Impact of hematopoietic cell transplantation and quizartinib in newly diagnosed patients with acute myeloid leukemia and FMS-like tyrosine kinase 3-internal tandem duplications in the QuANTUM-First trial.

QuANTUM-First (NCT02668653) was a randomized phase 3 trial in newly diagnosed FLT3-ITDQpositive acute myeloid leukemia (AML) patients treated with quizartinib or placebo plus standard induction and consolidation chemotherapy and/or allogeneic hematopoietic cell transplantation (allo-HCT), followed by single-agent maintenance therapy. We evaluated the impact of allo-HCT performed in first complete remission (CR1) or composite CR1 (CRc1) on overall survival (OS), considering treatment randomization. Post-hoc extended Cox regression multivariable analyses were conducted in patients who achieved CR/CRc by the end of induction, including allo-HCT in CR1/CRc1 as a time-dependent variable to identify prognostic and predictive factors for OS.

Separation Anxiety and Personality Domains in a Dimensional Perspective: A Cross-Sectional Study in a Sample of Adults with Personality Disorders.

Background: Recent developments have highlighted the importance of separation anxiety across the lifespan, positioning it as a longitudinal psychopathological dimension. Few studies in the past decade, have explored this correlation within the context of other psychiatric disorders. This study aims to assess the presence of childhood and adulthood separation anxiety in a sample of adults with personality disorders, and its potential contribution to specific personality domains.

Economic burden of antimicrobial resistance on patients in Pakistan.

Background: Antimicrobial resistance (AMR) occurs when microbes undergo changes that render antimicrobial drugs ineffective against them, resulting in limited, more expensive treatment options, longer hospital stays, and increased mortality rates. No study has estimated the costs related to AMR in hospitals in Pakistan. This study was conducted to determine the financial burden of antimicrobial resistance (AMR) in Pakistan and to compare it with the additional costs incurred by patients who respond well to antimicrobial treatments.

Antimicrobial Resistance and Migration: Interrelation Between Two Hot Topics in Global Health.

Antimicrobial resistance (AMR) and migration are two interlinked issues and both pose an escalating threat to global health. With an increasing trend, there are 281 million migrants globally, while AMR is contributing to over 5 million deaths annually, with a projected rise to 10 million by 2050 if left unaddressed. Both AMR and migration are multifaceted problems that extend beyond human health, involving animals, plants, and the environment-a fact highlighted by the One Health approach.

Guidance for stem cell therapy for juvenile systemic sclerosis patients.

Introduction: Autologous stem cell transplantation (ASCT) and cellular therapies (CTs) are emerging therapeutic options for both adult and juvenile-onset systemic sclerosis (jSSc) patients. However, most efficacy data are derived from adult studies, and it remains unclear whether adult stem cell transplant criteria are fully applicable to pediatric patients with jSSc. Given pediatric patients' unique potential for recovery and tissue remodeling, the stringent criteria used in adults need adaptation for children.

Cefiderocol for the Treatment of Nosocomial Bloodstream Infections Caused by Stenotrophomonas maltophilia: A Case Series and Literature Review.

Introduction: The treatment of Stenotrophomonas maltophilia bloodstream infections (BSI) remains challenging due to the organism's intrinsic multidrug resistance and the potential side effects of commonly used first-line antibiotics.

Methods: Here, we describe four cases of S. maltophilia BSI treated with cefiderocol (≥ 72 h) in different Italian hospitals.

Epidemiology of smoking habits among healthcare workers employed in a regional reference teaching hospital in Northern Italy: a cross-sectional study.

Introduction: Tobacco consumption is one of the most significant avoidable health risks and cause of premature death globally. Smoking in the workplace represents a potential combination of health risks due to the interactions of tobacco use and professional exposure. Occupational Health Professionals can aid in health promotion of workers and improvement of workplace environment.

Human Papillomavirus Infection in Partners of Women Attending Cervical Cancer Screening: A Pilot Study on Prevalence, Distribution, and Potential Use of Vaccines.

: Human Papillomavirus (HPV) cross-infection among couple's partners is a widespread event and could lead to persistent infections. Unfortunately, the influence of male sexual partners of HPV-positive women on their cervical lesions and the potential role of HPV vaccines have been under-investigated. We evaluated the HPV prevalence in male partners of HPV-infected women, focusing on the possible correlation between partners' cervical lesions and the role of HPV vaccination.

Occupational Injuries and Their Determinants Among Healthcare Workers in Western Countries: A Scoping Review.

Background: Healthcare workers (HCWs) in developed countries can be exposed to a wide range of hazards. The systematic identification of working conditions associated with the risk of occupational injury can significantly reduce this risk.

Methods: From January 2000 to December 2021, a scoping review was performed using PCC (Population, Concept, and Context) criteria and searching major scientific databases.

Use of an off the Shelf Inner Branch Thoraco-abdominal Endograft for the Treatment of Juxtarenal and Pararenal Aortic Aneurysms.

Objective: To investigate outcomes obtained using an off the shelf pre-loaded inner branched endograft (E-nside) for the treatment of juxtarenal and pararenal aortic aneurysms (J-PRAA).

Methods: Data from a multicentre registry (INBREED), including patients treated with E-nside endograft, were prospectively collected and analysed. Patients treated for J-PRAA were included.

Sex and gender differences during the lung lifespan: unveiling a pivotal impact.

Sex and gender differences significantly influence lung parenchyma development, beginning as early as the embryonic stages of human life. Although this association is well known in the clinical manifestations of some relevant pulmonary diseases, there is less data available regarding their effects on cell biological programmes across different stages of body development. A deep understanding of these mechanisms could help in defining preventive strategies tailored to a fully personalised approach to respiratory medicine.

How to Effectively Communicate Dismal Diagnoses in Dermatology and Venereology: From Skin Cancers to Sexually Transmitted Infections.

: One of the problematic situations dermatologists face with their patients is communicating dismal diagnoses. Examples are the diagnosis and prognosis of skin cancers like melanoma and Merkel cell carcinoma and the disclosure of the chronic nature of a disease that requires long-term therapies or can lead to scarring or disfiguring conditions. Likewise, receiving a diagnosis of a sexually transmitted infection can be a shocking event that can also put into question the patient's relationship with his/her partner/partners.

Genetic Background and Clinical Phenotype in an Italian Cohort with Inherited Arrhythmia Syndromes and Arrhythmogenic Cardiomyopathy (ACM): A Whole-Exome Sequencing Study.

Inherited arrhythmia syndromes include several different diseases, as well as Brugada syndrome (BrS), long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and short QT syndrome (SQTS). They represent, together with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), an important cause of sudden cardiac death in the young. Most arrhythmia syndromes are inherited in an autosomal dominant manner, and genetic studies are suggested.

Current management of patients affected by benign prostatic hyperplasia: a multi-institutional study from a contemporary large Italian cohort.

Background: Despite a large amount of literature focused on pharmacologic and surgical therapy for benign prostate hyperplasia (BPH), little is known about clinical presentation and management of outpatient clinic patients. We aimed to conduct a tailored analysis of BPH-affected patients, comparing men with known BPH versus newly diagnosed. The analysis was made through International Prostate Symptom Score (IPSS) and BPH Impact index (BII).

Ultra High-Density Mapping and Ablation of Localized Micro-Reentrant Tachycardias: Insight From the CHARISMA Registry.

Background: Recent advancements in ultra-high-density mapping (UHDM) featuring automated functionalities have enhanced our understanding of micro-reentrant atrial tachycardias (mAT) circuits and the precise localization of the origin.

Purpose: To evaluate the diagnostic support provided by an automated UHDM algorithm in guiding the ablation of mATs.

Methods: Consecutive patients eligible for AT ablation in 22 Italian centers were prospectively enrolled.

Gender Differences Are a Leading Factor in 5-Year Survival of Patients with Idiopathic Pulmonary Fibrosis over Antifibrotic Therapy Reduction.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with a median survival of 3-5 years. Antifibrotic therapies like pirfenidone and nintedanib slow progression, but the outcomes vary. Gender may influence disease presentation, progression, and response to treatment.

Primary Epithelioid Angiosarcoma of the Penis: A Case Report With a Brief Review of the Literature.

Angiosarcoma of the penis is an exceptionally rare mesenchymal tumor, with only about 30 cases documented in the literature. Because of its rarity and the often nonspecific clinical presentation, histopathological examination plays a critical role in accurate diagnosis. Angiosarcoma of the penis typically arises in the corpus cavernosum but has also been reported in the glans and urethra, often presenting with metastases.