Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum.

Plasma phosphorylated tau biomarkers open unprecedented opportunities for identifying carriers of Alzheimer's disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network disturbance in the form of cognitive impairment.

Temperature-driven development and reproduction in Cacopsylla citrisuga (Hemiptera: Psyllidae): insights from an age-stage, two-sex life table analysis.

The citrus pest Cacopsylla citrisuga (Yang & Li), a vector for Citrus Huanglongbing (HLB), exhibits distinct sensitivity to temperature variations. This study utilized an age-stage, 2-sex life table to evaluate the development and reproduction of C. citrisuga across 5 temperatures (17, 20, 25, 28, and 31 °C).

Electrochemically Driven Selective Olefin Epoxidation by Cobalt-TAML Catalyst.

Epoxides are versatile chemical intermediates that are used in the manufacture of diversified industrial products. For decades, thermochemical conversion has long been employed as the primary synthetic route. However, it has several drawbacks, such as harsh and explosive operating conditions, as well as a significant greenhouse gas emissions problem.

Vintages for New Fashion: Red-Shifted Photoswitching via the Triplet-Photoreaction Channel with Charge-Transfer Complex Sensitizers.

Triplet-sensitization has been proven invaluable for creating photoswitches operated over a full visible-light spectrum. While designing efficient triplet-sensitizers is crucial for establishing visible-light photochromism, it remains an appealing yet challenging task. In this work, we propose a versatile strategy to fabricate triplet-sensitizers with intermolecular charge-transfer complexes (CTCs).

Dual Pathways of Photorelease Carbon Monoxide via Photosensitization for Tumor Treatment.

Carbon monoxide (CO) gas therapy, as an emerging therapeutic strategy, is promising in tumor treatment. However, the development of a red or near-infrared light-driven efficient CO release strategy is still challenging due to the limited physicochemical characteristics of the photoactivated carbon monoxide-releasing molecules (photoCORMs). Here, we discovered a novel photorelease CO mechanism that involved dual pathways of CO release via photosensitization.

Strategies and Prospects for Engineering a Stable Zn Metal Battery: Cathode, Anode, and Electrolyte Perspectives.

ConspectusZinc metal batteries (ZMBs) appear to be promising candidates to replace lithium-ion batteries owing to their higher safety and lower cost. Moreover, natural reserves of Zn are abundant, being approximately 300 times greater than those of Li. However, there are some typical issues impeding the wide application of ZMBs.

Protocol for visualizing the chromatin assembly properties of epigenetic protein complexes via an HTM module-mediated artificial tethering system.

The detailed chromatin assembly processes for many epigenetic regulatory complexes are largely unknown. Here, we present a protocol utilizing heterochromatin-targeting module (HTM) module-mediated chromatin tethering followed by microscopy-based visualization to detect the recruitment priority between two components in Polycomb repressive complex 1 (PRC1). Moreover, we detail procedures for detecting the resultant histone-modifying activities of PRC1 using immunofluorescence (IF) analyses.

Hamiltonian learning for 300 trapped ion qubits with long-range couplings.

Quantum simulators with hundreds of qubits and engineerable Hamiltonians have the potential to explore quantum many-body models that are intractable for classical computers. However, learning the simulated Hamiltonian, a prerequisite for any quantitative applications of a quantum simulator, remains an outstanding challenge due to the fast increasing time cost with the qubit number and the lack of high-fidelity universal gate operations in the noisy intermediate-scale quantum era. Here, we demonstrate the Hamiltonian learning of a two-dimensional ion trap quantum simulator with 300 qubits.

Room-temperature continuous-wave pumped exciton polariton condensation in a perovskite microcavity.

Microcavity exciton polaritons (polaritons) as part-light part-matter quasiparticles garner considerable attention for Bose-Einstein condensation at elevated temperatures. Recently, halide perovskites have emerged as promising room-temperature polaritonic platforms because of their large exciton binding energies and superior optical properties. However, currently, inducing room-temperature nonequilibrium polariton condensation in perovskite microcavities requires optical pulsed excitations with high excitation densities.

One-dimensional nanosonosensitizer boosted multiple branches of immune responses against MHC-deficient immune-evasive urologic tumor.

Cancer immunotherapies rely on CD8 cytolytic T lymphocytes (CTLs) in recognition and eradication of tumor cells via antigens presented on major histocompatibility complex class I (MHC-I) molecules. However, we observe MHC-I deficiency in human and murine urologic tumors, posing daunting challenges for successful immunotherapy. We herein report an unprecedented nanosonosensitizer of one-dimensional bamboo-like multisegmented manganese dioxide@manganese-bismuth vanadate (BMMBV) to boost multiple branches of immune responses targeting MHC-I-deficient tumors.

Relationships between multivitamins, blood biochemistry markers, and BMC and BMD based on RF: A cross-sectional and population-based study of NHANES, 2017-2018.

Background: Previous studies have separately suggested a possible association between the vitamin exposure, blood biochemical indicators, and bone density. Our study aimed to investigate the relationship between vitamin exposure serum concentrations, blood biochemical indicator serum concentrations, and BMC and BMD using the NHANES 2017-2018 nutrient survey data. This population-based cross-sectional study aimed to explore these associations.

Nitroxyl protects H9C2 cells from H/R-induced damage and inhibits autophagy via PI3K/Akt/mTOR pathway.

Background: Myocardial ischemia-reperfusion injury (MIRI) is an important complication in the treatment of heart failure, and its treatment has not made satisfactory progress. Nitroxyl (HNO) showed protective effects on the heart failure, however, the effect and underlying mechanism of HNO on MIRI remain largely unclear.

Methods: MIRI model in this study was established to induce H9C2 cell injury through hypoxia/reoxygenation (H/R) in vitro.

Efficient Double-Layer Evaporators with Adjustable Pores for Sustainable Solar Evaporation.

Solar-driven desalination technology is currently an important way to obtain freshwater resources. Significantly, porous materials are used as substrate materials of interface solar evaporator, and their specific impact of water transport property and thermal management during evaporation is worth exploring. In this paper, poly(vinyl alcohol) (PVA) sponges were prepared by a chemical foaming method, adjusted the PVA polymerization degree, and formaldehyde-hydroxyl ratio to regulate the pore size, and polypyrrole (PPy) was grown in situ on the surface skeleton of PVA sponge to construct a new interfacial solar evaporator (PPy/PVA) with different pore structures.

Phase-Engineered ZrO for Tuning Catalytic Oxidation of Dichloromethane Over W/ZrO:Zr-Doped WO Clusters and the Hydrolysis-Oxidation Mechanism.

Catalytic elimination through an oxidative decomposition pathway is the most promising candidate for the purification of chlorinated volatile organic compound (CVOC) pollutants, but the complicated mechanisms and the formation pathways of hydrogenated byproducts still need to be clearly revealed. Herein, W/ZrO, as a structure-tunable catalyst, is used to catalytically oxidize dichloromethane (DCM) and clarify the formation pathway of monochloromethane (MCM). Crystal engineering of ZrO tailors surface WO species; practically, the predominant Zr-WO clusters and crystalline WO can be obtained on monoclinic (m-ZrO) and tetragonal (t-ZrO) phases.

Rhodium-Catalyzed Homogeneous Asymmetric Hydrogenation of Naphthol Derivatives.

Due to their strong aromaticity and difficulties in chemo-, regio-, and enantioselectivity control, asymmetric hydrogenation of naphthol derivatives to 1,2,3,4-tetrahydronaphthols has remained a long-standing challenge. Herein, we report the first example of homogeneous asymmetric hydrogenation of naphthol derivatives catalyzed by tethered rhodium-diamine catalysts, affording a wide array of optically pure 1,2,3,4-tetrahydronaphthols in high yields with excellent regio-, chemo-, and enantioselectivities (up to 98% yield and >99% ee). Mechanistic studies with experimental and computational approaches reveal that fluorinated solvent 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) plays vital roles in the control of reactivity and selectivity, and 1-naphthol is reduced via a cascade reaction pathway, including dearomative tautomerization, 1,4-hydride addition, and 1,2-hydride addition in sequence.

Competitive Effect of Surface Hydrophobicity-Hydrophilicity and the Number of Accessible Protons on Water-Assisted Proton Conductivity in Metal-Organic Frameworks: Dielectric σ-Relaxation Triggered by Disordered Guest Ionic Migration and Its Mechanism.

The rapid upsurge of metal-organic frameworks (MOFs) has sparked profound interest in their potential as proton conductors for proton exchange membrane fuel cells. However, proton-conducting behaviors of hydrophobic MOFs remain poorly understood compared with their hydrophilic counterparts, largely due to the absence of a microscopic phase separation structure akin to that found in Nafion membranes. Herein, we demonstrate a strategy for regulating the structures and proton conductivities of MOFs by separately incorporating hydrophobic -C(CF)- group alongside hydrophilic -O- and -SO- groups into organic ligands as linkers.

Constructing well-dispersed active phase spontaneous redox for electrochemical nitrate reduction to ammonia.

In this study, a distinctive multiple core-shell structure of Co nanoparticles inserted into N-doped carbon dodecahedron@Co hydroxide (Co/NCD@Co(OH)) was synthesized a spontaneous redox reaction between metallic Co and NO, ultimately materializing the fine dispersion and exposure of the active sites. The electronic interaction existing between the Co/NCD core and the Co(OH) shell brings a synergistic effect, conspicuously lessens the overpotential, and reinforces the yield-rate and faradaic efficiency of NH for electrochemical nitrate-ammonia conversion. This study underlines the spontaneous redox between the catalysts and substrate, rendering it as a synthetic strategy for designing genuine and well-dispersed active sites.

A mitochondria-targeted iridium(III) complex-based sensor for endogenous GSH detection in living cells.

Glutathione (GSH) plays an important role in maintaining redox homeostasis in biological systems. Development of reliable glutathione sensors is of great significance to better understand the role of biomolecules in living cells and organisms. Based on the advantages of the photophysical properties of iridium complexes, we proposed a "turn-on" phosphorescent sensor.

Monotropein represses the proliferation and angiogenesis via the AKT/NF-κB pathway in lung cancer.

Monotropein (Mon) is an iridoid glycosides extracted from Morinda officinalis F.C. How.

Discovery of potential VEGFR-2 inhibitors from natural products by virtual screening and molecular dynamics simulation.

Hepatocellular carcinoma (HCC) is the most common cancer worldwide and vascular endothelial growth factor receptor-2 (VEGFR-2) is an important target in the development of inhibitors for the treatment of liver cancer. So far, however, there are no effective drugs targeting VEGFR-2 to achieve complete treatment of liver cancer. In this study, we employed molecular docking, molecular dynamics simulations, molecular mechanics generalized Born surface area (MM-GBSA) method, quantum mechanics/molecular mechanics (QM/MM) calculations and steered molecular dynamics simulations to discover the potential inhibitors from COCONUT database targeting VEGFR-2.

Experimental and Theoretical Study of Two 3D Difunctional Electrocatalytic Hybrid Vanadate-Containing Metal-Organic Motifs.

Two novel 3D inorganic-organic hybrids based on [VO]/[VO] clusters, [Cu(bbpy)(VO)]·3HO () and [CuAg(pty)(VO)]·HO () (bbpy = 3,5-bis(1-benzimidazole) pyridine, pty = 4'-(4″-pyridyl)-2,2':6',2″-terpyridine), were isolated in the same POV/Cu/N-heterocycle ligand reaction systems. Hybrids and possess novel three-dimensional bimetallic frameworks derived from [VO]/[VO] clusters and Cu-organic complexes. In , bbpy ligands are grafted by Cu to a grid ribbon 2D sheet, which are connected with benzene-like [VO] to yield a 3D framework.

Cinnamaldehyde-Based ROS-Responsive Polymeric Gene Vectors for Efficient Gene Delivery and Tumor Cell Growth Inhibition.

Reactive oxygen species (ROS)-sensitive polymers are extensively used in cancer therapies. However, the ROS levels in the tumor microenvironment are often insufficient to trigger an adequate therapeutic response. Herein, we report a cinnamaldehyde ()-based ROS-responsive cationic polymer () and demonstrate its high efficiency in gene delivery and tumor cell growth inhibition.

Coordination-regulated copper single-atom active sites for electrochemical reduction of nitrate to ammonia.

The electrochemical conversion of nitrate to ammonia is necessary to restore the globally perturbed nitrogen cycle. Herein, the regulated coordination of active Cu single atoms to selectively modulate the energy barriers of proton-electron transfer steps was investigated and offered valuable insights for improving the selectivity and kinetics of the NORR.

A novel cellulose-derived graphite carbon/ZnO composite by atomic layer deposition as an over-wideband microwave absorbent.

It is a major challenge to obtain broadband microwave absorption (MA) properties using low dielectric or magnetic nanoparticle-decorated carbon composites due to the limited single conductive loss or polarization loss of the carbon materials used as substrates. Novel pure cellulose-derived graphite carbon (CGC) materials can be used as an exceptional substrate option due to their special defective graphitic carbon structure, which provides both conduction and polarization loss. Herein, CGC@ZnO composites were first synthesized by atomic layer deposition (ALD) for use as microwave absorbents.

Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria.

The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration of alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone to resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Gram-positive bacteria.