Residence time of particles in indoor surface networks.

Infectious microbes can spread rapidly from fomites (contaminated surfaces) via hand touch, with prolonged residence time on surfaces increasing transmission risk by extending exposure periods and/or involving more susceptible individuals. Existing studies have focused on decreasing microbial contamination, but not on the need for rapid removal from surface systems. This study introduces residence time as the time that a microbe spends within the surface system.

Migration of vanadium oxide nanoparticles in saturated porous media.

Vanadium oxides nanoparticles (VO-NPs) as emerging functional materials are widely applied in high-technology industries. However, their environmental behaviors remain largely known. In this study, the migration of three common VO-NPs (VO VO, and VO) in saturated porous media has been investigated.

Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013-2016.

People are continually and simultaneously exposed to various non-persistent pesticides as these chemicals are ubiquitously distributed in the environment. Toxicological studies have indicated the associations between non-persistent pesticides and liver fibrosis in vitro and in vivo. However, epidemical study on the deleterious effect of non-persistent pesticides on the risk of liver fibrosis is rather limited.

Analysis of pathogen distribution, drug sensitivity and inflammatory indicators related to pelvic infection after hysterectomy.

Objective: To analyse the distribution of pathogens, risk factors and inflammatory indicators related to pelvic infection after hysterectomy.

Methods: Patients who underwent hysterectomy at Women's Hospital of Nanjing Medical University between January 2022 and January 2023 were recruited into this study. Vaginal secretions from patients with suspected postoperative pelvic infection were collected for pathogen cultivation, identification, and antimicrobial susceptibility analysis.

Etiological features of status epilepticus of the in-patient cohort in Tibet: A retrospective comparative study.

Background: The etiology of status epilepticus (SE) in Tibet has not yet been reported. We aimed to establish the etiological baseline of SE in the Tibet Autonomous Region in China and compare it with a SE cohort from a regional neuroscience centre in Sichuan, Southwestern China to reveal whether there was a unique etiology distribution in the Tibetan region.

Methods: We retrospectively captured clinical data of patients diagnosed with SE in the People's Hospital of Xizang Autonomous Region from January 2015 to December 2020.

Household waste-specific ambient air shows greater inhalable antimicrobial resistance risks in densely populated communities.

Household waste is a hotspot of antibiotic resistance, which can be readily emitted to the ambient airborne inhalable particulate matters (PM) during the day-long storage in communities. Nevertheless, whether these waste-specific inhalable antibiotic resistance genes (ARGs) are associated with pathogenic bacteria or pose hazards to local residents have yet to be explored. By high-throughput metagenomic sequencing and culture-based antibiotic resistance validation, we analyzed 108 airborne PM and nearby environmental samples collected across different types of residential communities in Shanghai, the most populous city in China.

Vision transformer-based multimodal fusion network for classification of tumor malignancy on breast ultrasound: A retrospective multicenter study.

Background: In the context of routine breast cancer diagnosis, the precise discrimination between benign and malignant breast masses holds utmost significance. Notably, few prior investigations have concurrently explored the integration of imaging histology features, deep learning characteristics, and clinical parameters. The primary objective of this retrospective study was to pioneer a multimodal feature fusion model tailored for the prediction of breast tumor malignancy, harnessing the potential of ultrasound images.

Efficacy analysis of intratympanic injection of dexamethasone at different concentrations for the treatment of unilateral idiopathic sudden sensorineural hearing loss.

Objective: Our study tried to evaluate and compare the therapeutic efficacy of intratympanic injection of dexamethasone (DEX) at different concentrations for the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL).

Methods: A prospective randomized controlled study was conducted on 203 patients with unilateral ISSNHL. Patients were divided into four groups: the control group (n = 47, systemic treatment only), the high-concentration group (n = 51, intratympanic injection of DEX 20 mg/ml), the medium-concentration group (n = 55, 10 mg/ml), and the low-concentration group (n = 50, 5 mg/ml).

An unconventional separation method of α-Terpineol from its isomer 1,8-Cineole via in situ-association formation of deep eutectic solvent and machine learning.

α-Terpineol and 1,8-cineole are two important compounds in essential oils. This study developed an efficient method to recover α-terpineol from model oil (MO) based on association extraction by in situ formations of deep eutectic solvent (DES) between α-terpineol and some quaternary ammonium salts (QASs) by hydrogen-bond (HB) interaction. Such interaction could be broken almost completely by the introduction of water, due to the stronger HB interaction between water and QASs, which could release α-terpineol by liquid-liquid separation and save the organic solvents consumption.

Simulation of the performance of pillar array columns using the pore-throat ratio as efficiency descriptor.

Traditional packed beds in chromatography suffer from increased band broadening due to the random nature of packing, leading non-ideal fluid flow and channeling. To address these challenges, pillar array columns have been developed, offering improved performance over random packing thanks to their homogenous fluid profiles. The study aims to i) evaluate fluid dynamics and chromatographic performance across different PAC morphologies, ii) establish the influence of column morphology on performance, and iii) assess the correlation between chromatographic performance and hydrodynamic parameters.

CPJN: News recommendation with a content and popularity joint network.

Users may click on a news because they are interested in its content or because the news contains important information and is very popular. Modeling these two aspects is crucial for accurate news recommendation. Most existing studies focused on capturing users' preferences towards news content, and thus they are limited in investigating in depth users' preferences towards news popularity and independently capturing user content and popularity preferences.

High-throughput and sustainable B vitamins analysis in nutritional supplements, vegetables, and fruits via 2D carbon microfiber fractionation system coupled with mass spectrometry.

B vitamins are essential for energy metabolism, nervous health, blood production, and the immune system. Their quantification in nutritional supplements and food is mandatory to manage a correct daily intake and dosage. In this study, a fast and sustainable method for the analysis of 8 B vitamins (VB, VB, VB, nicotinamide, VB, VB, VB, VB) in real samples using a 2D-carbon microfiber fractionation system combined with a triple quadrupole mass spectrometer (2DμCFs-QqQ-MS/MS) is presented.

Portable pH meter-based competitive immunoassay of E-selectin using urease-encapsulated metal-organic frameworks.

E-selectin (CD62E) is an adhesion molecule expressed on the surface of endothelial cells (ECs) and its level increases significantly upon the stimulation of ECs by inflammatory factors. Quantitative analysis of CD62E is of great importance to early diagnosis and treatment of vascular diseases and hypertension. A new method for the determination of CD62E was developed using a portable pH meter in this work.

Hemagglutinin with a polybasic cleavage site confers high virulence on H7N9 avian influenza viruses.

H7N9 avian influenza virus (AIV) first emerged in February 2013 in China, and early isolates were all low pathogenic (LP). After circulation for a few years in live poultry markets of China, LP H7N9 AIVs evolved into a highly pathogenic (HP) form in late 2016. Deduced amino acid sequence analysis of hemagglutinin (HA) gene revealed that all HP H7N9 AIVs have obtained four-amino-acid insertion at position 339-342 (H7 numbering), making the cleavage site from a monobasic motif (LP AIVs) to a polybasic form (HP AIVs).

Multiple insights into differential Cd detoxification mechanisms in new germplasms of mung bean (Vigna radiata L.) and potential mitigation strategy.

Long-term cadmium (Cd) exposure inhibits plant growth and development, reduces crop yield and quality, and threatens food security. Exploring the Cd tolerance mechanisms and safe production of crops in Cd-contaminated environment has become a worldwide concern. In this study, mung bean (Vigna radiata L.

Adjuvant radiation therapy improves outcome of patients with surgical resected adrenocortical carcinoma.

Purpose: Adrenocortical carcinoma (ACC) is a rare malignancy known for high rates of recurrence and poor prognosis. Previous studies revealed controversial roles of adjuvant radiation therapy (RT) in patient management. This study aimed to investigate the role of adjuvant RT in postoperative ACC patients.

The role of adenoidectomy and/or tonsillectomy in the treatment of nocturnal enuresis in OSA children: a single-arm meta-analysis.

Purpose: To evaluate the efficacy of tonsillectomy and/or adenoidectomy for the treatment of nocturnal enuresis (NE) in children with obstructive sleep apnea (OSA).

Methods: PubMed, Embase, the Cochrane Library, and Web of Science were searched from inception to December 2023. We included all studies of children with OSA and NE who underwent adenoidectomy and/or tonsillectomy.

Pre-intercalated Sodium Ions Enhance Sodium Storage of MoS Anode by Mitigating Structural Dissociation.

Molybdenum disulfide (MoS) is a promising anode for sodium-ion batteries (SIBs) due to its high theoretical capacity and layered structure. However, a poor reversible conversion reaction and a low initial Coulombic efficiency (ICE) limit its practical application. This study systematically investigated the potential of pre-intercalated sodium ions molybdenum disulfide (Na-MoS) as an anode material for SIBs.

Ultralow Coordination Copper Sites Compartmentalized within Ordered Pores for Highly Efficient Electrosynthesis of -Propanol from CO.

Coordinatively unsaturated copper (Cu) has been demonstrated to be effective for electrifying CO reduction into C products by adjusting the coupling of C-C intermediates. Nevertheless, the intuitive impacts of ultralow coordination Cu sites on C products are scarcely elucidated due to the lack of synthetic recipes for Cu with low coordination numbers and its vulnerability to aggregation under reductive potentials. Herein, computational predictions revealed that Cu sites with higher levels of coordinative unsaturation favored the adsorption of C and C intermediates.

Ligand-Conditioned Side Chain Packing for Flexible Molecular Docking.

Molecular docking is a crucial technique for elucidating protein-ligand interactions. Machine learning-based docking methods offer promising advantages over traditional approaches, with significant potential for further development. However, many current machine learning-based methods face challenges in ensuring the physical plausibility of generated docking poses.

Surface Fluorination of Silicone Rubber with Enhanced Stain Resistance and Slip Properties.

Silicone rubber (SR) holds significant potential for everyday wearable devices due to its inherent sweat resistance and flexibility. However, its broader applicability is constrained by poor oil resistance and a suboptimal slip performance. In this study, we developed an SR with durable oil resistance and enhanced slip properties by forming a covalently bonded barrier layer on its surface through a one-step in situ fluorination reaction using F/N.

All-solid Conductive Elastomers Bridging Mechanical Performance and Sustainability for Durable and Multifunctional Electronics.

The next generation of stretchable electronics seeks to integrate superior mechanical properties with sustainability and sensing stability. Ionically conductive and liquid-free elastomers have gained recognition as promising candidates, addressing the challenges of evaporation and leakage in gel-based conductors. In this study, a sustainable polymeric deep eutectic system is synergistically integrated with amino-terminated hyperbranched polyamide-modified fibers and aluminum ions, forming a conductive supramolecular network with significant improvements in mechanical performance.

Discovery of an Enzyme-Activated Fluorogenic Probe for Profiling of Acylaminoacyl-Peptide Hydrolase.

Acylaminoacyl-peptide hydrolase (APEH), a serine peptidase that belongs to the prolyl oligopeptidase (POP) family, catalyzes removal of N-terminal acetylated amino acid residues from peptides. As a key regulator of protein N-terminal acetylation, APEH was involved in many important physiological processes while its aberrant expression was correlated with progression of various diseases such as inflammation, diabetics, Alzheimer's disease (AD), and cancers. However, while emerging attention has been attracted in APEH-related disease diagnosis and drug discovery, the mechanisms behind APEH and related disease progression are still unclear; thus, further investigating the physiological role and function of APEH is of great importance.

High-Performance Mechano-Sensitive Piezoelectric Nanogenerator from Post-Treated Nylon-11,11 Textiles for Energy Harvesting and Human Motion Monitoring.

Piezoelectric polymer textiles offer distinct advantages in the fabrication of wearable nanogenerators (NGs). One effective strategy to enhance the output capacity of NGs is to modulate the piezoelectric performance of the textiles. This paper focuses on further improving the piezoelectric properties of nylon-11,11 textiles through post-drawing and annealing treatments.