High quantum yield copper nanoclusters integrated with nitrogen-doped carbon dots for off-on ratiometric fluorescence sensing of S and Zn.

Pursuing nanomaterials with high fluorescence quantum yields is of great significance in the fields of bioimaging, medical diagnosis, and food safety monitoring. This work reports on orange-emitting aggregation-induced emission (AIE) copper nanoclusters (Cu NCs) integrated with blue-emitting nitrogen-doped carbon dots (N-CDs), which enables highly sensitive detection of S and Zn ions through an off-on ratiometric fluorescence method. The highly emissive Cu NCs was doped by Ce with a high quantum yield of 51.

Interfacial mechanisms of enhanced photoluminescence in AgI-doped red light emitting perovskite quantum dot glass.

Red light emitting perovskite quantum dot (PQD) glass, with narrow-band emission and excellent stability, holds great potential for applications in liquid crystal displays. However, its low photoluminescence quantum yield (PLQY) remains the biggest obstacle limiting its practical application. Additionally, the mechanism behind the enhancement of the PLQY is not well understood, which restricts the further improvement of the PLQY in red light emitting PQD glass.

Understanding the phase structure evolution and charge storage mechanism of FeCoNi-MOFs as electrodes for asymmetric supercapacitors.

Metal-organic frameworks (MOFs) due to abundant apertures, adjustable components, and multi-purpose structures have broad application prospects in supercapacitors. However, its low conductivity, poor stability, and difficulty growing evenly on the conductive substrate limit the electrochemical energy storage performance. Herein, with FeCoNi-OH nanosheets serving as the precursors, the trimetallic FeCoNi-MOF (FCNM) multilayer structure is successfully synthesized on activated carbon cloth (AC), and its optimal growth state (FCNM/AC-12 h) is achieved by regulating the reaction time.

Metal-based mesoporous polydopamine with dual enzyme-like activity as biomimetic nanodrug for alleviating liver fibrosis.

Liver fibrosis is a common pathological stage in the development of several chronic liver diseases, and early intervention can effectively reverse the developing process. Excessive reactive oxygen species (ROS) can promote the activation of hepatic stellate cells (HSCs), but existing treatments have not addressed this problem. In this study, different metal-based mesoporous polydopamine (MPDA) was prepared by the soft template method, and their free radical scavenging abilities, as well as the efficacy and safety of the carriers were investigated, so as to select Cu-coordinated MPDA (CMP) as the optimal nanocarrier.

Integrated ecological-health risk assessment of ofloxacin.

Antibiotics are emerging contaminants of significant concern, while previous research has mostly focused on their ecological or health impacts in isolation. This limited systematic research on its overall risk and the uncertainty relating to the risk evaluation is also unclear. This study addressed this gap by examining both ecological or health impacts by integrating interspecies correlation models, species sensitivity distribution curves, and health risk evaluation.

Agricultural amendments enhanced the redox cycling of iron species and hydroxyl radical formation during redox fluctuation of paddy soil.

Hydroxyl radical (OH) plays a critical role in accelerating organic contaminant attenuation during water-table decline in paddy soil, but the impacts of widely applied agricultural amendments (e.g., organic manure, rice straw, and biochar) on these processes have been rarely explored.

Multi-effect synergistic induction of unsaturated MnO on sandy sediment for enhanced manganese adsorption and byproduct resource recovery in solar evaporation.

The efficient removal of Mn(II) from wastewater is crucial for safeguarding water quality, yet existing adsorbents face significant challenges, including high costs, poor resistance to ionic interference, and scalability limitations. This study addresses these challenges by utilizing abundant natural sandy sediment (SS) as a substrate to load unsaturated MnO via in-situ oxidation, creating a novel adsorbent (MOSS). MOSS exhibits a remarkable Mn(II) adsorption capacity of 1.

Evaluation of the actinia-shaped composite coagulant for removal of algae in water: Role of charge density.

A series of novel cationic modified actinia-shaped composite coagulant (AMS-C), with similar tentacle length and distribution but different charge density (CD), was successfully designed and fabricated by combination of a cationic graft starch and attapulgite (ATP). AMS-C shows a high efficiency in coagulative removal of Microcystis aeruginosa from water over a wide pH range. The algae-harvesting efficiency of optimized AMS-C can reach to 92.

Ultrasensitive ammonia sensor with excellent humidity resistance based on PANI/SnS heterojunction.

The analysis of human exhaled gas is crucial for early and noninvasive diagnosis. However, the complex composition and high-humidity of exhaled gas pose significant challenges to the application of gas sensors. This research focuses on the development of a chemiresistive ammonia sensor based on the polyaniline/tin disulfide (PANI/SnS) heterojunction, which is fabricated by hydrothermal and in-situ polymerization techniques.

Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastases status.

Background: Current decision-making for the treatment of breast cancer liver metastases (BCLM) using ablation lacks strong evidence, especially for patients combined with extrahepatic metastases.

Purpose: To assess whether ablation plus systemic therapy (AS) improves survival outcomes in patients with BCLM compared to systemic therapy alone.

Materials And Methods: This retrospective study analyzed patients with BCLM who received either AS or systemic therapy alone.

GlSIRT1 deacetylates and activates pyruvate kinase to improve pyruvate content and enhance heat stress resistance in Ganoderma lucidum.

Heat stress is a prevalent environmental stressor. Previous studies have shown that heat stress drives many cellular changes in Ganoderma lucidum. Interestingly, glycolysis is activated during heat stress, which could contribute to increased heat resistance.

Optimizing the proportion of stimulation area in a grid stimulus for user-friendly SSVEP-based BCIs.

Objective: Steady-state visual evoked potentials (SSVEPs) rely on the photic driving response to encode electroencephalogram (EEG) signals stably and efficiently. However, the user experience of the traditional stimulation with high-contrast flickers urgently needs to be improved. In this study, we introduce a novel paradigm of grid stimulation with weak flickering perception, distinguished by a markedly lower proportion of stimulation area in the overall pattern.

Stereoselectivity of evodiamine enantiomers in neuroprotective activity, pharmacokinetics and the ability across the blood-brain barrier.

Evodiamine, a chiral quinazoline alkaloid in the traditional Chinese medicine Evodiae fructus, exhibited efficacy for CNS diseases. In this study, the pure enantiomers of evodiamine were prepared in large quantities via chemical resolution. Their structures were elucidated by MS, NMR and ECD.

Predicting cobalt ion concentration in hydrometallurgy zinc process using data decomposition and machine learning.

Solid waste is one of the primary contributors to environmental pollution currently, it is crucial to enhance the prevention and control of solid waste pollution in environmental management. The effectiveness of the second stage of purification in the industrial zinc hydrometallurgy is determined by the concentration of cobalt ion. Manual testing and monitoring of cobalt ion concentration are time consuming and costly, and prone to delays, which can result in discharge of cobalt ion concentration that does not meet the standards, leading to water pollution.

Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health.

Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1-cell stage as a model to assess the toxicity of sine waves, following OECD Test No.

CISD2-mediated mitochondrial dysfunction and iron redistribution contributes to ferroptosis in arsenic-induced nonalcoholic steatohepatitis.

Arsenic in the environment, such as sodium arsenic (NaAsO), is a frequently occurring hazard that has been linked to nonalcoholic steatohepatitis (NASH). Our prior research established the involvement of ferroptosis in arsenic-induced NASH, but the precise underlying mechanisms remain elusive. Here, we found that exposure to NaAsO had a suppressive effect on the expression of CDGSH iron-sulfur domain-containing protein 2 (CISD2) at the protein and gene levels, and overexpression of CISD2 inhibited NaAsO-induced ferroptosis and NASH.

Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota.

Zearalenone (ZEA), produced by Fusarium, is a fungal toxin commonly found in maize, wheat, and other cereals. ZEA has the ability to bind to estrogen receptors of humans and animals and is an environmental endocrine disruptor that may interfere with glucose homeostasis and lipid metabolism. In this study, we first investigated the effects of chronic exposure to low doses of ZEA with a high-fat-diet (HFD) in obese C57BL/6 J mice.

Hydrophobic PU fabric with synergistic conductive networks for boosted high sensitivity, wide linear-range wearable strain sensor.

Strain sensing fabrics are able to sense the deformation of the outside world, bringing more accurate and real-time monitoring and feedback to users. However, due to the lack of clear sensing mechanism for high sensitivity and high linearity carbon matrix composites, the preparation of high performance strain sensing fabric weaving is still a major challenge. Here, an elastic polyurethane(PU)-based conductive fabric(GCPU) with high sensitivity, high linearity and good hydrophobicity is prepared by a novel synergistic conductive network strategy.

Reconstruction of Local Three-dimensional Temperature Field of Tumor Cells with Low-toxic Nanoscale Quantum-dot Thermometer and Cepstrum Spatial Localization Algorithm.

The optimal method for three-dimensional thermal imaging within cells involves collecting intracellular temperature responses while simultaneously obtaining corresponding 3D positional information. Current temperature measurement techniques based on the photothermal properties of quantum dots face several limitations, including high cytotoxicity and low fluorescence quantum yields. These issues affect the normal metabolic processes of tumor cells.

Polydopamine-Mediated, Centrifugal Force-Driven Gold Nanoparticle-Deposited Microneedle SERS Sensors for Food Safety Monitoring Theoretical Study of the SERS Substrate Fabrication.

Microneedle (MN) sensors have great promise for food safety detection, but the rapid preparation of MNs for surface-enhanced Raman scattering (SERS) sensors with tunable and homogeneous nanoparticles remains a great challenge. To address this, a SERS sensor of gold nanoparticles@polydopamine@poly(methyl methacrylate) MN (AuNPs@PDA@PMMA-MN) was developed. The extended-Derjaguin-Landau-Verwey-Overbeek theory was applied to calculate the interaction energy between AuNPs and PDA.

Germanium Atoms Exceed the Tetrahedral Coordination in MFI Zeolite.

Germanium is known to occupy tetrahedral sites by substituting silicon in germanosilicate zeolites. In this study, we present pioneering findings regarding the synthesis of zeolites with an MFI structure (GeMFI) incorporating a high germanium amount (16% Ge). Remarkably, the germanium atoms feature a slight electron deficiency with respect to GeO, and the typical coordination number of 4, as usually reported for the germanosilicate zeolites, is exceeded, giving rise to Ge dimers in a double-bridge configuration.

Olfactory-Inspired Separation-Sensing Nanochannel-Based Electronics for Wireless Sweat Monitoring.

Human sweat has the potential to be sufficiently utilized for noninvasive monitoring. Given the complexity of sweat secretion, the sensitivity and selectivity of sweat monitoring should be further improved. Here, we developed an olfactory-inspired separation-sensing nanochannel-based electronic for sensitive and selective sweat monitoring, which was simultaneously endowed with interferent separation and target detection performances.

Physical Restraint in a Pediatric Intensive Care Unit: A Cross-Sectional, Observational Study in China.

Background: Research data on the extent of and protocols related to physical restraint (PR) in pediatric intensive care units (PICUs) are scarce. Most previous studies in China on this topic have focused on the prevalence, reasons, and background of PR use among adult patients.

Purpose: This study was designed to delineate the application of PR and the factors associated with PR use in PICUs in China.

Protective effect of luteinizing hormone on frozen-thawed ovarian follicles and granulosa cells.

Ovarian tissue cryopreservation addresses critical challenges in fertility preservation for prepubertal female cancer patients, such as the lack of viable eggs and hormonal deficiencies. However, mitigating follicle and granulosa cell damage during freeze-thaw cycles remains an urgent issue. Luteinizing hormone (LH), upon binding to luteinizing hormone receptors (LHR) on granulosa cells, enhances estrogen synthesis and secretion, contributing to the growth of granulosa cells and follicles.

Unusual Iron-Independent Ferroptosis-like Cell Death Induced by Photoactivation of a Typical Iridium Complex for Hypoxia Photodynamic Therapy.

Ferroptosis is a unique cell death mode that relies on iron and lipid peroxidation (LPO) and is extensively utilized to treat drug-resistant tumor. However, like the other antitumor model, requirement of oxygen limited its application in treating the malignant tumors in anaerobic environments, just as photodynamic therapy, a very promising anticancer therapy. Here, we show that an iridium(III) complex (Ir-dF), which was often used in proton-coupled electron transport (PCET) process, can induce efficient cell death upon photo irradiation, which can be effectively protected by the typical ferroptosis inhibitor Fer-1 but not by the classic iron chelating agents and ROS scavengers.