Revealing the decision-making practices in automated external defibrillator deployment: insights from Shanghai, China.

In recent years, the government has promoted the increased deployment of automated external defibrillators (AEDs) in public places with dense crowds, which is of great significance for ensuring that residents enjoy equal health rights. However, it is still unclear what factors decision-makers take into account when formulating deployment plans and whether these factors are related to local characteristics such as population distribution and socioeconomic conditions. Taking Shanghai, China as the research area, we adopted the kernel density estimation and spatial autocorrelation analysis to explore the spatial distribution characteristics of AEDs.

Association between traffic-related air pollution and risk of outpatient visits for dry eye disease in a megacity along the subtropical coast in South China.

Background: Traffic-related air pollution especially in highly socioeconomically developed megacity is usually considered as a severe problem leading to inevitable adverse health outcomes. This study aimed to investigate the associations between traffic-related air pollutants with risk of dry eye disease (DED) outpatient visits in a megacity (Guangzhou) along the subtropical coast in South China.

Methods: Daily data on DED outpatient visits and environmental variables from 1 January 2014 to 31 December 2020 in Guangzhou were obtained.

Comparative analysis of the whole transcriptome landscapes of muscle and adipose tissue in Qinchuan beef cattle.

Background: Muscle and adipose tissue are the most critical indicators of beef quality, and their development and function are regulated by noncoding RNAs (ncRNAs). However, the differential regulatory mechanisms of ncRNAs in muscle and adipose tissue remain unclear.

Results: In this study, 2,343 differentially expressed mRNAs (DEMs), 235 differentially expressed lncRNAs (DELs), 95 differentially expressed circRNAs (DECs) and 54 differentially expressed miRNAs (DEmiRs) were identified in longissimus dorsi muscle (LD), subcutaneous fat (SF) and perirenal fat (VF) in Qinchuan beef cattle.

The complete mitochondrial genome of Gyrodactylus pseudorasborae (Platyhelminthes: Monogenea) with a phylogeny of Gyrodactylidae parasites.

Background: Gyrodactylus von Nordmann, 1832, a genus of viviparous parasites within the family Gyrodactylidae, contains one of the largest nominal species in the world. Gyrodactylus pseudorasborae Ondračková, Seifertová & Tkachenko, 2023 widely distributed in Europe and China, although its mitochondrial genome remains unclear. This study aims to sequence the mitogenome of G.

A comparative study of two full-endoscopic foraminoplasty techniques for lumbar disc herniation.

Objective: This study aimed to compare the use of the endoscopic drill (ED) with the extra-endoscopic trephine (EET) in treating lumbar disc herniations with regard to efficiency, safety, and clinical outcomes.

Methods: From January 2022 and June 2023, 136 patients who had the single-level LDH and received the transforaminal endoscopic surgery were divided into two groups according to the foraminoplasty technique: the EET group (n = 69) and the ED group (n = 67). Surgery-related parameters, complications, Visual Analogue Scale (VAS, 0-10), and Oswestry Disability Index (ODI, 0-100%) were assessed and compared among two groups.

OsLOX1 positively regulates seed vigor and drought tolerance in rice.

The lipoxygenase (LOX) gene family is widely distributed in plants, and its activity is closely associated with seed viability and stress tolerance. In this study, we cloned the rice(Oryza sativa)lipoxygenase gene OsLOX1, a key participant in the 13-lipoxygenase metabolic pathway. Our primary focus was to investigate its role in mediating responses to drought stress and seed germination in rice.

Comparative metabolomic analysis of Haematococcus pluvialis during hyperaccumulation of astaxanthin under the high salinity and nitrogen deficiency conditions.

Revealing the differences of metabolite profiles of H. pluvialis during hyperaccumulation of astaxanthin under the high salinity and nitrogen deficiency conditions was the key issues of the present study. To investigate the optimum NaCl and NaNO concentration and the corresponding metabolic characteristic related to the astaxanthin accumulation in H.

Integrating genetics and transcriptomics to characterize shared mechanisms in digestive diseases and psychiatric disorders.

Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic and transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) and weighted gene co-expression network analysis (WGCNA) to explore shared mechanism between psychiatric and gastrointestinal disorders. Significant genetic correlations were found between these disorders, especially in irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), depression (DEP), and neuroticism (NE).

Effect of free gingival graft dimension on postsurgical shrinkage in posterior implant placement: A prospective parallel cohort study.

Statement Of Problem: The impact of free gingival graft (FGG) dimensions on the postsurgical shrinkage of keratinized tissue width (KTW) and surface area in posterior implant sites is unclear. Standardized assessments of how graft dimensions influence KTW and surface area shrinkage rates over a 6-month period after FGG are lacking.

Purpose: The purpose of this prospective parallel cohort study was to examine the impact of the graft dimensions on the postsurgical shrinkage of KTW and surface area over a 6-month follow-up period after FGG in the posterior regions.

Effects of rapid infrared radiation heating on the warping deformation and mechanical properties of selective laser melted Co-Cr dental alloy.

Statement Of Problem: Infrared radiation heating (IRH) technology has been innovatively applied to the annealing of selective laser melted (SLM) cobalt chromium (Co-Cr) frameworks. However, previous studies have not reported the effects of IRH on the warping deformation and mechanical properties of these frameworks.

Purpose: The purpose of this in vitro study was to investigate the effects of IRH on the warping deformation and mechanical properties of dental SLM Co-Cr alloy and to evaluate its potential applications in dental restorations.

Associations of glycemic status with dynamic disease trajectories of atrial fibrillation and dementia.

Background: Atrial fibrillation (AF) has been associated with elevated dementia risk, while few studies have examined the role of the optimal glycemic status in disease trajectories of AF and dementia.

Objectives: We aim to evaluate associations between glycemic status with disease trajectories of AF and dementia, as well as major dementia subtypes, including Alzheimer's disease and vascular dementia.

Design: Population-based cohort study.

Prognostic stratification of gastric cancer patients by intratumoral microbiota-mediated tumor immune microenvironment.

Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced GC are limited. Here, we observe that intratumoral microbiota controls chemokine expression, which in turn recruits immune cells into the tumor, and that immune infiltration is strongly associated with patient survival and disease attributes. Furthermore, microbiota regulation of chemokines is differentiated in GC patients with different survival risks.

Bisphenol A Exacerbates Colorectal Cancer Progression through Enhancing Ceramide Synthesis.

Bisphenol A (BPA) is a typical environmental endocrine disruptor which have been broadly confirmed to be associated with malignant tumors, including colorectal cancer (CRC). Lipid metabolism reprogramming performed important biological effects in cancer progression. While the role of lipid metabolism in CRC progression upon BPA exposure remain elusive.

Inactivation of β-coronavirus MHV-A59 by 2.8 GHz microwave.

From the severe acute respiratory syndrome coronavirus in 2003 to the severe acute respiratory syndrome coronavirus 2 in 2019, coronavirus has seriously threatened human health. Electromagnetic waves not only own high penetration and low pollution but also can physically resonate with the virus. Several studies have demonstrated that electromagnetic waves can inactivate viruses efficiently.

Gut microbiota and short-chain fatty acids signatures in postmenopausal osteoporosis patients: A retrospective study.

Studies have shown that gut microbiota (GM) and its metabolites, short-chain fatty acids (SCFAs), are associated with the development of postmenopausal osteoporosis (PMO). This study explored the clinical and laboratory evidence of the relationship of GM and SCFAs to PMO and attempted to determine the potential mechanism of action. 18 patients (Collected from the First Affiliated Hospital of Guangdong Pharmaceutical University between January 2021 and August 2021) were included in this retrospective study, including 10 PMO women and 8 healthy young women as the healthy control (HC) group from Guangzhou, China.

The impact of exercise during radiotherapy on treatment-related side effects in breast cancer patients: A systematic review and meta-analysis.

Purpose: Radiation therapy for breast cancer often causes side effects like cancer-related fatigue, depression, and sleep disorders, impacting health-related quality of life, psychosocial aspects, and physical function. Exercise therapy is commonly used to manage cancer-related fatigue, but its effectiveness remains uncertain due to varying patient conditions and adherence. This systematic review aims to assess exercise interventions during radiotherapy for their effects on physiological and psychological side effects in breast cancer patients, clarifying efficacy and exploring different intervention types.

The mechanism of Se in regulating the proliferation and apoptosis of sheep Leydig cells through the miR-200a/NRF2 pathway.

This study aimed to investigate the mechanism by which Se in regulates the proliferation and apoptosis of sheep Leydig cells via the miR-200a/NRF pathway. The cells were isolated and purified from the testes of 8-month-old sheep via a Percoll density gradient. After the cells were treated with different concentrations of Se (0, 2.

A self-aggregated thermally activated delayed fluorescence nanoprobe for HClO imaging and activatable photodynamic therapy.

Hypochlorous acid (HClO/ClO) is a common ROS that exhibits elevated activity levels in cancer cells. In this study, an ClO-triggered TADF probe, PTZ-MNI, was designed based on a naphthalimide core. PTZ-MNI self-assemble in aqueous environments, exhibiting significantly enhanced fluorescence that demonstrated typical aggregation-induced delayed fluorescence (AIDF) characteristics.

Oxygen vacancy and interface effect dual modulation of SnS/SnO heterojunction for boosting formaldehyde detection at low temperature.

Formaldehyde (HCHO) is a harmful volatile organic pollutant, which is commonly found in interior decoration and furniture products. Therefore, it is necessary to develop a gas sensor that can quickly and accurately detect formaldehyde for human health and environmental protection. In order to achieve this goal, in this work, SnS/SnO heterostructure was synthesized by in-situ sulfurization process on the basis of SnO nanospheres, and its formaldehyde sensing performance was studied.

High quantum yield copper nanoclusters integrated with nitrogen-doped carbon dots for off-on ratiometric fluorescence sensing of S and Zn.

Pursuing nanomaterials with high fluorescence quantum yields is of great significance in the fields of bioimaging, medical diagnosis, and food safety monitoring. This work reports on orange-emitting aggregation-induced emission (AIE) copper nanoclusters (Cu NCs) integrated with blue-emitting nitrogen-doped carbon dots (N-CDs), which enables highly sensitive detection of S and Zn ions through an off-on ratiometric fluorescence method. The highly emissive Cu NCs was doped by Ce with a high quantum yield of 51.

Integrated ecological-health risk assessment of ofloxacin.

Antibiotics are emerging contaminants of significant concern, while previous research has mostly focused on their ecological or health impacts in isolation. This limited systematic research on its overall risk and the uncertainty relating to the risk evaluation is also unclear. This study addressed this gap by examining both ecological or health impacts by integrating interspecies correlation models, species sensitivity distribution curves, and health risk evaluation.

Multi-effect synergistic induction of unsaturated MnO on sandy sediment for enhanced manganese adsorption and byproduct resource recovery in solar evaporation.

The efficient removal of Mn(II) from wastewater is crucial for safeguarding water quality, yet existing adsorbents face significant challenges, including high costs, poor resistance to ionic interference, and scalability limitations. This study addresses these challenges by utilizing abundant natural sandy sediment (SS) as a substrate to load unsaturated MnO via in-situ oxidation, creating a novel adsorbent (MOSS). MOSS exhibits a remarkable Mn(II) adsorption capacity of 1.

Evaluation of the actinia-shaped composite coagulant for removal of algae in water: Role of charge density.

A series of novel cationic modified actinia-shaped composite coagulant (AMS-C), with similar tentacle length and distribution but different charge density (CD), was successfully designed and fabricated by combination of a cationic graft starch and attapulgite (ATP). AMS-C shows a high efficiency in coagulative removal of Microcystis aeruginosa from water over a wide pH range. The algae-harvesting efficiency of optimized AMS-C can reach to 92.

Ultrasensitive ammonia sensor with excellent humidity resistance based on PANI/SnS heterojunction.

The analysis of human exhaled gas is crucial for early and noninvasive diagnosis. However, the complex composition and high-humidity of exhaled gas pose significant challenges to the application of gas sensors. This research focuses on the development of a chemiresistive ammonia sensor based on the polyaniline/tin disulfide (PANI/SnS) heterojunction, which is fabricated by hydrothermal and in-situ polymerization techniques.

Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastases status.

Background: Current decision-making for the treatment of breast cancer liver metastases (BCLM) using ablation lacks strong evidence, especially for patients combined with extrahepatic metastases.

Purpose: To assess whether ablation plus systemic therapy (AS) improves survival outcomes in patients with BCLM compared to systemic therapy alone.

Materials And Methods: This retrospective study analyzed patients with BCLM who received either AS or systemic therapy alone.