circ_0004662 contributes to colorectal cancer progression by interacting with hnRNPM.

Circular (circ)RNAs participate in colorectal cancer (CRC) occurrence and progression. However, the role of hsa_circ_0004662 (circ_0004662) in CRC remains unknown. Reverse transcription‑quantitative PCR noted high expression of circ_0004662 in CRC compared with normal colorectal epithelial cells.

SLC25A1 promotes lymph node metastasis of esophageal squamous cell carcinoma by regulating lipid metabolism.

Solute carrier family 25 member 1 (SLC25A1) affects lipid metabolism and energy regulation in multiple types of tumor cell, affecting their proliferation and survival. To the best of our knowledge, however, the impact of SLC25A1 on the proliferation and survival of esophageal squamous cell carcinoma (ESCC) cells has yet to be explored. Here, SLC25A1 expression was detected in ESCC tissues and cell lines.

Phytic Acid-Induced Gradient Hydrogels for Highly Sensitive and Broad Range Pressure Sensing.

Ionic conductive hydrogels have emerged as an excellent option for constructing dielectric layers of interfacial iontronic sensors. Among these, gradient ionic hydrogels, due to the intrinsic gradient elastic modulus, can achieve a wide range of pressure responses. However, the fabrication of gradient hydrogels with optimal mechanical and sensing properties remains a challenge.

Efficiently Re-Utilizing the High-Value Metals in the Spent LiNiMnCoO for the Trifunctional Electrocatalysts by a Novel One-Pot Method.

Traditional hydrometallurgy methods for recycling the spent lithium-ion battery materials face some challenges, including the complex processes, and difficulties in separating Ni/Co/Mn. To address these issues, this work proposes a simple one-pot method to achieve a high Li leaching efficiency (99.2%) and simultaneously transform the majority of Ni (99.

Beyond Tradition: A MOF-On-MOF Cascade Z-Scheme Heterostructure for Augmented CO Photoreduction.

Metal-organic frameworks (MOFs) are rigorously investigated as promising candidates for CO capture and conversion. MOF-on-MOF heterostructures integrate bolstered charger carrier separation with the intrinsic advantages of MOF components, exhibiting immense potential to substantially escalate the efficiency of photocatalytic CO reduction (CORR). However, the structural and compositional complexity poses significant challenges to the controllable development of these heterostructures.

[Retracted] Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib.

Following the publication of the above article, the authors noticed that they had inadvertently included a duplication of the same data in Fig. 3C, portraying colony formation experiments, where the results from differently performed experiments were intended to have been shown, and requested that a corrigendum be published to present the data in this figure accurately. Having investigated this matter in the Editorial Office, however, additional panels of overlapping data were identified, comparing between Figs.

Protective role of triiodothyronine in sepsis‑induced cardiomyopathy through phospholamban downregulation.

Sepsis is often a cause of mortality in patients admitted to the intensive care unit. Notably, the heart is the organ most susceptible to the impact of sepsis and this condition is referred to as sepsis‑induced cardiomyopathy (SIC). Low triiodothyronine (T3) syndrome frequently occurs in patients with sepsis, and the heart is one of the most important target organs for the action of T3.

A systematically investigation of plasma complement and coagulation-related proteins and adiponectin in gestational diabetes mellitus by multiple reaction monitoring technology.

Background: Gestational diabetes mellitus (GDM) is defined as a glucose intolerance resulting in hyperglycaemia of variable severity with onset during pregnancy, and is prevalent worldwide. The study of diagnostic markers of GDM in early pregnancy is important for early diagnosis and early intervention of GDM. The aim of this study was to search for biomarkers of GDM in early and mid-pregnancy using a targeted proteomics approach.

Bacillus subtilis MZ-01 alleviates diarrhea caused by ETEC K88 by reducing inflammation and promoting intestinal health.

Aims: The purpose of this study was to investigate the effects of Bacillus subtilis supplementation on the health of weaned piglets and whether Bacillus subtilis supplementation can reduce the damage of piglets induced by ETEC K88.

Methods And Results: The experiment was designed with a 2 × 2 factorial arrangement, comprising the control (CON) group, Bacillus subtilis (PRO) group, Escherichia coli K88 (ETEC) group, and Bacillus subtilis + ETEC (PRO + ETEC) group. Regardless of the presence of ETEC, the addition of PRO increased the piglets' final body weight (FW), average daily gain (ADG), and daily feed intake (ADFI).

Perovskite-Based Smart Eyeglasses as Noncontact Human-Computer Interaction.

More than 70% of human information comes from vision. The eye is one of the most attractive sensing sites to collect biological parameters. However, it is urgent to develop a cost-effective and easy-to-use approach to monitor eyeball information in a minimally invasive way instead of current smart contact lenses or camera-based eyeglasses.

Elaborating H-bonding effect and excited state intramolecular proton transfer of 2-(2-hydroxyphenyl)benzothiazole based D-π-A fluorescent dye.

2-(2-Hydroxyphenyl)benzothiazole (HBT) derivatives with donor-π-acceptor (D-π-A) structure have received extensive attention as a class of excited state intramolecular proton transfer (ESIPT) compounds in the fields of biochemistry and photochemistry. The effects of electron-donors (triphenylamine and anthracenyl), the position of substituents and solvent polarity on the fluorescence properties and ESIPT mechanisms of HBT derivatives were investigated through time-dependent density functional theory (TDDFT) calculations. Potential energy curves (PECs) and frontier molecular orbitals (FMOs) reveal that the introduction of the triphenylamine group on the benzene ring enhances intramolecular HB, thereby benefiting the ESIPT process.

Regulation of eumelanogenesis-related genes by ethanol extract of Melaleuca Leucadendron leaves.

Eumelanin, a type of skin melanin pigment, possesses the ability to absorb a wide range of wavelengths, providing protection to the skin from ultraviolet radiation. However, excessive production of eumelanin may result in hyperpigmentation. Consequently, the development of skin-brightening products that suppress eumelanin synthesis to achieve a lighter and more even skin tone is necessary.

Clinical Application of the Fetal HQ Technique in the Evaluation of Normal Fetal Cardiac Function at Different Gestational Weeks.

Objectives: To investigate the clinical value of fetal heart quantification (fetal HQ) in the evaluation of normal fetal heart size, morphology, and cardiac function at different gestational weeks.

Materials And Methods: A total of 101 pregnant women diagnosed with a healthy fetus by fetal echocardiography from September 2021 to December 2023 were selected and classified into four different periods of gestational weeks: 20-28 weeks (25 cases), 29-32 weeks (26 cases), 33-36 weeks (26 cases), and 37-40 weeks (24 cases). Quantitative analyses were performed by automatically tracking the endocardium using fetal HQ software that comes with the Voluson E10 from GE.

[Retracted] Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway.

Following the publication of the above paper, it was drawn to the Editors' attention by a concerned reader that certain of the western blotting data shown in Fig. 1C and D on p. 2386 were strikingly similar to data appearing in different form in a pair of other articles written by different authors at a different research institute that had already been published elsewhere prior to the submission of this paper to .

Superconductivity and high hardness in scandium-borides under pressure.

Exploration of new superconducting or superhard transition-metal borides has attracted extensive interest in the past few decades. In this study, we conducted comprehensive theoretical investigations in the scandium-boron binary system by employing a structural search method based upon first-principles density functional theory. Among the six predicted superconducting scandium-borides, ScB (3̄) has the highest superconducting transition temperature = 12.

A practical fluorometric and colorimetric dual-mode sensing platform based on two-dimensional porous organic nanosheets for rapid determination of trifluralin.

Trifluralin, a widely used dinitroaniline herbicide, poses significant toxic risks, necessitating the development of rapid detection methods for food safety. In this study, we prepared ultrathin two-dimensional triphenylamine porous organic nanosheets (TPA-PONs) through a facile liquid-phase exfoliation process. The TPA-PONs, characterized by their exceptional fluorescence properties and nanoscale thickness (1.

High Expression of GPR183 Predicts Poor Survival in Cytogenetically Normal Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) with a normal karyotype (CN-AML) constitutes approximately 50% of all AML cases, presenting significant prognostic variability, and highlighting the urgent need for the identification of novel molecular biomarkers. In this study, we systematically assessed GPR183 expression levels using qRT-PCR in our clinical follow-up study which included 283 CN-AML patients. Using Kaplan-Meier analysis, we found that patients with high GPR183 expression levels exhibited significantly worse overall survival (OS) (P = 0.

Cardiovascular protective effects of natural flavonoids on intestinal barrier injury.

Natural flavonoids may be utilized as an important therapy for cardiovascular diseases (CVDs) caused by intestinal barrier damage. More research is being conducted on the protective properties of natural flavonoids against intestinal barrier injury, although the underlying processes remain unknown. Thus, the purpose of this article is to present current research on natural flavonoids to reduce the incidence of CVDs by protecting intestinal barrier injury, with a particular emphasis on intestinal epithelial barrier integrity (inhibiting oxidative stress, regulating inflammatory cytokine expression, and increasing tight junction protein expression).

Control of water for high-yield and low-cost sustainable electrochemical synthesis of uniform monolayer graphene oxide.

With the rapid development of graphene industry, low-cost sustainable synthesis of monolayer graphene oxide (GO) has become more and more important for many applications such as water desalination, thermal management, energy storage and functional composites. Compared to the conventional chemical oxidation methods, water electrolytic oxidation of graphite-intercalation-compound (GIC) shows significant advantages in environmental-friendliness, safety and efficiency, but suffers from non-uniform oxidation, typically ~50 wt.% yield with ~50% monolayers.

Predictive risk model of mild cognitive impairment in patients with malignant haematological diseases after haematopoietic stem cell transplantation.

Objective: This study is to develop and validate a robust risk prediction model for mild cognitive impairment (MCI) in patients with malignant haematological diseases after haematopoietic stem cell transplantation (HSCT).

Methods: In this study, we analysed the clinical data of the included patients. Logistic regression analysis was used to identify independent risk factors for cognitive impairment after HSCT in patients with malignant haematological diseases, and a risk prediction model was constructed.

Recent innovations in strategies to prepare metal-organic framework-based mixed matrix membranes.

Mixed matrix membranes (MMMs) composed of metal-organic frameworks (MOFs) and polymer matrixes have garnered significant attention due to their potential to overcome the permeability-selectivity trade-off inherent in polymeric membranes. Nevertheless, the application and industrial production of MOF-based MMMs have been hindered by issues such as poor interfacial compatibility and cumbersome fabrication processes. Recently, strategies have emerged as promising approaches for fabricating MOF-based MMMs, offering enhanced interfacial compatibility between MOF fillers and polymers, as well as a simplified construction process.

Once-weekly IcoSema versus once-weekly semaglutide in adults with type 2 diabetes: the COMBINE 2 randomised clinical trial.

Aims/hypothesis: COMBINE 2 assessed the efficacy and safety of once-weekly IcoSema (a combination therapy of basal insulin icodec and semaglutide) vs once-weekly semaglutide (a glucagon-like peptide-1 analogue) 1.0 mg in individuals with type 2 diabetes inadequately managed with GLP-1 receptor agonist (GLP-1 RA) therapy, with or without additional oral glucose-lowering medications.

Methods: This 52 week, randomised, multicentre, open-label, parallel group, Phase IIIa trial was conducted across 121 sites in 13 countries/regions.

Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis.

Rheumatoid arthritis (RA), a long-term autoinflammatory condition causing joint damage and deformities, involves a multifaceted pathogenesis with genetic, epigenetic, and immune factors, including early immune aging. However, its precise cause remains elusive. Cellular senescence, a hallmark of aging marked by a permanent halt in cell division due to damage and stress, is crucial in aging and related diseases.