Layer-by-layer coated probiotics with tannic acid-Ca and casein phosphopeptide complexes for caries prevention and enamel remineralization.

Dental caries is a common disease resulting from tooth demineralization caused by bacterial plaque. Probiotics have shown great potential against caries by regulating the balance of oral flora. However, obstacles such as poor colonization and lysozyme sensitivity in oral cavity hinder their further application.

Computer-aided robotics for applications in fracture reduction surgery: Advances, challenges, and opportunities.

The advancement of information technology and AI has boosted global economic and social development. Robot systems (RS) and computer-aided technology (CAT) are used in various domains, including social production and human existence. Traditional fracture reduction surgery relies on the expertise and surgical skills of surgeons to realign fractures in patients.

Cell-membrane targeting sonodynamic therapy combination with FSP1 inhibition for ferroptosis-boosted immunotherapy.

Cell membrane targeting sonodynamic therapy could induce the accumulation of lipid peroxidation (LPO), drive ferroptosis, and further enhances immunogenic cell death (ICD) effects. However, ferroptosis is restrained by the ferroptosis suppressor protein 1 (FSP1) at the plasma membrane, which can catalyze the regeneration of ubiquinone (CoQ10) by using NAD(P)H to suppress the LPO accumulation. This work describes the construction of US-active nanoparticles (TiF NPs), which combinate cell-membrane targeting sonosensitizer TBT-CQi with FSP1 inhibitor (iFSP1), facilitating cell-membrane targeting sonodynamic-triggered ferroptosis.

Antibacterial carbon dots.

Bacterial infections significantly threaten human health, leading to severe diseases and complications across multiple systems and organs. Antibiotics remain the primary treatment strategy for these infections. However, the growing resistance of bacteria to conventional antibiotics underscores the urgent need for safe and effective alternative treatments.

Splicing to orchestrate cell fate.

Alternative splicing (AS) plays a critical role in gene expression by generating protein diversity from single genes. This review provides an overview of the role of AS in regulating cell fate, focusing on its involvement in processes such as cell proliferation, differentiation, apoptosis, and tumorigenesis. We explore how AS influences the cell cycle, particularly its impact on key stages like G1, S, and G2/M.

A self-hygroscopic, rapidly self-gelling polysaccharide-based sponge with robust wet adhesion for non-compressible hemorrhage control and infected wounds healing.

Uncontrollable non-compressible hemorrhage and traumatic infection have been major causes of mortality and disability in both civilian and military populations. A dressing designed for point-of-care control of non-compressible hemorrhage and prevention of traumatic infections represents an urgent medical need. Here, a novel self-gelling sponge OHN@ε-pL is developed, integrating N-succinimidyl ester oxidized hyaluronic acid (OHN) and ε-poly-L-lysine (ε-pL).

Revisiting the drivers of electricity consumption in designated Sub-Saharan African regions: Unraveling the role of education.

It has been established that steady supply of energy to various sectors of the economy is critical for societal growth and development. According to recent figures, barely one-third of the whole population in Sub-Saharan Africa has access to electricity, making the region the poorest in the world in terms of access to electrical power today. This stands in stark contrast to the vast energy resources that could be utilized to provide the necessary energy.

Analysis of HFE impact of COVID-19 on OHS in construction enterprises.

Human factors are critical to Occupational Health and Safety (OHS) in construction enterprises. However, comprehensive industry-wide recognition remains challenging, underscoring the need for Human Factors Engineering (HFE) research. This study develops an optimized HFE evaluation model based on fundamental HFE principles.

Assessing the impact of public perception and willingness-to-pay on reducing smog in Pakistan: Evidence from Lahore City.

Smog pollution is a major global issue affecting Pakistan's major cities, particularly Lahore. The study aims to explore the public perception and willingness to pay (WTP) for smog reduction via the Contingent Valuation Method (CVM). This study uses a structured interview schedule and interval regression model to analyse the public perception and willingness to pay for smog reduction.

Risk propagation in emergency supply chain during public health events - From a reliability perspective.

The emergency supply chain is a vital component of the emergency management system and serves as the cornerstone for delivering relief during emergencies. This paper focuses on investigating the propagation mechanism of supply chain risks in public health emergencies. Firstly, by analyzing the characteristics of emergency supply chains, this study enhances the formation mechanism of scale-free networks in emergency supply chains from a reliability perspective through the utilization of Decision Experimentation and Evaluation Laboratory (DEMATEL) and Analytic Network Process (ANP) methods.

Selenium enrichment enhances the alleviating effect of GG on alcoholic liver injury in mice.

Selenium-enriched probiotics have attracted much attention due to the physiological activities of both probiotics and selenium (organic selenium). In this study, we investigated the mitigating effect of selenium-enriched GG (LGG@Se) and its pathway on alcohol-induced liver injury (ALI) in mice. The results showed that LGG@Se was superior to LGG and sodium selenite in alleviating ALI.

Biodegradable copper-doped calcium phosphate nanoplatform enables tumor microenvironment modulations for amplified ferroptosis in cervical carcinoma treatment.

As a recently discovered form of regulated cell death, ferroptosis has attracted much attention in the field cancer therapy. However, achieving considerably enhanced efficacy is often restricted by the overexpression of endogenous glutathione (GSH) in tumor microenvironment (TME). In this work, we report a ferroptosis-inducing strategy of GSH depletion and reactive oxygen species (ROS) generation based on a biodegradable copper-doped calcium phosphate (CaP) with L-buthionine sulfoximine (BSO) loading (denoted as BSO@CuCaP-LOD, BCCL).

Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential.

Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are prepared to mimic the hierarchical structure of natural bones, through the inheritance of the hierarchical structure of fiber silk and the integration with a polyester matrix. Due to the robust interface between the matrix and fiber silk, CFSCs show maintained stable long-term mechanical performance under wet conditions.

Causal Relationships Between 4 Exposure Factors and Rotator Cuff Syndrome Using Mendelian Randomization Analysis.

Background: Although previous studies have investigated the risk factors for rotator cuff syndrome (RCS), there remains controversy due to uncontrolled and uncertain confounding factors in their analyses.

Purpose: To perform Mendelian randomization (MR) analysis using single-nucleotide polymorphisms to investigate the causal relationship between RCS and 4 risk factors: type 2 diabetes mellitus (T2DM), high blood pressure (HBP), body mass index (BMI), and low high-density lipoprotein cholesterol (HDL-C).

Study Design: Descriptive epidemiology study.

Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy.

Low tumor enrichment remains a serious and urgent problem for drug delivery in cancer therapy. Accurate targeting of tumor sites is still a critical aim in cancer therapy. Though there have been a variety of delivery strategies to improve the tumor targeting and enrichment, biological barriers still cause most delivered guests to fail or be excreted before they work.

Opportunities and challenges of lead-free metal halide perovskites for luminescence.

Metal halide perovskites (MHPs) have been developed rapidly for application in light-emitting diodes (LEDs), lasers, solar cells, photodetectors and other fields in recent years due to their excellent photoelectronic properties, and they have attracted the attention of many researchers. Perovskite LEDs (PeLEDs) show great promise for next-generation lighting and display technologies, and the external quantum efficiency (EQE) values of polycrystalline thin-film PeLEDs exceed 20%, which is undoubtedly a big breakthrough in lighting and display fields. However, the toxicity and instabilities of lead-based MHPs remain major obstacles limiting their further commercial applications.

A 3D four-fold interpenetrated conductive metal-organic framework for fast and robust sodium-ion storage.

Two-dimensional conductive metal-organic frameworks (2D c-MOFs) with high electrical conductivity and tunable structures hold significant promise for applications in metal-ion batteries. However, the construction of 3D interpenetrated c-MOFs for applications in metal-ion batteries is rarely reported. Herein, a 3D four-fold interpenetrated c-MOF (Cu-DBC) constructed by conjugated and contorted dibenzo[,]chrysene-2,3,6,7,10,11,14,15-octaol (DBC) ligands is explored as an advanced cathode material for sodium-ion batteries (SIBs) for the first time.

Recent advances and perspectives in synthetic applications of silylboronates as silyl radical precursors.

Silylboronates, as powerful and versatile reagents, have been widely used in synthetic chemistry over the past few decades, due to their ability to incorporate silicon and boron atoms into organic molecules. With the rapid development of radical chemistry, the use of silylboronates as silyl radical precursors has recently become a research focus in organic synthesis. Significant achievements have been made in the synthetic applications of silylboronates as silyl radical sources for various C-Si and C-X bond forming transformations.

Probiotics fermentation enhanced the bioactive properties of water extract and improved regulation ability of gut microbiota.

This study investigated the probiotic potential of fermented beverages derived from (). Three different beverages were prepared by fermenting water extract with A6-3 ( A6-3), A27-1 ( A27-1), or both for 48 h. The results demonstrated that bioactive compounds from promoted the growth of these two probiotics and preserved their viability for at least 28 days at 4 °C.

Nutritional and antioxidative characterization, antimicrobial and sensorial stability of flaxseed powder supplemented mutton patties.

Oxidative stress and microbial growth deteriorate food quality and cause safety risks. Therefore, the present study was investigated to explore the nutritional, sensorial, anti-oxidative and anti-microbial attributes of flaxseed powder (FP) supplemented at 2-8 % (i.e.

Recent Advances in Asymmetric Wettability Dressings for Wound Exudate Management.

The management of wound exudate is of vital importance for wound healing. Exudate accumulation around wound prolongs inflammation and hinders healing. Although traditional dressings can absorb wound exudate, they are unable to drain exudate in time, often resulting in a poor feature with wound healing.

A novel pigeon paramyxovirus type 1 isolated from a sick racing pigeon in the Qinghai-Tibet Plateau of China shows high virulence in chickens.

Pigeon paramyxovirus type-1 (PPMV-1) is the causative agent of pigeon Newcastle disease (ND), which has caused huge losses to the pigeon industry. In this study, a PPMV-1 strain, PPMV-1/QH-01/CH/23, was isolated from a sick racing pigeon in the Qinghai-Tibet Plateau, China in 2023. The mean death time of chicken embryos and the intracerebral pathogenicity index (ICPI) were 76.

Highly sensitive temperature sensors based on the fluorescence intensity ratio of dual-emissive lead-free metal halides.

Given that optical thermometers are widely used due to their unique advantages, this study aims to address critical challenges in existing technologies, such as insufficient sensitivity, limited temperature measurement ranges, and poor signal recognition capabilities. Herein, we develop a thermometer based on the fluorescence intensity ratio (FIR) of Sb-doped CsNaInCl (CsNaInCl:Sb). As the temperature increases from 203 to 323 K, the thermally induced transition from triplet to singlet self-trapped excitons (STEs) leads to enhanced 455 nm photoluminescence (PL) from singlet STE recombination.

Tyrosine-modified tilapia skin antioxidant peptides and their hydroxyl radical quenching activities.

In an antioxidant peptide study, the number and position of active amino acid sites, as well as the peptides' conformation, are found to be crucial for scavenging hydroxyl radicals (˙OH). Herein, ˙the OH scavenging activity of tilapia pentapeptide (P1, YGDQY) and its analogs including P2 (YYYGDQY), P3 (YYGDQYY) and P4 (YYGPDQYY) was investigated. The results showed that the tyrosine's amount, location and the peptides' conformation played important roles in determining peptides' scavenging activity (34.

formed CuSn alloy from multivariate metal-organic frameworks for tunable CO electroreduction.

A molecular ligand separation method based on multivariate metal-organic frameworks (MOF) is developed to precisely regulate CuSn alloy for tuning the selectivity of HCOOH and CO in CO reduction. With this method, the agglomeration and heterogeneous nucleations of metals are effectively inhibited during the electrochemical transformation of CuSn-MOFs into highly pure CuSn alloy. The low Sn content favors CO production, while the high Sn concentration facilitates HCOOH formation.