3 results match your criteria: "PLA Strategic Support Force Medical Center (The 306th Hospital of PLA)[Affiliation]"
Harnessing noncanonical trans-cleavage characteristics of Cas12 and Cas13a to enhance CRISPR-based diagnostics.
Commun Biol
October 2024
Zhongshan-Xuhui Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Cas12 and Cas13 are extensively utilized in molecular diagnostics for their trans-cleavage activities, yet their activation characteristics remain partially understood. Here, we conduct an in-depth investigation of Cas12a, Cas12f1, and Cas13a, uncovering the characteristics of their trans-DNase and trans-RNase activities with noncanonical activators. Our findings reveal that DNA can serve as a direct target for CRISPR-Cas13a, markedly increasing the detection sensitivity for single-base mismatches.
View Article and Find Full Text PDFTrends in metabolic indicators and microvascular complications in Chinese adults with newly diagnosed type 2 diabetes: A retrospective, single-centre study of twenty-years.
Diab Vasc Dis Res
June 2023
Department of Endocrinology, Diabetes Centre of People's Liberation Army (PLA), PLA Strategic Support Force Medical Center (The 306th Hospital of PLA), Sohu Inc, Beijing, China.
Background: The purpose of this study is to assess metabolic indicators and trends in microvascular complications among Chinese adults with newly diagnosed type 2 diabetes during 2000-2020.
Methods: 3,907 patients were included and divided into three groups according to a time period of 7 years. This study analyzed trends in proportions of patients reached therapeutic targets of blood glucose, pressure and lipids, and trends in albuminuria, retinopathy, and peripheral neuropathy.