Chromosome-level genome assembly and annotation of the gynogenetic large-scale loach (Paramisgurnus dabryanus).

The large-scale loach (Paramisgurnus dabryanus; Cypriniformes: Cobitidae) is primarily distributed in East Asia. It is an important economic fish species characterized by fast growth, temperature-dependent sex determination and the ability to breathe air. Currently, molecular mechanism studies related to some aspects such as sex determination, toxicology, feed nutrition, growth and genetic evolution have been conducted.

Modulation of Co spin state at CoO crystalline-amorphous interfaces for CO oxidation and NO decomposition.

Modulation of electronic spin states in cobalt-based catalysts is an effective strategy for molecule activations. Crystalline-amorphous interfaces often exhibit unique catalytic properties due to disruptions of long-range order and alterations in electronic structure. However, the mechanisms of molecule activation and spin states at interfaces remain elusive.

Solid waste management and resource recovery during the 4-crew 180-day CELSS integrated experiment.

In order to explore the management and treatment methods of solid waste in the Controlled Ecological Life Support System (CELSS) of future lunar bases, during the 4-crew 180-day integrated experiment, the Solid Waste Management and Treatment System (SWMTS) was built, in which the treatment of recyclable solid waste such as inedible plant parts and human excrement was completed through a combination of biological aerobic composting and high-temperature oxidation. Basic data on the types and amounts of solid waste generated during the 4-crew 180-day experiment mission were obtained. There were six types of solid wastes, including the work support wastes, the household support wastes, the plant cultivation wastes, the plant-based wastes, and crew feces.

Moxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity.

Background: Currently, there is limited research on the impact of abdominal infection on intestinal damage under microgravity conditions. Cordyceps polysaccharide (CPS), the main active ingredient of Cordyceps, has demonstrated various pharmacological effects, including anti-inflammatory, antioxidant, and immunomodulatory properties. Moxifloxacin (MXF) is a fourth-generation quinolone antibiotic that is believed to have a dual regulatory effect on immune system activation and suppression.

Space biological and human survival: Investigations into plants, animals, microorganisms and their components and bioregenerative life support systems.

Space life science has been a frontier discipline in the life sciences, aiming to study the life phenomena of earth organisms and their activity patterns under the special environment of space. This review summarizes studies in various key topics in space life science, namely, how microbiome changes in humans and plants, the development of space agriculture and the use of animal, plant and cell models to study the effect of space environments on physiology. We highlight the new possibilities of using high-quality protein crystals uniquely available when grown under space conditions to aid drug development on earth, and the state-of-the-art Bioregenerative Life Support Systems (BLSS) to achieve long term human survival in space.

Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans.

The space environment presents unique stressors, such as microgravity and space radiation, which can induce molecular and physiological changes in living organisms. To identify key reproducible transcriptomic features and explore potential biological roles in space-flown C. elegans, we integrated transcriptomic data from C.

Analysis of MRI-based vertebral bone quality (VBQ) scores in patients with degenerative lumbar scoliosis.

Introduction: Degenerative lumbar scoliosis (DLS) often causes various issues such as neural symptoms and osteoporosis (OP). Vertebral bone quality (VBQ) is a crucial factor that surgeons take into consider prior to surgery. However, little attention has been given to the use of VBQ in evaluating vertebral bone mass in DLS patients.

Clinical Features Evaluation of Myopic Fundus tessellation from OCTA and MfERG.

Purpose: To evaluate the differences in fundus tessellation among various severities using multifocal visual electrophysiology (MfERG) and optical coherence tomography angiography (OCTA) for clinical grading and treatment.

Methods: This study included 52 patients totaling 87 eyes. The Early Treatment Diabetic Retinopathy Study (ETDRS) grid division method was utilized to assess Grade of fundus tessellation.

Isolation, identification, and pathogenicity of a goose astrovirus 1 strain from goslings in Jiangsu province, China.

Goose astrovirus (GAstV) poses a large threat to the goose industry in China, with two genotypes: goose astrovirus genotype 1 (GAstV-1) and GAstV-2. GAstV-2 causes gout in goslings; however, understanding of GAstV-1 is limited. In this study, the GAstV-1 strain JY202323, was isolated from dead goslings, and its complete genome sequence was obtained using next-generation sequencing.

Protective effect of curcumin-loaded zeolitic imidazolate framework-8-based pH-responsive drug delivery system against Staphylococcus aureus infection.

Mastitis, generally caused by pathogenic microorganisms, is a serious disease in dairy farming. Staphylococcus aureus (S. aureus) is one of the main pathogens that induces mastitis in dairy cows.

Efficient Spermidine Production Using a Multi-Enzyme Cascade System Utilizing Methionine Adenosyltransferase from Lactobacillus fermentum with Reduced Product Inhibition and Acidic pH Preference.

Methionine adenosyltransferases (MATs; EC 2.5.1.

Association of pentachlorophenol in urine and follicular fluid with ovarian reserve and reproductive outcomes among women undergoing in vitro fertilization based on a prospective cohort study.

Pentachlorophenol (PCP), a persistent organic pollutant, has endocrine disrupting properties and there may be a link between its exposure and reproductive outcomes. In this study, we assessed the relationship of PCP exposure levels with ovarian reserve markers and reproductive health outcomes in women (N = 656) undergoing in vitro fertilization (IVF). PCP concentrations were determined in urine (n = 1,968; repeated measures) and follicular fluid samples (n = 603).

Combating Antibiotic Resistance in Persulfate-Based Advanced Oxidation Processes: Activation Methods and Energy Consumption.

Antibiotic resistant bacteria (ARB) and antibiotic resistant genes (ARGs) have become increasing concerning issues, threatening human health. Persulfate-based advanced oxidation processes (PS-AOPs), due to their remarkable potential in combating antibiotic resistance, have garnered significant attention in the field of disinfection in recent years. In this review, we systematically evaluated the efficacy and underlying mechanism of PS integration with various activation methods for the elimination of ARB/ARGs.

Bio-inspired mineralized collagen scaffolds with precisely controlled gradients for the treatment of severe osteoarthritis in a male rabbit model.

Osteoarthritis affects approximately 500 million individuals globally, with severe cases often leading to osteochondral defects. Biomimetic collagen-hydroxyapatite scaffolds have been investigated for the treatment of osteochondral defects. However, achieving precise mimicry of the intricate composition, gradient nanostructure, and biological function of native tissue remains a formidable challenge.

Urchin-like magnetic nanoparticles loaded with type X collagen siRNA and Stattic to treat triple negative breast cancer under rotating magnetic field like an "enchanted micro-scalpel".

Magnetic nanoparticles effectively target drug delivery, contrast agents, biosensors, and more. Urchin-like magnetic nanoparticles (UMN) with abundant spike-like structures exhibit superior magneto-mechanical force to destroy tumor cells compared with other shapes of magnetic nanoparticles. However, when cell contents are released from tumor cells induced by magneto-mechanical force, they can act on surrounding tumor cells to facilitate tumor development.

Certain soil fungi impact the biosynthesis of amylose in maize when manure is used instead of chemical fertilizer at equal levels of nitrogen.

The protracted and immoderate utilization of chemical fertilizers has been detrimental to the composition of fungi in the soil and quality of crops. To ameliorate the adverse effects, a 6-year positioning experiment was undertaken to investigate the impact of substituting 0 % (CF), 25 % (M25), 50 % (M50), 75 % (M75), and 100 % (M100) of 225 kg ha chemical fertilizer nitrogen with manure nitrogen on both soil fungi and maize quality. This study showed that the expansion of Aspergillus heterocaryoticus, Xerochrysium dermatitidis, and Aspergillus penicillioides contributed to heightened levels of amylose and soluble sugars.

Impact of prolonged versus intermittent infusion of meropenem on mortality and clinical outcomes in patients with severe infection: A systematic review and meta-analysis.

Objectives: To compare the clinical outcomes of patients with severe infection treated with prolonged or intermittent infusion of meropenem.

Methods: PubMed, Embase, and Cochrane Central databases were searched until July 2023. Randomized controlled trials (RCTs) or observational studies comparing prolonged versus intermittent infusion of meropenem were considered eligible.

Insights into the role of dissolved organic matter derived from paddy soils with different parent materials in the environmental behavior of heavy metal adsorbed by ferrihydrite.

The interaction between dissolved organic matter (DOM) and ferrihydrite (Fh) is a crucial process to control the environmental behavior of heavy metals (HMs) in soil environments, with DOM playing a particularly strong role in HMs fate. Since chemical properties of DOM vary based on different soil parent materials, the underlying impact of DOM-Fh associations on HMs binding remains unclear. This study systematically investigated the interactions between DOM from three soil parent materials (fluvial alluvium: FDOM, sand-shale: SDOM and granite: GDOM) and Fh, and meanwhile understand their effects on the environmental behavior of Cd and Pb under various environmental conditions.

Iron oleate containing lipid nanoparticles prepared by gradient solvent diffusion method for oxidative stress dependent antibacterial therapy.

This study was designed to assess the efficacy of iron oleate lipid nanoparticles (IO-LNPs) in inducing Fenton reaction as a therapeutic approach for bacterial infections caused by Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), both of which are common pathogens in skin wound infections.

A New target of ischemic ventricular arrhythmias-ITFG2.

ITFG2 is an intracellular protein known to modulate the immune response of T-cells. Our previous investigation revealed that ITFG2 specifically targets ATP5b to regulate ATP energy metabolism and maintain mitochondrial function, thereby protecting the heart from ischemic injury. However, the role of ITFG2 in ischemic ventricular arrhythmias and its underlying mechanisms have not been previously reported.

Novel tertiary diarylethylamines as functionally selective agonists of the kappa opioid receptor.

Novel kappa opioid receptor (KOR) agonists that preferentially activate G-protein signaling versus β-arrestin-2 recruitment are described. Starting from a literature-reported phenol-containing diphenethylamine KOR agonist, structure-activity relationship (SAR) studies revealed replacement of the phenol with various non-hydroxylated bicyclic heteroaromatics led to tertiary diarylethylamines which retained KOR agonist activity and improved metabolic stability in human liver microsomes. Further optimizations produced compound 39, a potent activator of G-protein signaling (GTPγS EC = 14 nM, 83 % E) that did not elicit a β-arrestin-2 recruitment functional response (E < 10 %).

Electrocatalytic synergy from Ni-enhanced WS for alkaline overall water splitting with tuning electronic structure and crystal phase transformation.

Due to the limited active sites and poor conductivity, the application of tungsten disulfide (WS) in alkaline water electrolysis remains a challenge. Herein, Ni-WS nanosheet arrays were in situ grown on the carbon fiber paper (Ni-WS/CFP) as an electrocatalyst for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in alkaline media, and the introduction degree of Ni can be regulated by adjusting the electrodeposition time. When the electrodeposition time is 3 min, Ni ions are doped into the lattice of WS, and by prolonging the electrodeposition time to 10 min, the nickel disulfide (NiS) crystal phase is generated to form NiS@WS heterojunction.

Efficient luminescent solar concentrators based on solvent polarity induced multiple-colored carbon dots.

Luminescent solar concentrators (LSCs) are large scale sunlight collector and can be used for building-integrated photovoltaics (BIPV). Achieving high-performance LSCs requires fluorophores with broad absorption, high quantum yield and a large Stokes shift. Nevertheless, conventional high-efficiency LSCs typically rely on heavy metal-based quantum dots as fluorophores.

CD47 is a tumor cell-derived exosomal signature and regulates tumor immune microenvironment and immunotherapy responses.

Background: The pathogenesis of ovarian cancer (OvCa) involves a complex interplay of genetic, environmental, and hormonal factors. With the in-depth exploration of tumor ecosystem, exosomes can mediate the immunological status of tumor microenvironment (TME). Therefore, we aimed to recognize the tumor-derived exosomes (TEXs) which can distinguish the immune-hot and cold tumors and reflect the immunotherapeutic responses.

Utilizing ultrasound for the extraction of polysaccharides from the tuber of Typhonium giganteum Engl.: Extraction conditions, structural characterization and bioactivities.

Polysaccharides from the dried tuber of Typhonium giganteum Engl. (TGEPs) were obtained by utilizing ultrasonic-assisted extraction (UAE) as the extraction method. The determination of optimal process parameters for the UAE of TGEPs (TGEP-U) was accomplished through the application of response surface methodology (RSM).