Ultrasound localization microscopy in the diagnosis of breast tumors and prediction of relevant histologic biomarkers associated with prognosis in humans: the protocol for a prospective, multicenter study.

Background: Benign and malignant breast tumors differ in their microvasculature morphology and distribution. Histologic biomarkers of malignant breast tumors are also correlated with the microvasculature. There is a lack of imaging technology for evaluating the microvasculature.

Primary bronchial leiomyosarcoma: a diagnostic challenge.

Background: Pulmonary bronchial leiomyosarcoma is an extremely rare malignant tumour of the lung originating from the mesenchymal tissue. The retroperitoneal region is the most common site of leiomyosarcoma. It exhibits a high degree of malignancy and a poor prognosis, thereby highlighting the significance of early diagnosis of this disease.

Erythema nodosum, malignant melanoma and non-melanoma skin cancer in relation to inflammatory bowel disease: a Mendelian randomization study.

Inflammatory bowel disease (IBD) is a multisystem condition that could affect the cutaneous systems, namely cutaneous extraintestinal manifestations (EIMs). It has been suggested that IBD is associated with erythema nodosum (EN), malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, the potential causal relationship between IBD and the mentioned above cutaneous EIMs is still unclear.

Development and validation of a prognostic nomogram for predicting outcomes in brainstem hemorrhage patients.

Brainstem hemorrhage is a severe neurological condition with high mortality and poor prognosis. This study aims to develop and validate a prognostic model for brainstem hemorrhage to facilitate early prediction of patient outcomes, thereby supporting clinical decision-making. Clinical data from 140 patients with brainstem hemorrhage were collected.

Predictive Value and Potential of Targeting Complement Factor C3 in Patients with Renal Injury in Preeclampsia.

Aim: The activation of the complement system is accompanied by the occurrence and development of preeclampsia, as well as kidney diseases. Here, the role of complement C3 [C3] in renal injury in preeclampsia was explored, and its potential application as an early diagnostic biomarker or drug target to ameliorate kidney injury induced by preeclampsia was preliminarily evaluated.

Method: A total of 48 subjects were included in the present study, and the complement C3 levels and renal function were analyzed.

Development of Tc-Labeled Complexes with a Niraparib HYNIC Derivative for PARP-Positive Tumor Imaging.

As an enzyme that plays an important role in DNA repair, poly(ADP-ribose) polymerase-1 (PARP-1) has become a popular target for cancer therapy. Nuclear medicine molecular imaging technology, supplemented by radiolabeled PARP-1 inhibitors, can accurately determine the expression level of PARP-1 at lesion sites to help patients choose an appropriate treatment plan. In this work, niraparib was modified with a hydrazinonicotinamide (HYNIC) group to generate the ligand NPBHYNIC, which has an affinity (IC) of 450.

Antibacterial mechanism of vitamin K-mediated photodynamic inactivation against Pseudomonas fluorescens and its influences on blunt bream (Megalobrama amblycephala) quality.

Photodynamic inactivation (PDI) has emerged as a novel non-thermal process technology for inactivating microorganisms due to its low cost, safety, and efficiency. This study aimed to investigate the antimicrobial effect of VK-mediated PDI against Pseudomonas fluorescens (P. fluorescens) and to assess its impact on the quality of the blunt bream contaminated with P.

Metatranscriptomic insights into the mechanism of 'Multiple Qu' utilization in Jian-flavor Baijiu fermentation.

The unique process of "Multiple-qu fermentation" (MF) is essential for the formation of the Jian-flavor Baijiu, but the mechanisms behind its aroma development remain not fully understood. This study compared the effects of "Single-qu fermentation"(SF) and MF on Baijiu production to elucidate the microbial and metabolic interactions responsible for its distinct aroma. Firstly, significant differences were observed in the microbial communities of the two types of Daqu.

Cellulose nanofiber-created air barrier enabling closed-cell foams prepared via oven-drying.

Cellulose foams are renewable and biodegradable materials that are promising substitutes for plastic foams. However, the scale-up fabrication of cellulose foams is severely hindered by technological complexity and cost- and time-consuming drying processes. Here, we developed a facile and robust method to fabricate cellulose foams via oven-drying following surfactant-assisted mechanical foaming of cellulose nanofibers (CNFs).

Polydopamine-integrated cellulose/graphene oxide monoliths: A versatile platform for efficient continuous-flow iodine capture and photothermal-enhanced reduction of Cr(VI).

The global challenge of wastewater contamination, especially from persistent pollutants like radioactive isotopes and heavy metals, demands innovative purification solutions. Radioactive iodine isotopes (I and I), stemming from nuclear activities, pose serious health risks due to their mobility, bioaccumulation, and ionizing radiation, particularly impacting thyroid health. Similarly, hexavalent chromium, Cr(VI), is highly toxic and persistent in water, linked to cancer and other severe health issues.

Effect of glycoside hydrolase-mediated wheat arabinoxylan hydrolysate on gut microbiota and metabolite profiles.

Cereal arabinoxylans (AX) are complex non-digestible polysaccharides and their molecular structural features significantly influence their degradation and metabolic behaviors within the body. This study focuses on investigating the impact of wheat AX hydrolysates produced by different glycoside hydrolases on the gut microbiota during colonic fermentation. Endo-1,4-β-xylanase (XYN) and arabinofuranosidase (ARF) were used to hydrolyze the xylan backbone and remove the arabinose side chains, respectively.

Development of a rapid enzymatic quantification method for hyaluronic acid based on the gene-mining of hyaluronate lyase.

Hyaluronic acid (HA), a vital polysaccharide naturally present in human tissues, is widely utilized in the food, pharmaceutical and cosmetic industries due to its diverse functionalities and bioactivity. Rapid and accurate quantification of HA is essential for the quality control of its products. Enzymatic quantification methods, known for their simplicity and high specificity, were employed for polysaccharide measurement.

One-pot ligation of multiple mRNA fragments on dsDNA splint advancing regional modification and translation.

Region-specific RNA modifications are crucial for advancing RNA research and therapeutics, including messenger RNA (mRNA)-based vaccines and immunotherapy. However, the predominant method, synthesizing regionally modified mRNAs with short single-stranded DNA (ssDNA) splints, encounters challenges in ligating long mRNA fragments due to the formation of RNA self-folded complex structures. To address this issue, we developed an efficient strategy using an easily obtained long double-stranded DNA (dsDNA) as a ligation splint after in situ denaturing, while parts of this dsDNA are the templates for transcribing mRNA fragments.

Sodium alginate-crosslinked montmorillonite nanosheets hydrogel for efficient gallium recovery.

An efficient adsorbent for Ga(III) recovery was developed by applying the geochemical principles of Ga mineralization, using Al-rich clay minerals with a natural affinity for Ga as the raw material. Sodium alginate (SA) facilitated the cross-linked assembly of montmorillonite nanosheets (MMTNS), forming a three-dimensional structured hydrogel. This was achieved through electrostatic interactions between -OH groups on the edges of MMTNS and -COO groups in SA, as well as the complexation of Ca and -COO groups.

Micro-corrugated chiral nematic cellulose nanocrystal films integrated with ionic conductive hydrogels leads to flexible materials for multidirectional strain sensing applications.

Multidirectional strain sensors are of technological importance for wearable devices and soft robots. Here, we report that flexible materials capable of multidirectional anisotropic strain sensing can be constructed leveraging diffusion-induced infiltration of monomers and in situ polymerization of metal ion-containing double network hydrogels in and on the surface of micro-corrugated chiral nematic cellulose nanocrystal/glucose films. Integrating the micro-corrugated cellulose nanocrystal/glucose chiral nematic films with ionic conductive hydrogels of PAA-co-AAm/sodium alginate/Al endows the materials with multidirectional mechanoelectrical resistivity and mechanochromism anisotropy.

Tandem modification strategy on technical lignin realize the balance of solubility and antioxidant activity in castor oil.

In this study, demethylated-acylated enzymatic hydrolysis lignin (DAEHL) with excellent solubility in castor oil and antioxidant activities were prepared via the tandem modification strategy. First, iodocyclohexane simultaneously achieved β-O-4 breakage and hydrogenation, which enhanced the antioxidant activity of lignin. Furthermore, the acylation reaction by palmitoyl chloride increased the alkyl content in the lignin, which can improve the solubility of lignin in castor oil.

Nanocellulose-reinforced nanofiber composite poly(aryl ether ketone) polymer electrolyte for advanced lithium batteries.

Solid polymer batteries (SPEs) are highly desirable for energy storage because of the urgent need for higher energy density and safer lithium ion batteries (LIBs). In this work, the single-ion lithium salt PAEK-LiCPSI was synthesized by grafting 3-chloropropanesulfonyl trifluoromethanesulimide lithium (LiCPSI) onto poly(aryl ether ketone) (PAEK). Nanocellulose (NCC), PAEK-LiCPSI, and poly(vinylidene fluoride) (PVDF-HFP) were compounded to obtain NCC reinforced high-performance nanofiber composite polymer electrolytes (NCC/PAEK/PVDF) through electrospinning, which presented tensile strength of 15.

Glutathione depletion-based pH-responsive injectable hydrogels for synergistic treatment of colon tumor.

In this paper, a pH-sensitive chitosan-grafted phenylboronic acid (CS-BA)/polyvinyl alcohol (PVA) hydrogel was constructed based on dynamic borate bonding for loading chemotherapeutic drug cisplatin (CDDP) and divalent Cu (CS-BA/PVA-Cu-CDDP). The hydrogel can respond and degrade specifically in the simulative acidic tumor microenvironment (TME), and the released Cu can deplete glutathione (GSH) in tumor cells and generate Cu. It is worth noting that, Cu can further catalyze the Fenton-like reaction to generate cancer cell-toxic hydroxyl radicals (OH•).

A novel photoelectrochemical biosensor for sensitive detection of nucleic acids based on recombinase polymerase amplification and 3D-array titania nanorods.

Nucleic acids detection is essential for diagnosing pathogens; however, traditional methods usually face challenges such as low sensitivity, lengthy reaction times, and strict temperature requirements. This study develops a novel photoelectrochemical (PEC) biosensor that integrates recombinase polymerase amplification (RPA) with a 3D-array titania (TiO) nanorods nanorod electrode, addressing the challenge of achieving sensitive detection of RPA-amplified nucleic acids products, thereby enabling earlier and more reliable pathogen detection. The biosensor utilizes a triple-binding mode involving FITC antibodies, target nucleic acids, and an HRP-streptavidin sandwich structure, significantly improving the bio-functionalization of the electrode surface.

Imaged capillary isoelectric focusing and online mass spectrometry for milk whey protein characterization in dairy products.

Characterizing major bovine milk proteins, including whey and casein, is of significant interest in the dairy industry. The diverse array of protein proteoforms can be different in terms of genetic variation, breed ways, lactation stage, and animal nutritional status. Current routine methods for bovine milk protein profiling are typically based on immunological techniques, infrared spectroscopy, slab gel isoelectric focusing, capillary electrophoresis, and high-performance liquid chromatography.

Advances in the impact of ASS1 dysregulation on metabolic reprogramming of tumor cells.

ASS1(argininosuccinate synthase 1) is a rate-limiting enzyme in the urea cycle, catalyzing the synthesis of argininosuccinate from citrulline and aspartate to ultimately produce arginine and support cellular metabolism. Increasing evidence suggests that ASS1 is commonly dysregulated in the tumor microenvironment, promoting tumor cell metastasis and infiltration. With a deeper understanding of tumor metabolic reprogramming in recent years, the impact of ASS1 dysregulation on abnormal tumor metabolism has attracted growing interest among researchers.

GFRs in Chinese CKD: A systematic review.

Purpose: This was an evidence-based study to assess which creatinine-based equation was most useful for estimated glomerular filtration rate (eGFR) in Chinese adults with chronic kidney disease (CKD).

Methods: Multiple databases were searched to collect relevant studies on creatinine-based eGFR equations for Chinese adults with CKD in Chinese and English from January 2009 to January 2023, using "glomerular filtration rate", "GFR equations", "Chinese CKD", "chronic kidney disease", "equation development" and "equation validation". The quality of each study was assessed using the diagnostic test accuracy review by RevMan 5.

Highly hydrophobic calixarene polymers for efficient enrichment of polar nitrobenzene compounds.

Macrocyclic polymer materials exhibit excellent selectivity and adsorption performance in pollutant adsorption due to unique host-guest recognition. Herein, three kinds of calixarene polymers (C4P, C6P and C8P) were synthesized through Sonogashira reaction, and were characterized through H NMR, FT-IR, SEM, and TEM. The water contact angle experiments revealed that three kinds of calixarene polymers were highly hydrophobic, and they all exhibited high enrichment efficiency for weak polar chloro-substituted benzene compounds (chlorobenzene, o-chlorotoluene, p-dichlorobenzene and o-dichlorobenzene) and BTEX (benzene, toluene, ethylbenzene and xylenes).

Scale effects on suspended sediment and their response to extreme precipitation in karst basins.

Extreme precipitation is a crucial trigger for soil erosion events in karst regions. However, the existence of a scale effect in suspended sediment characteristics of karst basins and which extreme precipitation variables control this effect remain unclear. To investigate this, we analyzed the scale effect on suspended sediment characteristics using monthly hydrological data from five karst basins of varying scales, consistently monitored from 2012 to 2019.

Predictive value of the nutritional risk index for postoperative complications in individuals with pancreatic cancer undergoing pancreaticoduodenectomy.

Purpose: To explore the predictive value of the geriatric nutritional risk index (GNRI) for postoperative complications and their severity in older adults with pancreatic cancer undergoing pancreaticoduodenectomy (PD).

Methods: This study conducted a retrospective analysis of 109 older adults with pancreatic cancer undergoing PD at the Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Quzhou Medical University, between May 2019 and May 2022. Statistical analysis of clinical data was performed to assess the predictive value of the GNRI for postoperative complications and their severity in older adults with pancreatic cancer undergoing PD.