their use and impact the overall treatment process.

Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1-NRF2 Pathway.

Oxidative stress represents a pivotal mechanism in the pathogenesis of numerous chronic diseases. The Kelch-like ECH-associated protein 1-transcription factor NF-E2 p45-related factor 2 (KEAP1-NRF2) pathway plays a crucial role in maintaining redox homeostasis and regulating a multitude of biological processes such as inflammation, protein homeostasis, and metabolic homeostasis. In this paper, we present the findings of recent studies on the KEAP1-NRF2 pathway, which have revealed that it is aberrantly regulated and induces oxidative stress injury in a variety of diseases such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases, respiratory diseases, digestive diseases, and cancer.

The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from .

Ginkgolic acids (GAs) are distinctive secondary metabolites of () primarily found in its leaves and seeds, with the highest concentration located in the exotesta. GAs are classified as long-chain phenolic compounds, and exhibit structural similarities to lignoceric acid. Their structural diversity arises from variations in the length of side chains and their number of double bonds, resulting in six distinct forms within extracts (GBE).

Advancements in the Research of for the Treatment of Colorectal Cancer.

Colorectal cancer, characterized by its high incidence, concealed early symptoms, and poor prognosis at advanced stages, ranks as the third leading cause of cancer-related deaths worldwide. (AM) refers to the dried roots of (Fisch.) Bge.

Advances in Pharmacological Research on Icaritin: A Comprehensive Review.

has been widely used in traditional Chinese medicine for several thousands of years. This plant is known for tonifying kidney Yang, strengthening muscles and bones, and dispelling wind and dampness. It is worth noting that icaritin, a prenylated flavonoid isolated from , has received increasing attention in recent years due to its wide range of pharmacological activities.

Gut Microbiota and Osteoarthritis: From Pathogenesis to Novel Therapeutic Opportunities.

Osteoarthritis (OA) is the most common chronic degenerative joint disease, characterized by cartilage damage, synovial inflammation, subchondral bone sclerosis, marginal bone loss, and osteophyte development. Clinical manifestations include inflammatory joint pain, swelling, osteophytes, and limitation of motion. The pathogenesis of osteoarthritis has not yet been fully uncovered.

Reusable Self-Powered Electrochromic Sensor Patch Based on Enzymatic Biofuel Cells for On-Site Visualized Monitoring of Lactic Acid.

Wearable sensors have broad application potential in motion assessment, health monitoring, and medical diagnosis. However, relying on a specialized instrument for power supply and signal reading makes sensors unsuitable for on-site detection. To solve this problem, a reusable self-powered electrochromic sensor patch based on enzymatic biofuel cells were constructed to realize the on-site visualized monitoring.

Multiple gRNAs-assisted CRISPR/Cas12a-based portable aptasensor enabling glucometer readout for amplification-free and quantitative detection of malathion.

Background: The threat of toxic malathion residues to human health has always been a serious food safety issue. The CRISPR/Cas system represents an innovative detection technology for pesticide residues, but its application to malathion detection has not been reported yet. In addition, the multiple-guide RNA (gRNA) powered-CRISPR/Cas biosensor has the advantages of being fast, sensitive and does not require pre-amplification.

Integration of ratiometric, ultrafast, sensitive detection as well as rapid and efficient removal of tetracycline based on a novel Zn (II) functionalized magnetic covalent organic framework.

Background: Based on the low volatility and refractory nature of Tetracycline (TC), excessive use leads to its continuous accumulation in water environments, posing serious risks to the ecological environment and human health. Although a very limited number of nanomaterials capable of simultaneously detecting and removing TC have been fabricated, they generally exist issues associated with a single detection signal ("on" or "off") or low adsorption rates with low adsorption capacities. As a result, it is crucial to develop a reliable technique to achieve ratiometric detection as well as rapid and efficient removal of TC.

Facile preparation of iridium-based AIE polymer dots for sensitive electrochemiluminescence immunoassay of CD44 protein.

The development of aggregation-induced emission (AIE) luminophores is a fascinating and promising topic in electrochemiluminescence (ECL) bioanalysis. Herein, the AIE-active but water-insoluble [Ir(bt)₂(acac)] (bt = 2-phenylbenzothiazole, acac = acetylacetonate) was encapsulated within poly(styrene-maleic anhydride) (PSMA) using a simple nanoprecipitation method. This encapsulation strategy could effectively limit the free motion of Ir(bt)₂(acac) and trigger the aggregation-induced electrochemiluminescence (AIECL) effect.

FSH exacerbates bone loss by promoting osteoclast energy metabolism through the CREB-MDH2-NAD axis.

Aims: Osteoclast energy metabolism is a promising target for treating diseases characterized by high osteoclast activity, such as osteoporosis. However, the regulatory factors involved in osteoclast bioenergetic processes are still in the early stages of being fully understood. This study reveals the effects of follicle-stimulating hormone (FSH) on osteoclast energy metabolism.