Nitrogenative Degradation of Polystyrene Waste.

Owing to massive production and poor end-of-life management, plastic waste pollution has become one of the most pressing environmental crises. In response to the mounting crisis, the past several decades have witnessed the development of numerous methods and technologies for plastic recycling. However, most of the current recycling technologies often produce low-quality or low-value products, making it difficult to recover the operating costs.

Structure-Guided Discovery of Novel -(Substituted Thiazol-2-yl)--(4-Substituted phenyl)pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability.

CDK2 and CDK9 play pivotal roles in cell cycle progression and gene transcription, respectively, making them promising targets for cancer treatment. Herein, we discovered a series of -(substituted thiazol-2-yl)--(4-substituted phenyl)pyrimidine-2,4-diamines as highly potent CDK2/9 dual inhibitors. Especially, compound significantly inhibited CDK2 (IC = 0.

Avermectins and Their Derivatives: Recent Advances in Biosynthesis and Application.

Avermectins (AVMs) and their derivatives are the most effective and widely used nematicides, insecticides, and acaricides against endo- and ectoparasites of plants, animals, and humans. Demand for avermectins and their highly effective derivatives has increased due to their high cost-effectiveness and wide range of applications as medicines and crop protection products. Due to the unique structures of these compounds and for industrial production purposes, numerous efforts and strategies have been dedicated to enhancing the production of avermectins and creating new analogues in recent years.

Insight into the Origin of Second Harmonic Generation and Rational Design in the Metal Halide Borates.

Metal halide borates are promising candidates for high-performance nonlinear optical (NLO) applications, yet the origins of their second harmonic generation (SHG) properties remain unclear. Using atom response theory combined with density functional theory calculations, this study investigates why halogen substitution leads to distinctly different SHG responses in halide monoborates (PbBOX) versus halide pentaborates (PbBOX). We find that the SHG origins vary between these two families due to differences in the strength of the Pb-X interactions.

DNA Self-Assembly Generated by Aptamer-Triggered Rolling Circle Amplification Cascades for Profiling Colorectal Cancer-Derived Small Extracellular Vesicles.

The analysis of small extracellular vesicles (sEVs) has shown clinical significance in early cancer diagnostics and considerable potential in prognostic assessment and therapeutic monitoring, offering possibilities for precise clinical intervention. Despite recent diagnostic progress based on blood-derived sEVs, the inability to specifically profile multiple parameters of sEVs proteins has hampered advancement in clinical applications. Herein, we report an approach to profile colorectal cancer (CRC)-derived sEVs by using multiaptamer-triggered rolling circle amplification (RCA) cascades.

A Single-Chain Peptide Probe Targeting Pathological Collagen for Precise Staging of Hepatic Fibrosis by MR Imaging.

Hepatic fibrosis, a chronic liver response to injury with potential severe outcomes like cirrhosis and liver cancer, necessitates urgent noninvasive diagnostic techniques to halt disease progression. We herein for the first time developed a single-chain peptide probe targeting pathological collagen for in vivo magnetic resonance imaging (MRI) of hepatic fibrosis. The novel (GhypO) probe, distinguished by its unique monomeric conformation achieved through Pro to (2,4)-hydroxyproline (hyp) substitution and subsequent disruption of hydrogen bonding, exhibits selectivity for pathological collagen over its intact counterpart in connective tissues.

Total Synthesis of Kasugamycin.

We present an efficient synthetic pathway for kasugamycin, an aminoglycoside antibiotic, utilizing naturally derived carbohydrates as starting materials. This synthesis effectively addresses stereochemical complexities by employing the selective reduction of d-fucal, which generates a crucial 3-deoxyglycal intermediate. This intermediate facilitates the introduction of amino groups at the C-2 and C-4 positions, which is essential for the synthesis of kasugamine.

Plutonium Marker for the Great Acceleration by Intensified Human Activities.

There has been a sharp rise in the extent and scale of human activities since the mid-20th century, termed the "Great Acceleration", and nuclear activities are one of the defining technological processes for this period. Pu released by atmospheric nuclear weapons tests provides an ideal chronostratigraphic marker for labeling this change due to its global fallout feature, temporal mutation, and long half-lives. However, the accumulation dynamics of plutonium from atmospheric deposition to preservation in the sediment is still controversial.

Stabilizing Nickel-Copper Co-Deposition Electrochromism with the Assistance of Bromine Redox.

As an attractive optical/heat dynamic management technology, reversible metal electrodeposition/dissolution electrochromism (RME-EC) shows many advantages, including high optical modulation amplitude, wide modulation band, and color neutrality, but also suffers from performance degradation because of uneven dendritic metal deposition as well as the formation/accumulation of isolated metal debris. In this paper, a facile RME-EC system is established in a green and affordable aqueous electrolyte, by making good use of the nondendritic Ni-Cu codeposition. Furthermore, an in situ self-healing strategy is further established by activating the Br/Br couple of the Br-containing electrolyte to improve the EC performance.

HCP-to-FCC Phase Transformation of Ruthenium Nanocrystals Selectively Activate Hydrogen Peroxide for Boosting Peroxidase-like Activity.

Due to the simultaneous activation of hydrogen peroxide (HO) and oxygen, Ru nanocrystals exhibit inherent peroxidase- and oxidase-like activities, thereby limiting their extensive application in biosensing. Phase engineering of Ru nanocrystals holds great promise for enhancing catalytic activity and selectivity but remains a challenge. Here, highly active Ru nanocrystals with a metastable face-centered cubic (fcc) structure were successfully synthesized via a facile wet-chemical method followed by an etching step, enabling selective activation of HO and demonstrating promising peroxidase-like activity.

Construction of an Efficient -Succinyl--homoserine Producing Cell Factory and Its Application for Coupling Production of -Methionine and Succinic Acid.

-Succinyl--homoserine (OSH) is an important C4 platform compound with broad applications. Its green and efficient production is receiving increasing attention. Herein, the OSH producing chassic cell was constructed by deleting the transcriptional negative regulation factor, blocking the OSH consumption pathway, and inhibiting the competitive bypass pathways.

Aluminum Cluster Molecular Ring-Based Heterometallic Framework Materials for Iodine Capture.

With the development of the nuclear industry, the risk of elements that are difficult to degrade in nuclear fission has been gradually increasing. Therefore, the efficient capture of iodine (I) has attracted considerable attention in recent years. The aluminum cluster-based metal framework materials show great advantage in iodine adsorption due to the designable pore sizes, excellent physicochemical stability, and cheap raw materials.

Mix-Charged Nanofiltration Membrane for Efficient Organic Removal from High-Salinity Wastewater: The Role of Charge Spatial Distribution.

The efficient removal of organic contaminants from high-salinity wastewater is crucial for resource recovery and achieving zero discharge. Nanofiltration (NF) membranes are effective in separating organic compounds and monovalent salts, but they typically exhibit an excessive rejection of divalent salts. Modifying the charge characteristics of NF membranes can improve salt permeation; however, the role of charge spatial distribution in governing salt transport behavior is not fully understood.

Design, Synthesis, and Biological Evaluation of 1,3,4-Thiadiazole Derivatives as Novel Potent Peptide Deformylase Inhibitors for Combating Drug-Resistant Gram-Positive and -Negative Bacteria.

The prevalence of drug-resistant bacteria is a major challenge throughout the world, especially with respect to Gram-negative bacteria, such as drug-resistant , which are regarded as the greatest bacterial threat to human health by the World Health Organization (WHO). In this work, 1,3,4-thiadiazole was introduced into the main skeleton of the classical peptidomimetic peptide deformylase (PDF) inhibitor in pursuit of highly efficient and broad-spectrum bacteriostatic drugs. Upon detailed structure-activity relationship study, PDF inhibitors that possess satisfactory activity against both Gram-positive and Gram-negative bacteria as well as a lower potential for methemoglobin toxicity were screened out.

Platinum(IV)-Backboned Polymer Prodrug-Functionalized Manganese Oxide Nanoparticles for Enhanced Lung Cancer Chemoimmunotherapy via Amplifying Stimulator of Interferon Genes Activation.

The stimulator of interferon genes (STING) pathway exhibits great potential in remodeling the immunosuppressive tumor microenvironment and initiating antitumor immunity. However, how to effectively activate STING and avoid undesired toxicity after systemic administration remains challenging. Herein, platinum(IV)-backboned polymer prodrug-coated manganese oxide nanoparticles (DHP/MnONP) with pH/redox dual responsive properties are developed to precisely release cisplatin and Mn in the tumor microenvironment and synergistically amplify STING activation.

Interpretable Machine Learning Models Delivering a New Perspective for the Reaction Mechanism between Organic Pollutants and Oxidative Radicals.

Machine learning (ML) is expected to bring new insights into the impact of organic structures on the reaction mechanisms in reactive oxygen species oxidation. However, understanding the underlying chemical mechanisms still faces challenges due to the limited interpretability of the ML models. In this study, interpretable ML models were established to predict the second-order rate constants between hydroxyl radicals (OH) and organics ().

Drug in Drug: Quorum Sensing Inhibitor in Star-Shaped Antibacterial Polypeptides for Inhibiting and Eradicating Corneal Bacterial Biofilms.

Biofilm-related bacterial keratitis is a severe ocular infection that can result in drastic vision impairment and even blindness. However, the therapeutic efficiency of clinical antibiotic eyedrops is often compromised because the bacteria in the biofilms resist bactericide the community genetic regulation, namely, bacterial quorum sensing. Herein, quercetin (QCT)-loaded star-shaped antibacterial peptide polymer (SAPP), QCT@SAPP, is developed based on a "drug" in a "drug" strategy for inhibiting and eradicating biofilms on the cornea.

Optimal Synergy between Azulenes and Acenes in Azuacenes with 6-7-5 Ring Topology.

Azuacenes, defined as azulene fused with acenes in a 6-7-5 ring topology and spanning lengths from 3 to 6 rings, have been synthesized using a new skeleton editing and [3 + 2] annulation synthesis protocol as a distinction regarding the procedures to obtain the 6-5-7 isomers. Comprehensive studies on ground-state and excited-state spectroscopy, electrochemical properties, chemical stability, and solid-state structure have been conducted to compare these azuacenes with acenes. For the same number of rings, we found that azuacenes improve the chemical stability of acenes (i.

Two-Component Hydrogels Built from Chinese Herbal Medicine-Derived Glycyrrhizic Acid and Puerarin: Assembly Mechanism, Self-Healing Properties, and Selective Antibacterial Activity.

Chinese herbal medicine has offered a great treasure for discovering intrinsically bioactive low molecular weight gelators (LMWGs). Herein, the two-component hydrogels comprising glycyrrhizic acid (GA) and puerarin (PUE), the primary bioactive components, respectively, from herbs and are successfully prepared. Combined spectroscopic characterizations reveal that hydrogen bonds are formed between GA and PUE molecules, which further drives the growth of nanofiber assemblies into gel networks.

FcγR1-Expressing Cell Membrane-Coated Nanoparticle (FcγR1-CMNP) for T-Cell-Engaging Bispecific Nanoantibody Construction.

T-cell-engaging bispecific antibodies (BiTEs), which can simultaneously bind to antigens on tumor cells and T cells, show good potential in cancer immunotherapy. A practical and feasible approach for emulating BiTEs involves immobilizing two types of monoclonal antibodies (mAbs) onto a single nanoparticle; however, this approach involves complex immobilization processes and chemical reactions. To overcome these challenges, we achieved gentle antibody immobilization through receptor-ligand interactions by constructing a mAb delivery system known as Fcγ receptor 1 (FcγR1)-expressing cell membrane-coated nanoparticles (abbreviated as FcγR1-CMNPs).

Uncovering the Performance Enhancing Mechanism of Methanesulfonate Ligands in Perovskite Quantum Dots for Light-Emitting Devices.

Perovskite quantum dots (PQDs) have attracted more and more attention in light-emitting diode (LED) devices due to their outstanding photoelectric properties. Surface ligands not only enable size control of quantum dots but also enhance their optoelectronic performance. However, the efficiency of exciton recombination in PQDs is often hindered by the desorption dynamics of surface ligands, leading to suboptimal electrical performance.

Evaluation of the Effect of the Live Vaccine (Strain 168) in Ningxiang Pigs.

[Background/Objectives] () is widespread in the global swine industry, leading to significant economic losses, and is particularly severe in native Chinese pig breeds. The Ningxiang pig, a well-known native breed in China, is susceptible to , exhibiting high morbidity and mortality rates. This study was designed to evaluate the clinical effectiveness of the live vaccine (strain 168).

Adaptive Memory-Augmented Unfolding Network for Compressed Sensing.

Deep unfolding networks (DUNs) have attracted growing attention in compressed sensing (CS) due to their good interpretability and high performance. However, many DUNs often improve the reconstruction effect at the price of a large number of parameters and have the problem of feature information loss during iteration. This paper proposes a novel adaptive memory-augmented unfolding network for compressed sensing (AMAUN-CS).

A Systematic Review and Meta-Analysis of Type 2 Diabetes Prevention Through Lifestyle Interventions in Women with a History of Gestational Diabetes-A Summary of Participant and Intervention Characteristics.

: We aimed to review the effect of lifestyle interventions in women with a history of gestational diabetes mellitus (GDM) based on the participants and intervention characteristics. : We systematically searched seven databases for RCTs of lifestyle interventions published up to 24 July 2024. We included 30 studies that reported the incidence of type 2 diabetes mellitus (T2DM) or body weight.

Effects of Illumination Color on Hypothalamic Appetite-Regulating Gene Expression and Glycolipid Metabolism.

Irregular illumination is a newly discovered ambient factor that affects dietary and metabolic processes. However, the effect of the modulation of long-term light exposure on appetite and metabolism remains elusive. Therefore, in this current study, we systematically investigated the effects of up to 8 weeks of exposure to red (RL), green (GL), and white light (WL) environments on appetite, food preferences, and glucose homeostasis in mice on both high-fat and low-fat dietary patterns.