Transcriptome-Wide Association Study Identified Novel Blood Tissue Gene Biomarkers for Prostate Cancer Risk.

Objective: A number of susceptibility genes in prostate tissue have been identified to be associated with prostate cancer (PCa) risk. However, the reported genes based on assessing prostate tissue could not fully explain PCa genetic susceptibility. It is believed that genes functioning in the immune system may fill in the gap of some missing heritability.

Large Electromechanical Response and Field-Induced Shape Memory Effect in Ferroelectric Ceramics.

Electric-field-induced shape memory effect has potential applications in electromechanical actuator. Here, this study proposes the a phase structure design routine in (1-x)(75NaBiTiO-25SrTiO)-xPbTiO ceramics to obtain large electromechanical response and shape memory effect. It is found that the shape memory effect is closely related to the bending deformation induced by asymmetric polarization between positive and negative electrodes, which is resulted from the reductions of Bi and Pb because of electron injection from negative electrode.

Programmable Stapling Peptide Based on Sulfonium as Universal Vaccine Adjuvants for Multiple Types of Vaccines.

Adjuvants are non-specific immune enhancers commonly used to improve the responsiveness and persistence of the immune system toward antigens. However, due to the undefined chemical structure, toxicity, non-biodegradability, and lack of design technology in many existing adjuvants, it remains difficult to achieve substantive breakthroughs in the adjuvant research field. Here, a novel adjuvant development strategy based on stapling peptides is reported to overcome this challenge.

Manganese-Based Nanozyme Alleviates Acute Kidney Injury via Nrf2/HO-1 and PI3K/Akt/NF-κB Signaling Pathways.

Acute renal injury (AKI) has a high incidence rate and mortality, but current treatment methods are limited. As a kind of nanomaterial with enzyme-like activity, nanozyme has shown outstanding advantages in treating AKI according to recent reports. Herein, we assess the potential of manganese-based nanozymes (MnO-BSA NPs) with excellent biosafety in effectively alleviating AKI.

Mitochondria-localized dinuclear iridium(III) complexes for two-photon photodynamic therapy.

Photodynamic therapy (PDT), as a non-invasive cancer treatment, offers significant advantages including high temporal-spatial selectivity, minimal surgical intervention, and low toxicity, thereby garnering considerable research interest from across the world. In this study, we have developed a series of dinuclear cyclometalated Ir(III) complexes as potential two-photon photodynamic anticancer agents. These Ir(III) complexes demonstrate significant two-photon absorption (2PA) cross-sections ( = 66-166 GM) and specifically target mitochondria.

WBSCR16 is essential for mitochondrial 16S rRNA processing in mammals.

Mitochondrial rRNAs play important roles in regulating mtDNA-encoded gene expression and energy metabolism subsequently. However, the proteins that regulate mitochondrial 16S rRNA processing remain poorly understood. Herein, we generated adipose-specific Wbscr16-/-mice and cells, both of which exhibited dramatic mitochondrial changes.

Prediction Model of the T Cell-mediated Rejection After Liver Transplantation in Children and Adults: a Case-controlled Study.

Objective: T cell-mediated rejection (TCMR) is a major concern following liver transplantation (LT), and identifying its predictors could help improve post-transplant prognosis. This study aimed to develop a model to predict the risk of TCMR in children and adults after LT.

Method: Pre-transplant demographic characteristics, intraoperative parameters, and especially early post-transplant laboratory data for 1,221 LT recipients (1,096 adults and 125 children) were obtained from Hospital, University, between 1 January 2015, and 1 January 2022.

Palladium-Catalyzed Modular Synthesis of Thiophene-Fused Polycyclic Aromatics via Sequential C-H Activation.

A palladium-catalyzed Catellani-type [2+2+2] annulation reaction of aryl iodides, bromothiophenes, and norbornadiene, which proceeds via a tandem Heck coupling/double C-H bond activation and retro-Diels-Alder pathway to access thiophene-fused polyaromatics, is reported. The key feature of this protocol represents a NBD/NBE retaining annulation.

Best evidence summary for the management of exercise in patients with central venous access devices.

Background: Central venous access devices (CVAD) are widely used in patient care, providing an essential, reliable pathway for patients to receive chemotherapy, long-term infusions, and nutritional support. However, a system of exercise management has not been developed in patients with CVAD.

Purpose: To evaluate and summarize the evidence for management exercise in patients with CVAD and provide guidance for clinical practice.

I-Catalyzed benzylation of NH-sulfoximines with diarylmethanes and alkylarenes.

A practical transition metal-free approach for the selective benzylation of NH-sulfoximines has been disclosed by using simple elemental iodine as the catalyst and -butyl hydroperoxide (TBHP) as the terminal oxidant. Comparing with known methods for the construction of -benzylated sulfoximines, our protocol shows broad substrate scope with respect to both diarylmethanes and alkylarenes, and can be conducted in air with good functional group tolerance.

Recognizing drivers' sleep onset by detecting slow eye movement using a parallel multimodal one-dimensional convolutional neural network.

Slow eye movements (SEMs) are a reliable physiological marker of drivers' sleep onset, often accompanied by EEG alpha wave attenuation. A parallel multimodal 1D convolutional neural network (PM-1D-CNN) model is proposed to classify SEMs. The model uses two parallel 1D-CNN blocks to extract features from EOG and EEG signals, which are then fused and fed into fully connected layers for classification.

Construction of Photosensitizer Candidates in Photodynamic Therapy: Computer Aided Design, Calculation, and Screening.

Thiophene and pyrrole units are extensively utilized in light-responsive materials and have significantly advanced the field of organic photovoltaics (OPV). This progress has inspired our exploration of photosensitizers (PS) for photodynamic therapy (PDT). Currently, traditional PS face limitations in clinical application, including a restricted variety and narrow applicability.

Dynamics and kinetics exploration of the oxygen reduction reaction at the Fe-N/C-water interface accelerated by a machine learning force field.

Understanding the oxygen reduction reaction (ORR) mechanism and accurately characterizing the reaction interface are essential for improving fuel cell efficiency. We developed an active learning framework combining machine learning force fields and enhanced sampling to explore the dynamics and kinetics of the ORR on Fe-N/C using a fully explicit solvent model. Different possible reaction paths have been explored and the O adsorption process is confirmed as the rate-determining step of the ORR at the Fe-N/C-water interface, which needs to overcome a free energy barrier of 0.

Non-Luminal Disease Score for Everolimus in Patients with Hormone Receptor‑positive and Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: A Multicenter and Retrospective Study.

Purpose: This study aims to explore the role of the non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC).

Methods: NOLUS has previously been established as an algorithm: NOLUS (0-100) = - 0.45 × ER(%) - 0.

Dimethyl fumarate alleviate hepatic ischemia-reperfusion injury through suppressing cGAS-STING signaling.

Hepatic ischemia-reperfusion (I/R) injury frequently occurs during the perioperative phase of liver surgery. Inappropriate activation of STING signaling can trigger excessive inflammation response to aggravate hepatic I/R injury. Dimethyl fumarate (DMF) is an FDA-approved immunomodulatory drug used to treat multiple sclerosis and psoriasis due to its notable anti-inflammation properties.

Difficulties in the diagnosis and treatment of axillary malignant triton tumors: A case report.

Malignant triton tumor (MTT), a subtype of malignant peripheral nerve sheath tumor, is a rare soft-tissue sarcoma with a difficult diagnosis and poor prognosis. The course of MTT progression is rapid and the degree of malignancy is high. Patients with MTT can be treated with postoperative adjuvant radiotherapy and chemotherapy; however, treatment results are still poor.

The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice.

Purpose: The effective compound combination of Bufei Yishen formula III (ECC-BYF III) has shown protective effects against chronic obstructive pulmonary disease (COPD). However, its effect on mitochondrial dysfunction remains unclear. The current study aimed to investigate the effect of ECC-BYF III on mitochondrial dysfunction in COPD mice and elucidate its potential mechanisms.

Role of limited medical resources in an epidemic model with media report and general birth rate.

This paper formulates an SEIRSHM epidemic model with general birth rate, media report and limited medical resources. Firstly, the well-posedness of the solutions and the extinction of the disease are discussed. Then, the existence of the endemic equilibrium is discussed and we find when ∗ > 1 and  = 1, there exhibits a backward bifurcation, if ∗ < 1 and  = 1, there exhibits a forward bifurcation.

Single-Step Ethylene Purification and MTO Product Separation in a Nitrogen-Rich Microporous Metal-Organic Framework.

The nitrogen-rich metal-organic framework (MOF) , featuring a melamine (MA) functional group, enables efficient one-step CH purification and methanol-to-olefins (MTO) product separation. At 298 K, its adsorption capacity follows the order CH > CH > CH > CH. Breakthrough experiments showed that produced pure CH from C mixtures with a productivity of 22.

Precise detection of NSE and ProGRP with nanoprobes for early diagnosis of small cell lung cancer.

A DNA strand-based fluorescent probe was developed for the direct simultaneous detection of small cell lung cancers' tumor markers NSE and ProGRP. The probe offers stability, simplicity, and rapid response, making it highly promising for application in clinical serum samples' diagnosis.

Self-assembly processes of 2D Au(I)-S(CH)COOH lamellae.

Solving the assembled structure of Au(I)-thiolate linear coordination polymers has been a challenging task as they generally lack good crystallinity. This has prevented the elucidation of their assembly processes at the molecular level. In this paper, selected area electron diffraction (SAED) patterns of two-dimensional (2D) Au(I)-S(CH)COOH (Au(I)-MPA) lamellae are obtained by applying cryogenic transmission electron microscopy.

Zengye decoction regulated the expression of aquaporin in colon tissue of rats with constipation through miR-10a-5p targeting Drd2/AC/cAMP axis.

Slow transit constipation (STC) is a colonic motor disorder characterized by a marked delay in the movement of substances through the colon. Traditional Chinese medicine (TCM) is a treasure trove of natural compounds, which is effective in treating constipation with relatively minor side effects. Zengye decoction (ZYD), a classic herbal formula in TCM, is used for moistening the intestines and relieving constipation.

Recent advances in antiaromatic metallacycles.

Several antiaromatic metallacycles have been reported in the past 5 years, opening an emerging area of (anti)aromaticity and organometallic chemistry. In this work, we briefly review the synthesis and characterization of these complexes. Generally, experimental criteria, including planarity, bond length alternation, NMR chemical shift, chemical transformation, and theoretical criteria, mainly involving NICS, AICD, ASE or ISE, are applied for the antiaromaticity judgement.

An ultra-high absorptivity solar absorber with excellent thermal radiation efficiency based on a metal-dielectric stacked structure.

Metamaterials hold great promise for application in the field of perfect absorbers due to their remarkable ability to manipulate electromagnetic waves. In this work, a full-spectrum ultra-wideband solar absorber with a multilayer metal-dielectric stacked structure is designed. Our absorber is simple and easy to manufacture, with Ti serving as the substrate, overlaid with SiN spacer layers and four pairs of Ti-SiN ring columns.

Top-Down Strategy Enabling Elastic Wood Nanocarbon Sponges with Wrinkled Multilayer Structure and High Compressive Strength for High-Performance Compressible Supercapacitors.

3D porous carbon electrodes have attracted significant attention for advancing compressible supercapacitors (SCs) in flexible electronics. The micro- and nanoscale architecture critically influences the mechanical and electrochemical performance of these electrodes. However, achieving a balance between high compressive strength, electrochemical stability, and cost-effective sustainable production remains challenging.