Construction of N-E bonds via Lewis acid-promoted functionalization of chromium-dinitrogen complexes.

Direct conversion of dinitrogen (N) into N-containing compounds beyond ammonia under ambient conditions remains a longstanding challenge. Herein, we present a Lewis acid-promoted strategy for diverse nitrogen-element bonds formation from N using chromium dinitrogen complex [Cp*(IPrMe)Cr(N)]K (1). With the help of Lewis acids AlMe and BF, we successfully trap a series of fleeting diazenido intermediates and synthesize value-added compounds containing N-B, N-Ge, and N-P bonds with 3 d metals, offering a method for isolating unstable intermediates.

Effect of free gingival graft dimension on postsurgical shrinkage in posterior implant placement: A prospective parallel cohort study.

Statement Of Problem: The impact of free gingival graft (FGG) dimensions on the postsurgical shrinkage of keratinized tissue width (KTW) and surface area in posterior implant sites is unclear. Standardized assessments of how graft dimensions influence KTW and surface area shrinkage rates over a 6-month period after FGG are lacking.

Purpose: The purpose of this prospective parallel cohort study was to examine the impact of the graft dimensions on the postsurgical shrinkage of KTW and surface area over a 6-month follow-up period after FGG in the posterior regions.

Effects of rapid infrared radiation heating on the warping deformation and mechanical properties of selective laser melted Co-Cr dental alloy.

Statement Of Problem: Infrared radiation heating (IRH) technology has been innovatively applied to the annealing of selective laser melted (SLM) cobalt chromium (Co-Cr) frameworks. However, previous studies have not reported the effects of IRH on the warping deformation and mechanical properties of these frameworks.

Purpose: The purpose of this in vitro study was to investigate the effects of IRH on the warping deformation and mechanical properties of dental SLM Co-Cr alloy and to evaluate its potential applications in dental restorations.

Associations of glycemic status with dynamic disease trajectories of atrial fibrillation and dementia.

Background: Atrial fibrillation (AF) has been associated with elevated dementia risk, while few studies have examined the role of the optimal glycemic status in disease trajectories of AF and dementia.

Objectives: We aim to evaluate associations between glycemic status with disease trajectories of AF and dementia, as well as major dementia subtypes, including Alzheimer's disease and vascular dementia.

Design: Population-based cohort study.

Enhanced Prediction of CO-Brine Interfacial Tension at Varying Temperature Using a Multibranch-Structure-Based Neural Network Approach.

Interfacial tension () between CO and brine depends on chemical components in multiphase systems, intricately evolving with a change in temperature. In this study, we developed a convolutional neural network with a multibranch structure (MBCNN), which, in combination with a compiled data set containing measurement data of 1716 samples from 13 available literature sources at wide temperature and pressure ranges (273.15-473.

DNA origami-based composite nanosandwich for iteratively potentiated chemo-immunotherapy.

Developing effective nanoplatforms for chemo-immunotherapy to achieve enhanced tumor suppression and systemic antitumor immunity has recently received extensive attention. Herein, we formulated a multifunctional DNA sandwich nanodevice, DSWAC/siPD-L1, based on triangular DNA origami, to implement enhanced cancer chemo-immunotherapy. Taking advantage of the tumor-targeting ability of the AS1411 aptamer, DSWAC/siPD-L1 efficiently delivered doxorubicin (DOX), CpG, and siPD-L1 into tumor cells.

Static and dynamic connectivity structure of white-matter functional networks across the adult lifespan.

Aging of the human brain involves intricate biological processes, resulting in complex changes in structure and function. While the effects of aging on gray matter (GM) connectivity are extensively studied, white matter (WM) functional changes have received comparatively less attention. This study examines age-related WM functional dynamics using resting-state fMRI across the adult lifespan.

A low chemical consumption cationization and salt-free dyeing process for cotton fabrics by reusing polyallylamine modification bath.

Cationic polymers have been used in the cationization of cotton fabrics for salt-free dyeing, but commonly used polymers are limited by their high molecular weight and low adsorption efficiency, leading to high dosage or complex modification conditions. In this study, polyallylamine with low molecular weight was found to be an efficient cationic agent for cotton modification and the modified fabrics can be salt-free dyed with different kinds of reactive dyes after the optimization of the modification process. Furthermore, the modification bath was reused by replenishing a small amount of cationic agent and adjusting the pH to the original level.

Exosome-carried miR-1248 from adipose-derived stem cells improves angiogenesis in diabetes-associated wounds.

Chronic non-healing wounds are a common complication of diabetes, marked by impaired angiogenesis. This study explores how exosomes (Exo-miR-1248) from miR-1248-overexpressing adipose-derived stem cells enhance diabetic wound healing by modulating endothelial cell function. Adipose-derived stem cells were transfected with a lentivirus carrying miR-1248 to produce Exo-miR-1248, isolated via differential centrifugation.

Role of silane compatibilization on cellulose nanofiber reinforced poly (lactic acid) (PLA) composites with superior mechanical properties, thermal stability, and tunable degradation rates.

Poly (lactic acid) (PLA) is a widely produced bio-based polymer known for its biodegradability and renewability, but its brittleness, low heat resistance, and weak mechanical properties limit its broader use. To address these challenges, TEMPO-oxidized cellulose nanofibers (TOCNF) were extracted from dissolving pulp using TEMPO oxidation and high-pressure homogenization. These TOCNF were modified with silane to reduce hydrophilicity and improve compatibility with PLA.

Construction of isopentenol utilization pathway and artificial multifunctional enzyme for miltiradiene synthesis in Saccharomyces cerevisiae.

Miltiradiene serves as a pivotal precursor for the synthesis of numerous abietane-type diterpenes with important pharmacological activities. The endogenous mevalonate (MVA) pathway is tightly regulated in Saccharomyces cerevisiae, which limits the availability of precursors for the heterologous production of miltiradiene. In this study, the orthogonal isopentenol utilization pathway (IUP) was constructed and investigated for its adaptability with mitochondria and peroxisomes in S.

Apoptosis in polycystic ovary syndrome: Mechanisms and therapeutic implications.

Polycystic ovary syndrome (PCOS) is a common disorder that affects the female reproductive system, with an incidence of 8 % to 15 %. It is characterized by irregular menstruation, hyperandrogenemia, and polycystic abnormalities in the ovaries. Nevertheless, there is still much to learn about the molecular pathways underlying PCOS.

Study on the detoxification and toxic effects of clam Ruditapes philippinarum exposed to 2,6-ditert-butyl-4-methylphenol (BHT): oxidative stress, neurotoxicity, respiratory toxicity, and immunotoxicity.

The bioaccumulation and toxic effects of synthetic phenolic antioxidants (SPAs) in aquatic ecosystems are of growing concern due to their widespread use and potential environmental persistence. This study investigated the detoxification and toxicological impacts of 2,6-ditert-butyl-4-methylphenol (BHT), a representative SPAs, on clams Ruditapes philippinarum using environmentally relevant exposure concentrations. BHT bioaccumulation was observed in both gills and digestive glands, with higher levels in the latter.

Structural analyses of Cryptosporidium parvum epitopes reveal a novel scheme of decapeptide binding to H-2K.

Cryptosporidium has gained much attention as a major cause of diarrhea worldwide. Here, we present the first structure of H-2K complexed with a decapeptide from Cryptosporidium parvum Gp40/15 protein (Gp40/15-VTF10). In contrast to all published structures, the aromatic residue P3-Phe of Gp40/15-VTF10 is anchored in pocket C rather than the canonical Y/F at P5 or P6 reported for octapeptides and nonapeptides.

Prognostic stratification of gastric cancer patients by intratumoral microbiota-mediated tumor immune microenvironment.

Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced GC are limited. Here, we observe that intratumoral microbiota controls chemokine expression, which in turn recruits immune cells into the tumor, and that immune infiltration is strongly associated with patient survival and disease attributes. Furthermore, microbiota regulation of chemokines is differentiated in GC patients with different survival risks.

Bisphenol A Exacerbates Colorectal Cancer Progression through Enhancing Ceramide Synthesis.

Bisphenol A (BPA) is a typical environmental endocrine disruptor which have been broadly confirmed to be associated with malignant tumors, including colorectal cancer (CRC). Lipid metabolism reprogramming performed important biological effects in cancer progression. While the role of lipid metabolism in CRC progression upon BPA exposure remain elusive.

Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.

Itaconate is a metabolite catalyzed by cis-aconitate decarboxylase (ACOD1), which is mainly produced by activated macrophages and secreted into the extracellular environment to exert complex bioactivity. In the tumor microenvironment, itaconate is concentrated and induces an immunosuppressive response. However, whether itaconate can be taken up by tumor cells and its mechanism of action remain largely unclear.

Inactivation of β-coronavirus MHV-A59 by 2.8 GHz microwave.

From the severe acute respiratory syndrome coronavirus in 2003 to the severe acute respiratory syndrome coronavirus 2 in 2019, coronavirus has seriously threatened human health. Electromagnetic waves not only own high penetration and low pollution but also can physically resonate with the virus. Several studies have demonstrated that electromagnetic waves can inactivate viruses efficiently.

Gut microbiota and short-chain fatty acids signatures in postmenopausal osteoporosis patients: A retrospective study.

Studies have shown that gut microbiota (GM) and its metabolites, short-chain fatty acids (SCFAs), are associated with the development of postmenopausal osteoporosis (PMO). This study explored the clinical and laboratory evidence of the relationship of GM and SCFAs to PMO and attempted to determine the potential mechanism of action. 18 patients (Collected from the First Affiliated Hospital of Guangdong Pharmaceutical University between January 2021 and August 2021) were included in this retrospective study, including 10 PMO women and 8 healthy young women as the healthy control (HC) group from Guangzhou, China.

The impact of exercise during radiotherapy on treatment-related side effects in breast cancer patients: A systematic review and meta-analysis.

Purpose: Radiation therapy for breast cancer often causes side effects like cancer-related fatigue, depression, and sleep disorders, impacting health-related quality of life, psychosocial aspects, and physical function. Exercise therapy is commonly used to manage cancer-related fatigue, but its effectiveness remains uncertain due to varying patient conditions and adherence. This systematic review aims to assess exercise interventions during radiotherapy for their effects on physiological and psychological side effects in breast cancer patients, clarifying efficacy and exploring different intervention types.

The mechanism of Se in regulating the proliferation and apoptosis of sheep Leydig cells through the miR-200a/NRF2 pathway.

This study aimed to investigate the mechanism by which Se in regulates the proliferation and apoptosis of sheep Leydig cells via the miR-200a/NRF pathway. The cells were isolated and purified from the testes of 8-month-old sheep via a Percoll density gradient. After the cells were treated with different concentrations of Se (0, 2.

A self-aggregated thermally activated delayed fluorescence nanoprobe for HClO imaging and activatable photodynamic therapy.

Hypochlorous acid (HClO/ClO) is a common ROS that exhibits elevated activity levels in cancer cells. In this study, an ClO-triggered TADF probe, PTZ-MNI, was designed based on a naphthalimide core. PTZ-MNI self-assemble in aqueous environments, exhibiting significantly enhanced fluorescence that demonstrated typical aggregation-induced delayed fluorescence (AIDF) characteristics.

Oxygen vacancy and interface effect dual modulation of SnS/SnO heterojunction for boosting formaldehyde detection at low temperature.

Formaldehyde (HCHO) is a harmful volatile organic pollutant, which is commonly found in interior decoration and furniture products. Therefore, it is necessary to develop a gas sensor that can quickly and accurately detect formaldehyde for human health and environmental protection. In order to achieve this goal, in this work, SnS/SnO heterostructure was synthesized by in-situ sulfurization process on the basis of SnO nanospheres, and its formaldehyde sensing performance was studied.