Combined Blockade of Lipid Uptake and Synthesis by CD36 Inhibitor and SCD1 siRNA Is Beneficial for the Treatment of Refractory Prostate Cancer.

Drug resistance is an important factor for prostate cancer (PCa) to progress into refractory PCa, and abnormal lipid metabolism usually occurs in refractory PCa, which presents great challenges for PCa therapy. Here, a cluster of differentiation 36 (CD36) inhibitor sulfosuccinimidyl oleate sodium (CD36i) and stearoyl-CoA desaturase 1 (SCD1) siRNA (siSCD1) are selected to inhibit lipid uptake and synthesis in PCa, respectively. To this end, a multiresponsive drug delivery nanosystem, HA@CD36i-TR@siSCD1 is designed.

A Three-Dimensional, Flexible Conductive Network Based on an MXene/Rubber Composite for Lithium Metal Anodes.

Flexibility enhancement is a pressing issue in the current development of advanced lithium-metal battery applications. Many types of organic polymers are inherently flexible, which can form a composite structure enhancing electrode flexibility. However, organic polymers have a negative influence on the plating and stripping of lithium-metal anodes, and the large number of polymers block the pore of the material, reducing the utilization of the active site.

Transcriptome analysis reveals heat shock protein 70 (HSP70) induced by tembusu virus infection is associated with immune responses.

The outbreak and prevalence of tembusu virus (TMUV) endanger the breeding industry of waterfowls. However, little is known about the molecular mechanism underlying TMUV infection. It was reported that heat shock protein 70 (HSP70) was a positive regulator of the infection of TMUV.

Effects of air flow micro pulverized wheat bran dietary fiber on physicochemical, structural, and digestive properties of wheat starch.

The effects of wheat bran dietary fiber (WBDF) treated by air flow micro-pulverization on gelatinization, thermal, rheological, structural properties, and in vitro digestion of wheat starch (WS) were investigated. Different particle sizes of WBDF were obtained by conventional knife grinding and airflow micro-grinding. Compared with conventional knife grinding, the particle size of WBDF treated by air flow micro-pulverization decreased, the particle size distribution was concentrated at small particle sizes, the specific surface area increased, and the hydraulic and oil-holding power decreased, which was mainly related to the change of WBDF spatial structure and the increase of solubility.

TaqMan-based quantitative real-time polymerase chain reaction assay to detect porcine circovirus-like virus.

The aim of this study was to develop a rapid, sensitive and highly specific TaqMan quantitative real-time polymerase chain reaction PCR (qPCR) assay for porcine circovirus-like virus (PCLV). The primers and probe were designed based on the conserved regions of the PCLV ORF4 gene. The assay has a good detection performance (y=-3.

Tuning the Selectivity in the Nonoxidative Alkane Dehydrogenation Reaction by Potassium-Promoted Zeolite-Encapsulated Pt Catalysts.

The significance of the nonoxidative dehydrogenation of middle-chain alkanes into corresponding alkenes is increasing in the context of the world's declining demands on transportation fuels and the growing demand for chemicals and materials. The middle-chain alkenes derived from the dehydrogenation reaction can be transformed into value-added chemicals in downstream processes. Due to the presence of multiple potential reaction sites, the reaction mechanism of the dehydrogenation of middle-chain alkanes is more complicated than that in the dehydrogenation of light alkanes, and there are few prior studies on elucidating their detailed structure-reactivity relationship.

Lighting Up and Identifying Metal-Binding Proteins in Cells.

Metal ions, either essential or therapeutic, play critical roles in life processes or in the treatment of diseases. Proteins and enzymes are involved in metal homeostasis and the action of metallodrugs. Imaging and identifying these metal-binding proteins will facilitate the elucidation of metal-mediated life processes.

Sequential Pore Functionalization in MOFs for Enhanced Carbon Dioxide Capture.

The capture of carbon dioxide (CO) is crucial for reducing greenhouse emissions and achieving net-zero emission goals. Metal-organic frameworks (MOFs) present a promising solution for carbon capture due to their structural adaptability, tunability, porosity, and pore modification. In this research, we explored the use of a copper (Cu(II))-based MOF called .

Machine-Learning-Aided Engineering Hemoglobin as Carbene Transferase for Catalyzing Enantioselective Olefin Cyclopropanation.

In this study, we developed a machine-learning-aided protein design strategy for engineering hemoglobin (VHb) as carbene transferase. A Natural Language Processing (NLP) model was used for the first time to construct an algorithm (EESP, enzyme enantioselectivity score predictor) and predict the enantioselectivity of VHb. We identified critical amino acid residue sites by molecular docking and established a simplified mutation library by site-saturated mutagenesis.

Maternal Psychological Aggression, Problem Behaviors, and the Mediating Roles of Psychological Resilience and Self-Control in Preschoolers.

Objective: This study examines the relationship between maternal psychological aggression (PA) and preschoolers' problem behaviors (PB), focusing on the mediating roles of psychological resilience (PR) and self-control (SC), and gender differences.

Methods: Mothers of 1141 preschoolers (52.9% boys, 47.

Nonemissive Iridium(III) Solvent Complex as a Self-Reporting Photosensitizer for Monitoring Phototherapeutic Efficacy in a "Signal on" Mode.

Photodynamic therapy (PDT) has long been receiving increasing attention for the minimally invasive treatment of cancer. The performance of PDT depends on the photophysical and biological properties of photosensitizers (PSs). The always-on fluorescence signal of conventional PSs makes it difficult to real-time monitor phototherapeutic efficacy in the PDT process.

A Magnetic-Responsive Biomimetic Nanosystem Coated with Glioma Stem Cell Membranes Effectively Targets and Eliminates Malignant Gliomas.

Glioblastoma multiforme (GBM) is among the most challenging malignant brain tumors, making the development of new treatment strategies highly necessary. Glioma stem cells (GSCs) markedly contribute to drug resistance, radiation resistance, and tumor recurrence in GBM. The therapeutic potential of nanomaterials targeting GSCs in GBM urgently needs to be explored.

The effect of aging on the ciliary muscle and its potential relationship with presbyopia: a literature review.

Background: The ciliary muscle is known to play a part in presbyopia, but the mechanism has not received a comprehensive review, which this study aims to achieve. We examined relevant articles published from 1975 through 2022 that explored various properties of the muscle and related tissues in humans and rhesus monkeys. These properties include geometry, elasticity, rigidity, and composition, and were studied using a range of imaging technologies, computer models, and surgical methods.

Comparison of activated sludge and virus interactions in aerobic and anaerobic membrane bioreactors.

Membrane bioreactors (MBRs) are effective sewage treatment technologies, yet the differences in virus removal efficiency between aerobic (AeMBR) and anaerobic membrane bioreactors (AnMBR), remain inadequately understood. This study compared the virus removal efficiency of AeMBR and AnMBR, focusing on the interactions between aerobic (AeS) and anaerobic (AnS) activated sludge and viruses in the sewage treatment process. Results showed average log removal values (LRVs) for MS2 of 2.

Uncovering novel therapeutic clues for hypercoagulable active ulcerative colitis: novel findings from old data.

Background: Hypercoagulability has been shown to act as an important component of ulcerative colitis (UC) pathogenesis and disease activity, and is strongly correlated with the occurrence of venous thromboembolism (VTE). This study aimed at providing novel therapeutic clues for hypercoagulable active UC.

Methods: The coagulation score model was developed using VTE cohorts, and the predictive performance of this model was evaluated by coagulation subtypes of UC patients, which were clustered by the unsupervised method.

A Regiospecific Co-Assembly Method to Functionalize Ordered Mesoporous Metal Oxides with Customizable Noble Metal Nanocrystals.

An efficient regiospecific co-assembly (RSCA) strategy is developed for general synthesis of mesoporous metal oxides with pore walls precisely decorated by highly dispersed noble metal nanocrystals with customized parameters (diameter and composition). It features the rational utilization of the specific interactions between hydrophilic molecular precursors, hydrophobic noble metal nanocrystals, and amphiphilic block copolymers, to achieve regiospecific co-assembly as confirmed by molecular dynamics simulations. Through this RSCA strategy, we achieved a controllable synthesis of a variety of functional mesoporous metal oxide composites (e.

Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice.

Objectives: Deletion of gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells. Cisplatin, an antitumor drug, can cause various side effects, including ototoxicity. The aim of this study was to investigate the effects of on cisplatin-induced hearing impairment in mice and to explore the possible mechanism.

Preliminary study of the role of inner ear proteins in vestibular neuritis.

Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.

Methods: In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension.

Mechanically Stable and Damage Resistant Freestanding Ultrathin Silver Nanowire Films with Closely Packed Crossed-Lamellar Structure.

One-dimensional (1D) functional nanowires are widely used as nanoscale building blocks for assembling advanced nanodevices due to their unique functionalities. However, previous research has mainly focused on nanowire functionality, while neglecting the structural stability and damage resistance of nanowire assemblies, which are critical for the long-term operation of nanodevices. Biomaterials achieve excellent mechanical stability and damage resistance through sophisticated structural design.

The Effect of Thermal Cycle on Hot Cracking Evolution and Formation Mechanism in Thin Wall, Single Layer, and Cubic Samples of High-Strength Al-Cu-Mg-Mn Alloys Fabricated by Laser Powder Bed Fusion.

Thermal cracking is one of the serious issues that deteriorates the processibility of laser powder bed fusion (LPBF) high-strength aluminum components. To date, the effects of processing parameters on crack formation are still not well understood. The purpose of this study is to understand the correlation between the thermal cycle and the hot cracking during LPBF of Al-Cu-Mg-Mn alloys.

Corrigendum to 'Osteostaticytes: A novel osteoclast subset couples bone resorption and bone formation'[Journal of Orthopaedic Translation 47 (2024) 144-160].

[This corrects the article DOI: 10.1016/j.jot.

Synergy of Copper Doping and Carbon Defect Engineering in Promoting C-C Coupling for Enhanced CO Photoreduction to Ethanol Activity.

Photocatalytic conversion of carbon dioxide (CO) to fuel provides an ideal pathway to achieving carbon neutrality. One significant hindrance in achieving the reduction of CO to higher energy density multicarbon products (C) was the difficulty in coupling C-C bonds efficiently. Copper (Cu) is considered the most suitable metal catalyst for C-C coupling to form C products in the CO reduction reaction (CORR), but it encounters challenges such as low product selectivity and slow catalytic efficiency.

Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis.

Purpose: To clarify the prognostic role of pretreatment albumin-bilirubin (ALBI) grade in lung cancer patients.

Methods: The PubMed, EMBASE, Web of Science and CNKI databases were searched up to April 20, 2024. Primary outcomes included the overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS).

Retraction notice to "Investigation on the evolution of hydrothermal biochar"[Chemosphere 307 (2022) 135774].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).