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Tamoxifen induced multinucleated cells (symplasts) and distortion of seminiferous tubules in rat testis.

Asian J Androl

September 2003

Department of Physiology, School of Medical Sciences, PPSP University Science Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.

Aim: To evaluate the effect of tamoxifen citrate on male reproductive system of rat.

Methods: Groups of male rats were gavaged with tamoxifen at doses of 200 mg x kg(-1) x d(-1), 400 mg x kg(-1) x d(-1) or 800 mg x kg(-1) x d(-1) in 0.1 mL olive oil for 10 consecutive days.

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