Microbial community analysis of supragingival plaque in patients with fixed prostheses.

Statement Of Problem: Harmony between prostheses and periodontal tissues is essential. The presence of a fixed prosthesis has been reported to increase the risk of periodontal lesion onset in abutment teeth and to affect longevity. However, studies comparing the supragingival plaque biofilm on fixed prostheses and natural teeth are lacking.

Preparation, structural changes and functional properties of the covalent complexes of almond protein and phloretin.

Proteins and polyphenols exhibit distinct biological activities and functional properties. A comprehensive investigation into the formation mechanisms, structures, and functional properties of protein-polyphenol complexes will deepen our understanding of their interactions and establish a theoretical foundation and technical support for development of novel functional foods and pharmaceutical products. The almond protein-phloretin (AP-PHL) covalent complex was synthesized through the covalent binding of hydroxyl radicals to phloretin (PHL), utilizing almond protein (AP) as the raw material.

A "cyclodextrin-salicylic acid-chitosan" bifunctional monomer magnetic hydrophilic imprinted sandwich gel for targeted adsorption and slow release of ginkgolic acid.

This study aims to address the challenge of detoxifying ginkgolic acid and transform it from waste into a valuable resource. By using pseudo-template molecular imprinting technology to chemically modify polysaccharide materials, we developed a polysaccharide-based molecular imprinted material (MMCC-CD/CS-MIP) for the targeted separation and controlled release of ginkgolic acid. Under optimal conditions, MMCC-CD/CS-MIP demonstrated excellent adsorption performance (Q = 47.

Development and validation of a support vector machine-based nomogram for diagnosis of obstetric antiphospholipid syndrome.

Background: Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder characterized by arterial or venous thrombosis and/or pregnancy complications. This study aims to develop a diagnostic model for Obstetric APS (OAPS) using the Support Vector Machine (SVM) algorithm.

Methods: Data were retrospectively collected from 102 patients with OAPS and 80 healthy controls (HC).

A review on molecularly imprinted magnetic solid phase extraction emphasizing the analysis of antibiotics in complex matrices:Design, preparation, and application.

Magnetic solid phase extraction (MSPE) has been widely employed in the isolation and enrichment of antibiotics in complex matrices because it presents various unique advantages over traditional SPE including simple operation, fast extraction procedure, low cost and eco-friendliness. In recently years, magnetic molecularly imprinted nanoparticles (MMINs) containing highly specific recognition performance have been widely used to specific extraction of antibiotics under the format of MSPE. In this connection, recent advances of MMINs in the analysis of antibiotic residues are reviewed.

Chicken hnRNPK suppresses interferon production, thereby enhancing IBDV replication.

Heterogeneous ribonucleoprotein K (hnRNPK) is a well-known RNA-binding protein initially identified for its role in inhibiting the growth of various human tumors. Members of the hnRNP family have also been implicated in both interferon production and RNA virus replication. However, the role of chicken hnRNPK (chhnRNPK) in the replication of Infectious Bursal Disease Virus (IBDV) remains unclear.

Social isolation and depressive symptoms among chinese older adults: Serial mediating roles of social support and resilience.

Background: Social isolation is a significant risk factor for depressive symptoms in older adults, with social support and resilience serving as protective factors. However, the mechanisms underlying this association are not well understood.

Methods: A cross-sectional survey was performed of 1020 participants (aged ≥ 60years) in the northern, central and southern parts of Jiangsu Province, China.

Development models to predict complication and prognosis following liver resection for hepatocellular carcinoma in patients with clinically significant portal hypertension.

Background: Postoperative complications are potential factors influencing the prognosis of patients with HCC combined with CSPH. This study aims to explore the risk factors affecting the occurrence of postoperative complications, investigate potential factors influencing long-term prognosis in these patients, and establish predictive models.

Methods: From April 2018 to December 2021, a total of 190 patients with HCC combined with CSPH who underwent curative liver resection in our hospital were included, comprising 69 cases in the complication group and 121 cases in the non-complication group.

IGF2BPs-regulated TIN2 confers the malignant biological behaviors of gastric cancer cells.

Background: Telomere maintenance is an important feature of tumor cells. Telomeric-repeat binding factor 1 interaction nuclear protein 2 (TIN2), a key member of the shelterin proteins, functions in regulating telomere structure, length and function. Our work sought to investigate the role of TIN2 in controlling gastric cancer (GC) malignant biological behaviors.

Integrated removal of chromium, lead, and cadmium using nano-zero-valent iron-supported biochar: Mechanistic insights and eco-toxicity assessment.

The contamination of water and soil by heavy metals (HMs) is a global issue that should be given much more concern. Modified nano-zero-valent iron (nZVI) composites offer an effective strategy for HMs remediation, but few studies have focused on removing coexisting HMs and the eco-toxicity of the composite. In this study, corn straw biochar-supported nZVI composites (nZVI-BC) were synthesized, characterized and used for the removal of Cr, Pb, and Cd in single and multi-system at different composites dosages, metal concentrations, and solution pH.

Highly efficient metal-free electrochemical membrane enables zero-valent sulfur recovery from thiourea wastewater.

Electrochemical recovery of zero-valent sulfur (S) from thiourea (TU) wastewater offers a promising waste-to-value strategy that expects to promote the sulfur resource cycle in water treatment but still suffer from electrode poisoning and sulfur over-oxidation. Herein, we designed a metal-free CNT electrochemical membrane for selective oxidation of thiourea and recovery of S. We found that defect sites on the carbon nanotube surface enable direct electron transfer for thiourea oxidation and may form carbon-sulfur bridge bonds, thereby facilitating the generation of S and urea.

Spectral and molecular insights into the variations of dissolved organic matter in shallow groundwater impacted by surface water recharge.

Dissolved organic matter (DOM) represents one of the most active elements in aquatic systems, whose fraction is engaged in chemical and biological reactions. However, fluorescence, molecular diversity and variations of DOM in groundwater systems with the alteration of surface water recharge remain unclear. Herein, Excitation-emission matrix (EEM) fluorescence spectroscopy and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) combined with principal component coefficients, parallel factor analyses (PARAFAC) with two‒dimensional correlation spectroscopy (2D-COS) were applied in this study.

Efficient photoresponsive one-dimensional covalent organic framework as oxidase-like enzyme for ultrasensitive detection of antioxidants.

Natural polyphenolic antioxidants are widely present in foods such as fruits and vegetables, meanwhile applied in food processing and storage to prevent the formation of harmful compounds. While excessive antioxidants lead to negative impacts on human health. Hence, it is crucial to accurately detect antioxidant levels in order to enhance the overall nutritional content and food safety.

CRISPR-Cas12a-driven aptasensor for sensitive detection of alternariol by using a personal glucose meter.

Alternariol (AOH) has attracted much attention as an emerging toxin in edible herbs that can pose potential carcinogenic risks to human. However, the rapid detection of AOH to ensure food safety remains a challenge. Here, a CRISPR-Cas12a-mediated aptamer-based sensor (aptasensor) was proposed for the sensitive quantification of AOH by using a personal glucose meter.

Application and development of biosensing strategies for the analysis of the activity of the tumour-associated enzyme FEN1.

As a core genetic biomolecule in ecosystems, the metabolic processes of DNA, particularly DNA replication and damage repair, are regulated by Flap endonuclease 1 (FEN1). Abnormal expression and dysfunction of FEN1 may lead to genomic instability, which can induce a variety of chromosome-associated disorders, including tumours. FEN1 has emerged as a prominent tumour marker.

FeO/Ni nanoparticles anchored nitrogen-doped porous carbon derived from core-shell MOF for simultaneous electrochemical detection of dopamine and 5-hydroxytryptamine.

Pre-designed core-shell metal-organic frameworks (MOFs@MOFs) with customized functionalities can enhance the material properties compared to conventional single MOFs. The porous carbon composites derived from MOFs@MOFs also have excellent functionality due to the presence of multiple metal/metal oxide nanoparticles. This paper synthesized a novel MOFs@MOFs composite (MIL-101(Fe)@Ni-MOF) with a core-shell structure with MIL-101(Fe) as the core and Ni-MOF as the shell.

1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid as a novel MALDI matrix for enhanced analysis of metabolites induced by imidacloprid exposure.

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a robust tool for analyzing a variety of biomacromolecules. However, the strong background interference produced by conventional organic matrices hinders the detection of small molecule analytes, which restricts the widespread application of MALDI-MS in metabolomics studies. Consequently, developing new organic matrices is urgently needed to overcome these issues.

Comprehensive approaches to heavy metal bioremediation: Integrating microbial insights and genetic innovations.

The increasing contamination of ecosystems with heavy metals (HMs) due to industrial activities raises significant jeopardies to environmental health and human well-being. Addressing this issue, recent advances in the field of bioremediation have highlighted the potential of plant-associated microbiomes and genetically engineered organisms (GEOs) to mitigate HMs pollution. This review explores recent advancements in bioremediation strategies for HMs detoxification, with particular attention to omics technologies such as metagenomics, metabolomics, and metaproteomics in deepening the understanding of microbial interactions and their potential for neutralizing HMs.

Enterolactone combined with m6A Reader IGF2BP3 inhibits malignant angiogenesis and disease progression in ovarian cancer.

Background: Among all gynecological cancers, ovarian cancer is the leading cause of death. Epithelial ovarian cancer (EOC) accounts for over 85 % of ovarian cancer cases and is characterized by insidious onset, early metastasis, and a high recurrence rate. Alterations in gut microbiota, often as a consequence of chemotherapy, can promote cancer development and exacerbate the disease.

Structure characterization and preliminary immune activity of a glucomannan purified from Allii Tuberosi Semen.

A novel glucomannan, named ATSW-1, was obtained from Allii Tuberosi Semen by ion and gel permeation chromatography purification. Its structure was characterized using high-performance chromatography, Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry, and nuclear magnetic resonance spectroscopy. The in vitro immune activities of ATSW-1 were examined using the Cell Counting Kit-8, the neutral red phagocytosis assay, and the secretion of related cytokines.

Single-incision Laparoscopic Surgery for Neonatal Congenital Duodenal Obstruction: A Retrospective Study of 130 Patients.

Objectives: This study sought to assess the advantages of utilizing the single-incision laparoscopic surgery (SILS) procedure for repairing neonatal congenital duodenal obstruction (CDO) in terms of clinical outcomes and complication rates.

Methods: In a retrospective cohort study conducted at a single center, neonates with CDO who underwent SILS were compared to those who underwent conventional laparoscopic surgery (CLS) between January 2018 and December 2022. The demographic and operative characteristics of CDO patients who underwent SILS or CLS were analyzed, including conversion rates and postoperative complications.

Bimetallic nanoreactor mediates cascade amplification of oxidative stress for complementary chemodynamic-immunotherapy of tumor.

As a promising tumor treatment, chemodynamic therapy (CDT) can specifically catalyze HO into the cytotoxic hydroxyl radical (·OH) via Fenton/Fenton-like reaction. However, the limited HO and weakly acidic pH in tumor microenvironment (TME) would severely restrict the therapeutic efficiency of CDT. Here, a weakly acid activated, HO self-supplied, hyaluronic acid (HA)-functionalized Ce/Cu bimetallic nanoreactor (CBPNs@HA) is elaborately designed for complementary chemodynamic-immunotherapy.