443,035 results match your criteria: "PR China; Anhui Provincial Institute of Stereotactic Neurosurgery[Affiliation]"

A heparinase III (NsHep-III) from Niabella sp. was identified, cloned, and expressed as soluble form in E. coli BL21 (DE3).

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Point-of-care testing methods are essential for the large-scale diagnosis and monitoring of bacterial infections. This study introduces an integrated platform designed for the simultaneous detection of pathogenic bacteria. Users can simply inject samples into the system, which then conducts the entire procedure in a fully automated manner, eliminating the need for external power sources, all within 60 min or less.

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The occurrence of chemical effluents in different water bodies is an emerging concern. However, the effect of laboratory effluents on the canal ecosystem in Bangladesh is largely unknown. In this study, we collected 10 components of the canal ecosystem including sediments, water, fish, crabs, snails, phytoplanktons, and weeds specifically from canals that directly receive laboratory effluents.

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Comparison of crossed and parallel rod configurations used in posterior occipitocervical and atlantoaxial fixations: a retrospective cohort study.

J Orthop Surg Res

December 2024

The First School of Clinical Medicine, Southern Medical University, No.1838 North of Guangzhou Road, Guangzhou, 510515, People's Republic of China.

Background: This study is aimed to compare the differences in clinical outcomes between the crossed rod configuration and the parallel rod configuration applied in posterior occipitocervical and atlantoaxial fixations, and to assess the clinical applicability of crossed rods.

Methods: From January 2015 to December 2021, 21 patients with craniocervical junction disorders were treated surgically with the crossed rod technique (CR group). Meanwhile, 27 corresponding patients treated with the conventional parallel rod technique were included as control (PR group).

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End-to-end multi-scale residual network with parallel attention mechanism for fault diagnosis under noise and small samples.

ISA Trans

December 2024

Faculty of Mechanical and Civil Engineering, Department of Automatic Control, Robotics and Fluid Technique, University of Kragujevac, Kraljevo 36000, Serbia. Electronic address:

When the fault diagnosis datasets contains noise disturbances, small samples, compound faults, and mixed conditions, the feature extraction capability of the neural network will face significant challenges. This paper proposes an end-to-end multi-scale residual network with parallel attention mechanism to address the above complex problems. Firstly, the adaptive mixing pooling method is employed to facilitate the model's ability to retain effective feature information present within the timing signal.

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A generalized maximum correntropy based constraint adaptive filtering: Constraint-forcing and performance analyses.

ISA Trans

December 2024

School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, PR China. Electronic address:

The quadratic cost functions, exemplified by mean-square-error, often exhibit limited robustness and flexibility when confronted with impulsive noise contamination. In contrast, the generalized maximum correntropy (GMC) criterion, serving as a robust nonlinear similarity measure, offers superior performance in such scenarios. In this paper, we develop a recursive constrained adaptive filtering algorithm named recursive generalized maximum correntropy with a forgetting factor (FF-RCGMC).

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Wastewater-based monitoring of antipyretics use during COVID-19 outbreak in China and its associated ecological risks.

Environ Res

December 2024

Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, 100871 Beijing, PR China. Electronic address:

At the end of 2022, a sudden policy shift in China triggered an unprecedented COVID-19 outbreak that led to a dramatic increase in the consumption of antipyretics. In this study, the occurrence of the two most commonly used antipyretics (ibuprofen and paracetamol) and their metabolites were analyzed in the wastewater of nine major cities in China, covering the periods before, during, and after the policy change. The remarkable surge after the policy change for ibuprofen and paracetamol reached 67 times (in Nanning) and 311 times (in Lanzhou) compared to pre-pandemic levels, respectively.

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The Association of Red Blood Cell Transfusion with Mortality in Pediatric Patients with Sepsis, Severe Sepsis, and Septic Shock: a single-center retrospective cohort study.

Transfus Clin Biol

December 2024

Department of Blood Transfusion, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province, P.R. China. Electronic address:

Background/objectives: Pediatric patients with sepsis are frequently subjected to red blood cell (RBC) transfusions but yet its association with mortality is still controversial.

Methods: We consecutively selected 125 patients with sepsis, severe sepsis, and septic shock admitted to intensive care unit (ICU) in our center from January 2022 to January 2023, and finally 100 patients were included in this retrospective cohort study. The patients were divided into two groups: group I who received RBC transfusion and group II who did not receive RBC transfusion.

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Introduction: Spinal arachnoiditis (SA) involves chronic inflammation of the spinal arachnoid membrane, often due to surgery, trauma, infections, or autoimmune issues. It leads to ongoing pain and sensory disturbances in the back and lower limbs, along with possible bladder and bowel issues. Treatments focus on symptom relief and improving life quality.

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Intermittent Social Isolation Enhances Social Investigation but Impairs Social Memory in Adult Male Mice.

Physiol Behav

December 2024

School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing, PR China; The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, The School of Life Science and Technology, Southeast University, 2 Sipailou Road, Nanjing, PR China. Electronic address:

Social isolation profoundly impacts motivated behavior and neural plasticity. While the effects of acute and chronic social isolation have been extensively studied, the consequences of intermittent isolation during adulthood, particularly relevant to modern lifestyles, remain poorly understood. This study investigated the impact of intermittent social isolation (ISI) on social behavior and brain activation in adult male mice.

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Halcinonide activates smoothened to ameliorate ischemic stroke injury.

Life Sci

December 2024

School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China; State Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Lanzhou University, Lanzhou 730000, PR China; Southeast Research Institute, Lanzhou University, Lanzhou 730000, PR China. Electronic address:

Objectives: The Shh pathway may shed new light on developing new cell death inhibitors for the therapy of ischemic stroke. We aimed to examine whether the Shh co-reporter SMO or its agonist halcinonide can upregulate Bcl-2 to suppress neuronal cell death, ultimately improving behavioral deficits and reducing cerebral infarction in an ischemic stroke model.

Methods: Halcinonide or genetic manipulation of SMO was conducted in PC12 cells to examine their impacts on oxidative or OGD/R stress, and the chemical, along with AAV-SMO or AAV-EGFP were tested in MCAO rats to investigate their potential protective effects against neuronal damages due to cerebral I/R injury.

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Bovine serum albumin (BSA) is one of the most abundant proteins in serum, and its high-throughput detection is still one of the current challenges. Nitrogen‑phosphorus co-doped carbon dots (CDs) were synthesized by a hydrothermal method. Adenosine monophosphate (AMP) was used as a precursor for the synthesis of CDs, providing the required carbon, nitrogen and phosphorus sources for the CDs.

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Gut microbiome and obesity in late adolescence: a case-control study in "Children of 1997" birth cohort.

Ann Epidemiol

December 2024

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, PR China.

Purpose: Although the gut microbiome is important in human health, its relation to adolescent obesity remains unclear. Here we assessed the associations of the gut microbiome with adolescent obesity in a case-control study.

Methods: In the "Children of 1997" birth cohort, participants with and without obesity at ~17.

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Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.

Metabolism

December 2024

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background: Delineating the shared genetic architecture of type 2 diabetes with muscle mass and function and frailty is essential for unraveling the common etiology and developing holistic therapeutic strategies for these co-existing conditions.

Methods: In this genome-wide pleiotropic association study, we performed multi-level pairwise trait pleiotropic analyses using genome-wide association study summary statistics from up to 461,026 European ancestry individuals to dissect the shared genetic factors and causal relationships of type 2 diabetes and seven glycemic traits with four muscle mass- and function-related phenotypes and the frailty index.

Results: We first identified 27 pairs with significant genetic correlations through the linkage disequilibrium score regression and high-definition likelihood analysis.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint deformity and ultimately disability. The metabolite of quercetin, 4-Methylcatechol (4-MC), has been acknowledged for its anti-inflammatory and antioxidant properties; however, the protective effects of 4-MC on RA and its underlying mechanisms remain incompletely elucidated. In a collagen-induced arthritis (CIA) model, we observed that 4-MC effectively mitigated joint inflammation and bone destruction in CIA mice.

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Fluorescent biosensor for ultra-stability detection of Pax-5a based on a double cascade amplification strategy.

Spectrochim Acta A Mol Biomol Spectrosc

December 2024

Key Laboratory of Energy Catalysis and Conversion of Nanchang, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, PR China. Electronic address:

The development of B-lymphoblastic leukemia is tightly associated with aberrant expression of Pax-5a. This work presented a novel dual signal amplification strategy-based Pax-5a detection method by combining the rolling circle amplification reaction (RCA) and the Entropy-driven toehold-mediated strand displacement (ETSD). Particularly noteworthy is the employed ETSD, which effectively improves the rate and stability of the reaction due to its unique entropy-driven principle.

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A fluorescent signal amplification strategy via host-guest recognition for cortisol detection.

Spectrochim Acta A Mol Biomol Spectrosc

December 2024

School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, Guangdong 518060, PR China.

Psychological stress is a major contributor to individual health disparities. Accurate and quantitative detection of stress markers is crucial preventing mental health related problems. Supramolecular chemistry is widely used in drug delivery, catalysis, sensors and other applications.

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Dual-mode exosome detection leveraging a nanozyme-active artificial receptor: PDA@Fe@Zn-based nucleic acid aptamer sensor.

Talanta

December 2024

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, PR China. Electronic address:

Exosomes, extracellular vesicles crucial for intercellular communication, are emerging as significant biomarkers for disease diagnosis, especially in cancer. This study presented a dual-mode exosome detection platform using polydopamine microspheres doped with iron and zinc ions (PDA@Fe@Zn). These materials served as both artificial receptors for nucleic acid aptamers and nanozymes with peroxidase-like activity.

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Biologically-driven RAFT polymerization-amplified platform for electrochemical detection of antibody drugs.

Talanta

December 2024

Center for Advanced Analytical Science, Guangzhou Key Laboratory of Sensing Materials and Devices, Guangdong Engineering Technology Research Center for Sensing Materials and Devices, School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, 510006, PR China. Electronic address:

The individualized administration and pharmacokinetics profiling are integral to the safe use of antibody drugs in immunotherapy. Here, we propose an electrochemical platform for the highly sensitive and selective detection of antibody drugs, taking advantage of the affinity capture by the peptide mimotopes together with the signal amplification by the biologically-driven RAFT polymerization (BDRP). Briefly, the BDRP-based platform involves the capture of antibody drugs by peptide mimotopes, the labeling of multiple reversible addition-fragmentation chain-transfer (RAFT) agents to the glycan chains of antibody drugs, and the BDRP-enabled controlled recruitment of numerous redox labels.

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A manganese porphyrin wrapped DNA dendrimer (Mn-DD) was developed through enzyme-free DNA self-assembly and simple and mild groove binding of porphyrin. The Mn-DD not only possessed plenty of manganese porphyrin to amplify the chemiluminescence (CL) signal, but also can be modified with diverse groups via DNA hybridization. Combined with an immunosensor array, Mn-DD can be utilized for CL immunoassay of multiple mycotoxins as a universal tag.

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Dietary supplementation with lycopene improves semen quality and antioxidant status in breeder roosters.

Poult Sci

December 2024

Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, PR China; Key Laboratory of Agricultural Product Processing and Quality Control (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, PR China. Electronic address:

This study investigated the effects of dietary lycopene supplementation on semen quality, testicular histology, antioxidant capacity, and reproductive hormone levels in aging breeder roosters. A total of 96 roosters were randomly divided into four groups and supplemented with 0, 50, 100, and 200 mg/kg of lycopene for six weeks. Lycopene significantly improved semen volume, sperm concentration, motility, viability, and morphological parameters at all doses (P < 0.

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GPR120 exacerbates the immune-inflammatory response in chicken liver by mediating acetochlor induced macrophage M1 polarization.

J Hazard Mater

December 2024

College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang 150040, PR China. Electronic address:

Acetochlor is a widely used and highly effective herbicide. Its overuse poses significant threats to biosecurity and ecological integrity, particularly affecting free-ranging birds. Data on its impact, especially mechanisms of liver toxicity in chickens, are lacking.

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Effects of compound immobilized bacteria on remediation and bacterial community of PAHs-contaminated soil.

J Hazard Mater

December 2024

MOE Key Laboratory of Pollution Processes and Environmental Criteria, Tianjin Key Laboratory of Urban Ecology Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, PR China.

Immobilized microorganism technology is expected to enhance microbial activity and stability and is considered an effective technique for removing soil polycyclic aromatic hydrocarbons (PAHs). However, there are limited high-efficiency and stable bacterial preparations available. In this study, alkali-modified biochar (Na@CBC700) was used as the adsorption carrier, sodium alginate (SA) and polyvinyl alcohol (PVA) as embedding agents, and CaCl as the cross-linking agent to prepare immobilized Acinetobacter (CoIMB) through a composite immobilization method.

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