Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue.

Obesity and its related metabolic disorders seriously threaten our health and significantly reduce our life expectancy. The aim of the present study was to explore the effects of bone marrow mesenchymal stem cells (BMSCs) on high-fat diet (HFD)-induced obesity mice. The results demonstrated that BMSCs significantly reduced body weight, improved glucose tolerance and insulin sensitivity in obese mice.

Amplification of benzo[a]pyrene toxicity persistence in earthworms by polystyrene nanoplastics: From organismal health to molecular responses.

Typically, nanoplastics (NPs) are contaminated before entering soil, and the impact of NPs on the biotoxicity of Persistent Organic Pollutants (POPs) they carry remains unclear. This study simulated two environmentally relevant scenarios: singular exposure of benzo[a]pyrene (BaP) in soil and exposure via NPs loading (NP-BaP). Correlation analysis and machine learning revealed that injury in earthworms exposed for 28 days was significantly associated with NPs.

Differentiated distribution between albumen, yolk and eggshell of parents and metabolites neonicotinoids and their reproductive exposure risk.

Differential distribution of neonicotinoids (NEOs) in albumen, yolk, and eggshell is a critical factor influencing their bio-accumulative behavior and the subsequent human health risks. However, there is currently no relevant research available. We collected 62 egg samples from 31 sampling sites across China and analyzed the concentrations and characteristics of 12 parents NEOs (p-NEOs) and 8 metabolites NEOs (m-NEOs) in albumen, yolk, and eggshell.

The smartphone-assisted sensing platform based on manganese dioxide nanozymes for the specific detection and degradation of hydroquinone.

Hydroquinone (HQ) is a prevalent pollutant in aquatic environments, posing significant risks to ecosystems and human health. Practical methods for the simultaneous detection and degradation of HQ are essential. To address this requirement, a dual-mode detection and degradation strategy has been developed utilizing designed nanozymes (DM) consisting of a porous SiO core and MnO shell.

Hepatic arterial infusion chemotherapy enhances the efficacy of lenvatinib and PD-1 inhibitors for advanced hepatocellular carcinoma: A meta-analysis and trial sequential analysis.

Background: Hepatic arterial infusion chemotherapy (HAIC) was an effective treatment for advanced hepatocellular carcinoma (HCC), and its effectiveness in combination with targeted immunotherapy regimens was controversial. This meta-analysis was performed to evaluate the efficacy of adding HAIC to lenvatinib in combination with programmed death-1 (PD-1) inhibitors.

Methods: Literature related to the efficacy of HAIC in combination with lenvatinib plus PD-1 inhibitors in the treatment of advanced HCC was searched through PubMed, Cochrane Library, Embase, and Web of Science databases.

Prenatal diagnosis and molecular cytogenetic analyses of a rare 17q12 microduplication family.

Objective: To report a rare 17q12 microduplication family.

Case Report: A 29-year-old woman (gravida 1, para 0) underwent amniocentesis at 21 weeks' gestation because of double bubble sign and polyhydramnios of the fetus on prenatal ultrasound. Chromosomal microarray analysis (CMA) from this family revealed a 1.

Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents.

Background: Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked to the development of childhood obesity. However, the evidence is limited.

Template-assembly activation of primer exchange reaction for on-site and sensitive detection of copper ions in blood.

The sensitive and accurate detection of copper ions is crucial for public health, medical research, and environmental monitoring. In this study, we developed a sensor based on template-assembly activation of the primer exchange reaction (PER) for the on-site detection of copper ions in blood. Copper ions triggered the assembly of two template fragments into a hairpin structure via a click-chemistry reaction, activating the PER.

Trace detection of antibiotics in wastewater using tunable core-shell nanoparticles SERS substrate combined with machine learning algorithms.

Surface-enhanced Raman scattering (SERS) show great potential for rapid and highly sensitive detection of trace amounts of contamination from the environment in the surface aquatic ecosystem. The widespread use of antibiotics has resulted in serious degradation of the water environment in the past few years, and their substantial residual contamination of wastewater has a harmful effect on ecosystems, which is associated with the development of antibiotic-resistant bacterial strains. However, in this study, a novel approach of core-shell nanoparticles GNRs@1,4-BDT@Ag was used for the quantitative measurement of the concentration of antibiotics in wastewater solutions using the SERS technique coupled with computational methods.

Self-calibrating temperature sensing strategy based on KBaY(MoO):Pr phosphor luminescence characteristics with excellent relative temperature sensitivity.

Non-contact temperature sensors have gained immense popularity due to their inherent benefits, including the absence of physical interaction with targets and rapid response characteristics. In this work, KBaY(MoO):Pr was successfully synthesized utilizing a high-temperature solid-phase method. Experimental studies have indicated that multi-phonon relaxation (MPR), cross-relaxation (CR), and the unique intervalence charge transfer state (IVCT) exhibited by Pr-Mo contribute to the changes in luminescence properties.

Single-cell RNA sequencing of the spleen reveals differences in Salmonella typhimurium infection mechanisms between different chicken breeds.

Bacterial infections remain an important cause of morbidity in poultry production. The molecular characteristics and dynamic changes in immune cell populations after bacterial infection have yet to be fully understood. Beijing-You chicken and Cobb broiler, two broiler breeds with different disease resistance, were infected with Salmonella typhimurium, and inflammation models were constructed.

Beneficial effects of ε-polylysine on growth performance, antioxidant capacity, intestinal morphology, and gut microbiota in broilers fed a lysine-deficient diet.

This study was conducted to investigate the effects of dietary ε-polylysine supplementation on growth performance, antioxidant capacity, intestinal morphology, and gut microbiota in broilers fed a lysine-deficient diet. A total of 960 one-day-old yellow-feathered broilers were randomly allocated into six groups with eight replicates and 20 birds per replicate. Birds in the six groups were fed a lysine-deficient basal diet (-0.

Characterization and comparative transcriptomic analysis of high-altitude adaptation in Tibetan chicken using RNA-sequencing.

Tibetan chicken, an indigenous breed, inhabit highland regions and are crucial livestock for local Tibetans. Compared with other chicken breeds that have migrated from lowlands to highlands, Tibetan chicken exhibits superior physiological adaptations to high-altitude environments. However, the genetic mechanisms underlying these adaptations remain unclear.

Comparative impact of exercise variants on depressive symptoms in cancer patients: A systematic review and network meta-analysis.

Purpose: The aim of this study was to conduct a network meta-analysis to assess the effectiveness of various forms of exercise as an intervention for post-cancer depression and to provide a guiding program based on evidence-based medicine for subsequent clinical practice.

Methods: This review was registered on the PROSPERO website with ID CRD42023485407. Pubmed, Embase, Cochrane Library, and Web of Science were comprehensively searched to obtain published articles from the establishment of the database until October 7, 2023.

A novel electrochemical biosensor based on TiO nanotube array films for highly sensitive detection of exosomes.

Exosomes have emerged as a powerful biomarker for early cancer diagnosis, however, accurately detecting cancer-derived exosomes in biofluids remains a crucial challenge. In this study, we present a novel label-free electrochemical biosensor utilizing titanium dioxide nanotube array films (TiONTAs) for the sensitive detection of exosomes in complex biological samples. This innovative biosensor takes advantage of the excellent electrochemical properties of TiONTAs and their specific interactions with the phosphate groups of exosomes.

Translation and psychometric validation of the Peer Evaluation Scale for Team-based Learning (PES-TBL) for Chinese medical students.

Aim: To translate, culturally adapt and evaluate the psychometric properties of the Peer Evaluation Scale for Team-based Learning (PES-TBL) for students in nursing and medical disciplines.

Background: Effective peer evaluation tools provide a more scientific and objective assessment of collaborative learning. However, there is a lack of peer evaluation instruments designed for group learning in China.

Application of minimally invasive debridement for deep second-degree facial burns in the early postburn phase.

Objective: This study aimed to evaluate the therapeutic efficacy of minimally invasive dermabrasion for deep second-degree facial burn wounds during the early postburn phase.

Methods: A total of 35 patients with deep second-degree facial burns underwent minimally invasive debridement using a hydrosurgery system within 2-4 days post-injury. Subsequently, the wounds were covered with human biological dressings.

Two-dimensional Czochralski growth of single-crystal MoS.

Batch production of single-crystal two-dimensional (2D) transition metal dichalcogenides is one prerequisite for the fabrication of next-generation integrated circuits. Contemporary strategies for the wafer-scale high-quality crystallinity of 2D materials centre on merging unidirectionally aligned, differently sized domains. However, an imperfectly merged area with a translational lattice brings about a high defect density and low device uniformity, which restricts the application of the 2D materials.

Designer topological-single-atom catalysts with site-specific selectivity.

Designing catalysts with well-defined, identical sites that achieve site-specific selectivity, and activity remains a significant challenge. In this work, we introduce a design principle of topological-single-atom catalysts (T-SACs) guided by density functional theory (DFT) and Ab initio molecular dynamics (AIMD) calculations, where metal single atoms are arranged in asymmetric configurations that electronic shield topologically misorients d orbitals, minimizing unwanted interactions between reactants and the support surface. Mn/CeO catalysts, synthesized via a charge-transfer-driven approach, demonstrate superior catalytic activity and selectivity for NO removal.

RNA mA involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.

Cadmium has been identified as an environmental pollutant and a carcinogen. N-methyladenosine (mA) plays a crucial role in the development of lung tumors, but the mechanisms remain incompletely clarified. In present study, our data demonstrated that prolonged treatment of 1 μmol/L CdSO for 40 passages in bronchial epithelial cells (Beas-2B cells) resulted in the development of a malignant phenotype, which manifested as boosted proliferation, migration and invasion capacity as well as apoptosis reduction.

MOFs-derived porous carbon embedded Fe nanoparticles as peroxymonosulfate activator for efficient degradation of organic pollutants.

Achieving the harmless degradation of organic pollutants remains a challenging task for the advanced oxidation processes. Metal-organic frameworks have emerged in the field of energy and environmental catalysis. Herein, MIL-101(Fe) was employed as the precursor to prepare a porous carbon embedded Fe nanoparticles (Fe@C) via a pyrolytic process under N protection.

Construction of non-noble decorated Z-scheme Bi-BiVO-BiTiO for enhanced full solar-spectrum driven photocatalytic activity.

Currently, to deal with the increasingly severe energy crisis and environmental consequences, photocatalytic technology is considered as a promise solution, and the construction of Z-scheme heterostructures are important strategies to maximize the utilization of solar energy and improve photocatalytic performance. Herein, a novel full spectrum-responsive Z-scheme Bi-BiVO-BiTiO heterojunction was constructed by a facile hydrothermal method without any templates or surfactants. A series of detailed analyses revealed that the novel Bi-BiVO-BiTiO heterojunction catalyst were prepared successfully.

Ultrasound-laccase pre-treatment enhances agarwood essential oil extraction and bioactivity.

Agarwood essential oil is prized for its elegant aroma and pharmacological properties; however, the traditional hydrodistillation method suffers from inefficiencies, constraining the industrial potential of agarwood. We proposed an ultrasonic-assisted laccase synergistic pretreatment technique that enhanced extraction throughput by 70.90 % compared to the traditional method by facilitating pore formation in agarwood and expediting the release of essential oil.

Chemical activation of cotton fibers with varied regents induces distinct morphology of activated carbon and adsorption capacity of methylene blue.

Some biomasses like cotton contain natural fibrous structures. This is a desirable structural feature for exposure of adsorption sites on cotton-derived activated carbon (AC). This was verified herein by conducting activation of cotton with ZnCl, HPO, KCO or KOH, probing whether structural transformation during activation could be confined inside a cotton fiber.