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PR China; National Resource Center for ... Publications | LitMetric

443,284 results match your criteria: "PR China; National Resource Center for Chinese Materia Medica[Affiliation]"

The incidence of hyperuricemia has increased recently, posing a serious threat to public health. Hyperuricemia is associated with an increased risk of gout, chronic kidney disease (CKD), obesity, metabolic syndrome, type 2 diabetes mellitus, hypertension, hypertriglyceridaemia, metabolic dysfunction‑associated steatotic liver disease, acute kidney injury, coronary heart disease and cardiovascular disease (CVD). These diseases are commonly accompanied by varying degrees of kidney damage.

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Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the TUNEL assay data shown in Fig. 4B were strikingly similar to data appearing in different form in another article written by different authors at different research institutes that had already been submitted for publication to the journal (which has subsequently been retracted). Owing to the fact that these contentious data had already apparently been submitted for publication prior to the receipt of this paper to , the Editor has decided that this paper should be retracted from the Journal.

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Recent advances in nanomaterials for the detection of mycobacterium tuberculosis (Review).

Int J Mol Med

March 2025

Orthopedics of Chun'an First People's Hospital, Zhejiang Provincial People's Hospital Chun'an Branch, Affiliated Chun'an Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 311700, P.R. China.

The world's leading infectious disease killer tuberculosis (TB) has >10 million new cases and ~1.5 million mortalities yearly. Effective TB control and management depends on accurate and timely diagnosis to improve treatment, curb transmission and reduce the burden on the medical system.

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Thermodynamics and models for small nanoparticles upon protein adsorption.

Phys Chem Chem Phys

December 2024

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.

Proteins are some of the most important components in living organisms. When nanoparticles enter a living system, they swiftly interact with proteins to produce the so-called "protein corona", which depicts the adsorption of proteins on large nanoparticles (normally tens to hundreds of nanometers). However, the sizes of small nanoparticles (typically, fluorescent nanomaterials such as quantum dots, noble metal nanoclusters, carbon dots, ) are less than 10 nm, which are comparable or even much smaller than those of proteins.

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Osteoarthritis (OA) is a common joint disorder involving the cartilage and other joint tissues. Quercetin (QCT) serves a protective role in the development of OA. However, to the best of our knowledge, the regulatory mechanisms of QCT in the progression of OA have not yet been fully elucidated.

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Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review).

Int J Mol Med

March 2025

Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China.

Bupleurum, a Traditional Chinese Medicine (TCM) herb, is widely used in China and other Asian countries to manage chronic liver inflammation and viral hepatitis. Saikosaponin D (SSD), a triterpenoid saponin extracted from Bupleurum, exhibits extensive pharmacological properties, including anti‑inflammatory, antioxidant, anti‑apoptotic, anti‑fibrotic and anti‑cancer effects, making it a therapeutic candidate for numerous diseases. Clarifying the targets and molecular mechanisms underlying TCM compounds is essential for scientifically validating TCM's therapeutic roles in disease prevention and treatment, as well as for identifying novel therapeutic targets and lead compounds.

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Our previous research identified that lncRNA PVT1 is upregulated in patients with IA. However, the precise functions of PVT1 in IA remain unclear. We compared the levels of PVT1, caspase-3, caspase-1, and NLRP3 in normal and IA patients.

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In this work, magnetic molecularly imprinted polymer (MMIP) capable of selectively recognizing and adsorbing cordycepin was prepared. The MMIP was prepared using cordycepin as the template molecule, methacrylic acid and acrylamide as the functional monomer and ethylene glycol dimethacrylate as the crosslinker. The MMIP was analyzed using various techniques including transmission electron microscopy, thermogravimetric analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometer and x-ray diffraction.

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Species of the genus Ganoderma are important medicinal and edible mushrooms, with polysaccharides being its main active ingredient. The submerged fermentation of Ganoderma is an important source of polysaccharides in the mycelia. In this study, a single factor test and an orthogonal test were employed to optimize the medium and fermentation conditions with the objective of obtaining a high content of polysaccharide in the liquid submerged fermentation culture mycelia of Ganoderma species.

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Phosphaguanidinate yttrium carbene, carbyne and carbide complexes: three distinct C1 functionalities.

Dalton Trans

December 2024

Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Jiangwan Campus, Fudan University, Shanghai 200438, China.

The phosphaguanidinate rare-earth-metal bis(aminobenzyl) complexes [(PhP)C(NCHPr-2,6)]Ln(CHCH NMe-) (Ln = Y(1-Y) and Lu(1-Lu)) were synthesized by the protonolysis of (PhP)[C(NHR)(NR)] (R = 2,6-(Pr)CH) with Ln(CHCHNMe-) (Ln = Y and Lu). Interestingly, the ring-opening rearrangement product [-MeNCHCHC(NCHPr-2,6)]Lu(CHCHNMe-)[O(CH)PPh] (2) was obtained when the acid-base reaction was carried out in THF solution at 60 °C for 36 h. Additionally, the trinuclear homometallic yttrium multimethyl/methylidene complex {[(PhP)C(NCHPr-2,6)]Y(μ-Me)}(μ-Me)(μ-CH) (3) was synthesized by the treatment of 1-Y with AlMe (2 equiv.

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Enzyme-Responsive Nanoparachute for Targeted miRNA Delivery: A Protective Strategy Against Acute Liver and Kidney Injury.

Adv Sci (Weinh)

December 2024

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P. R. China.

MicroRNA (miRNA)-based therapy holds significant potential; however, its structural limitations pose a challenge to the full exploitation of its biomedical functionality. Framework nucleic acids are promising owing to their transportability, biocompatibility, and functional editability. MiRNA-125 is embedded into a nucleic acid framework to create an enzyme-responsive nanoparachute (NP), enhancing the miRNA loading capacity while preserving the attributes of small-scale framework nucleic acids and circumventing the uncertainty related to RNA exposure in conventional loading methods.

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Dual-purpose elemental sulfur for capturing and accelerating biodegradation of petroleum hydrocarbons in anaerobic environment.

Water Res X

January 2025

MOE Key Laboratory of Pollution Processes and Environmental Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, Nankai University, No. 38 Tongyan Road, Jinnan District, Tianjin 300350, PR China.

Hydrophobic organic pollutants in aqueous environments are challenging to biodegrade due to limited contact between microorganisms, the pollutants and the electron acceptor, particularly under anaerobic or anoxic conditions. Here, we propose a novel strategy that uses inexpensive, dual-function elemental sulfur (S) to enhance biodegradation. Using petroleum hydrocarbons as the target pollutants, we demonstrated that hydrophobic and nonpolar S° can concentrate hydrocarbons while simultaneously serving as an electron acceptor to enrich hydrocarbon-degrading bacteria.

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species have commonly been reported as important plant pathogenic fungi with wide host ranges and geographic distributions. With the increase in the number of cryptic species being described, a comprehensive global taxonomic revision of the genus is required. The present study includes 399 isolates from 32 countries.

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Physicochemical properties and fermentation characteristics of a novel polysaccharide degraded from residues polysaccharide.

Food Chem X

December 2024

College of Life Sciences, Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun 130118, Jilin, PR China.

() residues polysaccharide (FVRP) is a high molecular weight polysaccharide with diverse bioactivities extracted from residues (FVR). However, high molecular weight polysaccharides have been shown to face significant challenges in crossing the cell membrane barrier, thereby limiting their absorption and application in the body. Therefore, an ultrasonic-assisted HO-Fe method was employed for the first time to degrade FVRP, resulting in the production of a new polysaccharide, FVRPF.

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Comparative lipidomics analysis reveals changes in lipid profile of Arabica coffee at different maturity.

Food Chem X

December 2024

Yunnan Agricultural Reclamation Coffee Co., Ltd Kunming, 650228, Yunnan, PR China.

This study aimed to investigate the effects of maturity on the changes in major lipid metabolites of coffee and their associated pathways. UPLC-ESI-MS/MS was used to compare the lipidomic profiles of coffee beans at five different maturity stages. A total of 516 lipid metabolites across 26 subclasses were identified, with 111 showing significant differences.

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() serves as a critical indicator microorganism for assessing the prevalence and dissemination of antibiotic resistance, notably harboring various antibiotic-resistant genes (ARGs). Among these, the emergence of the gene represents a significant threat to public health, especially since carbapenem antibiotics are vital for treating severe infections caused by Gram-negative bacteria. This study aimed to characterize the antibiotic resistance features of -positive strains isolated from waterfowl in several regions of China and elucidate the dissemination patterns of the gene.

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Objective: This study aimed to explore how dyadic coping (DC) influences the psychological resilience (PR) levels of patients with cervical cancer (CC) and their spouses.

Methods: From April to June 2024, this cross-sectional study involved 177 dyads of patients with CC and their spouses from the gynecology and oncology wards of two tertiary hospitals in Xinjiang. Data were collected through questionnaires on demographic information, clinical characteristics, the Resilience Scale, and the Dyadic Coping Inventory, all of which were self-report measures.

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Under industrial conditions, efficient catalytic oxidation of Chlorinated volatile organic compounds is an important challenge, not only because of the poisonous effect of Chlorinated volatile organic compounds on catalysts, but also because of their high reaction temperature, which has an adverse impact on industrialization. In a recent article ( Ru/CeO ) [1], we developed a strategy for preparing a simple and efficient monolithic catalyst for the catalytic combustion of chlorobenzene. Ru/CeO was loaded on the industrial support cordierite by a Sol-gel method.

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Dermal white adipose tissue: A new modulator in wound healing and regeneration.

Regen Ther

March 2025

Department of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, PR China.

Dermal white adipose tissue (dWAT), distinguished by its origin from cells within the dermis and independence from subcutaneous fat tissue, has garnered significant attention for its non-metabolic functions. Characterized by strong communication with other components of the skin, dWAT mediates the proliferation and recruitment of various cell types by releasing adipogenic and inflammatory factors. Here, we focus on the modulatory role of dWAT at different stages during wound healing, highlighting its ability to mediate the adipocyte-to-myofibroblast transition which plays a pivotal role in the physiology and pathology processes of skin fibrosis, scarring, and aging.

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The aim of the present study was to employ CELLSEARCH technology for the detection of circulating tumor cells (CTCs) in the peripheral blood of head and neck cancer (HNC) patients, and to assess the association between CTC count and patient prognosis. In this retrospective study, a cohort of 56 patients diagnosed with HNC and receiving treatment at the Department of Otolaryngology, Head and Neck Surgery (Beijing Tongren Hospital) between December 2013 and June 2018 were selected. Utilizing CELLSEARCH technology, the presence of CTCs were detected in samples of peripheral blood from patients with head and neck cancer (HNC) patients, and CTC counts were documented.

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Nanoparticle-assembled interconnected PbO hollow spheres enabled by PVP-driven transformation of β-PbO and self-sacrificial templating for superior lithium storage.

Nanoscale

December 2024

Key Laboratory of Advanced Energy Storage and Conversion of Wenzhou, Key Laboratory of Carbon Materials of Zhejiang Province, College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China.

Lead oxides (PbO, 1 ≤ ≤ 2) are promising high-capacity and low-cost anodes for lithium ion batteries (LIBs). However, the huge lithiation-induced volume expansion of conventional large-sized PbO particles leads to severe electrode pulverization with poor cycling stability. Herein, a rare mixed-valence PbO with a unique hierarchical architecture of nanoparticle-assembled interconnected hollow spheres (denoted PbO NAHSs) is crafted by introducing polyvinylpyrrolidone (PVP) into the solution of generating β-PbO microspheres (MSs), which is exploited for the first time as a potential advanced anode material for LIBs.

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Stable and Lead-Free Perovskite Hemispherical Photodetector for Vivid Fourier Imaging.

Adv Sci (Weinh)

December 2024

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, P.R. China.

The filterless single-pixel imaging technology is anticipated to hold tremendous competitiveness in diverse imaging applications. Nevertheless, achieving single-pixel color imaging without a filter remains a formidable challenge. Here a lead-free perovskite hemispherical photodetector is reported for filterless single-pixel color imaging.

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A Novel Nuclear Protein Complex Controlling the Expression of Developmentally Regulated Genes in Toxoplasma Gondii.

Adv Sci (Weinh)

December 2024

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, P. R. China.

Toxoplasma gondii is a ubiquitous protozoan parasite with a complex life cycle containing multiple developmental stages. The parasites have distinct gene expression patterns at different stages to enable stage specific life activities, but the underlying regulatory mechanisms are largely unknown. In this study, a nuclear complex is identified that controls the expression of developmentally regulated genes.

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A Comprehensive Transcriptome Atlas Reveals the Crucial Role of LncRNAs in Maintaining Nodulation Homeostasis in Soybean.

Adv Sci (Weinh)

December 2024

National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.

Symbiotic nitrogen fixation (SNF) provides nitrogen for soybean. A primary challenge in enhancing yield through efficient SNF lies in striking a balance between its high energy consumption and plant growth. However, the systemic transcriptional reprogramming during nodulation remains limited.

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Neuropathic pain, one of the most refractory pain diseases, remains a formidable medical challenge. There is still an unmet demand for effective and safe therapies to address this condition. Herein, a rat model of nerve injury-induced neuropathic pain is first established to explore its pathophysiological characteristics.

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