The Impact of Mood Disorders on Adherence, on Life Satisfaction and Acceptance of Illness-Cross-Sectional Observational Study.

Mood disorders are among the most prevalent and debilitating mental conditions in worldwide populations. The aim of this study was to identify the factors influencing life satisfaction, disease acceptance, and therapeutic adherence among people with mood disorders. : This survey-based study included 103 people with mood disorders.

Is Fluoride Blameless?-The Influence of Fluorine Compounds on the Invasiveness of the Human Glioma-like Cell Line U-87.

Glioblastoma remains one of the most treatment-resistant and malignant human cancers. Given the documented harmful effects of fluoride on the developing central nervous system and the rising incidence of brain tumors, especially among children, it is pertinent to explore the role of environmental toxins, including fluoride compounds, in the context of brain cancer. This study represents the first investigation into the influence of fluoride on mechanisms related to the invasiveness of human glioblastoma cells.

Characterization of Platelet Receptors and Their Involvement in Immune Activation of These Cells.

The article characterises platelets, pointing out the role and contribution of their numerous receptors determining their specific and broad immune activity. Three types of platelet receptors are described, that is, extracellular and intracellular receptors-TLR (toll-like receptors), NLR (NOD-like receptor), and RLR (RIG-I-like receptor); extracellular receptors-selectins and integrins; and their other extracellular receptors-CLR (C-type lectin receptor), CD (cluster of differentiation), TNF (tumour necrosis factor), among others. Outlining the contribution of these numerous platelet receptors to the intravascular immunity, it has been shown that they are formed by their fusion with pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and lifestyle-associated molecular patterns (LAMPs).

The Association of Short-Chain Fatty Acids with the Occurrence of Gastrointestinal Symptoms in Infants.

Short-chain fatty acids (SCFAs) are produced by the fermentation of undigested polysaccharides; they are a group of metabolites resulting from the activity of intestinal bacteria. The main SCFAs are acetic, butyric, propionic, valeric, and caproic acid, and their levels and proportions depend on various factors. The aim of this study was to investigate the relationship between the concentration of SCFAs and the occurrence of specific gastrointestinal symptoms in infants.

Antiaging Properties of Ethanol Extract-Ex Vivo and In Vitro Studies.

Species of the genus have a long history of therapeutic use in ethnomedicine, linked to their remarkable medical properties. These species include succulents, which grow in tropical regions. Despite the great interest in this plant, there are no reports about its therapeutic effects on the skin.

Diet Biofunctionality in Modulating Cardiovascular Parameters in Obese Patients After Bioenteric Intragastric Balloon Bariatric Surgery.

Background/objectives: Adiposopathy is the cause of many secondary disorders in the function and structure of many organs and systems in the body. In the progression of obesity and the increasing dysfunction of anti-inflammatory me-diators, chronic inflammation occurs. This may be accompanied by the development of metabolic complications.

The Role of Light in Enhancing the Nutritional and Antioxidant Qualities of Basil, Mint and Lemon Balm.

Mint ( L.), basil, () and Melissa ( L.) are herbaceous plants from the family.

Factors affecting pain experience after lower third molar germectomy in teenagers-a clinical study.

Aim: This study aimed to investigate the correlation between subjective pain threshold (SPT), daily pain recovery (PR) during the first postoperative week, and patient/surgical characteristics, while evaluating changes in SPT across multiple surgeries. Additionally, it assessed how perceived quality of life correlates with SPT and PR in adolescents undergoing lower third molar germectomy.

Methods: A prospective clinical study was conducted at the Paediatric Surgery Unit, Sapienza University of Rome, involving 51 patients aged 10-16 years undergoing lower third molar germectomy.

Initial Multicenter Experience With the New Castor Arch Branched Device in Europe: A Middle-term Results Study.

Background: Published reports demonstrate that the use of Castor stent-graft is a promising treatment of aortic pathologies with the need to land in zone 2. However, there is a lack of publications on the medium-term results of Castor in the European population. This research evaluates the mid-term results of the Castor stent-graft in several Polish centers for the treatment of aortic pathologies and enriches the current knowledge of Castor stent-grafts.

The association between patients' personality traits and pain perception during orthodontic treatment: a systematic review.

Background: Orthodontic treatment is frequently correlated with different levels of discomfort and pain, caused by the application of forces to move the teeth. The mechanism of orthodontic pain is based on the initially activation of sensory receptors in periodontal tissues which results in a cascade of nociceptive pain processing and transduction in both the central and peripheral nervous systems that is finally experienced by patients. The perception of pain is subjective and varies among people, as it is influenced by both general and individual elements.

Choline kinases: Enzymatic activity, involvement in cancer and other diseases, inhibitors.

One of the aspects of tumor metabolism that distinguish it from healthy tissue is the phosphorylation of choline by choline kinases, which initiates the synthesis of phosphatidylcholine. Presently, there is a lack of comprehensive reviews discussing the current understanding of the role of choline kinase in cancer processes, as well as studies on the anti-tumor properties of choline kinase inhibitors. To address these gaps, this review delves into the enzymatic and non-enzymatic properties of CHKα and CHKβ and explores their precise involvement in cancer processes, particularly cancer cell proliferation.

Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers.

A double primary colorectal cancer (CRC) in a familial setting signals a high risk of CRC. In order to identify novel CRC susceptibility genes, we whole-exome sequenced germline DNA from nine persons with a double primary CRC and a family history of CRC. The detected variants were processed by bioinformatics filtering and prioritization, including STRING protein-protein interaction and pathway analysis.

Identifying the unknown: Application of molecular epidemiology tools to identify clustering and HIV transmission routes in Poland.

Background: Understanding the dynamics of HIV-1 transmission is essential for developing effective screening and intervention strategies. Viral genetic sequences provide valuable information that can be used to infer the history and patterns of viral transmission.

Purpose: Our study explores the structure and dynamics of HIV transmissions in Poland from 1999 to 2022 to elucidate key patterns related with national epidemics.

GLP-1 Receptor Agonists: A Promising Therapy for Modern Lifestyle Diseases with Unforeseen Challenges.

Modern lifestyle diseases remain a persistent challenge in healthcare. Currently, about 422 million people worldwide are affected by diabetes, while 1 in 8 people are living with obesity. The development of glucagon-like peptide 1 receptor agonists (GLP-1RAs) has marked a significant milestone in treating these conditions.

The Role of Vitamin D3 Deficiency and Colonization of the Oral Mucosa by Yeast-like Fungi in the Pathomechanism of Psoriasis.

Psoriasis is a chronic inflammatory skin disease with complex pathogenesis and variable severity. Performed studies have indicated the impact of vitamin D3 deficiency on the pathogenesis of psoriasis and its severity. However, there is no clear evidence of the influence of the mucosal microbiome on the onset and progression of psoriasis.

Analysis of the Influence of Personality Traits on the Level of Knowledge and Health Behaviours of Cardiac Patients.

: Numerous risk factors of cardiac diseases are influenced by health behaviours. An individual's health behaviours, somatic symptoms and even cardiac outcomes can be influenced by their personality. The aim of this study was to analyse the influence of personality traits on the knowledge and health behaviour of cardiac patients.

Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage-The Results of an Observational Cohort Study.

Subarachnoid hemorrhage (SAH) is associated with high mortality and a high level of disability. Progress in surgical and endovascular techniques has lowered the mortality rate in patients with SAH. However, many patients are left with neurological impairment.

Propolis in Dental Implantology: A Systematic Review of Its Effects and Benefits.

Dental implants are widely recognized for their effectiveness in restoring missing teeth, yet their success is often compromised by infections or inadequate osseointegration. Propolis, a natural resinous substance with potent antimicrobial, anti-inflammatory, and osteogenic properties, has emerged as a promising adjunct in dental implantology. This systematic review critically evaluates the current evidence on the incorporation of propolis into dental implants, focusing on its impact on antimicrobial efficacy, bone healing, and overall implant stability.

Empowering EVAR: Revolutionizing Patient Understanding and Qualification with 3D Printing.

Background: This study addresses the need for enhanced patient education in the context of abdominal aortic aneurysm (AAA) and its treatment through endovascular aneurysm repair (EVAR). Effective patient education is essential for improving comprehension and engagement, particularly for those facing complex medical conditions.

Methods: A total of 55 patients scheduled for EVAR participated in the study.

Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents.

Objective: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide.

Method: This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization-Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori- defined individual/cumulative risk factors were measured.

Epithelioid inflammatory myofibroblastic sarcoma with exceptionally long response to lorlatinib-a case report.

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and aggressive subtype of inflammatory myofibroblastic tumor. The disease is associated with rearrangements of the anaplastic lymphoma kinase (ALK). In this paper, we present the clinicopathological features and treatment of a female patient diagnosed with EIMS.