The released micro/nano-plastics from plastic containers amplified the toxic response of disinfection by-products in human cells.

Micro- and nanoplastics (MNPs) released from plastic containers pose significant food safety concerns; however, their release patterns in different containers along with their impacts on other pollutants remain poorly understood. This study revealed that feeding bottles, food containers, and paper cups released approximately 10 microplastics and 10 nanoplastics after hot water treatment. These released MNPs were nontoxic in six cell types, whereas they significantly amplified the toxicity of disinfection by-products (DBPs), a widely existing contaminant in drinking water.

Magnetic fields improve the gel properties of myofibrillar proteins in low-salt myofibrillar protein emulsion systems.

The effect of magnetic field on the properties of emulsified gels containing myofibrillar protein (MP-emulsified gels) with different salt concentration (0, 0.2, 0.4, 0.

An aptasensor consisting of the integrated MOF-derived Zn-MOF-on-Co-MOF coupled with AuNPs nanocomposites and aptamer for ultrasensitive assay of fipronil.

The conductivity of Zn-MOF-on-Co-MOF synthesized by one-pot method is improved by searching for the optimum carbonization temperature, which overcomes the limitation of traditional MOF. In order to further enhance electron transfer, the mesoporous PtPdCo trimetal was introduced, which provided considerable load capacity for methylene blue (MB) and reverse complementary DNA (sDNA), and also showed excellent catalytic activity for MB. In this study, the conductivity of aptasensor was improved by modifying carbonized MOF as the base material.

Enhancing the texture and modulating digestive behavior of gluten-free quinoa sponge cakes via microwave-assisted alkaline amino acid treatment.

This study investigated the effects of microwave treatment combined with lysine and arginine on gluten-free quinoa sponge cakes. The results indicated that the addition of these amino acids during microwave treatment significantly increased the cakes' specific volume by 49 %. X-ray diffraction analysis revealed that cake crystallinity reached 56.

Mechanism of Fangji Huangqi decoction against acute kidney injury based on network pharmacology and experimental validation.

Background: Fangji Huangqi Decoction (FJHQD), a famous Traditional Chinese Medicine (TCM) formula, has been widely applied in improving renal function. However, the interaction of bioactives from FJHQD with the targets involved in acute renal injury (AKI) has not been elucidated yet.

Purpose: A network pharmacology-based approach combined with molecular docking and in vitro and in vivo validation was performed to determine the bioactives, key targets, and potential pharmacological mechanism of FJHQD against AKI.

Establishment and application of TaqMan probe-based quantitative real-time PCR for rapid detection and quantification of Ichthyophthirius multifiliis in farming environments and fish tissues.

Ichthyophthirius multifiliis, a pathogenic ciliate, is a crucial pathogen of freshwater fish and can result in severe economic loss in the aquaculture industry worldwide. It is necessary to develop a sensitive and accurate method for detecting I. multifiliis in farming environments and fish skin and gills to protect fishes from infection of the parasite due to a lack of both safe and effective treatment drugs.

Pathogenicity comparison between porcine G9P[23] and G5P[23] RVA in piglets.

Rotavirus Group A (RVA) is a primary pathogen that causes viral diarrhea in humans and animals. Porcine rotaviruses (PoRVs) are widely epidemic in pig farms in China, causing great economic losses to the swine industry. In the past 30 years, the G5 RVA had been the main epidemic genotype in pig farms worldwide.

Fast ramp fraction loss SVM classifier with low computational complexity for pattern classification.

The support vector machine (SVM) is a powerful tool for pattern classification thanks to its outstanding efficiency. However, when encountering extensive classification tasks, the considerable computational complexity may present a substantial barrier. To reduce computational complexity, the novel ramp fraction loss SVM model called L-SVM is introduced.

A mini-invasive injectable hydrogel for temporomandibular joint osteoarthritis: Its pleiotropic effects and multiple pathways in cartilage regeneration.

There are two bottlenecks in the treatment of TMJOA (temporomandibular joint osteoarthritis): ① lacking of easy-to-use repairing materials for damaged condylar cartilage; ② local inflammation interfering with in situ regeneration. In response to them, we constructed a biomimetic tilapia type I gelatin/hyaluronic acid (TGI/HA) hydrogel in this paper. It was endowed with the capability to immunoregulate mircoenvironment and concurrently induce regeneration in multiple ways.

A Machine Vision Perspective on Droplet-Based Microfluidics.

Microfluidic droplets, with their unique properties and broad applications, are essential in in chemical, biological, and materials synthesis research. Despite the flourishing studies on artificial intelligence-accelerated microfluidics, most research efforts have focused on the upstream design phase of microfluidic systems. Generating user-desired microfluidic droplets still remains laborious, inefficient, and time-consuming.

Giant Photogalvanic Effect-Induced Terahertz Wave Emission in Wafer-Scale Type-II Dirac Semimetal PtTe.

Terahertz (THz) emission arising from the second-order nonlinear photocurrent effects in two-dimensional quantum materials has attracted significant attention due to its high efficiency and ease of polarization manipulation. However, in centrosymmetric quantum materials, the terahertz emission is typically suppressed, caused by the directional symmetry of the photocurrent generated under femtosecond laser excitation. In this work, we report that wafer-scale type-II Dirac semimetal PtTe with lattice centrosymmetry exhibits remarkably high THz emission efficiency (2 orders of magnitude greater than that of a ZnTe nonlinear crystal with equivalent thickness) and pronounced polarization sensitivity at room temperature.

Supramolecular DNA Nanodevice Assembled via RCA and HCR Cascade Reaction on Tetrahedral DNA Nanostructure for Sensitive Detection and Intracellular Imaging of Dual-miRNAs Associated with Liver Cancer.

Herein, a supramolecular DNA nanodevice was formed via the rolling circle amplification (RCA) and hybridization chain reaction (HCR) cascade reaction on a tetrahedral DNA nanostructure (TDN) to achieve simultaneous sensitive detection and intracellular imaging of dual-miRNAs related to liver cancer. The supramolecular DNA nanodevice effectively addressed the limitations of low probe loading capacity in traditional TDN nanodevices by enriching plenty of signal probes around a single TDN, significantly enhancing the fluorescence signal. Impressively, the supramolecular DNA nanodevice with a TDN fulcrum and dense DNA structure imparted the nanodevice with strong rigidity, ensuring the stability of the signal probes to decrease aggregation quenching for further increasing the fluorescence response.

Ancestral Nitrilase Mining and Semi-Rational Engineering for Enhanced Thermal Stability in Rapeseed Meals-Derived Nitriles Degradation.

Rapeseed meal (RSM), a protein-rich byproduct, holds potential as a high-quality animal feed, but nitrile compounds derived from glucosinolates (GSLs) in RSM pose a toxicity risk. Nitrilases, enzymes that hydrolyze toxic nitriles to carboxylic acids, offer a potential solution for detoxification. However, the low thermal stability of nitrilases restricts their industrial applicability.

Global Burden, Trends, and Inequalities of Gallbladder and Biliary Tract Cancer, 1990-2021: A Decomposition and Age-Period-Cohort Analysis.

Background: Gallbladder and biliary tract cancer (GBTC) increasingly aggravates the global malignancy burden. This study aimed to evaluate the updated condition of GBTC temporal burden trends and inequalities from 1990 to 2021.

Methods: Data on GBTC were extracted from the Global Burden of Disease (GBD) 2021 study.

Gene Associated with Breast Cancer: A Genetic and Bioinformatic Study.

Female breast cancer is the most common and the fifth deadliest cancer worldwide. It is influenced by a combination of genetic, hormonal, and environmental factors. The excision repair cross-complementation group 3 gene () has recently been identified as a breast cancer susceptibility gene in various cohorts of different geographical and ethnic origin.

Effect of Estrogen Receptor on the Relationship Between HER2 Immunohistochemistry Score and Pathological Complete Response to Neoadjuvant Treatment in HER2-Positive Breast Cancer.

We aimed to investigate whether estrogen receptor (ER) status affects the predictive role of the human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) score on the efficacy of neoadjuvant treatment for HER2-positive breast cancer. This retrospective study comprised 167 individuals diagnosed with HER2-positive invasive breast cancer who had undergone neoadjuvant treatment and surgery. Uni- and multivariable logistic regression analyses were performed on the relationship between the HER2 IHC score and total pathological complete response (tpCR), breast pathological complete response (bpCR), or axillary partial response (apCR).

Lanthanide (Substituted-)Cyclopentadienyl Bis(phosphinimino)methanediide Complexes: Synthesis and Characterization.

Design and synthesis of high-performance single-molecule magnets (SMMs) have long been a research focus. Inspired by the best dysprosium(III) metallocene SMMs and dysprosium(III) bis(methanediide) SMMs, we assumed dysprosium SMMs, which had electrical neutrality by combining the two types of ligands. As the Dy center is coordinated by one (substituted-)cyclopentadienyl (Cp) ligand and one methanediide ({C(PPhNSiMe)}) ligand on the axial sites, this ideal structure with linear C-Dy-Cp would strengthen the magnetic anisotropy and exhibit excellent SMM properties.

Numerical Homogenization Calculation of Effective Stiffness of Fused Deposition Modeling Printing Carbon Fiber Reinforced Polylactic Acid Composites.

The varied material and the inherent complex microstructure make predicting the effective stiffness of fused deposition modeling (FDM) printed polylactic acid (PLA)/carbon fiber (CF) composite a troublesome problem. This article proposes a microstructure scanning electron microscope (SEM) mapping modeling and numerical mean procedure to calculate the effective stiffness of FDM printing PLA/CF laminates. The printed PLA/CF parts were modeled as a continuum of 3D uniform linear elasticity with orthotropic anisotropy, and their elastic behavior was characterized by orthotropic constitutive relations.

Permeability and Porosity of Artificial-Similar Material for Biomimetic Geotechnical Engineering via Direct Ink Writing for Sustainability.

Direct ink writing of multiple mineral materials (M) coupled with simulation analysis is an optimization solution in accordance with low-carbon and sustainable manufacturing. It improves the ability to imitate natural biological iterative optimization, and accurately obtained data for geological model tests to effectively help prevent natural disasters. This article investigates the effects of equivalent materials on the direct ink writing and permeability behaviors through geological simulation models.

Integrated transcriptomic and proteomic analyses provide insights into the biosynthesis of Lycii fructus polysaccharides from different cultivation regions.

Polysaccharides from L. fructus (LFPs) serve as important active biomacromolecules for the wide spectrum of bioactivities exhibited by Lycii fructus. However, the influence of ecological environments on the biosynthesis and structural characteristics of LFPs remains largely unexplored.

Design and Regulation of Anthraquinone's Electrochemical Properties in Aqueous Zinc-Ion Batteries via Benzothiadiazole and Its Dinitro Derivatives.

Organic cathode materials are widely considered as highly promising for aqueous zinc-ion batteries (AZIBs) due to their tunable properties, low cost, and ease of processing and synthesis. Benzothiadiazoles have demonstrated significant potential as organic electrode materials in AZIBs, owing to their strong electron-accepting capabilities and the presence of multiple reversible redox sites in anthraquinone. In this study, we designed a polymer, poly(2-methyl-6-(7-methyl-5,6-dinitrobenzo[][1,2,5]thiadiazol-4-yl)anthracene-9,10-dione) (PBDQ), with multielectron transfer capability through a copolymerization approach.

Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment.

Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been reported that mitochondrial transfer is associated with the pathogenesis of multiple CVDs and obesity.