Identification of a functional vitamin D response element in the promoter of goose anti-Müllerian hormone gene.

Anti-Müllerian hormone (AMH) plays an important role in avian ovarian follicle development. The high mRNA expression of AMH in avian ovarian prehierarchical follicles helps prevent premature granulosa cell differentiation. Vitamin D3 was reported to downregulate AMH mRNA expression in granulosa cells of prehierarchical follicles in hens; however, the underlying molecular mechanism remains unknown.

SEEG seizure onset patterns in mesial temporal lobe epilepsy: A cohort study with 76 patients.

Objectives: In the present study with a large cohort, we aimed to characterize intracerebral seizure onset patterns (SOP) of mesial temporal lobe epilepsy (mTLE), with or without hippocampal sclerosis (HS) as identified via magnetic resonance imaging (MRI).

Methods: We retrospectively analyzed 255 seizures of 76 consecutive patients with mTLE explored by stereoelectroencephalography (SEEG), including HS-mTLE (n = 52) and non-HS- mTLE (n = 24). Relevant results were obtained by a combination of spectral analysis and manual review.

Prognosis prediction and drug guidance of ovarian serous cystadenocarcinoma through mitochondria gene-based model.

Background: Mitochondrial dysregulation contributes to the chemoresistance of multiple cancer types. Yet, the functions of mitochondrial dysregulation in Ovarian serous cystadenocarcinoma (OSC) remain largely unknown.

Aim: We sought to investigate the function of mitochondrial dysregulation in OSC from the bioinformatics perspective.

Thioether functionalized degradable poly(amino acids) and its calcium sulfate/calcium hydrogen phosphate composites: Reducing oxidative stress and promoting osteogenesis.

The imbalance of redox homeostasis, especially the abnormal levels of reactive oxygen species (ROS), is a key obstacle in the bone repair process. Therefore, developing materials capable of scavenging ROS and modulating the microenvironment of bone defects is crucial for promoting bone repair. In this study, to endow poly(amino acids) (PAA) and its composites with anti-oxidative stress properties and enhanced osteogenic differentiation, we designed and prepared a calcium sulfate/calcium hydrogen phosphate/poly(amino acids) (PCDM) composite material with a thioether structure (-S-) in the molecular chain of PAA matrix through situ polymerization and physical blending method.

Diamide insecticides in PM: The unreported rural and urban air pollutants.

The broad application of various pesticides guarantees the development of agriculture all over the word but has ultimately led to their ubiquitous release into the environment as hazardous chemical residues. Diamide insecticides (DAIs) are regarded as new choice for prevention and protection of agricultural crops and city landscaping plants from the pests in more and more countries. However, their presence in fine particulate matter (PM) and associated health risks have not been studied.

The fate of intracellular and extracellular antibiotic resistance genes during ultrafiltration-ultraviolet-chlorination in a full-scale wastewater tretament plant.

Effluent from wastewater treatment plants (WWTPs) is recognized as a significant source of antibiotic resistance genes (ARGs) in the environment. Advanced treatment processes such as ultrafiltration (UF), ultraviolet (UV) light disinfection, and chlorination have emerged as promising approaches for ARG removal. However, the efficacy of sequential disinfection processes, such as UF-UV-chlorination on intracellular (iARGs) and extracellular ARGs (eARGs), remains largely unknown.

Electrochemical destruction of PFAS at low oxidation potential enabled by CeO electrodes utilizing adsorption and activation strategies.

The persistence and ecological impact of per- and poly-fluoroalkyl substances (PFAS) in water sources necessitate effective and energy-efficient treatment solutions. This study introduces a novel approach using cerium dioxide (CeO) electrodes enhanced with oxygen vacancy (O) to catalyze the defluorination of PFAS. By leveraging the unique affinity between cerium and fluorine-containing species, our approach enables adsorptive preconcentration and catalytic degradation at low oxidation potentials (1.

Magnetic field-oriented conductive decellularized extracellular matrix hydrogel synergizes with electrical stimulation to promote spinal cord injury repair and electrophysiological function restoration.

Spinal cord injury (SCI) results in electrophysiological and behavioral dysfunction. Electrical stimulation (ES) is considered to be an effective treatment for mild SCI; however, ES is not applicable to severe SCI due to the disruption of electrical conduction caused by tissue defects. Therefore, the use of conductive materials to fill the defects and restore electrical conduction in the spinal cord is a promising therapeutic strategy.

Two-dimensional identification of lower limb gait features based on the variational modal decomposition of sEMG signal and convolutional neural network.

Background: Gait feature recognition is crucial to improve the efficiency and coordination of exoskeleton assistance. The recognition methods based on surface electromyographic (sEMG) signals are popular. However, the recognition accuracy of these methods is poor due to ignoring the correlation of the time series of sEMG signals.

Multi-functional electrochemiluminescence biosensor for efficient capture, elimination, and sensitive monitoring of Staphylococcus aureus.

In this study, we developed a novel strategy for effective bacteria capture, elimination, and detection. The aptamer of Staphylococcus aureus (S. aureus) was immobilized on FeO NPs and partly hybridized with the T strand, which exhibited good bacterial capture efficiency.

Polarity-Sensitive fluorescent probes based on triphenylamine for fluorescence lifetime imaging of lipid droplets.

Non-alcoholic fatty liver disease (NAFLD) is a disease closely associated with metabolic abnormalities. Lipid droplets (LDs) serve as organelles that store intracellular neutral lipids and maintain cellular energy homeostasis. Their abnormalities can cause metabolic disorders and disease, which is also one of the distinctive characteristics of NAFLD patients.

Acetochlor degradation in anaerobic microcosms with hyporheic sediments: Insights from biogeochemical data, transformation products, and isotope analysis.

Steep redox gradients and diverse microbial communities in the anaerobic hyporheic zone create complex pathways for the degradation of herbicides, often linked to various terminal electron-accepting processes (TEAPs). Identifying the degradation pathways and their controlling factors under various TEAPs is of great significance for understanding mechanisms of water purification in the hyporheic zone. However, current research on herbicides in this area remains insufficient.

Ultrathin zwitterionic COF membranes from colloidal 2D-COF towards precise molecular sieving.

Membrane technology is an important component of resource recovery. Covalent organic frameworks (COFs) with inherent long-range ordered structure and permanent porosity are ideal materials for fabricating advanced membrane. Zwitterionic COFs have unique features beyond single ionic COFs containing anions or cations.

Self-driven electrochemical system for struvite and energy recovery from digested wastewater: Device optimization strategy and long-term operation.

A self-driven electrochemical system (SDES) was utilized to treat anaerobic digestate wastewater, aiming to achieve wastewater resource utilization and energy generation. The efficiencies of pollutant removal, resource recovery, and energy production were enhanced by adjusting device parameters (anode area, external resistance, and electrode spacing). The high pollutant removal rates and struvite purity were achieved with the magnesium anode area of 15 cm, external resistance of 10 Ω, and electrode spacing of 10 cm.

Magnetic nanoparticle modified moss Biochar: A novel solution for effective removal of enrofloxacin from aquaculture water.

The presence of residual antibiotics in water constitutes a potential threat to aquatic environments. Therefore, designing environmentally friendly and efficient biochar adsorbents is crucial. Aquaculture by-product moss (bryophyte) was transformed into biochar, which can eliminate antibiotics from wastewater through adsorption.

Co-application of hydrothermal carbonization aqueous phase and biogas slurry reduced ammonia volatilization in paddy.

Application of biogas slurry (BS) can promote ammonia (NH) volatilization. Algae sludge and Quercus acutissima leaves are rich in resources and nutrients, and can be effectively converted into valuable products. Hydrothermal carbonization technology (HTC) is a sustainable method for the treatment of wet biomass.

Atomically Dispersed Metal-Nitrogen-Carbon Catalysts for Acidic Oxygen Reduction Reaction.

Designing efficient and cost-effective electrocatalysts toward oxygen reduction reaction (ORR) under demanding acidic environments plays a critical role in advancing proton exchange membrane fuel cells (PEMFCs). Metal-nitrogen-carbon (M-N-C) catalysts with atomically dispersed metals have gained attention for their affordability, excellent catalytic performance, and distinctive features including consistent active sites and high atomic utilization. Over the past decade, significant achievements have been made in this field.

A prospective, phase II, neoadjuvant study based on chemotherapy sensitivity in HR+/HER2- breast cancer-FINEST study.

Background: Hormone receptor-positive (HR+)/humaal growth factor receptor 2-negative (HER2-) breast cancer, the most common breast cancer type, has variable prognosis and high recurrence risk. Neoadjuvant therapy is recommended for median-high risk HR+/HER2- patients. This phase II, single-arm, prospective study aimed to explore appropriate neoadjuvant treatment strategies for HR+/HER2- breast cancer patients.

Characteristics of Soluble PD-L1 and PD-1 Expression and Their Correlations With Immune Status and Prognosis in Advanced Lung Cancer.

Purpose: Our study aims to evaluate the characteristics of serum soluble PD-1 (sPD-1) and soluble PD-L1 (sPD-L1) levels and their correlations with immune status and prognosis in advanced lung cancer patients.

Methods: Patients diagnosed with advanced lung cancer based on histology or cytology in Peking University People's Hospital from July 2020 to November 2021 were enrolled. Clinicopathological data were recorded and analyzed.

APOM Modulates the Glycolysis Process in Liver Cancer Cells by Controlling the Expression and Activity of HK2 via the Notch Pathway.

The metabolic pathway of aerobic glycolysis in tumor cells has garnered significant attention in tumor research because of its high activation in cancer cells. Previous research conducted by our team has demonstrated that Apolipoprotein M (APOM) exhibits potential as a factor against liver cancer. However, further investigations are needed to elucidate the precise approach and mechanism that are involved in this process.

Sorghum grain as a bio-template: emerging, cost-effective, and metal-free synthesis of C-doped g-CN for photo-degradation of antibiotic, bisphenol A (BPA), and phenol under solar light irradiation.

Due to the industry's rapid growth, the presence of organic pollutants, especially antibiotics, in water and wastewater resources is the main concern for wildlife and human health. Therefore, these days, a significant challenge is developing an efficient, sustainable, and eco-friendly photocatalyst. Natural biological models have numerous advantages compared to artificial model materials.

Chiral Nanostructures from Artificial Helical Polymers: Recent Advances in Synthesis, Regulation, and Functions.

Helical structures such as right-handed double helix for DNA and left-handed α-helix for proteins in biological systems are inherently chiral. Importantly, chirality at the nanoscopic level plays a vital role in their macroscopic chiral functionalities. In order to mimic the structures and functions of natural chiral nanoarchitectures, a variety of chiral nanostructures obtained from artificial helical polymers are prepared, which can be directly observed by atomic force microscopy (AFM), scanning tunneling microscopy (STM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

High-Performance Thermoelectric Composite of BiTe Nanosheets and Carbon Aerogel for Harvesting of Environmental Electromagnetic Energy.

Intensifying the severity of electromagnetic (EM) pollution in the environment represents a significant threat to human health and results in considerable energy wastage. Here, we provide a strategy for electricity generation from heat generated by electromagnetic wave radiation captured from the surrounding environment that can reduce the level of electromagnetic pollution while alleviating the energy crisis. We prepared a porous, elastomeric, and lightweight BiTe/carbon aerogel (CN@BiTe) by a simple strategy of induced in situ growth of BiTe nanosheets with three-dimensional (3D) carbon structure, realizing the coupling of electromagnetic wave absorption (EMA) and thermoelectric (TE) properties.

Anisotropic Plasmon Resonance in TiCT MXene Enables Site-Selective Plasmonic Catalysis.

The ever-growing interest in MXenes has been driven by their distinct electrical, thermal, mechanical, and optical properties. In this context, further revealing their physicochemical attributes remains the key frontier of MXene materials. Herein, we report the anisotropic localized surface plasmon resonance (LSPR) features in TiCT MXene as well as site-selective photocatalysis enabled by the photophysical anisotropy.

Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy.

The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due to their defects in inducing potent ICD signaling. Here, we report a dual-enzyme-instructed peptide self-assembly platform of (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) to promote ICD and engage systemic adaptive immunity for tumor rejection.