3 results match your criteria: "PLA Navy No. 971 Hospital[Affiliation]"
Ginsenoside Rh1 regulates the immune microenvironment of hepatocellular carcinoma via the glucocorticoid receptor.
J Integr Med
November 2024
Department of Traditional Chinese Medicine, PLA Navy No. 971 Hospital, Qingdao 266071, Shandong Province, China. Electronic address:
Article Synopsis
- Ginsenoside Rh1 (G-Rh1) has potential therapeutic effects on hepatocellular carcinoma (HCC), although its impact was previously unclear, as it has shown effectiveness against other cancers like breast and colon cancer.
- The study used various methods, including bioinformatics and in vitro & in vivo experiments, to examine G-Rh1's effects on HCC cells and the immune environment of tumors.
- Results indicated that G-Rh1 did not significantly impact HCC cell growth but improved the immune response by enhancing the infiltration of key immune cells and increasing MHC-I expression, suggesting its role in fighting cancer by modifying the tumor microenvironment.
MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2.
Br J Cancer
September 2022
State Key Laboratory of Proteomics, Institute of Basic Medical Sciences, National Center of Biomedical Analysis, 100850, Beijing, China.
Background: The mechanism of recurrence and metastasis of hepatocellular carcinoma (HCC) is complex and challenging. Methyl-CpG binding domain protein 3 (MBD3) is a key epigenetic regulator involved in the progression and metastasis of several cancers, but its role in HCC remains unknown.
Methods: MBD3 expression in HCC was detected by immunohistochemistry and its association with clinicopathological features and patient's survival was analysed.
Antimicrobial peptide AR-23 derivatives with high endosomal disrupting ability enhance poly(l-lysine)-mediated gene transfer.
J Gene Med
November 2020
Department of Stem Cell and Regenerative Medicine, Institute of Health Service and Transfusion Medicine, Beijing, China.
Background: pH-sensitive peptides are a relatively new strategy for conquering the poor endosomal release of cationic polymer-mediated transfection. Modification of antimicrobial peptides by exchanging positively-charged residues with negatively-charged glutamic acid residues (Glu) greatly improves its lytic activity at the endosomal pH, which could improve cationic polymer-mediated transfection.
Methods: In the present study, we investigated the effect of the number of Glu substituted for positively-charged residues on the endosomal escape activity of AR-23 and the ability of mutated AR-23 with respect to enhancing cationic polymer-mediated transfection.