Enantioselective reductive cross-couplings to forge C(sp)-C(sp) bonds by merging electrochemistry with nickel catalysis.

Motivated by the inherent benefits of synergistically combining electrochemical methodologies with nickel catalysis, we present here a Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity. This catalytic reaction can not only be applied to aryl chlorides/bromides, which are challenging to access by other means, but also to benzyl chlorides containing silicon groups. Additionally, the absence of a sacrificial anode lays a foundation for scalability.

Quantification and optimization of platinum-molybdenum carbide interfacial sites to enhance low-temperature water-gas shift reaction.

Pt/α-MoC catalysts exhibit exceptional activity in low-temperature water-gas shift reactions. However, quantitatively identifying and fine-tuning the active sites has remained a significant challenge. In this study, we reveal that fully exposed monolayer Pt nanoclusters on molybdenum carbides demonstrate mass activity that exceeds that of bulk molybdenum carbide catalysts by one to two orders of magnitude at 100-200 °C for low-temperature water-gas shift reactions.

Coupling CuO clusters and imine-linked COFs on microfiltration membranes for fast and robust water sterilization.

As bacterial contamination crises escalate, the development of advanced membranes possessing both high flux and antibacterial properties is of paramount significance for enhancing water sterilization efficiency. Herein, an ultrathin layer of TbPa (an imine-linked covalent organic framework) and nanosized CuO clusters, sequentially deposited onto polyethersulfone membranes, demonstrate exceptional water flux performance, reaching a permeance level of 16000 LHM bar. The deposited TbPa, generating uniformly distributed reduction sites under illumination, facilitates the uniform formation of CuO clusters.

Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance.

The understanding of neuroimmune function has evolved from concepts of immune privilege and protection to a new stage of immune interaction. The discovery of skull meninges channels (SMCs) has opened new avenues for understanding central nervous system (CNS) immunity. Here, we characterize skull bone marrow and SMCs by detailing the anatomical structures adjacent to the skull, the differences between skull and peripheral bone marrow, mainstream animal processing methods, and the role of skull bone marrow in monitoring various CNS diseases.

Design, Structure Optimization, and Preclinical Characterization of JAB-21822, a Covalent Inhibitor of KRAS.

KRAS is the most frequently mutated driver oncogene in human cancer, and KRAS mutation is commonly found in non-small-cell lung cancer (NSCLC), colorectal cancer (CRC), and pancreatic ductal adenocarcinoma (PDAC). Inhibitors that covalently modify the mutated codon 12 cysteine have completed proof-of-concept studies in the clinic. Here, we describe structure-based design and cocrystal-aided drug optimization of a series of compounds with the 1,8-naphthyridine-3-carbonitrile scaffold.

Bias-Induced Ga-O-Ir Interface Breaks the Limits of Adsorption-Energy Scaling Relationships for High-Performing Proton Exchange Membrane Electrolyzers.

Rationally manipulating the in-situ formed catalytically active surface of catalysts remains a significant challenge for achieving highly efficient water electrolysis. Herein, we present a bias-induced activation strategy to modulate in-situ Ga leaching and trigger the dynamic surface restructuring of lamellar Ir@Ga2O3 for the electrochemical oxygen evolution reaction. The in-situ reconstructed Ga-O-Ir interface sustains high water oxidation rates at OER overpotentials.

Prediction-based rapid force control of a single-acting pneumatic cylinder under hysteresis nonlinearity.

Hysteresis characteristics widely affects the performance and reliability of pneumatic systems across various industrial applications. Addressing this challenge can significantly enhance system efficiency and precision. This paper aims to develop a rapid and accurate method for controlling the actuating force of a Single-Acting Pneumatic Cylinder (SAPC), considering hysteresis characteristic.

Brain-Computer Interface and Electrochemical Sensor Based on Boron-Nitrogen Co-Doped Graphene-Diamond Microelectrode for EEG and Dopamine Detection.

The simultaneous detection of electroencephalography (EEG) signals and neurotransmitter levels plays an important role as biomarkers for the assessment and monitoring of emotions and cognition. This paper describes the development of boron and nitrogen codoped graphene-diamond (BNGrD) microelectrodes with a diameter of only 200 μm for sensing EEG signals and dopamine (DA) levels, which have been developed for the first time. The optimized BNGrD microelectrode responded sensitively to both EEG and DA signals, with a signal-to-noise ratio of 9 dB for spontaneous EEG signals and a limit of detection as low as 124 nM for DA.

Diverse pathways for the treatment of Parkinson's disease: Integration and development of traditional and emerging therapies.

Parkinson's disease (PD) is the second most common central neurodegenerative disease in the world after Alzheimer's disease (AD), which mainly occurs in middle-aged and elderly people, and is increasing with the aging of the population. With the increasing incidence of PD, it is particularly important to explore its pathology and provide effective interventions and treatments. The pathogenesis of PD involves a variety of factors such as genetics, environment, and age, and is not yet fully understood.

Deep eutectic solvent-mediated extraction of lignin: A novel strategy for producing high-quality biopolymers in controlled-release mulching applications.

Microplastic contamination of low-density polyethylene mulch and nutrient loss from fertilizers present significant challenges in the crop-growing. In this study, the focus was on creating a biodegradable film that combines the advantages of plastic film, thermal insulation and water retention, as well as the controlled release of fertilizer. A key innovation was the efficient introduction of low molecular weight and low dispersibility of poplar lignin into chitosan and polyvinyl alcohol matrices.

Flame retardancy and durability of cotton fabric modified with high-efficiency diboraspiro rings groups flame retardant.

The synthesis of highly efficient and environmentally friendly flame retardants through the synergistic interaction of boron, phosphorus and nitrogen is becoming a new research direction. In this study, N-DBSPA, a flame retardant with high flame retardancy, high thermal stability and high efficiency, was prepared by the reaction between pentaerythritol borate and amino trimethylene phosphate, and the limiting oxygen index (LOI) of the modified cotton fabric increased from 18 % to 44.7 % at a weight gain (WG) of 20.

Targeted Gut Microbiome Therapy: Applications and Prospects of Probiotics, Fecal Microbiota Transplantation and Natural Products in the Management of Type 2 Diabetes.

Type 2 diabetes mellitus (T2DM) is considered as one of the most pressing public health challenges worldwide. Studies have shown significant differences in the gut microbiota between healthy individuals and T2DM patients, suggesting that gut microorganisms may play a key role in the onset and progression of T2DM. This review systematically summarizes the relationship between gut microbiota and T2DM, and explores the mechanisms through which gut microorganisms may alleviate T2DM.

Exploring the genetic causal inference between plasma lipidome and hemorrhagic stroke.

Objectives: Recent research indicates that the plasma lipidome composition may undergo alterations following hemorrhagic stroke. Nevertheless, the causal inference between plasma lipidome and hemorrhagic stroke remains elusive.

Materials And Methods: Exposure data were achieved from a recent Genome-wide Association Study (GWAS) study of 179 lipid species involving 7,174 individuals, while the outcome data were obtained from the FinnGen consortium (R10), including intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and non-traumatic intracranial hemorrhage (nITH).

Lung-targeted delivery of PTEN mRNA combined with anti-PD-1-mediated immunotherapy for In Situ lung cancer treatment.

mRNA-based protein replacement therapy has become one of the most widely applied forms of mRNA therapy, with lipid nanoparticles (LNPs) being extensively studied as efficient delivery platforms for mRNA. However, existing LNPs tend to accumulate in the liver or kidneys after intravenous injection, highlighting the need to develop vectors capable of targeting specific organs. In this study, we synthesized a small library of ionizable lipids and identified PPz-2R as a promising candidate, exhibiting lung-targeting capabilities, high mRNA transfection efficiency, and good stability through structure-activity relationship studies.

Regulatory networks of bZIPs in drought, salt and cold stress response and signaling.

Abiotic stresses adversely impact plants survival and growth, which in turn affect plants especially crop yields worldwide. To cope with these stresses, plant responses depend on the activation of molecular networks cascades, including stress perception, signal transduction, and the expression of specific stress-related genes. Plant bZIP (basic leucine zipper) transcription factors are important regulators that respond to diverse abiotic stresses.

Lift-CM: An integrated lift-heater centrifugal microfluidic platform for point-of-care pathogen nucleic acid detection using isothermal amplification and CRISPR/Cas12a.

Pathogen nucleic acid detection technology based on isothermal amplification and CRISPR/Cas12a system offers advantages in terms of high sensitivity, high specificity, and rapidity. However, this method has not been widely applied because of its shortcomings in utilizing conventional instruments, which cannot satisfy the requirements for Point of Care Testing (POCT), such as integration, convenience, and miniaturization. In this study, we developed an integrated lift-heater centrifugal microfluidic platform (Lift-CM) to automate the processes of isothermal amplification and CRISPR/Cas12a detection.

Development and validation of a prediction model of frailty risk in community-dwelling older adults: From a national longitudinal survey.

Objectives: This study aimed to develop and validate a risk prediction model for frailty in elderly using a nationally representative longitudinal survey database.

Study Design: Longitudinal study based on public databases.

Methods: Three continuous cohorts of elderly aged 65 years or older from the Chinese Longitudinal Healthy Longevity Survey, with the 2008-2018 cohort as the development cohort.

Algal organic matter alters protistan community structure and assembly processes in coastal sediments.

Diatom blooms are a global ecological perturbation that releases algal organic matter (AOM), significantly affecting coastal ecosystems by altering microbial community dynamics. AOM, derived from algal cell lysis, may serve as a nutrient source influencing protistan communities. However, the effects of AOM on protistan ecology, including the community structure and assembly processes, remain largely unexplored in coastal sediments.

Comprehensive multiomics analysis reveals the effects of French fries and chicken breast meat on the oxidative degradation of lipids in soybean oil during deep-frying.

This study investigated the oxidative degradation of lipids in soybean oil used for frying French fries (SOFFF) and chicken breast meat (SOFCBM) using integrated volatolomics and oxidative lipidomics. Water in the food matrix promotes triglyceride hydrolysis. The rate of lipid hydrolysis was higher in SOFCBM, whereas the rate of lipid oxidation was higher in SOFFF.

Experience of multidisciplinary cooperation in treating 15 extensively burned casualties：The Zhejiang LNG tanker explosion on 13 June 2020.

Background: On June 13, 2020, an explosion involving a liquefied natural gas (LNG) tanker truck occurred in eastern China. Fifteen patients with extremely severe burns (referred to as "June 13" patients) were treated in the burn-intensive care unit (ICU) joint ward within the general ICU.

Methods: A multidisciplinary treatment team comprising 129 doctors, 126 nurses, and 165 auxiliary staff members was assembled.

Hollow mesoporous silica nanoparticles for drug formulation and delivery: Opportunities for cancer therapy.

The advantages of large surface area, high volume ratio, good biocompatibility, and controllable surface functionalization make hollow mesoporous silica nanoparticles (HMSNs) an ideal drug carrier. HMSNs can achieve high efficiency, targeting, and controlled release by adjusting the microstructure and surface modification of its particles, which makes it broad application prospects in the field of medical therapy, especially in cancer therapy. Numerous studies have shown that preparation method, shape, particle size, hollow inner diameter, aperture and wall thickness of the HMSNs, the characteristics of the drugs, the interaction between the drugs and the carriers, and the external environment all closely affect the drug delivery, release, and efficacy.

The global, regional, and national late-life depression burden and trends from 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021.

Background: Late-life depression (LLD) represents a growing global public health concern. This study aimed to assess the worldwide burden of LLD using comprehensive data.

Methods: Leveraging the latest evidence from the Global Burden of Disease Study, we analyzed trends in LLD burden from 1990 to 2021, encompassing incidence, prevalence, and disability-adjusted life years (DALYs).

Auriculotherapy may help to reduce gastrointestinal reactions and improve quality of life post chemotherapy.

Aim: To compare the effectiveness of auriculotherapy in managing nausea and vomiting caused by platinum-based chemotherapy METHODS: 96 patients with gastrointestinal cancer undergoing platinum chemotherapy were randomly divided into three groups, with 32 patients in each group. The control group received conventional treatment, including 5-hydroxytryptamine 3 receptor antagonist and routine nursing care; the remaining two groups received additional auricular point sticking or ear scraping. The outcomes measured included the incidence and frequency of acute and delayed nausea and vomiting, severity of nausea, appetite, and quality of life function index 24 h and 5 d post chemotherapy.

Design and synthesis of fluorinated polyimides with low thermal expansion and enhanced dielectric properties.

Modern microelectronics industries urgently require dielectric materials with low thermal expansion coefficients, low dielectric constants, and minimal dielectric loss. However, the design principles of materials with low dielectric constants and low thermal expansion are contradictory. In this study, a new diamine monomer containing a dibenzocyclooctadiene unit (DBCOD-NH) was designed and synthesized, which was subsequently polymerized with high fluorine content 4,4'-hexafluoroisopr-opylidene diphthalic anhydride and 4,4'-diamino-2,2'-bis(trifleoromethyl)biphenyl to obtain a series of fluorinated polyimides (PIs).