An ultra-high absorptivity solar absorber with excellent thermal radiation efficiency based on a metal-dielectric stacked structure.

Metamaterials hold great promise for application in the field of perfect absorbers due to their remarkable ability to manipulate electromagnetic waves. In this work, a full-spectrum ultra-wideband solar absorber with a multilayer metal-dielectric stacked structure is designed. Our absorber is simple and easy to manufacture, with Ti serving as the substrate, overlaid with SiN spacer layers and four pairs of Ti-SiN ring columns.

Top-Down Strategy Enabling Elastic Wood Nanocarbon Sponges with Wrinkled Multilayer Structure and High Compressive Strength for High-Performance Compressible Supercapacitors.

3D porous carbon electrodes have attracted significant attention for advancing compressible supercapacitors (SCs) in flexible electronics. The micro- and nanoscale architecture critically influences the mechanical and electrochemical performance of these electrodes. However, achieving a balance between high compressive strength, electrochemical stability, and cost-effective sustainable production remains challenging.

Oxygen Evolution Reaction of Amorphous/Crystalline Composites of NiFe(OH)/NiFeO.

Orbital structures are strongly correlated with catalytic performance, whereas their regulation strategy is still in pursuit. Herein, the Fe 3 and O 2 orbital hybridization was optimized by controlling the content of amorphous NiFe(OH) (a-NiFe(OH)), which was grown in situ on crystalline NiFeO (c-NiFeO) using an ultrasonic reduction method. The results of electron energy loss spectroscopy (EELS) and X-ray absorption spectra (XAS) revealed that the Fe-O orbital hybridization in a-NiFe(OH) is effectively strengthened by jointing with the adjacent oxygen (O) in c-NiFeO, which is further confirmed by the higher antibonding orbital energies based on density functional theory (DFT) calculations.

Chiral Locomotion Transitions of an Active Gel and Their Chemomechanical Origin.

Transitions between chiral rotational locomotion modes occur in a variety of active individuals and populations, such as sidewinders, self-propelled chiral droplets, and dense bacterial suspensions. Despite recent progress in the study of active matter, general principles governing rotational chiral transition remain elusive. Here, we study, experimentally and theoretically, rotational locomotion and its chiral transition in a 2D polyacrylamide (PAAm)-based BZ gel driven by Belousov-Zhabotinsky reaction-diffusion waves.

Facile Access to Highly Efficient 3D Printing Using Robust Self-Healing CDs/Polymer Hybrids.

3D printing efficiency, as a key indicator of additive manufacturing technology, directly affects its competitiveness in rapid prototyping, small batch production, and even large-scale industrial applications. Compared with traditional manufacturing methods, the high efficiency of 3D printing is often considered a bottleneck, hindering its application across various fields. Herein, a versatile and efficient strategy is proposed, namely, the dimensional reduction printing (DRP) process, to break the obstacle of high efficiency of 3D printing.

Tandem construction of flavone-bridged conjugated porous polymers for photosynthesis of 2,3-dihydrobenzofurans.

Conjugated porous polymers bearing flavone moieties (FL-CPPs) were synthesized a tandem approach. The carbonylative Sonogashira coupling in tandem with cyclization guided the assembling of building blocks with the accompanied production of flavone skeletons. The FL-CPPs were proved to be efficient metal-free photocatalysts for the [3+2] cycloaddition of phenols with olefins under the irradiation of visible-light.

Dynamic regulation of ferroelectric polarization using external stimuli for efficient water splitting and beyond.

Establishing and regulating the ferroelectric polarization in ferroelectric nano-scale catalysts has been recognized as an emerging strategy to advance water splitting reactions, with the merits of improved surface charge density, high charge transfer rate, increased electronic conductivity, the creation of real active sites, and optimizing the chemisorption energy. As a result, engineering and tailoring the ferroelectric polarization induced internal electric field provides significant opportunities to improve the surface and electronic characteristics of catalysts, thereby enhancing the water splitting reaction kinetics. In this review, an interdisciplinary and comprehensive summary of recent advancements in the construction, characterization, engineering and regulation of the polarization in ferroelectric-based catalysts for water splitting is provided, by exploiting a variety of external stimuli.

Enantioselective Catalytic Synthesis of Inherently Chiral Calixarenes.

Since the introduction of the concept of inherent chirality by Böhmer, an important part of research focused on the asymmetric synthesis of calixarene macrocycles. However, long synthetic procedures and tedious separation strategies hampered the application of this technology in many topics of organic chemistry, including enantioselective molecular recognition and catalysis. Very recently, a new generation of enantioselective catalytic methodologies has been reported, able to provide highly functionalized, inherently chiral calixarenes in a straightforward manner.

Advances in adhesion of microneedles for bioengineering.

Microneedles have provided promising platforms in various fields thanks to their safety, painlessness, minimal invasiveness and ease of operation. The excellent adhesion of microneedles is the key characteristic to achieve long-term and comfortable treatment. However, a complex environment, such as the roughness of skin, various bodily fluids , and the movement of the body, presents great challenges to the adhesion characteristics of microneedles.

A biomass-derived multifunctional conductive coating with outstanding electromagnetic shielding and photothermal conversion properties for integrated wearable intelligent textiles and skin bioelectronics.

Intelligent electronic textiles have important application value in the field of wearable electronics due to their unique structure, flexibility, and breathability. However, the currently reported electronic textiles are still challenged by issues such as their biocompatibility, photothermal conversion, and electromagnetic wave contamination. Herein, a multifunctional biomass-based conductive coating was developed using natural carboxymethyl starch (CMS), dopamine and polypyrrole (PPy) and then further employed for constructing multifunctional intelligent electronic textiles.

Advancements in 2D Titanium Carbide (MXene) for Electromagnetic Wave Absorption: Mechanisms, Methods, Enhancements, and Applications.

With the advent of the 5G era, there has been a marked increase in research interest concerning electromagnetic wave-absorbing materials. A critical challenge remains in improving the wave-absorbing properties of these materials while satisfying diverse application demands. MXenes, identified as prominent "emerging" 2D materials for wave absorption, offer unique advantages that are expected to drive advancements and innovations in this field.

ZNF169 promotes thyroid cancer progression via upregulating FBXW10.

Background: Zinc finger protein 169 (ZNF169) plays a key role in cancer development. However, the specific role of ZNF169 in the tumorigenesis of thyroid carcinoma (THCA) remains poorly understood.

Methods: The expression of ZNF169 was measured using immunohistochemistry, RT-qPCR, and western blot.

Alzheimer's disease: an integrative bioinformatics and machine learning analysis reveals glutamine metabolism-associated gene biomarkers.

Background: Alzheimer's disease (AD), a hallmark of age-related cognitive decline, is defined by its unique neuropathology. Metabolic dysregulation, particularly involving glutamine (Gln) metabolism, has emerged as a critical but underexplored aspect of AD pathophysiology, representing a significant gap in our current understanding of the disease.

Methods: To investigate the involvement of GlnMgs in AD, we conducted a comprehensive bioinformatic analysis.

Investigating the role of intratumoral Streptococcus mitis in gastric cancer progression: insights into tumor microenvironment.

Growing evidence implicates that intratumoral microbiota are closely linked to cancer progression; however, research on the role of these microbiota in the development of gastric cancer remains limited. Here, using 16 S rRNA sequencing, tumor tissue proteomics and serum cytokines analysis, we identified enrichment of specific microbial communities within tumors of gastric cancer patients, possibly affecting the tumor microenvironment by immune modulation, metabolic processes, and inflammatory responses. Based on the results of in vivo experiments and intratumoral microbiota analysis, we found that Streptococcus mitis can inhibit gastric cancer progression via suppressing M2 macrophage polarization and infiltration, as well as altering the intratumoral microbial community.

Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer.

Background: DNA hypomethylation and uracil misincorporation into DNA, both of which have a very important correlation with colorectal carcinogenesis. Folate plays a crucial role in DNA synthesis, acting as a coenzyme in one-carbon metabolism, which involves the synthesis of purines, pyrimidines, and methyl groups. MTHFR, a key enzyme in folate metabolism, has been widely studied in relation to neural tube defects and hypertension, but its role in colorectal cancer remains underexplored.

Research Progress in the Molecular Mechanism of NLRP3 Inflammasome in Alzheimer's Disease and Regulation by Natural Plant Products.

Alzheimer's disease (AD) is a prominent neurodegenerative disorder affecting the central nervous system in the elderly. Current understanding of AD primarily centers on the gradual decline in cognitive and memory functions, believed to be influenced by factors including mitochondrial dysfunction, β-amyloid aggregation, and neuroinflammation. Emerging research indicates that neuroinflammation plays a significant role in the development of AD, with the inflammasome potentially mediating inflammatory responses that contribute to neurodegeneration.

The Efficacy and Safety of Durvalumab and Tremelimumab with Concomitant Treatment for MSS/pMMR Metastatic Colorectal Cancer: A Single Arm Meta-Analysis.

Objectives: To address the issue that most microsatellite-stable (MSS) and proficient mismatch repair (pMMR) metastatic colorectal cancer (mCRC) patients have minimal response to immunotherapy, this meta-analysis evaluated the efficacy and safety of durvalumab and tremelimumab with concomitant treatment in treating MSS/pMMR metastatic colorectal cancer.

Methods: All included trials were prospective studies with a median patient age of 63 years, of which 94.2% were MSS/pMMR mCRC patients, with a male to female ratio of 1.

End-to-End Deep Learning Prediction of Neoadjuvant Chemotherapy Response in Osteosarcoma Patients Using Routine MRI.

This study aims to develop an end-to-end deep learning (DL) model to predict neoadjuvant chemotherapy (NACT) response in osteosarcoma (OS) patients using routine magnetic resonance imaging (MRI). We retrospectively analyzed data from 112 patients with histologically confirmed OS who underwent NACT prior to surgery. Multi-sequence MRI data (including T2-weighted and contrast-enhanced T1-weighted images) and physician annotations were utilized to construct an end-to-end DL model.

Structural basis for human NKCC1 inhibition by loop diuretic drugs.

Na-K-Cl cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are first-line medicines for the treatment of edema and hypertension. NKCC1 activation by the molecular crowding sensing WNK kinases is critical if cells are to combat shrinkage during hypertonic stress; however, how phosphorylation accelerates NKCC1 ion transport remains unclear.

Ubiquitin-specific protease 7 exacerbates acute pancreatitis progression by enhancing ATF4-mediated autophagy.

Acute pancreatitis (AP) is a serious inflammatory disease with high incidence rate and mortality. It was confirmed that overactivation of autophagy in acinar cells can increase the risk of AP. Nevertheless, the regulatory mechanism of autophagy in AP is unclear.

Prediction model and real-time diagnostics of hydraulic fracturing pressure for highly deviated wells in deep oil and gas reservoirs.

It is a common occurrence in the fracture processes of deep carbonate reservoirs that the fracturing construction pressure during hydraulic fracturing operation exceeds 80 MPa. The maximum pumping pressure is determined by the rated pressure of the pumping pipe equipment and the reservoir characteristics, which confine the fracture to the target area. When the pump pressure exceeds the safety limit, hydraulic fracturing has to reduce the construction displacement to prevent potential accidents caused by overpressure.

A practical methodology for incorporating volume-translated equation of states in isochoric-isothermal phase equilibrium calculations for liquid phase pressure prediction.

Accurately predicting the phase behavior and properties of reservoir fluid plays an essential role in the simulation of petroleum recovery processes. Similar to the inaccurate liquid-density prediction issue in the isobaric-isothermal (PT) phase equilibrium calculations, an inaccurate pressure prediction issue can also be observed in isothermal-isochoric (VT) phase equilibrium calculations which involves a liquid phase. In this work, a practical methodology is proposed to incorporate a volume-translated equation of state in VT phase equilibrium calculations for more accurate pressure predictions.

A copy number variation detection method based on OCSVM algorithm using multi strategies integration.

Copy number variation (CNV) is an important part of human genetic variations, which is associated with various kinds of diseases. To tackle the limitations of traditional CNV detection methods, such as restricted detection types, high error rates, and challenges in precisely identifying the location of variant breakpoints, a new method called MSCNV (copy number variations detection method for multi-strategies integration based on a one-class support vector machine model) is proposed. MSCNV establishes a multi-signal channel that integrates three strategies: read depth, split read, and read pair.

Impacts of climate change on the suitable habitat of Angelica sinensis and analysis of its drivers in China.

Climate change is shifting optimal habitats for medicinal plants, potentially compromising the efficacy and therapeutic value of herbal remedies. Global warming and increased extreme weather events threaten the sustainability and pharmaceutical integrity of Angelica sinensis (Oliv.) Diels (A.

Enhanced phosphorus weathering contributed to Late Miocene cooling.

Late Miocene climate evolution provides an opportunity to assess Earth's climate sensitivity to carbon cycle perturbation under warmer-than-modern conditions. Despite its relevance for understanding the climate system, the driving mechanisms underlying profound climate and carbon cycle changes - including the enigmatic Late Miocene cooling from 7 to 5.4 million years ago - remain unclear.